HomeRadiologyVol. 303, No. 3 PreviousNext Reviews and CommentaryFree AccessImages in RadiologyX-ray Dark-field Chest Radiography of LymphangioleiomyomatosisFlorian T. Gassert , Franz PfeifferFlorian T. Gassert , Franz PfeifferAuthor AffiliationsFrom the Department of Diagnostic and Interventional Radiology, School of Medicine & Klinikum Rechts der Isar, Technical University of Munich, Ismaninger Str 22, 81675 Munich, Germany (F.T.G., F.P.); and Department of Physics, School of Natural Sciences (F.P.), and Institute for Advanced Study (F.P.), Technical University of Munich, Garching, Germany.Address correspondence to F.T.G. (e-mail: [email protected]).Florian T. Gassert Franz PfeifferPublished Online:Mar 29 2022https://doi.org/10.1148/radiol.212490MoreSectionsPDF ToolsImage ViewerAdd to favoritesCiteTrack CitationsPermissionsReprints ShareShare onFacebookTwitterLinked In A 31-year-old woman presented to our emergency department with persistent pain following epigastric herniotomy. Abdominal CT showed no evidence of recurrent hernia or incarceration. However, the partially imaged lung bases showed cystic changes in the parenchyma and multiple small nodules. A dedicated chest CT scan confirmed these findings throughout both lungs, consistent with lymphangioleiomyomatosis (LAM) (Fig 1). Transbronchial biopsy revealed cystically dilated alveolar spaces, confirming the diagnosis of LAM. LAM is a rare, idiopathic disease resulting from the proliferation of abnormal smooth muscle LAM cells in the lungs and other organs. It almost exclusively affects women of childbearing age. It is a slowly progressive disease that can lead to chronic respiratory insufficiency, and lung transplant is currently the only effective treatment available.Figure 1: (A) Coronal and (B) axial reformatted chest CT images in a 31-year-old woman show thin-walled cysts of variable sizes (arrowheads) surrounded by normal lung parenchyma as well as interlobular septal thickening in all lobes and multiple vessel-associated round foci, most likely corresponding to pulmonary arteriovenous malformations (arrows in A). The yellow line in A indicates the position of the axial reformation.Figure 1:Download as PowerPointOpen in Image Viewer X-ray dark-field chest radiography is a novel imaging technique that exploits the wave character of x-rays by measuring the amount of refraction occurring at air-tissue interfaces such as in the alveoli. Therefore, it enables assessment of the alveolar integrity and provides additional information complementing conventional, attenuation-based radiography (1,2). In animal models (3–5), dark-field imaging has previously been shown to be beneficial for the assessment of various pulmonary pathologic conditions, including lung cancer, pulmonary fibrosis, pneumonia, pneumothorax, and emphysema. In the presented case, additional x-ray dark-field chest radiography was performed, yielding both a conventional, attenuation-based radiograph and an x-ray dark-field chest radiograph (6) (Fig 2). The x-ray dark-field chest radiograph in the patient with LAM exhibited an overall low and inhomogeneous signal with focal areas of signal loss, predominantly in the right inferior lung field, corresponding well to the most affected lower lobe on the respective CT scan.Figure 2: (A, D) Conventional attenuation-based chest radiographs, (B, E) x-ray dark-field chest radiographs, and (C, F) color-coded dark-field images laid over inverted conventional radiographs in a 31-year-old woman diagnosed with lymphangioleiomyomatosis (LAM) (top row) and a healthy 33-year-old man (bottom row). The same window and level settings were applied within the respective modality. For the color-coded overlays in C and F, the dark-field signal (blue) was laid over the inverted chest radiograph. While the dark-field chest radiograph of the healthy man (E) exhibits a high, homogeneous signal, the dark-field chest radiograph of the patient with LAM (B) exhibits an overall low and inhomogeneous signal with focal areas of signal loss, predominantly in the right inferior lung field (arrowheads), corresponding well to the multiple cysts, in particular those present in the right lower lobe in the respective CT scan (Fig 1, arrowheads). The color-coded overlays combine information on both attenuating tissues and alveolar structure.Figure 2:Download as PowerPointOpen in Image Viewer Disclosures of conflicts of interest: F.T.G. No relevant relationships. F.P. No relevant relationships.Supported by the European Research Council (AdG 695045) and the Deutsche Forschungsmeinschaft (GRK 2274). This work was carried out with the support of the Karlsruhe Nano Micro Facility, a Helmholtz Research Infrastructure at Karlsruhe Institute of Technology.
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