Deodorization Effect Research Articles

Deodorization mechanism of the main aroma compounds on the fishy odor in boiled fish during heating.

A boiled fish simulation system was constructed to explore the deodorization effect of main aroma compounds (MAC) on myofibrillar protein (MP) with main fishy compounds (MFC) during heating. The results showed that the MFC content of boiled fish was reduced by 63.10-78.10% when boiled by heat-stable emulsions loading MAC. Specifically, adding linalool, anethole, and myrcene significantly elevated the free percentage of hexanal, heptanal, and 1-octen-3-ol after heating, while the free percentage of octanal and nonanal markedly increased by adding anethole and limonene. Molecular docking exhibited that MAC and MFC possessed co-binding sites with myosin. Linalool and anethole were competitively bound to MP through hydrophobic and hydrogen bonding sites, while myrcene and limonene were via hydrophobic interaction sites. Moreover, MAC-MP formed a relatively stable structure, exhibiting increased α-helix content and decreased surface hydrophobicity, which reduced the available sites for MFC binding, ultimately desorbed MFC (65.46%-95.89%).

Research on the deodorization effect, mechanism and high-temperature rheological properties of SBS-modified asphalt by plant extract aldehyde modifier

ABSTRACT Asphalt produces harmful fumes during the heating process at high temperatures, seriously harming the environment and human health. To reduce the negative impacts that SBS modified asphalt fume emissions, this study has added three types of plant extract aldehyde modifier to SBS modified asphalt. Through an examination of the constituent parts and quantities of volatile organic compounds (VOCs) in the flue gas, the deodorizing potential of aldehyde modifiers has been assessed. The deodorization mechanism was revealed by microscopic means such as fluorescence microscopy experiments and scanning electron microscopy. Lastly, the high-temperature rheological characteristics of the aldehyde modified asphalt have been examined by dynamic shear rheological (DSR) tests. The results of the study showed that the incorporation of aldehyde modifier greatly reduced the number and concentration of VOCs in the flue gas of SBS modified asphalt. Aldehyde modifiers increase the swelling level of SBS polymers in asphalt, promoting the formation of a tighter network structure among SBS polymers, which restricts the escape of asphalt fumes. They also improve the asphalt’s resistance to deformation and restored creep levels. It is made possible to reduce the pressure of hazardous asphalt flue gas on the environment by the deodorization treatment of SBS modified asphalt.

Tracing the odor source of crumb rubber modified asphalt emissions and evaluating the deodorization effect of attapulgite

Crumb rubber modified asphalt (CRMA) is widely used in road construction due to its excellent performance. However, it generates significant odorous gases during paving. To analyze the odor contribution, both untreated crumb rubber and desulfurized rubber were involved in this study to prepare CRMA and desulfurized rubber modified asphalt (DRMA). Attapulgite was selected as an emission reduction agent to reduce the odorous emissions released from CRMA and DRMA. An indoor fume collection system and gas chromatography-mass spectrometry (GC-MS) analysis were used to trace the odor source and quantify the odorous emissions. A comprehensive olfactory thresholds database for CRMA emissions was further established to evaluate the odor level of various rubberized asphalt binders by using three-point comparative odor bag method, along with known olfactory thresholds of certain compounds reported in the literature. Dynamic shear rheometer (DSR), multiple stress creep recovery (MSCR), bending beam rheometer (BBR) and Brookfield viscosity tests were used to analyze the effect of attapulgite on rheological properties of CRMA and DRMA. Results indicated that odor emission rate of CRMA containing 1 %, 3 %, and 5 % attapulgite was decreased by 42.62 %, 63.29 %, and 71.06 %, respectively. Benzothiazole, derived from tire rubber vulcanization accelerator, can be reduced by 60.25 % with 1 % attapulgite, demonstrating excellent performance in terms of reducing target odor emissions. Although DRMA has a lower emission rate than that of conventional CRMA, the addition of 1 % attapulgite can further reduce the odor emission rate of DRMA by 37.92 %. The addition of attapulgite has less impact on the overall performance of CRMA and DRMA. Besides, it was found that attapulgite can reduce the viscosity of rubberized asphalt binders, which is beneficial for rubberized asphalt mixture paving and compaction. Considering odor reduction, performance, and economic factors, the optimal attapulgite content was determined to be 5 % for CRMA and 1 % for DRMA. This approach successfully reduces odorous emissions while maintaining the desirable properties of CRMA, making it a viable solution for environmentally friendly road construction.

Effect of mild subcritical fluid treatment on meat quality of farmed large yellow croakers

Farmed large yellow croaker fish have stronger fishy smell and less tender texture than wild-caught ones, mostly caused by the high fat accumulation from aquaculture feeding patterns. To improve the commercial value of fillets, this study investigated a mild subcritical fluid treatment with subcritical butane (SBE) and dimethyl ether (SDME). Changes in the chemical compositions, volatile flavor compounds (VFCs) and protein denaturation were determined for 1–5 h treatments. The results showed 24 % and 44 % defatting levels under SBE and SDME treatment, respectively. GC-MS showed that SDME could induce a significant reduction of total VFC content, especially for the dominant aldehydes. There was less n-nonanal (14.65–40.13 mg/kg) and octanal content (1.67–7.21 mg/kg), no detection of trans, trans-2,4-decadienal in the SDME treated samples in comparison to those treated with SBE. The results showed that SDME treatment for 3 h had the best defatting effect, good deodorization effect and less degradation of fish protein.

Investigation into the effects of the refining steps before deodorization on the formation of trans fatty acids in linseed oils

Trans fatty acids (TFAs) are formed in refined linseed oil during the deodorization step. Effects of deodorization on TFA formation in vegetable oils have been intensively investigated. However, the role of refining process (degumming, neutralization, bleaching) before deodorization on TFA formation in the deodorization step remains unclear. In this study, TFA generation potential in linseed oils refined by different ways of degumming, neutralization, bleaching was evaluated, and changes in their quality indexes were also measured. Results showed that adequate refining could improve the quality of linseed oil, while inadequate neutralization or bleaching induced more TFA formation during the deodorization step, suggesting that pigments or free fatty acids in linseed oils might promote TFA formation. Meanwhile, spiked experiments, in which partly refined linseed oils were spiked with pigments or α-linolenic acid, confirmed that pigments or free fatty acids in linseed oils induced the isomerization of unsaturated fatty acids. This study demonstrated that TFA formation in refined linseed oils could be mitigated by optimizing refining processes before deodorization, and also provided theoretical basis for oil refining industry to control the oil quality.

Control of nitrogen and odor emissions during chicken manure composting with a carbon-based microbial inoculant and a biotrickling filter

Although aerobic composting is usually utilized in livestock manure disposal, the emission of odorous gases from compost not only induces harm to the human body and the environment, but also causes loss of nitrogen, sulfur, and other essential elements, resulting in a decline in product quality. The impact of biotrickling filter (BTF) and insertion of carbon-based microbial agent (CBMA) on compost maturation, odor emissions, and microbial population during the chicken manure composting were assessed in the current experiment. Compared with the CK group, CBMA addition accelerated the increase in pile temperature (EG group reached maximum temperature 10 days earlier than CK group), increased compost maturation (GI showed the highest increase of 41.3% on day 14 in EG group), resulted in 36.59% and 14.60% increase in NO3−-N content and the total nitrogen retention preservation rate after composting. The deodorization effect of biotrickling filter was stable, and the removal rates of NH3, H2S, and TVOCs reached more than 90%, 96%, and 56%, respectively. Furthermore, microbial sequencing showed that CBMA effectively changed the microbial community in compost, protected the ammonia-oxidizing microorganisms, and strengthened the nitrification of the compost. In addition, the nitrifying and denitrifying bacteria were more active in the cooling period than they were in the thermophilic period. Moreover, the abundance of denitrification genes containing nirS, nirK, and nosZ in EG group was lower than that in CK group. Thus, a large amount of nitrogen was retained under the combined drive of BTF and CBMA during composting. This study made significant contributions to our understanding of how to compost livestock manure while reducing releases of odors and raising compost quality.

Effects of Salt Soaking Treatment on the Deodorization of Beef Liver and the Flavor Formation of Beef Liver Steak.

In this study, based on the evaluation of fishy value and sensory evaluation, this study determined that soaking in a 1% salt solution for 60 min had a significant impact on the deodorization of beef liver (p < 0.05). The results showed that salt infiltration promoted the release of fishy substances, improving the edible and processing performance of beef liver. The identification of flavor compounds in raw and roasted beef liver via GC-IMS implies that (E)-2-octenal-M, (E)-3-penten-2-one-M, ethyl acetate-M, ethyl acetate-D, and methanethiol are closely related to improving the flavor of beef liver; among them, (E)-2-octenal-M, (E)-3-penten-2-one-M, and methanethiol can cause beef liver odor, while nonanal-M, octanal-M, benzene acetaldehyde, n-hexanol-D, butyl propanoate-M, heptanal-D, heptanal-M, and 3-methylthiopropanal-M had significant effects on the flavor formation of beef liver steak. The determination of reducing sugars revealed that salt soaking had no significant effect on the reducing sugar content of beef liver, and the beef liver steak was significantly reduced (p < 0.05), proving that reducing sugars promoted the formation of beef liver steak flavor under roasting conditions. Fatty acid determination revealed that salt soaking significantly reduced the content of polyunsaturated fatty acids in beef liver (p < 0.05), promoting the process of fat degradation and volatile flavor production in the beef liver steak. Salt plays a prominent role in salting-out and osmosis during deodorization and flavor improvement. Through controlling important biochemical and enzymatic reactions, the release of flavor substances in a food matrix was increased, and a good deodorization effect was achieved, which lays a foundation for further research on the deodorization of beef liver and the flavor of beef liver steak.

Screening of skatole-degrading bacteria and control of human fecal odor by compound bacteria

PurposeThe biodegradation of skatole was used as a starting point in this study, and existing strains of degrading NH3 and H2S in the laboratory were combined to create a composite deodorant. The deodorization effect of the composite deodorant on human feces was investigated in order to provide a foundation for fecal odor gas treatment.MethodsSkatole-degrading bacteria were identified, degradation conditions were optimized, and skatole metabolites were identified using liquid chromatography-mass spectrometry (LC-MS). The skatole-degrading bacteria were combined with the existing strains of degrading NH3 and H2S in the laboratory to make a compound deodorizer, and the deodorizing effect of the compound deodorizer on fresh human feces and old human feces was compared. Liquid chromatography, specific sensors, and gas chromatography were used to determine the contents of skatole, NH3, H2S, and volatile organic compounds, and the microbial diversity was examined.ResultsMicrobial agents H and Y capable of utilizing skatole were screened out under aerobic and facultative anaerobic conditions, respectively. Within 48 h, the degradation rate of skatole by microbial agent Y was 88.52%. Following condition optimization, the optimum temperature for skatole degradation by microbial agent Y was 33 °C, and the optimum pH was 7. The main functional bacteria were Acinetobacter xiamenensis. The metabolites of skatole were determined by liquid chromatography-mass spectrometry (LC–MS), and six possible metabolites were found, including 3-aldehyde indole, 3-carboxyl indole, 1H-indole-2,3-dione, and 3-methyl indole pyruvate. The skatole-degrading bacteria Lactobacillus rhamnosus and Saccharomyces cerevisiae were then combined in proportion to form a composite deodorant. The 5-day degradation rate of skatole in the old manure group was 88.11%, while the 5-day degradation rate in the fresh manure group was 47.56%.ConclusionsThe compound microbial agent developed in this study has a solid deodorizing effect, particularly in the control of the odor of obsolete feces. The use of composite microbial agents can efficiently degrade skatole in human feces, providing a theoretical foundation for the use of microbial remediation in the actual world.Graphical

Establishment of a novel loach-deodorization technology based on gas chromatography-ion mobility spectroscopy analysis

Fishy odor has been a major limiting factor for the production and commercialization of loach. Herein, this study aims to develop an efficient deodorization process using single-factor experiments and Design-Expert response surface methodology. The deodorization capability is evaluated using gas chromatography-ion mobility spectroscopy (GS-IMS). As a result, the trehalose-sweet wine koji method was selected and the final optimal deodorization conditions were shown as follows: the compound ratio of trehalose to sweet wine koji was 51:1, the content of sweet wine koji was 0.10%, and the deodorization time was 33 min at 17 °C. Under the conditions, the final trimethylamine content of loach was reduced by 89%. A total of 29 volatile compounds in loach samples before and after deodorization were identified by GC-IMS, including 11 aldehydes, 8 alcohol, 7 ketones, 1 ester, and 2 olefins. Volatile compounds responsible for fish-like odor, such as hexanal, pentanal, heptanal, benzaldehyde, octanal, nonanal, n-butanol, pentanol, and acetone, were decreased in intensity. Principal component and fingerprint analysis confirmed the deodorization effect of this process on loach was significant (p < 0.05). Collectively, the study developed an efficient loach deodorization method, which will improve the quality of loach production.

Mechanism and process optimization for H2S removal by plant-derived deodorant

Plant-derived deodorant shows exciting prospect for odorous gas control, while controversy still exists on its effect of removing the malodorous substances with the fact that the removal mechanism and parameter optimization of this deodorization technology were rarely reported. Herein, a laboratory-scale bubbling absorption tower was used to conduct orthogonal test designed with three factors of five levels to investigate the efficiency of plant-derived deodorant to remove hydrogen sulfide (H2S). Compared with water, the aqueous solution of plant-derived deodorants could effectively remove H2S with a maximum removal efficiency of 99.99%. In particular, the removal efficiency of deodorant was about 40% higher than that of water at the H2S concentration of 70 mg/m3. After treated by the aqueous solution of plant-derived deodorants, the outlet concentration of H2S could be lower than 0.02 mg/m3, meeting the requirement of the odor pollutant emission standards in many countries, which exhibited the feasibility of using it an effective way to control H2S. Among the parameters including air input, concentration of H2S, and concentration of plant-derived deodorant, concentration of deodorant was the parameter that presented the most significant impact on the deodorization effect. The calculation results of absorption and reaction parameters showed that the removal of H2S by plant-derived deodorants is a process controlled by chemical absorption.

Effects of deodorization on the content of polycyclic aromatic hydrocarbons (PAHs), 3-monochloropropane-1,2-diol esters (3-MCPDE) and glycidyl esters (GE) in rapeseed oil using ethanol steam distillation at low temperature

High temperature is beneficial for the removal of polycyclic aromatic hydrocarbons (PAHs) from oil via steam, but leads to an increase in the content of 3-monochloropropane-1,2-diol esters (3-MCPDE) and glycidyl esters (GE). To inhibit the production of 3-MCPDE and GE during the removal of PAHs, rapeseed oil was deodorized using ethanol steam at low-temperature (140–220 °C) (L-ESD) and the content changes were studied for PAHs, 3-MCPDE and GE, and compared with conventional high-temperature water steam deodorization (H-WSD) (250 °C for 60 min). The removal rates of PAHs in L-ESD oil can be higher than those in conventional H-WSD oil, and the contents of 3-MCPDE and GE in L-ESD oil (140–180 °C for 60–100 min) ranged from 48.32 to 73.65 % and 50.49–69.90 %, respectively, in H-WSD oil due to the lower temperature of ethanol steam deodorization. These results indicate that L-ESD is beneficial in minimizing the contents of PAHs, 3-MCPDE and GE in vegetable oil.

Effect of β-cyclodextrin deodorization on the volatile chemicals and functional properties of three types of gelatins.

The exploration of deodorization is important for the application of gelatin in food industry. In this work, the effect of β-cyclodextrin (β-CD) deodorization on the volatile chemicals and functional properties of three types of gelatins (commercial porcine skin gelatin, cold water fish skin gelatin, and Chinese longsnout catfish skin gelatin) were studied. The results suggested the odors of commercial gelatins were significantly less than home-extracted gelatins. The β-CD deodorization efficiency was dependent on both β-CD concentration and volatile chemical. (E)-2-Octenal (C8H14O), 1-octen-3-ol (C8H16O), 2-pentyl-furan (C9H14O), and hentriacontane (C17H36) could be deodorized at low β-CD concentration (even at 2 mg/mL). The best β-CD deodorization concentration for 66.7 mg/mL of Chinese longsnout catfish skin gelatin was 30 mg/mL. β-CD addition could not change the gel forming ability and emulsion activity of gelatins, whereas it had different and concentration-dependent effects on the emulsion stability of gelatins. β-CD addition had no obvious effects on the droplet sizes, droplet coalescence and liquid-gel transition behaviors, but had different effects on the creaming of the emulsions stabilized by three types of gelatins. The encapsulation of β-carotene did not significantly change the droplet trimodal size distribution and liquid-gel transition of fish oil-loaded emulsions. However, β-carotene might delay the droplet coalescence. The creaming stability of β-carotene/fish oil-loaded gelatin/β-CD-stabilized emulsions was dependent on the gelatins, β-CD, and β-carotene. Finally, the β-carotene retention in the emulsions was dependent not on β-CD addition but on the nature of the gelatins. These results provided useful information to understand the molecular deodorization behaviors and explore the deodorization of emulsifiers for food emulsions.

Nitrogen removal characteristics of efficient heterotrophic nitrification-aerobic denitrification bacterium and application in biological deodorization

A heterotrophic nitrifying aerobic denitrifying (HN-AD) strain HY-1 with excellent capacity, identified as Paracoccus denitrificans, was isolated from activated sludge. HY-1 was capable of removing NH4+, NO2–, and NO3– with the corresponding rate of 17.33 mg-N L−1 h−1, 21.83 mg-N L−1 h−1, and 32.37 mg-N L−1 h−1, as well as the mixture of multiple nitrogen sources. Meanwhile, HY-1 could execute denitrification function under anaerobic conditions with a rate of 14.56 mg-N L−1 h−1. HY-1 required less energy investment, which exhibited average denitrification rate of 5.19 mg-N L−1 h−1 at carbon–nitrogen ratio was 1. After nitrification–denitrification metabolic pathway analysis, HY-1 was applied in a biological trickling filter reactor for compost deodorization. The results showed that adding of HY-1 greatly reduced the ionic concentration of NH4+ and NO3– in the circulating liquid without impairing the deodorization effect (NH3 removal rate＞98.07%). These findings extend the field of application of HN-AD and provide new insights for biological deodorization.

Formaldehyde Deodorization Effect and Far-Infrared Emission Characteristics of Ceramics Prepared with Sawdust, Risk Husk, and Charcoal: Effect of Material Mixing Ratio

Indoor air quality is a very important environmental factor in modern society. However, air pollutants generated from various interior construction materials significantly affect the human body, including formaldehyde (HCHO) and volatile organic compounds that threaten public health by deteriorating indoor air quality. Effective in removing these harmful substances are porous materials, such as woodceramics. In this study, charcoal, a porous material, was added to rice husk, an agricultural by-product, and sawdust generated during the sawing process to prepare boards and ceramics at different mixing ratios, and the HCHO deodorization performance and far-infrared emission characteristics were measured. As the mixing ratio of charcoal increased, the deodorization rate of the boards and ceramics tended to increase. Overall, the deodorization rate was measured to be 80% to 90%, indicating that the boards and ceramics prepared with charcoal are suitable to be used for the purpose of deodorization. The effect of the material mixing ratio on far-infrared emissivity and emission power was insignificant.

Study on deodorization effect of nano-attapulgite/CaCO3 carriers

In this study, in order to develop a new inorganic carrier to adsorb sulfur-containing organic compounds, the nano-attapulgite/CaCO3 carriers were developed with clay, nano-attapulgite, nano-calcium carbonate and silica as raw materials. The best raw material ratio of nano-attapulgite/CaCO3 carriers was optimized by single factor test and response surface experiments, and the deodorization effect of nano-attapulgite/CaCO3 carriers was further verified. The results showed that the optimal ratio of raw matrixes was 9.77 g of clay, 4.15 g of attapulgite, 2.80 g of nano-calcium carbonate, and 2.08 g of silica. The nano-attapulgite/CaCO3 carriers were prepared by calcining these mixed materials at 800 °C for 4 hours, and the water absorption was up to 31.78%. Besides, the deodorization effect of nano-attapulgite/CaCO3 carriers on fermented onion odor was as high as 45%, and the deodorization effect on rotten egg odor is up to 30%, indicating that the carrier has a high deodorization effect on sulfur compounds.

Effects of Deodorization on the Formation of Processing Contaminants and Chemical Quality of Sunflower Oil.

Tocopherols and phytosterols are generally considered to be nutritionally beneficial, and 3-Monochloropropane-1,2-diol esters (3-MCPD esters), glycidyl esters (GEs) and trans fatty acids (TFAs) are generally considered to be harmful. The high temperature deodorization step is when these harmful 3-MCPD esters, GEs and TFAs are generated. Knowing how deodorization conditions affect levels of these substances is essential for designing refining processes that will produce nutritious, high quality edible oils. This study analyzed the changes of these components of sunflower oil at different temperatures (210, 230, 250 and 270°C) and times (60, 80, 100 and 120 min) during deodorization. Our research found that during the whole deodorization process (including undeodorized sunflower oil), the contents of 3-MCPD esters, GEs and TFAs all progressively increased, from 0.47 to 11.18 mg/kg, 0.24 to 18.42 mg/kg and 0.062% to 0.698%, respectively. However, the deodorization process significantly decreased the levels of tocopherols (from 535.94 to 240.26 mg/kg) and phytosterols (from 2803.58 to 1864.34 mg/kg). Meanwhile, the retention ratios of total tocopherols and total phytosterols also decreased from 96.29% to 44.83% and 92.29% to 66.50%, respectively.

A Study on the Deodorant Effect of Rush

A Study on the Deodorant Effect of Rush

A combined deodorization reflux system and tidal flow constructed wetland for sewage treatment performance

The biggest problem in the treatment of septic tank wastewater of scattered farmers is the high concentration of chemical oxygen demand (COD), ammonia nitrogen (NH4+-N), total phosphorus (TP), and odor (threshold odor number, TON). A combined process of reflux deodorization and tidal flow constructed wetland was developed, and its removal efficiencies of COD, NH4+-N, TP, sulfide (S2-), and TON were evaluated. The effect of reflux ratio on system pollutant removal is significant. The removal efficiencies of COD, NH4+-N, S2-, and TON increased as R increased. When R is 150%, the system achieves the optimal operation effect. By analyzing the microbial community and functional bacteria in the system, it was found that Thiobacillus could conduct simultaneous denitrification and deodorization in the deodorization pool. The effects of ρ(NO3--N)/ρ(S2-) and ρ(COD)/ρ(NO3--N) on the denitrification and deodorization of the deodorization pool were studied to further reveal the mechanism and law of denitrification and deodorization in the deodorization pool. It was found that with the increase of ρ(NO3--N)/ρ(S2-), the denitrification effect of the deodorizing pool decreased and the deodorization effect increased. When ρ(NO3--N)/ρ(S2-) is 0.8, good denitrification and deodorization effect can be achieved in the deodorization pool. With the increase of ρ(COD)/ρ(NO3--N), the denitrification effect of the deodorizer was enhanced, but the deodorization effect was weakened. When ρ(COD)/ρ(NO3--N) is 4, good denitrification and deodorization effect can be achieved in the deodorization pool.

Chitosan-coated organosilica nanoparticles as a dual responsive delivery system of natural fragrance for axillary odor problem

Citronellol (CI)-loaded, chitosan (CS)-enclosed dendritic mesoporous organosilica nanoparticles (CI@D-MONs@CS) are successfully fabricated. The synthesized CI@D-MONs@CS present spherical shape with the particle size of 424±24 nm in diameter and dendritic mesopores. CI loading ratio of CI@D-MONs@CS is about 12.42% from TGA analysis. CI release from CI@D-MONs@CS exhibits pH-redox dual responsiveness. More interesting, the axillary deodorant effect is investigated with Staphylococcus haemolyticus in an artificial sweat model. The results show that CI@D-MONs@CS present an excellent bacteria-killing effect and the smell of artificial sweat is greatly improved, avoiding the formation of undesirable odorant compounds from the bacteria. The obtained CI@D-MONs@CS is a potential carrier of natural fragrance or actives with dual responsive release. The application of CI@D-MONs@CS is a new and effective strategy to the axillary odor problem.

Development of the composition and technology of the curative preventive toothpaste with antimicrobial and deodorating properties

The significant prevalence of diseases of the oral cavity predetermine the relevance of preventive means aimed at maintaining the dental health of the population. The application of toothpastes and elixirs with anti-inflammatory, antimicrobial and deodorant properties improves the condition of the oral cavity, and is also one of the means for the prevention and treatment of periodontal disease and halitosis.&#x0D; The aim of the work was to develop the composition and laboratory technology of curative and prophylactic toothpaste and to study the indicators of its quality.&#x0D; Research materials: carbopol, xanthan gum, propolis tincture, bee bread tincture, thyme essential oil, xylitol, sorbitol, and a sample of toothpaste. Pharmacological-technical methods, potentiometric and alkalimetric study methods were used.&#x0D; In order to develop the composition of a toothpaste, requirements of the current regulatory documents for the composition and characteristics of toothpastes were analyzed. The composition and quantity of components for the curative and prophylactic toothpaste have been theoretically substantiated. Carbopol and xanthan gum were used as gelling agents. Calcium carbonate was chosen as the abrasive basis of the toothpaste, which helps to remove plaque from the tooth enamel. Such polyhydric alcohols as sorbitol, glycerin, xylitol and propylene glycol were used as plasticizers. Considering the antioxidant, anti-inflammatory, antimicrobial and radioprotective properties of propolis tincture and bee bread tincture, they were incorporated in the toothpaste composition. The technology of laboratory batches of toothpaste was based on the general principles of obtaining suspension gels and pastes. The quality of the toothpastes was controlled for organoleptic and physicochemical indicators in accordance with the requirements of the regulatory documents.&#x0D; The theoretical and experimental justification of the composition of the curative and prophylactic toothpaste of antimicrobial actvity with a deodorant effect. This paste contained carbopol, xanthan gum, calcium carbonate, xylitol, tinctures of bee products (propolis and bee bread) and thyme essential oil. On the basis of pharmacological-technical research, a rational technology of the curative and prophylactic toothpaste has been developed. Organoleptic and physicochemical indicators of the quality of the developed curative and prophylactic toothpaste have been established and its classification characteristics have been determined.