Local anesthetics are the most efficient substances used to manage pain in dental medicine. Articaine is the only amide-type local anesthetic that contains also an ester group (thiophene group), thus its metabolism occurs both in plasma and in liver. This study aims to determine the haematological changes induced by local and also loco-regional anesthesia with articaine among a group of dental pacients. The values obtained at baseline were compared with those evaluated after 30 and 60 minutes, respectively. Results showed that haematological modifications are minimal and not significant from statistical point of view. Further analysis are recommended for all parameters with continuous modifications during the studied period of time, especially for patients with associated general diseases. Keywords: articaine, haematology, dental anesthesia