Abstract Confluences are marked by converging streamlines, complex hydrodynamics features and mixing processes. Understanding such intricate flow patterns and their effects on the mixing at natural river junctions is difficult, particularly for large confluences with a compound channel tributary, due to the scarcity of field data. This research aims to assess the effects of density differences on hydrodynamics and mixing at the large river confluence between the Yangtze River and its tributary, the Poyang Lake, whose outflow channel has a large inner-side floodplain. Field data were collected during three surveys under various flow conditions to analyse how the alternate flow mechanism (compound channel vs single channel) of the Poyang Lake outflow channel influences the confluence mixing process. In high flow and relatively high flow conditions, the Poyang Lake outflow channel functioned as a compound channel and switched to a single channel in low flow. Acoustic Doppler current profiling (ADCP) was used in all three surveys to explore the features of hydrodynamics and the mixing process at the confluence, supplemented by water quality sampling to characterise the mixing patterns. Secondary flows observed during the field surveys were found to be affected by alterations in the flow mechanism (compound channel vs single channel) of the Poyang Lake outflow channel and the density effects, which were characterised using the densimetric Froude number Frd. Ultimately, the findings obtained in these field surveys confirm the role of density differences between the tributaries in significantly affecting hydrodynamics features and the mixing process at river confluences.