Clarifying the spatiotemporal changes in the supply and demand of water-related ecosystem services (WESs) can provide comprehensive support information for ecological governance decisions. However, the spatial mismatch between the supply and demand of WESs is often overlooked, resulting in a lack of targeted decision-making. At the grid scale, while preserving both natural and social attributes, this study quantitatively analyzed the spatiotemporal changes in the supply and demand of WESs in the Southern River Basin from 2000 to 2020. Ecological zoning was performed based on the temporal changes in WESs supply and demand. The OPGD model was used to investigate the impacts of socio-economic and natural factors on different WESs supply factors and further explore the spatial correlation of WESs supply and demand changes in different zones. The results show that there is significant spatial heterogeneity in the changes in WESs supply and demand. Economic belts and megacities have experienced remarkable changes, with WESs supply decreasing and WESs demand increasing. WESs demand changes significantly affect WESs supply changes. The supply of WESs in all zones is influenced by WESs demand. In the high supply–low demand zone, WY has the highest explanatory power for WESs demand changes. From the high supply–middle demand zone to the low supply–middle demand zone and then to the high supply–high demand zone, the explanatory power of PE for WESs demand changes gradually increases. As WESs demand starts from the middle level, HAI gradually dominates WESs demand changes. The increase in land use changes may promote the impact of WESs demand changes on WESs supply changes. This study contributes to incorporating the supply and demand changes of WESs and their correlations into the ecological protection and restoration system, providing a new perspective and method for regional sustainable management.
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