Dengue Hemorrhagic Fever Cases Research Articles

Hubungan Tingkat Pengetahuan, Sikap dan Karakteristik Masyarakat dengan Pencegahan Demam Berdarah Dengue di Puskesmas Bola

Dengue hemorrhagic fever (DHF) is an infectious disease caused by the dengue virus through the bite of the Aedes aegypti mosquito which still affects the world's population today. DHF cases at the Bola Health Center are still very high so it is necessary to pay attention so that preventive measures can be taken. This study aims to analyze the relationship between the level of knowledge, attitudes and characteristics (age, income, employment, education) of the community and the prevention of dengue hemorrhagic fever in the Working Area of the Bola Health Center in 2022. The type of research used was an analytic observational study with a cross-sectional design. . This research was conducted in the working area of the Bola Health Center with a sample of 97 families. The data analysis used was univariate and bivariate analysis with the chi square statistical test . The results of this study indicate that there is a relationship between knowledge (p=0.011), attitude (p=0.040), education (p=0.044) and prevention of dengue hemorrhagic fever in the working area of the Bola Health Center. Meanwhile, those that were not related to the prevention of dengue hemorrhagic fever (DHF) in the working area of the Bola Health Center were age (p=0.711), income (p=0.062), occupation (p=0.544). It is hoped that the community will be more active in finding out about DHF and things that must be considered in preventing in the surrounding environment and taking real action by carrying out prevention efforts recommended by health workers.

Carica papaya extract: a new leaf in treating dengue?

Carica papaya extract: a new leaf in treating dengue?

Thực trạng sốt xuất huyết dengue tại tỉnh Tiền Giang giai đoạn 2012 – 2019

Objective: Descriptive statistics on the number of dengue hemorrhagic fever (DHF) cases by location and month of the year in Tien Giang province, thereby providing clearer evidence for dengue prevention in the province. Methods: In this study, we carried out in Tien Giang province from December 2020 to July 2021, using cross-sectional studies. The subjects of this study are people with dengue, recorded in the infectious disease surveillance system of the preventive health system of Tien Giang province. Main findings: The total number of dengue cases during the study period was 23,750 cases, the highest number of years was 2019, the lowest number of years was 2014. The number of cases tends to increase in the rainy season from May, with an average of 4 cases. /day, until the end of October with an average of 11 cases/day. The disease is distributed throughout the province, in which the most in My Tho City with an average of 511 cases/year, besides, the subjects with dengue are mainly in the group of children <15 years old. Conclusions: The distribution of dengue cases in Tien Giang over the past 8 years shows that there were 2 major epidemics in 2012 and 2019. Dengue disease occurs all year round, tends to increase in the rainy season from May to the end of October. The disease is distributed throughout the province, in which the most in My Tho City with an average of 511 cases/year, in At that time in 2019 with 815 cases/100,000 people. Recommendations: The study recommends measures to strengthen dengue prevention early, implemented from March to April – the time before the start of the rainy season (the rainy season starts from May), especially in areas areas with high population density such as in My Tho City. Keywords: Dengue hemorrhagic fever

PEMBERDAYAAN IBU PKK DESA GUWANG DALAM PENGGUNAAN OVITRAP BERBAHAN ALAMI UNTUK MEMBERANTAS VEKTOR PENYAKIT DEMAM BERDARAH DENGUE

Sourced from data obtained at the Sukawati 1 Health Center, the highest dengue hemorrhagic fever case in the working area of the Sukawati 1 Health Center is Guwang Village. In 2020, 64 cases of dengue hemorrhagic fever were found in Guwang Village. This service aims to empower the community to increase motivation to live clean and healthy to play an important role in controlling dengue hemorrhagic fever cases. The method used in this service is counseling and training for PKK mothers in Guwang village with a minimum number of participants of 30 people. The location of this activity is at Banjar Sakih, Guwang Village, which will be held in September 2022. The results of this activity are expected to increase the knowledge and skills of PKK women in using and making ovitrap made from natural ingredients as measured through pretest and posttest. The result of this service is an increase in the knowledge and attitude of PKK mothers in eradicating mosquito nests, using ovitrap made from natural ingredients.

Relationship analysis of protection strategy and the number of containers with the existence of Aedes aegypti larvae at Tebing Tinggi city in 2022

Background: Dengue hemorrhagic fever (DHF) is an endemic disease in Tebing Tinggi, the number of DHF cases in 2022 reached 175. Protection strategy and the number of landfills are risk factors for the presence of Aedes aegypti mosquito larvae. This study aimed to analyze the relationship between protection strategy and the number of containers in the presence of Aedes aegypti. Methods: This type of research was an analytic survey with a cross-sectional research design. The study population was all families living in 5 sub-districts in Tebing Tinggi city with 500 houses selected using a cluster sampling technique. Primary data collection used a questionnaire containing questions on protection strategy and location points, also observation sheets containing the type of landfills, and the number and presence of larvae. Data were analyzed by Chi-Square test. Results: The results showed that Aedes aegypti larvae were found in 144 houses and 14% of families had made protection strategies, 41% of houses had more than 4 containers. Protection strategies against the presence of grass bushes within a radius of 100 meters from the house and the number of landfills had a relationship with the presence of Aedes aegypti mosquito larvae (p<0.05). Conclusions: Tebing Tinggi city is an area that has a high potential risk of DHF. Suggestions for increasing DHF protection strategy and eliminating resting places and breeding places are important for empowering jumantik at the family level as well as providing ongoing assistance and education.

Kebijakan Penanggulangan Demam Berdarah Dengue (DBD) pada Berbagai Daerah di Indonesia

The environment and behavior play an important role in the occurrence of health problems or diseases, such as Dengue Hemorrhagic Fever (DHF). DHF problems always occur from year to year, especially the number of cases, both globally and nationally and even locally. In Indonesia each region has different policies- in addressing DHF problems in their regions. This paper aims to describe several local government policies in dealing with DHF problems in several regions based on research results published in several journals. This research is in the nature of a review or article review. The results of the research reviewed in this article are 6 (six) articles, namely the range of 2018-2022. The aspects that are looked at are the title, author, year, objectives, methods, results and conclusions. The results of the study found that most local governments have different policies in tackling DHF, but with the aim the same thing, namely reducing DHF cases and preventing extraordinary events (KLB), such as by community empowerment, field action strategies and utilization of local wisdom. The conclusion is that regional policies in tackling DHF from 2018 to 2022 are able to reduce or control the incidence of DHF. To overcome unresolved problems related to behavior, it is better to use the Emotional Demonstration (Emo Demo) approach.

Implementasi Kebijakan Penanggulangan Demam Berdarah Dengue di Kota Sampang Jawa Timur

Aides aegypti or Aides albopictus is a type of mosquito that carries and transmits dengue virus to humans. Dengue hemorrhagic fever appears as an Extraordinary Event (KLB), causing panic in the community because it has the risk of causing death and spreads very quickly. Based on records from the Directorate for Prevention and Control of Infectious Diseases (P2PM) until Week 36, the cumulative number of confirmed cases of DHF from January 2022 was reported as 87,501 cases (IR 31.38/100,000 population) and 816 deaths (CFR 0.93%). Sampang Regency, East Java, is currently starting to anticipate the possibility of an outbreak of dengue fever. After the local regency government released three districts that were considered prone to Dengue Hemorrhagic Fever (DHF), namely Sampang District, Omben District and Torjun District. The Health and Family Planning Service (Dinkes-KB) of Sampang Regency, East Java, noted that cases of dengue hemorrhagic fever (DHF) in the area have decreased in 2021 compared to the number of cases that occurred in previous years. This study aims to determine the implementation of dengue hemorrhagic fever (DHF) prevention policies in Sampang District and what are the inhibiting factors. In this study, researchers used a qualitative descriptive method that used data collection such as interviews, observation and documentation studies. Based on the research results in assessing the Implementation of Dengue Hemorrhagic Fever (DHF) Management Policies in Sampang Regency, it has not been maximized when viewed from several indicators of evaluating the implementation of public policies, namely (1) Policy resources such as a lack of health workers, sufficient health facilities and funds, (2) ) the disposition or attitude of the executors is not firm and the lack of community participation in PSN activities, (3) economic, social and political conditions that are not conducive.

ROLE OF PLATELET INDICES IN DENGUE FEVER CASES IN CORRELATION WITH SEROLOGICAL MARKERS – A STUDY OF 100 CASES

Objective: This study aims to evaluate the utility of various platelet indices, i.e., platelet count, mean platelet volume (MPV), platelet distribution width (PDW), and plateletcrit (PCT) in dengue fever and to study different serological markers (NS1 Ag, IgM, and IgG) and compare them with platelet counts. Methods: This was a retrospective, observational, and cross-sectional study done over 6 months. A total of 100 cases with symptoms of dengue and seropositive for any of the rapid tests (NS1 Ag, Ig M, and Ig G antibodies) were included. Platelet count, MPV, (PDW), and (PCT) were determined using six-part Hematology analyzer. Based on the platelet count, all dengue seropositive cases were divided into 5 groups, and platelet indices were analyzed and tested for statistical significance using Chi-square test and Anova test. Results: Thrombocytopenia was more common in the NS1 Ag-only reactive cases. Dengue hemorrhagic fever (DHF) cases (12) had significantly low MPV, high PDW, and low PCT. Statistical analysis between mean MPV, mean PDW, mean PCT, and platelet count among various groups was significant. Low MPV, high PDW, and low PCT were more evident when platelet count was < 1lakh. Conclusion: Our study showed that thrombocytopenia was more common in the NS1 Ag-only reactive cases than other serological markers.A Low MPV with a spike in PDW, and a plummeted PCT in cases with thrombocytopenia indicate severity of dengue infection. These platelet indices act as surrogate markers in predicting the risk of bleeding.

PEMETAAN DAERAH RAWAN PENYAKIT DEMAM BERDARAH DENGUE (DBD) DI KOTA BANDUNG MENGGUNAKAN APLIKASI QGIS

Dengue Hemorrhagic Fever (DHF) is a viral disease spread by a vector, Aedes Aegypti mosquitoes. This study aims to map the distribution of high vulnerability areas in Bandung City. The data used are secondary data from the 2021 District Health Office and 2022 the Central Agency of Statistics (BPS) from 30 sub-district reports in Bandung City. Map of Bandung City obtained from the Geospatial Information Agency via the website tanahair.indonesia.go.id. DHF case data and data that have a direct influence on the natural development of mosquitoes, including rainfall, air humidity, and population density are scored and classified. Then the data is assessed and analyzed to produce vulnerability level zones using the QGIS 3.28.0 application. The result shows that there are 5 sub-districts with high vulnerability level, sub-districts with medium vulnerability level, and 15 sub-districts with low vulnerability level. The five sub-districts with high vulnerability are Antapani, Bojongloa Kaler, Cibeunying Kidul, Kiaracondong, and Sukajadi sub-districts. Knowing the distribution of dengue-prone areas, it is hoped that it will make it easier for the Bandung City Health Service to take preventive measures and handle DHF cases by prioritizing sub-districts with a high level of vulnerability. The government is expected to increase community participation in programs to prevent and control DHF incidents in each sub-district. In addition, it is hoped that further research will examine other environmental factors and societal behavior factors that lead to the vulnerability of DHF cases so that the DHF disease control program in Bandung City is more specific, especially considering the characteristics of each region.

DENGUE HEMORRHAGIC FEVER INCLINATION TENDENCY IN EAST JAVA PROVINCE VILLAGES COMMUNITY-BASED TOTAL SANITATION

Background: Dengue Hemorrhagic Fever (DHF) is one of the endemic diseases throughout the tropics and parts of the subtropics. One of the provinces that felt the impact of the dengue outbreak was East Java. Overall, villages implementing STBM coverage in East Java Province is good but incidence of DHF is still found in all districts or cities in the last 3-year period. Purpose: This study aims to analyze the relationship and the inclination tendency of Dengue Hemorrhagic Fever in East Java). Methods: This type of research is an observational study with a cross-sectional study design. The sample population used 38 regencies/cities in East Java Province. The data used are the health profile data of East Java Province in 2018, 2019, and 2020. The data analysis technique used descriptive by utilizing the Health Mapper application version 4.3.0.0 with product version 4.03. Results: The distribution of DHF incidence with the coverage of villages implementing STBM East Java in 2018, 2019, 2020 showed decrease the coverage of villages implementing STBM is also followed by an increase DHF cases every year. The coverage of villages that implement Community Based Total Sanitation (STBM) fluctuates every year. Conclusion: Areas with STBM villages cannot guarantee DHF-free zones but can prevent the transmission of Dengue Hemorrhagic Fever (DHF) by changing hygiene and sanitation behavior through community empowerment to create a good sanitation.

Dengue Hemorrhagic Fever in The Working Area of Abeli Public Health Center, Kendari City

Dengue Hemorrhagic Fever (DHF) is an infectious illness spread by vectors caused by a virus. According to data, DHF cases at Abeli Health Center in 2021 have increased compared to the previous year, namely 19 cases. These cases have increased compared to the incidence of DHF, with 3 cases in 2020 and 6 cases in 2019. The primary goals of this study are to explain the description of dengue fever incidents at the Abeli Health Center in Kendari City in 2022. In 2021, This type of research will employ an observational survey with secondary data obtained from health data in the Abeli Health Center work area. Furthermore, it is linked to reports of DHF events in the Abeli Health Center’s operating area. The type of investigation data was numerical. The investigative information was displayed within the frame of charts and narratives. This study found no association between the description of Dengue Hemorrhagic Fever in the working region Abeli Public Health Care, Kendari City, in 2022. This was because most of the houses in the district met the requirements of healthy homes. Meanwhile, the cases of Dengue Hemorrhagic Fever (DBD) and Wastewater Disposal Channel (WWDC)inAbeli District, Kendari City, 2022, still had a relationship. This was because many Wastewater Disposal Channels still did not meet the requirements, which risk causing dengue fever in Abeli District, Kendari City, in 2022.
 Keywords: Dengue Hemorrhagic Fever (DHF), Wastewater Disposal Channel (WWDC)

Characteristics, 3M Behavior, and Climate Factors with Cases of Dengue Heart Fever (DHF) in Indonesia (Literature Review 2015-2021)

Dengue Hemorrhagic Fever (DHF), has become the fastest growing Vector Borne disease (VBD) in the world over the last few decades, with an increase of 30 times. This study aims to analyze the relationship between the characteristics, behavior of 3M, and climate factors with cases of Dengue Hemorrhagic Fever (DHF) in Indonesia. This research was conducted using a literature review method. The research was conducted online by taking research objects in English and Indonesian journals that discussed cases of DHF in Indonesia. The sample used was appropriate and determined in this study totaling 45 research articles. The results showed that men were more likely to be infected with DHF because they were more active outside the home. The age prone to DHF is the age under 16 years old, or the toddler, child, and early teens. The education of the head of the family is also an important factor in efforts to control the dengue outbreak. The results of the literature review show that the characteristics have a significant relationship with dengue cases. Not all people are aware of the importance of 3M behavior, seen from the proportion of people who apply 3M less than people who apply 3M. 3M's behavior is a factor that can reduce the occurrence of dengue cases. Stakeholders or policy makers in the health sector, especially those in charge of controlling the dengue outbreak, should take the results of this study into consideration in determining regulations or policies related to dengue outbreak control.

Integration of climate, transmission, and spread of dengue hemorrhagic fever in endemic areas

Introduction. Dengue Hemorrhagic Fever (DHF) is still a public health problem even in the era of the COVID-19 pandemic in 2020, including in Indonesia. This study aimed to analyze the incidence of DHF based on the integration of climatic factors, including rainfall, humidity, air temperature, and duration of sunlight and their distribution. Materials and Methods. This was an ecological time series study with secondary data from the Surabaya City Health Office covering the incidence of DHF and larva-free rate and climate data on rainfall, humidity, air temperature, and duration of sunlight obtained from the Meteorology and Geophysics Agency (BMKG). Silver station in Surabaya, the distribution of dengue incidence during 2018-2020. Results and Discussion. The results showed that humidity was correlated with the larvae-free rate. Meanwhile, the larva-free rate did not correlate with the number of DHF cases. DHF control is estimated due to the correlation of climatic factors and the incidence of DHF, control of vectors and disease agents, control of transmission media, and exposure to the community. Conclusions. The integration of DHF control can be used for early precautions in the era of the COVID-19 pandemic by controlling DHF early in the period from January to June in Surabaya. It is concluded that humidity can affect the dengue outbreak and it can be used as an early warning system and travel warning regarding the relative risk of DHF outbreak.

HYBRID K MEANS-MULTIVARIATE ADAPTIVE REGRESSION SPLINES FOR DISTRIBUTION OF DENGUE FEVER RISK MAPPING IN BOJONEGORO DISTRICT

Dengue Hemorrhagic Fever (DHF) is a dangerous disease transmitted by Aedes aegypti and Aedes albopictus mosquitoes’ bites. WHO data shows that almost half of the world's humans are exposed to Dengue Hemorrhagic Fever. The number of mortality caused by dengue disease is around 20,000 every year. In East Java, Bojonegoro District has the highest number of dengue hemorrhagic fever cases (416). To reduce this number, the causative factors need to be known. Additionally, it's important to pinpoint the region or cluster where the variables driving the spread are located so that prevention and treatment efforts are effective. Based on the elements contributing to the transmission of Dengue Hemorrhagic Fever, this study seeks to identify and categorize locations at risk for the spread of the illness. This study uses Hybrid K Means-Multivariate Adaptive Regression Splines (MARS) which is a combination of K-Means and MARS methods in the hope of providing better analytical results. This is because the data was divided into simpler parts by considering the Oakley distance. The results obtained from the K Means-MARS hybrid shows the relationship between response variables and predictor variables for each cluster. There are three clusters of risk for the spread of dengue hemorrhagic fever in Bojonegoro district with categories: high risk cluster, medium risk cluster and low risk cluster. The high risk cluster consists of 7 sub-districts (Baureno, Kepohbaru, Balen, Sumberrejo, Kedungadem, Bojonegoro and Dander). The variables affecting the DHF Sufferer in the high risk cluster were population density (X2), Altitude (X3) and Health Worker (X6). Meanwhile, the medium risk cluster consists of 10 sub-districts (Kalitidu, Kanor, Kapas, Ngasem, Ngraho, Padangan, Sugihwaras, Sukosewu, Tambakrejo, and Trucuk). The variables that affect the DHF Sufferer in the medium cluster are Number of Dead (X1), Population Density (X2) and Health Facility (X5). The low risk cluster consisted of 11 sub-districts (Bubulan, Gayam, Gondang, Kasiman, Kedewan, Malo, Margomulyo, Ngambon, Purwosari, Sekar, and Temayang). The variables affecting the DHF Sufferer rate in the low risk cluster were number of dead (X1) and population density (X2).

Utilization of Animated Films as Digital-based Socialization Media for Prevention of Dengue Hemorrhagic Fever Outbreaks in the Malang City Region during the COVID-19 Pandemic

BACKGROUND: The increase in dengue cases in the coronavirus disease (COVID-19) pandemic is affected by restrictions on human movement, climate, human behavior, and knowledge. Animated film for communication media based on digital technology as a promotional and preventive tool regarding dengue hemorrhagic fever (DHF) in the era of the COVID-19 pandemic. AIM: The purpose of this study is to increase knowledge and attitudes among productive-age youth as part of efforts to prevent DHF cases during the COVID-19 pandemic and in the future. METHODS: A pre-experimental study design with a one-group pre-test and post-test design was used in this study, so only one group was studied. In this study, using total sampling, as many as 30 respondents from the total population who are Grade 1 students at one of the junior high schools in Malang City. RESULTS: The difference test on knowledge produced an asymptotic sig value of 0.000, which is (<0.05). This means that the average post-test score obtained is higher and significantly different from the pre-test. In addition, based on the results of the difference test on attitudes, an Asymp Sig value of 0.001 is obtained, which is (<0.05). This means that the average post-test score obtained is higher and significantly different from the pre-test. CONCLUSION: Animated films as digital-based socialization media can help increase students’ knowledge and attitudes in efforts to prevent DHF outbreaks.

The Influence of Thrombocytopenia in Covid-19 Patients on Dengue Hemorrhagic Fever Cases

The increasing cases of Dengue Hemorrhagic Fever in all regions of Indonesia are a disease transmitted through a vector amid the ongoing COVID-19 Pandemic, which can seriously threaten public health. This study aims to analyze the relationship between thrombocytopenia in patients with COVID-19 and cases of dengue hemorrhagic fever. This research was conducted from February to March 2022. The tools used in this study were the Abbot Cell-Dyn Ruby Hematology Autoanalyzer and questionnaires as well as PCR secondary data. Anas used Pearson's Correlation Test statistic and used a cross-sectional study design with 389 respondents who came to check blood at the laboratory. Based on the data obtained, 128 respondents had thrombocytopenia (32.9%) diagnosed with Dengue Hemorrhagic Fever, and as many as 70 out of 128 respondents had been exposed to COVID-19 (54.7%). The analysis results show a relationship between the influence of thrombocytopenia in patients with COVID-19 and cases of Dengue Hemorrhagic Fever. It is necessary to improve anamnesis in patients suspected of Dengue Hemorrhagic Fever, it is hoped that they will carry out investigations related to previous exposure to COVID-19, so that they can provide, fast, precise and accurate treatment and treatment.

Penerapan Metode K-Medoids Clustering Pada Penanganan Kasus Demam Berdarah

The number of cases of the spread of dengue hemorrhagic fever (DHF) in Beringin Country Village every year has increased for this reason, it is necessary to handle dengue hemorrhagic fever so that the spread does not increase dengue hemorrhagic fever cases every year. The vast natural conditions of Banyan Country Village make it difficult to monitor the spread of diseases based on the most cases. This causes slow prevention and control of the disease. For this reason, it is necessary to group or cluster diseases based on the number of cases that occur each year. This study aims to apply the K-Medoids algorithm to group dengue hemorrhagic fever data based on the number of cases each year. The process of solving problems can be done by processing data. Data mining is a data processing process for extracting information stored in the data set, in data mining the process of grouping data for the process of handling dengue hemorrhagic fever is included in clustering techniques. The K-medoids algorithm is a limiting clustering method for grouping a collection of objects into clusters. The data used is in the form of data on dengue sufferers, from 2017-2022. Test results were obtained for high cluster dengue disease of 72 members and low 28 members. The K-medoids algorithm can help facilitate the process of forming dengue hemorrhagic fever treatment clusters. Testing using manual calculations and the Rapidminer application gets the same results as the system. This shows that the system has worked well.

Climate Factors and DHF Cases in Padang During the COVID-19 Pandemic

Background: Dengue Hemorrhagic Fever is transmitted within regions characterised by tropical weather. The present study reports the incidence rate of Dengue Hemorrhagic Fever (DHF) in Padang City during the year 2021, which is estimated to be 37.2 cases per 100,000 individuals in the community.Purpose: The objective of this study is to examine the correlation between specific components of the physical environment, specifically the climate, and the occurrence of Dengue Hemorrhagic Fever (DHF) in Padang City amidst the Covid-19 Pandemic.Method: The present study employs ecological research methodologies. The study utilised a sample consisting of all instances of dengue hemorrhagic fever (DHF) that were documented at the Padang City Health Service, along with climatic data obtained from the BMKG for the period spanning from March 2020 to March 2022. The findings of the study indicate a temporal increase in cases of dengue hemorrhagic fever (DHF) in Padang City throughout the period from July to December 2021.Result: The findings from the examination of incidences of dengue hemorrhagic fever (DHF) in relation to climate factors during the Covid-19 pandemic revealed a statistically significant association with wind speed (p = 0.018). Wind speed emerged as the prevailing environmental determinant in instances of dengue hemorrhagic fever (DHF) within the Covid-19 pandemic. The wind speed was identified as a climate variable that exerted influence on the occurrence of Dengue Hemorrhagic Fever (DHF) in Padang amongst the Covid-19 pandemic.

Strategy to control and eradicate dengue hemorrhagic fever vectors in Bali

Dengue hemorrhagic fever cases in Bali have increased in the past decade. Control and eradication efforts must be optimized. In order to create dengue-free zones, accurate information and a comprehensive strategy for accelerating dengue vector management are required. This paper is based on empirical, field, and epidemiological studies and program evaluations guided by the health belief model approach. In this regard, Bali's lesson on dengue cases fluctuated from 2018 to 2020. The incidence and death rates are increasing, especially during the COVID-19. Many factors affect the disease agent, the host, and the environment. The SIGAP strategy is a policy brief that is studied and implemented to accelerate dengue vector control in Bali, which includes: awareness of the importance of 4M-Plus (draining, closing, reusing used goods, and monitoring) and mosquito nest control; integration of dengue information services; using natural insecticides and larvicides; observing and reporting the presence of vectors to the larva monitoring officer; and regular monitoring weekly. Implementing the SIGAP strategy can reduce dengue vectors and speed up the process of getting rid of dengue disease in Bali.

Potency of Carica papaya Leaf Extract as Thrombocytopenia Therapy for Dengue Hemorrhagic Fever: A Systematic Review of Randomized Control Trials

Background: Dengue fever is a common disease in tropical countries. According to the data from the Indonesia Ministry of Health, there were 71.633 Dengue Haemorrhagic Fever (DHF) cases reported in Indonesia, with approximately 459 people dying from the disease. Thrombocytopenia is the most common clinical feature of DHF and often causes serious complications if not treatedproperly. Several studies have analyzed the potency of Carica papaya leaf which has been proven asan effective therapy for thrombocytopenia. Objectives: This systematic review aims to discover the potency of Carica papaya leaf extract as a therapy for thrombocytopenia. Method: Literature was searched by using keywords in accordance with the topic, then filtered according to the inclusion criteria that had been determined according to the PRISMA rules. Publication bias in this reviewwas conducted subjectively using the Revman 5.4 software. Results: From 138 studies, it wasfound that screening was carried out based on inclusion criteria, including a randomized controlled trial study in humans with a population of dengue fever patients and received the intervention of papaya leaf extract so that 6 studies were included in the inclusion study, which was then carried out by qualitative synthesis from the study. Based on the results of the qualitative analysis, it wasfound that there was a faster and more significant improvement in the platelet count between the intervention group compared to the control group in the 6 studies. Conclusion: Carica papaya leaf extract has potential as a thrombocytopenia therapy in dengue fever patients.