Purposeful and deliberate exercise improves postprandial glucose control. However, there is less information concerning the effects of simple physical activities (standing, walking, circuit exercise) that can easily be integrated into a person’s day. Furthermore, the optimal timing between such an activity and a meal that elicits the most optimal glucose control is completely unknown. Three groups of 16 healthy adults volunteered to participate in three separate interventions: Stand (30-minutes standing still; RPE = 6±1), Walk (30-min treadmill walk at a self-selected brisk pace; RPE = 11±2, 5.6±0.8 kph), and Circuit (three sets of 10 squats, 10 push-ups, 10 lunges, 10 sit-ups; RPE = 11±2, 7.1±1.8 minutes to complete). In each intervention, participants completed four trials during which they drank a mixed-nutrient breakfast shake containing 500 kcals. Interstitial glucose responses were measured by continuous glucose monitoring (Dexcom G5). Postprandial glucose tolerance was quantified during the 2-hours period after meal ingestion. In each trial, the physical activity was completed either 2-hours after (trial A; control), immediately before (trial B), immediate after (trial C), or 30-minutes after (trial D) the meal. While trials B and D showed some improvement in postprandial glucose control compared to trial A, this was not statistically significant. Trial C, however, showed a significant improvement in mean glucose, standard deviation for glucose, and the area under the glucose curve in all three interventions (P<0.05), when compared to trial A. Energy intake (diet records) and energy expenditure (Actigraph) were consistent throughout the studies and did not influence the findings. In conclusion, low to moderate-intensity physical activity (either standing, walking, or body-weight circuit exercise) is best implemented soon after a meal to induce the greatest improvement in blood glucose control, in young healthy adults. Disclosure T.P. Solomon: None. E. Tarry: None. C.O. Hudson: None. A.I. Fitt: None. M. Laye: None. Funding Physiological Society