Route Of Delivery Research Articles

Expert Opinions on the Management of Hemophilia A in India: The Role of Emicizumab.

Hemophilia A (HA) is a genetic disorder of hemostasis associated with a deficiency or reduced activity of clotting factor VIII (FVIII). This disorder remains unacceptably underdiagnosed in India. Early diagnosis and appropriate management of HA can substantially prevent morbidity and mortality. Currently, HA is managed with regular replacement therapy using standard or extended half-life FVIII concentrates or non-factor drug products. The challenges associated with FVIII concentrates include plateauing of drug effect, issues with its administration and adherence to treatment, breakthrough bleeds, and the development of inhibiting antibodies against administered clotting factors. Emicizumab is a bispecific antibody, launched in India in April 2019, for managing patients with HA. To investigate the role of emicizumab in Indian patients with HA, opinions were sought from 13 eminent hematologists and experts from India on the effectiveness of emicizumab in preventing all bleeds, spontaneous bleeds, perioperative bleeds, and intracranial hemorrhage; resolving target joints; and reducing the rate of hospitalizations and fatality associated with HA in children and adults, with or without inhibitors. The benefits of emicizumab over traditional FVIII concentrates include the subcutaneous route of delivery, less frequent dosing, and a lack of inhibitor development, in addition to providing sustained hemostasis without in-depth monitoring. It is a safe and effective management option for all HA patients, especially for patients with certain archetypes, such as those with inhibitors, those with high annualized bleed rates, those living far away from hemophilia care centers, pediatric patients and infants with intravenous access challenges, and those with a history of life-threatening bleeding events.

Research on end-route planning for community group purchasing for vehicles with different energy sources

To address the issue of final delivery route planning in the community group purchase model, this study takes into full consideration logistics vehicles of different energy types. With the goal of minimizing the sum of vehicle operating costs, delivery timeliness costs, goods loss costs, and carbon emissions costs, a multi-objective optimization model for community group purchase final delivery route planning is constructed. An improved genetic algorithm with a hill-climbing algorithm is utilized to enhance adaptive genetic operators, preventing the algorithm from getting stuck in local optima and improving the solution efficiency. Finally, a case study simulation is conducted to validate the feasibility of the model and algorithm. Experimental results indicate that currently, among the three types of vehicles, fuel logistics vehicles still have an advantage in terms of vehicle usage cost. Electric logistics vehicles exhibit the poorest performance with the highest cost per hundred kilometers, but their sole advantage lies in their high energy release efficiency, enabling optimal low-carbon vehicle performance. Battery-swapping logistics vehicles perform the best in terms of carbon emissions, combining the advantages of both fuel-based and electric logistics vehicles. Therefore, battery-swapping logistics vehicles are a favorable choice for replacing fuel-based logistics vehicles in the future, offering promising prospects for future development.

Waves of Food- Food Ordering App: A Descriptive Study

A fantastic new app called "Waves of Food" is revolutionising the way we have our favourite dishes delivered. It makes ordering meals a joy and is quite simple to use. With only a few touches, you may explore a wide variety of culinary options, and the app makes recommendations based on your preferences. You can monitor your order in real time, allowing you to know the exact location of your food at all times. Additionally, the app offers secured payment alternatives so you don't have to worry about losing your money. It also guarantees that your food will taste well and arrive on schedule. Waves of Food is the food delivery industry's super hero, improving and streamlining everything for everyone. "Food ordering App " introduces a game-changing mobile application in the food delivery landscape. This innovative platform redefines convenience and satisfaction, offering users a seamless experience from start to finish. With intuitive navigation and personalized recommendations, users can easily explore a diverse range of cuisines. Real-time order tracking ensures transparency and peace of mind, while secure payment options guarantee financial security. The app optimizes delivery routes for efficiency and freshness, promising timely arrivals of delicious meals. Waves of Food sets a new standard for food delivery, making every dining experience a breeze. The food delivery industry has witnessed a significant transformation in recent years, driven by advancements in mobile technology and changing consumer preferences. This abstract presents a comprehensive overview of a cutting-edge food delivery application designed to revolutionize the way consumers order and receive meals. Keywords—Hyper test markup langage(HTML), Cascading Style Sheets(CSS), Application Programming Interface(API), Hypertext Transfer Protocol(HTTP), Extensible Markup Language(XML).

Nanogels as Drug Delivery Carrier: A Narrative Review on Formulation Techniques, Characterization, Applications, and Patents.

Under the umbrella of targeted drug delivery systems, several techniques are unleashed in the market that allow a drug or other pharmacologically active material to be delivered to the target cell to treat a condition or health problem. The improvement of the pharmaceutical delivery systems' effectiveness, safety, and stability is accomplished through the Formulation of the nano-gel-based delivery system. Nanogels are aqueous dispersions of submicronsized, three-dimensional, strongly cross-linked networks of hydrophilic polymers that are inflated by water. Through a variety of delivery routes, such as oral, pulmonary, nasal, parenteral, and intraocular, an active pharmaceutical agent or therapeutic agent with a high or low molecular weight can be easily encapsulated into nanogels. Nanogels have been researched as drug delivery systems due to their beneficial qualities, such as biocompatibility, high stability, flexible particle size, drug loading capacity, and potential surface modification for active targeting by attaching ligands that recognize cognate receptors on target cells or tissues. By responding to internal or external stimuli, including pH, temperature, light, and redox, nano gels can be made to be stimulus-responsive, allowing for regulated drug release. Thus, in the fact of said characteristics' of nano gels, this review manuscript aims to provide an overview of characterization, evaluation, formulation technique, recent applications, and patents of nano gels.

Research on integration of enterprise ERP and E-commerce systems based on adaptive ant colony optimization

Integrating the E-commerce system with an enterprise resource planning tool can help the firm improve performance, maintain customers, and increase sales. In Enterprise Resource Planning, integration features can be provided either as developed features or as separate assignments and contributions. Problems with the online platform, improper addresses, rejected payments, and especially apparent transactions are frequent problems for online buyers. The enhanced Adaptive Ant Colony Optimization is utilized to optimize the rural E-commerce express of transportation. Several innovative routes can lower the downlink transportation cost and reach all collecting places with a fast delivery route. Convolutional Neural Networks were utilized to increase the collective innovation of the E-commerce platform and simplify network communication. E-commerce is a mechanism used to market information services and products. Hence, ERP-AACO-CNN has been designed to integrate Enterprise Resource Planning and E-commerce, and business operations can stream smoothly from the front to the back of the business. Statistics on sales orders, customers, stock levels, price, and essential performance measurement systems. The automated invoices, frequent communications, financial report preparation, product and service delivery, and material requirements planning. The most significant results will likely finance businesses that employ it as a stimulant for a wide-ranging process improvement. In addition, E-commerce is a valuable innovation that connects buyers and sellers in various corners of the globe. Customer satisfaction is projected to be more significant than fault detection at 95.2 % accuracy for the proposed method’s E-commerce system with the superior value. According to client demand, an E-commerce system is the most accurate development at a given input level, and a future ERP is 64.9% efficient. The proposed approach has a 24.5% random error rate and a 13.2% mean square error rate. A comparison of E-commerce and enterprise ERP precision to the proposed technique yields 83.8% better results.

Targeted Clindamycin Delivery Systems: Promising Options for Preventing and Treating Bacterial Infections Using Biomaterials.

Targeted therapy represents a real opportunity to improve the health and lives of patients. Developments in this field are confirmed by the fact that the global market for drug carriers was worth nearly $40 million in 2022. For this reason, materials engineering and the development of new drug carrier compositions for targeted therapy has become a key area of research in pharmaceutical drug delivery in recent years. Ceramics, polymers, and metals, as well as composites, are of great interest, as when they are appropriately processed or combined with each other, it is possible to obtain biomaterials for hard tissues, soft tissues, and skin applications. After appropriate modification, these materials can release the drug directly at the site requiring a therapeutic effect. This brief literature review characterizes routes of drug delivery into the body and discusses biomaterials from different groups, options for their modification with clindamycin, an antibiotic used for infections caused by aerobic and anaerobic Gram-positive bacteria, and different methods for the final processing of carriers. Examples of coating materials for skin wound healing, acne therapy, and bone tissue fillers are given. Furthermore, the reasons why the use of antibiotic therapy is crucial for a smooth and successful recovery and the risks of bacterial infections are explained. It was demonstrated that there is no single proven delivery scheme, and that the drug can be successfully released from different carriers depending on the destination.

Carbon reduction and understanding through simulation of transportation (CRUST) for e-commerce

Online shopping has replaced a substantial percentage of brick-and-mortar shopping in the last two decades, and many consumers remain uninformed about the CO2 emission impact for both. FedEx and ShopRunner have a unique combination of data that enables the simulation of e-commerce order delivery as well as passenger vehicle trips to brick-and-mortar locations. In this work, we study the potential distribution of CO2 emissions for customer trips to retail locations and contrast this with the impact of individual e-commerce orders on CO2 emissions for delivery routes. We do this by simulating the result of adding customers to delivery routes and also simulating likely customer routes to retailer locations. These two simulations allow us to directly compare the expected CO2 emissions for both methods of shopping. The scope of this work is correspondingly limited to the trade-off in last mile delivery emissions resulting from the choice of online shopping or traveling to a retailer. This work contributes to the discussion of CO2 emissions and commerce by simulating CO2 emissions for last-mile carrier delivery or pickup by an individual. The research done in this study concludes that, when considering last-mile delivery or pickup only under the specific scenarios used for the study, having purchases delivered likely has a lower CO2 impact than traveling to a store or location to pick up a product purchased online. In addition, survey results that were gathered as a part of this study indicate a consumer preference for environmentally friendly purchase options. We also show how this information can be estimated for presentation to customers during the checkout process in an understandable manner. This study provides practical information to supply chain companies and consumers, showing that shipping and delivery options can have a positive impact on CO2 emissions.

The Role of Financial Institution Facilities in Ensuring Customer Contentment in Commercial Banking Institutions in Bamenda-Cameroon

Banks across the globe have been experiencing fast changes in recent years. The banking industry in particular has benefited greatly from the expansion of information technology which has allowed for numerous delivery routes for online consumers and the rapid resolution of concerns. This study seeks to find out the role of financial institution facilities in ensuring customer contentment in commercial banking institutions in Bamenda-Cameroon. A questionnaire was used in the study and it was administered to bank employees, government employees and some business owners. Simple random sampling technique was employed as a sample technique and simple linear regression analysis was used to analyze the data. The population size for this study was 700 and a total of 280 questionnaires were distributed but 254 questionnaires were returned resulting to a sample size of 254. The findings of this study revealed that frequent use of ATM cards has a significant positive effect on consumer contentment, financial institution facilities also has a positive effect on the consumer contentment and internet banking has a significant negative effect on consumer contentment. Digitalization of banking activities also helps to reduce fraud because information cannot be altered. The study recommends that financial institution facilities should involve uploading of documents for account opening and loan request. Consumer contentment is priority to achieving banking goals based on the quality of services provided by banks to meet the needs of customers. It is recommended that banks should improve on the quality of digitalized services in order to increase the customer base of the bank.

Measurement and Analysis of Last-Mile Parcel Delivery Truck Vibration Levels in Korea

South Korea has one of the largest e-commerce markets in the world. The last-mile delivery segment of e-commerce often causes critical damage to products in protective packages. Despite the rapid growth of the e-commerce market in Korea, the last-mile distribution environment has not yet been thoroughly investigated. The main aim of this study was to provide an understanding of the vibration levels that were measured from various parcel delivery routes within Seoul, Korea, using common types of parcel delivery trucks. Vibration levels of ten delivery trucks were measured and analyzed in terms of power spectral densities (PSDs) and presented as PSD spectra. The last-mile delivery vehicle vibration levels in Korea were found to be consistently lower (in the 1 to 200 Hz frequency range) than those recommended by international standards and lower than the vibration levels of parcel delivery vehicles in the U.S. and Hungary. The results also revealed that the highest intensity peak of the PSD spectrum for Korea was located in the lower frequency range (1.5 to 2 Hz) compared to the ISTA 3A pickup and delivery test profile (3 to 4 Hz) and the test profile recommended for Hungary (13 to 16 Hz). A smoothed composite spectrum was also provided to support Korean packaging engineers in optimizing their packages by simulating proper last-mile truck delivery vibration levels in lab conditions.

An exact method for a last-mile delivery routing problem with multiple deliverymen

The demand for efficient last-mile delivery systems in large cities creates an opportunity to develop innovative logistics schemes. In this paper, we study a problem in which each vehicle may travel with more than one deliveryman to serve multiple customers with a single stop of the vehicle, increasing the delivery efficiency. We extend the vehicle routing problem with time windows and multiple deliverymen by explicitly considering the deliveryman routes. We introduce the problem, formally define it with a formulation, propose valid inequalities, and develop a tailored branch-and-Benders-cut (BBC) algorithm to solve it. The BBC is capable of solving 89% of the instances to proven optimality in reasonable times, many of them of realistic sizes. Additionally, we show the benefits of evaluating the deliveryman routes considering a cost minimization perspective, and discuss relevant solutions for urban logistics problems that can help decrease congestion and emissions.

C1q/Tumor Necrosis Factor-Related Protein-9 Enhances Macrophage Cholesterol Efflux and Improves Reverse Cholesterol Transport via AMPK Activation.

Cholesterol efflux from foam cells in atherosclerotic plaques is crucial for reverse cholesterol transport (RCT), an important antiatherogenic event. ATP-binding cassette (ABC) transporters, ABCA1 and ABCG1, are key receptors in the cholesterol efflux pathway. C1q/tumor necrosis factor-related protein-9 (CTRP9) is a newly discovered adipokine and exhibits an atheroprotective activity. However, the role of CTRP9 in RCT still remains unknown. In this work, we investigated the effect of subcutaneous administration of CTRP9 protein on RCT and atherosclerotic lesion formation in ApoE-/- mice fed with a high-fat diet. CTRP9-dependent regulation of cholesterol efflux and ABC transporters in RAW 264.7 foam cells was determined. Our results showed that CTRP9 protein decreased atherosclerotic lesions, increased cholesterol efflux, and upregulated liver ABCA1 and ABCG1 expression in ApoE-/- mice. CTRP9 treatment dose-dependently increased mRNA and protein expression of ABCA1, ABCG1, and LXR-α in RAW 264.7 foam cells. Moreover, the expression and phosphorylation of AMPK was potentiated upon CTRP9 treatment. Notably, CTRP9-induced cholesterol efflux and upregulation of ABCA, ABCG1, and LXR-α were impaired when AMPK was knocked down. AMPK depletion restored cholesterol accumulation in CTRP9-treated RAW 264.7 cells. Taken together, subcutaneous injection is an effective novel delivery route for CTRP9 protein, and exogenous CTRP9 can facilitate cholesterol efflux and promote RCT in an animal model of atherosclerosis. The atheroprotective activity of CTRP9 is mediated through the activation of AMPK signaling.

Current and future microbiome-based therapies in inflammatory bowel disease.

The role of the microbiome and dysbiosis is increasingly recognized in the pathogenesis of inflammatory bowel disease (IBD). Intestinal microbiota transplant (IMT), previously termed fecal microbiota transplant has demonstrated efficacy in restoring a healthy microbiome and promoting gut health in recurrent Clostridioides difficile infection. Several randomized trials (RCTs) highlighted IMT's potential in treating ulcerative colitis, while smaller studies reported on its application in managing Crohn's disease and pouchitis. This review delves into the current understanding of dysbiosis in IBD, highlighting the distinctions in the microbiota of patients with IBD compared to healthy controls. It explores the mechanisms by which IMT can restore a healthy microbiome and provides a focused analysis of recent RCTs using IMT for inducing and maintaining remission in IBD. Lastly, we discuss the current knowledge gaps that limit its widespread use. The body of evidence supporting the use of IMT in IBD is growing. The lack of a standardized protocol impedes its application beyond clinical trials. Further research is needed to identify patient profile and disease phenotypes that benefit from IMT, to delineate key donor characteristics, optimize the delivery route, dosage, and frequency.

A reinforcement learning framework for improving parking decisions in last-mile delivery

This study leverages simulation-optimisation with a Reinforcement Learning (RL) model to analyse the routing behaviour of delivery vehicles (DVs). We conceptualise the system as a stochastic k-armed bandit problem, representing a sequential interaction between a learner (the DV) and its surrounding environment. Each DV is assigned a random number of customers and an initial delivery route. If a loading zone is unavailable, the RL model is used to select a delivery strategy, thereby modifying its route accordingly. The penalty is gauged by the additional trucking and walking time incurred compared to the originally planned route. Our methodology is tested on a simulated network featuring realistic traffic conditions and a fleet of DVs employing four distinct lastmile delivery strategies. The results of our numerical experiments underscore the advantages of providing DVs with an RL-based decision support system for en-route decision-making, yielding benefits to the overall efficiency of the transport network. Highlights Combining simulation and optimisation algorithms with reinforcement learning Model DVs en-route parking decisions with a k-armed bandit algorithm Evaluating the impacts of delivery strategies on traffic congestion and in last-mile delivery efficiency

SOFTWARE FOR SOLVING THE TWO-STAGE LOCATION-ALLOCATION PROBLEMS

This article explores the construction of the mathematical model, method, and algorithm for solving the two-stage optimal location-allocation problem, along with the software implementation for algorithm execution. The developed algorithm enables the resolution of resource management and transportation problems from supply centers to consumer spaces. Considering that in the contemporary world where all resources and goods are transported over considerable distances in substantial volumes, the task of optimizing delivery routes and minimizing delivery costs remains relevant. The created algorithm can be integrated into a logistics system comprising two layers of resource delivery: initially to an intermediate supply center and subsequently to the ultimate consumer.

Local Renal Treatments for Acute Kidney Injury: A Review of Current Progress and Future Translational Opportunities.

Acute kidney injury (AKI) constitutes a significant public health concern, with limited therapeutic options to mitigate injury or expedite recovery. A novel therapeutic approach, local renal treatment, encompassing pharmacotherapy and surgical interventions, has exhibited positive outcomes in AKI management. Peri-renal administration, employing various delivery routes, such as the renal artery, intrarenal, and subcapsular sites, has demonstrated superiority over peripheral intravenous infusion. This review evaluates different drug delivery methods, analyzing their benefits and limitations, and proposes potential improvements. Renal decapsulation, particularly with the availability of minimally invasive techniques, emerges as an effective procedure warranting renewed consideration for AKI treatment. The potential synergistic effects of combined drug delivery and renal decapsulation could further advance AKI therapies. Clinical studies have already begun to leverage the benefits of local renal treatments, and with ongoing technological advancements, these modalities are expected to increasingly outperform systemic intravenous therapy.

Nonelective cesarean section is associated with the prevalence of asthma among Mexican children who attended childcare centers.

The cesarean section (CS) mode of delivery can influence the prevalence of bronchial asthma (BA), allergic rhinitis (AR), or atopic dermatitis (AD) by promoting modifications in the infantile microbiome. To analyze the prevalence of asthma in children who were born through CS and attended childcare centers. The data were obtained through an online survey that was answered anonymously by one of the parents; the survey inquired about the route of delivery of the child and the prevalence of BA, AR, and AD. A total of 525 children were included. The frequency of births by vaginal, elective CS, or nonelective CS was 34.1%, 37.9%, and 28.0%, respectively, and the prevalence of BA, AR, and AD was 4.8%, 19.8%, and 12.4%, respectively. Multivariate analyses identified nonelective CS as a factor associated with the prevalence of BA (odds ratio: 3.51, P = 0.026). Our study shows that being born through nonelective CS can increase the probability of BA in children who attended daycare centers.

Biodistribution and Safety of Human Multi-Chimeric Cells After Systemic Intraosseous and Intravenous Administration in the Experimental Mouse Model.

Cellular therapies provide promising options for inducing tolerance in transplantation of solid organs, bone marrow, and vascularized composite allografts. However, novel tolerance-inducing protocols remain limited, despite extensive research. We previously introduced and characterized a human multi-chimeric cell (HMCC) line, created through ex vivo fusion of human umbilical cord blood (UCB) cells derived from three unrelated donors. In this study, we assessed in vivo biodistribution and safety of HMCCs in the NOD.Cg-PrkdcscidIl2rgtm1Wjl/SzJ NOD scid gamma (NSG) mouse model. Twenty-four NSG mice were randomly assigned to four groups (n = 6/group) and received intraosseous (IO.) or intravenous (IV.) injections of 0.6 × 106 donor UCB cells or fused HMCC: Group 1-UCB (IO.), Group 2-UCB (IV.), Group 3-HMCC (IO.), and Group 4-HMCC (IV.). Hematopoietic phenotype maintenance and presence of human leukocyte antigens (HLA), class I antigens, in the selected lymphoid and nonlymphoid organs were assessed by flow cytometry. Weekly evaluation and magnetic resonance imaging (MRI) assessed HMCC safety. Comparative analysis of delivery routes revealed significant differences in HLA class I percentages for IO.: 1.83% ± 0.79%, versus IV. delivery: 0.04% ± 0.01%, P < 0.01, and hematopoietic stem cell marker percentages of CD3 (IO.: 1.41% ± 0.04%, vs. IV.: 0.07% ± 0.01%, P < 0.05) and CD4 (IO.: 2.74% ± 0.31%, vs. IV.: 0.59% ± 0.11%, P < 0.01). Biodistribution analysis after IO. delivery confirmed HMCC presence in lymphoid organs and negligible presence in nonlymphoid organs, except for lung (IO.: 0.19% ± 0.06%, vs. IV.: 6.33% ± 0.56%, P < 0.0001). No evidence of tumorigenesis was observed by MRI at 90 days following IO. and IV. administration of HMCC. This study confirmed biodistribution and safety of HMCC therapy in the NSG mouse model, both following IO. and IV. administration. However, IO. delivery route confirmed higher efficacy of engraftment and safety profile, introducing HMCCs as a novel cell-based therapeutic approach with promising clinical applications in solid organ, bone marrow, and vascularized composite allotransplantation transplantation.

Prandial Insulins: A Person-Centered Choice.

Postprandial hyperglycemia, or elevated blood glucose after meals, is associated with the development and progression of various diabetes-related complications. Prandial insulins are designed to replicate the natural insulin release after meals and are highly effective in managing post-meal glucose spikes. Currently, different types of prandial insulins are available such as human regular insulin, rapid-acting analogs, ultra-rapid-acting analogs, and inhaled insulins. Knowledge about diverse landscape of prandial insulin will optimize glycemic management. Human regular insulin, identical to insulin produced by the human pancreas, has a slower onset and extended duration, potentially leading to post-meal hyperglycemia and later hypoglycemia. In contrast, rapid-acting analogs, such as lispro, aspart, and glulisine, are new insulin types with amino acid modifications that enhance their subcutaneous absorption, resulting in a faster onset and shorter action duration. Ultra-rapid analogs, like faster aspart and ultra-rapid lispro, offer even shorter onset of action, providing better meal-time flexibility. The Technosphere insulin offers an inhaled route for prandial insulin delivery. The prandial insulins can be incorporated into basal-bolus, basal plus, or prandial-only regimens or delivered through insulin pumps. Human regular insulin, aspart, lispro, and faster aspart are recommended for management of hyperglycemia during pregnancy. Ongoing research is focused on refining prandial insulin replacement and exploring newer delivery methods. The article provides a comprehensive overview of various prandial insulin options and their clinical applications in the management of diabetes.

The ER-SURF pathway uses ER-mitochondria contact sites for protein targeting to mitochondria

Most mitochondrial proteins are synthesized on cytosolic ribosomes and imported into mitochondria in a post-translational reaction. Mitochondrial precursor proteins which use the ER-SURF pathway employ the surface of the endoplasmic reticulum (ER) as an important sorting platform. How they reach the mitochondrial import machinery from the ER is not known. Here we show that mitochondrial contact sites play a crucial role in the ER-to-mitochondria transfer of precursor proteins. The ER mitochondria encounter structure (ERMES) and Tom70, together with Djp1 and Lam6, are part of two parallel and partially redundant ER-to-mitochondria delivery routes. When ER-to-mitochondria transfer is prevented by loss of these two contact sites, many precursors of mitochondrial inner membrane proteins are left stranded on the ER membrane, resulting in mitochondrial dysfunction. Our observations support an active role of the ER in mitochondrial protein biogenesis.

Evaluation of Maternal and Perinatal Outcomes in Pregnancy with Preeclampsia at Aljala Maternity Hospital

Hypertensive disorders of pregnancy (HDP) accounts for 18% of maternal deaths worldwide, with an estimated number of about 62, 000–77, 000 deaths occur each year. The current study aimed to assess maternal and perinatal outcomes of pregnancies complicated by hypertension in Aljala Maternity Hospital. A retrospective, descriptive, case series analysis for four hundred patients was done on the outcome of hypertensive disorder among pregnant women who admitted and were managed at Aljala teaching hospital with preeclampsia during the years 2019 and 2020. Demographic data involving age, parity, gestational week, clinical and laboratory findings were recorded from the medical files. Additionally, delivery route, indications of cesarean section, fetal and maternal complications were determined. The current finding reported high prevalence of perinatal and maternal mortality among pregnant women with preeclampsia. Moreover, other severe maternal and perinatal complications such as Hemolysis Elevated Liver Enzyme Platelet (HELLP) syndrome, placental abruption, eclamptic fits, as well as low birth weight were also commonly reported. The current study showed early onset of preeclampsia was associated with increased risk of developing adverse maternal-fetal/neonatal outcomes compared to late-onset after 36 weeks. Our findings call for special consideration and close surveillance of those women with early-onset diseases.