‘This article gives an overview of craniofacial microsomia (CFM), its diagnostic features and relevant classification systems. Craniofacial microsomia is the most common facial anomaly after cleft lip and palate. It has a wide phenotypic variance and requires a multidisciplinary approach for comprehensive management. We outline both the facial and dental manifestations and orthodontic implications. CPD/Clinical Relevance: CFM patients often require comprehensive dental and orthodontic care and it is necessary for the clinician to be aware of the clinical challenges in treating this cohort of patients. By having a thorough understanding of the aetiology and clinical features, it can help direct appropriate clinical care.