Accompanied by the booming development of the global tourism industry and the growing hospitality industry, the training demand for hotel tourism majors has become more and more significant. However, how to cultivate high-quality professionals who are adapted to the needs of the industry and have practical skills and innovative thinking has become an important challenge for hotel tourism majors in vocational schools. Based on this, the article launched a study on the development path of hotel tourism profession in vocational schools based on the integration of production, learning and research, analyzed the significance of the development of hotel tourism profession in vocational schools based on the integration of production, learning and research, elaborated the problems of the development of hotel tourism profession in vocational schools based on the integration of production, learning and research and gave effective measures to solve the problems, aiming to cultivate more professionals with practical operation ability and innovative spirit through the study.