Clarifying the interaction between ecosystem service supply (ESS) and demand (ESD) and its response to land use change is essential for achieving ecological security. Previous research mainly focused on how land use change affects ESS, ignoring its impact on the interaction between ESS and ESD, making it difficult to guide regional sustainability in social–ecological coupled systems. Taking the Yangtze River Delta as the study area, after evaluating five types of ESS and ESD during 2000–2020, this study analyzed the interaction between changes in ESS and ESD using Geodetector from a spatial zoning perspective and subsequently explored the impact of land use intensity on ESS, ESD, and their interaction using Spearman correlation analysis and regression analysis. The results showed that there was obvious spatial–temporal heterogeneity in ESS and ESD. Different ecosystem services varied in their interaction between ESS and ESD, and the demand changes in water conservation and soil retention significantly influenced their supply changes, while supply changes in carbon sequestration were not influenced by its demand changes. The effect of ESD changes on ESS changes also showed spatial heterogeneity. All interactions between ESS changes and ESD changes, except carbon sequestration, were significant in the Supply Increases–Demand Increases zone. Soil retention and water conservation showed a significant supply–demand interaction in the Supply Decreases–Demand Decreases zone and the Supply Decreases–Demand Increases zone, respectively, while no ecosystem service showed significant supply–demand interaction in the Supply Increases–Demand Decreases zone. Land use intensity had linear and nonlinear effects on different ESS and ESD, and it was also found that the effect of ESD changes on corresponding ESS changes was relatively obvious in regions with dramatic land use change. Finally, this paper incorporated the changes in ESS and ESD, as well as their interaction, into land use management, which can provide implications for regional sustainability.
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