Delayed Tooth Eruption Research Articles

Orofacial features and medical profile of eight individuals with Kabuki syndrome.

BackgroundTo evaluate oral, craniofacial and systemic characteristics of eight patients with Kabuki syndrome (KS), aged between 3 and 16 years old.Material and MethodsIn this retrospective study, medical records of all patients were reviewed for information on family history, growth and development, medications in use, general systemic complications and oral and craniofacial characteristics.ResultsThe medical alterations found included recurrent infections such as pneumonia and otitis media (n = 6), cardiovascular malformations (n = 4), kidney abnormalities (n = 2), epilepsy (n = 2) and visual deficiency (n = 2). The individuals exhibited dental caries (n = 5), agenesis (n = 5), delayed tooth eruption (n = 4), cleft lip/palate (n = 2) enamel hypoplasia (n = 2), fusion (n = 1) and microdontia (n = 1).ConclusionsThere was a great diversity of oral, craniofacial and systemic characteristic among the KS patients, suggesting that an inter-disciplinary approach should be taken for their dental treatment. Key words:Kabuki syndrome, oral manifestations, medical alterations.

Exploring Parental Knowledge and Indigenous Practices for Infant Teething in Indian Population: A Cross-sectional Study

ABSTRACTTo assess the parental knowledge and practices regarding infant teething and attitude towards infant oral health among parents of infants aged 6 months to 3-years.Materials and methodsA cross-sectional study was conducted among 400 parents who met the inclusion criteria. A self-designed, validated questionnaire comprising 13 questions was used. Questionnaire comprised of sociodemographic details, knowledge and experience of teething symptoms, practices used to relieve it and overall attitude towards infant oral health. Descriptive statistics and Chi-square test was applied.ResultsParents attributed fever (87%), diarrhea (65%), gum irritation (71%) and desire to bite (78%) as common teething symptoms. Ninety-eight percent of the participants did not know that delayed tooth eruption could be an indicator for systemic disease. In case of first born child, parental knowledge was poor as compared to 2nd or 3rd born child (p = 0.023). Parents had a positive attitude regarding consulting a physician for teething problems and visiting a dentist for issues related to infant oral health. Tlismi necklaces (67%) and homeopathic tablets (25.8%) were two unique remedies identified in this population. Parents also reported over-the-counter use of systemic analgesics (58.2%). Emergence of upper teeth before lower teeth was considered as a bad omen by few parents.ConclusionParents wrongly attributed several systemic illnesses as teething symptoms. Though parents had a positive attitude towards infant oral care, it was not inculcated into practice.Clinical significanceParents should be advised against self-medication and to report systemic illness in children to pediatricians and pediatric dentists for correct diagnosis and appropriate treatment. This study also highlights the need for educating parents about infant teething and oral care practices related to primary dentition for eruption of healthy permanent dentition.How to cite this articleMore SG, Sankeshwari R, Ankola AV. Exploring Parental Knowledge and Indigenous Practices for Infant Teething in Indian Population: A Cross-sectional Study. Int J Clin Pediatr Dent 2019;12(6):479–483.

Surgical repositioning of the impacted permanent maxillary central incisor

Clinically missing or unerupted permanent teeth manifest in early childhood itself, yet they may be misdiagnosed or left untreated due to the lack of knowledge or experience, which might have a major impact on facial esthetics and psychological aspect of the individual. Physical obstruction is the primary local cause for delayed tooth eruption. These obstacles can be due to the presence of supernumerary teeth, mucosal barrier, scar tissue, and tumors. The procurement of conventional radiographs is restricted with the advent of cone-beam computed tomography which is considered as a best tool in an localizing impacted tooth in the field of dentistry. The present case report depicts a 2-year follow-up of a horizontally impacted maxillary permanent central incisor associated with odontoma that was surgically reimplanted successfully.

Incontinentia pigmenti – a description of three cases

Incontinentia pigmenti (IP) or the Bloch-Sulzberger syndrome is a rare genetic dermatosis that occurs in females, which is classified as an ectodermal dysplasia. Papulovesicular eruptions appear on the skin in the first days of a patient’s life and then, with the lapse of time they become verrucous and hyperpigmentation lesions evolving into incontinentia pigmenti achromians. Apart from such characteristic cutaneous lesions, female patients suffering from incontinentia pigmenti may also present other cutaneous symptoms, as well as motor system and ophthalmological dysfunctions. In 54 per cent of patients dental symptoms are observed, those including mainly hypodontia, pegged teeth and delayed tooth eruption. <b>Aim.</b> The aim of this study was to describe three cases of female patients diagnosed with the IP syndrome who were being treated in the Department of Orthodontics of the Medical University of Warsaw. <b>Case descriptions.</b> Descriptions of three cases of female patients with diagnosed IP were presented. The patients had cutaneous lesions typical for IP. Medical interviews and physical examinations were conducted with them all; radiographs were performed and diagnostic casts were made. Class III malocclusions were diagnosed as well as dental abnormalities characteristic for IP (hypodontia, malformation of teeth). Conclusions. An early diagnosis allows for a child to receive a multispecialist medical and dental care. An interdisciplinary approach makes it possible to reach, functionally and esthetically, satisfactory results in the treatment and maintain patients’ teeth in good health until the period of adultness thus ensuring that the physical and mental state of female patients affected by the syndrome improves.

POLR3B-associated leukodystrophy: clinical, neuroimaging and molecular-genetic analyses in four patients: clinical heterogeneity and novel mutations in POLR3B gene.

White matter disorders represent a spectrum of neurological diseases frequently associated with an unfavourable prognosis and a delay in diagnostics. We report the broad phenotypic spectrum of a rare hypomyelinating leukodystrophy and three novel mutations. Further, we aim to explore the role of the combined clinical and neuroimaging diagnostic approach in the era of whole exome sequencing. We present a clinical, neuroimaging and molecular-genetic characterisation of four patients from three families suffering from a rare genetic leukoencephalopathy. Two severely affected siblings (P1, P2) manifested a profound developmental delay, cerebellar symptomatology, microcephaly, failure to thrive, short stature and delayed teeth eruption with oligodontia. The other two patients (P3, P4), on the contrary, suffer from substantially less serious impairment with mild to moderate developmental delay and cerebellar symptomatology, delayed teeth eruption, or well-manageable epilepsy. In all four patients, magnetic resonance revealed cerebellar atrophy and supratentorial hypomyelination with T2-weight hypointensities in the areas of the ventrolateral thalamic nuclei, corticospinal tract and the dentate nuclei. Using whole-exome sequencing in P1, P2 and P3, and targeted sequencing in P4, pathogenic variants were disclosed in POLR3B, a gene encoding one of 17 subunits of DNA-dependent RNA polymerase III - all patients were compound heterozygotes for point mutations. Three novel mutations c.727A>G (p.Met243Val) and c.2669G>A (p.Arg890His) (P1, P2), and c.1495G>A (p.Met499Val) (P3) were found. Magnetic resonance revealed the characteristic radiological pattern of POLR3-leukodystrophies in our patients. The diagnosis of POLR3-associated leukodystrophies can be significantly accelerated using the combined clinical and neuroradiological recognition pattern. Therefore, it is of crucial importance to raise the awareness of this rare disorder among clinicians. Molecular-genetic analyses are indispensable for a swift diagnosis confirmation in cases of clear clinical suspicion, and for diagnostic search in patients with less pronounced symptomatology. They represent an invaluable tool for unravelling the complex genetic background of heritable white matter disorders.

Influences of Domestication and Island Evolution on Dental Growth in Sheep

Domestication and island evolution can lead to changes of life history along the slow-fast gradient. Shifts of life history patterns, in turn, are potentially related to alterations of patterns and timing of tooth eruption. Schultz’s rule predicts an earlier eruption of molars relative to premolars as fecundity increases during the domestication process. On the other hand, evolution on a predator-free, resource limited island might lead to a generally slow life history and delayed tooth eruption, as in the Plio-Pleistocene Balearic caprine Myotragus. In this study, we investigate tooth eruption and its relation to life history in a unique sheep population that is an example of both domestication and island evolution: the ancient and feral Soay sheep (Ovis aries) of the St. Kilda archipelago, Scotland. Tooth eruption timing and sequence is investigated in a comparative framework featuring new data on other domestic sheep (O. aries), including European mouflon (O. a. musimon), as well as wild sheep (O. vignei, O. cycloceros, O. arkal, O. orientalis, O. ammon). These data indicate that the order of eruption is similar in wild and domestic sheep, despite the fundamental life history changes that came about with domestication. However, in contrast to other domestic sheep breeds, Soay sheep erupt their teeth at an absolute older age and also tend to grow more slowly, which resembles the evolutionary trend in island-adapted Myotragus. Despite these similarities, Soay sheep do not share the slow life history pattern inferred for Myotragus, highlighting the distinctive nature of tooth eruption in Soay sheep.

Enamel defects and tooth eruption disturbances in children with sickle cell anemia.

Sickle cell anemia, a genetic disease caused by a mutation in the beta-globin gene, can present oral manifestations such as delayed tooth eruption and hypomineralized enamel and dentin. The aim of the present study was to evaluate the prevalence and severity of developmental defects of enamel (DDE) and delayed tooth eruption in children with sickle cell anemia. The sample comprised 56 male and female children with sickle cell anemia aged 6 to 12 years and treated at the Hematology and Hemotherapy Center of Pernambuco, Brazil. The data were collected according to the WHO criteria for DDE and tooth eruption. The prevalence of DDE was 58.2% and increased with age, affecting 43.8% of children aged 6 to 8 years and 66.7% of those aged 10 to 12 years (p>0.05; Pearson's chi-square test). There was no significant association between DDE and sex; the most prevalent type of DDE was diffuse opacity (6.2%). Tooth eruption was delayed in 18 children (32.1%). The delay increased with age and was detected in 11.8% of children aged 6 to 8 years, in 20.0% of those aged 8 to 10 years and in 54.2% of those aged 10 to 12 years (p<0.05; Pearson's chi-square test). Delayed tooth eruption was higher in males (36.7%, p>0.05). The prevalence of DDE was high, increased with age and was similar between sexes, while delayed eruption was higher in males and showed a significant association with age.

Dental and periodontal manifestations of glycogen storage diseases: a case series of 60 patients.

Glycogen storage diseases (GSDs) are rare genetic disorders of glycogen metabolism where the liver, kidneys, respiratory and cardiac muscles, as well as the immune and skeletal systems can be affected. Oral manifestations can also be present, but the specificity and frequency of these manifestations in the different forms of GSD are unknown. Analysis of a case series of 60 patients presenting four types of GSD (Ia, Ib, III, and IX) showed that the different types of GSDs have common and specific oral manifestations. In none of the GSD types studied, the prevalence of caries was higher than in the general population, especially in patients benefiting from current nutritional therapy, while in all GSD types the prevalence of delayed tooth eruption, agenesis, and tooth shape abnormalities was increased compared to the general population. Severe periodontitis prevalence was increased in patients with GSD Ib and neutropenia. Our results show that GSDs have oral manifestations and suggest some specificity depending on the type of GSDs.

The Brain-Lung-Thyroid syndrome (BLTS): A novel deletion in chromosome 14q13.2-q21.1 expands the phenotype to humoral immunodeficiency

Genetic defects of NKX2-1 are classically associated with hypothyroidism, benign chorea and neonatal respiratory distress. The purpose of this study was to identify the genetic pathogenesis of the “NKX2-1 triad” in a 10 year-old female presenting additional features barely described in the disorder. In the neonatal period, she presented with generalized hypotonia and respiratory distress, with later episodes of frequent wheezing. At 3 month-age developmental dysplasia of the hip was diagnosed and at 10 months, primary hypothyroidism was detected and treated. Subsequently, delayed achievement of developmental milestones and then subtle choreic movements of extremities were identified at 2 years of age. Furthermore, delayed teeth eruption and agenesis of some dental pieces, short stature and joint hyperlaxity were also noticed. At 10 years, a poor immune response to polysaccharide antigens and hypogammaglobulinemia, including all IgG subclasses were detected. Surprisingly, no mutations were identified in the complete coding region of NKX2-1 by PCR and Sanger sequencing. MLPA showed a de novo loss of gene dosage in all 3 probes located in NKX2-1 exons. A CGH-array identified a deletion of 3.32 Mb in chromosome 14q13.2-q21.1 containing 20 genes, including NKX2-1, PAX9 and two candidate genes (NFKB1A and PPP2R3C) involved in immune response. The Brain-Lung-Thyroid syndrome (OMIM#610978; ORPHA:209905) associated with other clinical phenotypes should suggest monoallelic deletions of chromosome 14 causing haploinsufficiency of NKX2-1, and other contiguous genes like PAX9 (hypodontia) or other dosage-sensitive genes in the chromosomal vicinity that emerge as candidates for hypogammaglobulinemia, mainly NFKBIA.

Modulation of incisor eruption in rats by sympathetic efferents

IntroductionIntact neural supply is necessary for tooth eruption. Sympathetic denervation accelerates or decelerates the eruption rate depending on the tooth condition (intact or injured). The aim of this study is to reexamine the role of the sympathetic innervation, through the observation of the effects of pre or post ganglionic chemical sympathectomy on the eruption of intact rat incisors. Materials and methodsDifferent groups of rats were subjected to either ganglionic or peripheral chemical sympathectomy and the observed effects on incisor eruption were compared to those made on intact/sham groups or on rats subjected to inferior alveolar nerve (IAN) lesion. ResultsThe total amount of eruption in control/naïve rats, measured over a total period of 144 h, was 3 ± 0.15 mm and decreased to 2.57 ± 0.06 mm (n = 8; p < 0.01) or 2.8 ± 0.10 mm (n = 8; p < 0.05) following treatment with guanethidine and hexamethonium, respectively. This amount decreased to 1.8 ± 0.14 mm (p < 0.001 vs. control, n = 7; or p < 0.01 vs. sham, n = 5) in rats subjected to IAN lesion. ConclusionSympathectomy delayed tooth eruption. Blocking the sympathetic effectors with guanethidine exerted more potent effects than ganglionic block with hexamethonium. Intact sympathetic supply is required for tooth growth under normal conditions.

Fluoride, Thyroid Hormone Derangements and its Correlation with Tooth Eruption Pattern Among the Pediatric Population from Endemic and Non-endemic Fluorosis Areas

To comparatively evaluate the status of fluoride in the body with thyroid activity in the pediatric population of endemic fluorosis areas. The present study also attempted to elucidate whether any correlation exists between fluoride and thyroid hormone derangement with delayed tooth eruption. A total of 400 pediatric subjects were included in the present study. All the patients were divided into two broad groups; groups A and B. Group A included 200 subjects who belonged to the endemic fluorosis area while Group B included remaining 200 subjects, who belonged to the fluorosis non-endemic area. Group B subjects were taken as control. Group A subjects were further divided into two study groups as follows: Group A1: 100 Pediatric subjects with dental fluorosis, and Group A 2: A total of one hundred pediatric subjects without dental fluorosis. Dean's index of fluorosis was calculated in all the patients. Blood samples were collected and were sent to a laboratory for assessment of thyroid hormone levels. All the results were subjected to statistical analysis by Statistical Package for the Social Sciences (SPSS) software. Mean thyroid stimulating hormone (TSH), water fluoride levels, urine fluoride levels and serum fluoride levels of subjects in group 1 were found to be significantly higher than that of subjects of group 2. Delayed tooth eruption was absent in subjects of group B while it was present in 100 subjects of group A. Thyroid hormone level derangement was seen in 54 percent subjects of group B, while it was seen in 67.5% subjects of group A. Positive correlation exists between fluorosis and thyroid functional activity. However; the tooth eruption pattern is independent up on the thyroid hormone derangement. Delayed tooth eruption and alteration in thyroid hormone levels can occur in subjects of the endemic fluoride areas. Therefore, adequate measures should be taken for controlling such adverse effects.

The effects of gingival biotype on delayed tooth eruption in different age groups: A preliminary cross-sectional study

Aim: The aim of this study is to determine the relationship between gingival biotype and delayed eruption using the probe transparency technique in different age groups.The hypothesis of the present study is that the thick gingival biotype may lead to delayed eruption. Material and Methods: A total of 131 patients (mean age, 90.21± 27.76 months), including 68 males and 63 femaleswere included in the study.Patientswereexamined in 3 groupsaccordingtotheirdentitionperiods: betweentheages of 3-5 years in Group 1 (G1), 6-8 years in Group 2 (G2), and 9-12 years in Group 3 (G3). Clinically, thegingivalbiotypewasrecordedbyprobetransparency technique. Dentalage of thepatientswasevaluatedaccordingtoDemirjianmethod on digitalpanoramicradiographs. Statistically the chi-square test was used for analysing between the gingival biotype and delayed eruption. Results: The thick gingival biotype was observed in 88.4% and 79.1% in the maxilla and mandible in G1, respectively. In G2, thick biotype-related maxillary delayed eruption was observed in 35% of patients.In G3, thepatientswhohave a thingingivalbiotype in mandibulararchshowedprematureeruption. Conclusion: Delayederuptionmay be relatedespecially in thickgingivalbiotype in maxillaryarch.

Nutritional status is associated with permanent tooth eruption chronology

Either obesity and underweight are public health concerns that affect the development of children. Aim: The aim of this study was to evaluate whether the nutritional status affects permanent tooth eruption chronology in Brazilian children. Methods: A hundred sixty children were examined by a pediatric dentistry and at the clinical examination, the number of erupted permanent teeth was evaluated. The anthropometric measurements of the children were determined, and they were divided into groups: underweight, eutrophic, overweight and obese. The association between delayed tooth eruption and nutritional status groups was evaluated using chi-square test. The Shapiro–Wilk test was used to verify the normality of the data. To compare the mean number of delayed teeth according to nutritional status’ groups Kruskal-Wallis test with multiple comparison by Dunn's test was performed. Results: Fifty-six children had delayed tooth eruption in at least one permanent teeth and delayed tooth eruption was more common in underweight children than in eutrophic children (p=0.0091). Conclusion: In conclusion, our study suggests that underweight Brazilian children have a higher incidence of delayed eruption.

‘Pinky' Tooth: A Rare Faces Of Delayed Tooth Eruption

Introduction: Delayed tooth eruption (DTE) is the emergence of a tooth into oral cavity that deviates from norms established for different races, ethnics and sexes, which commonly caused either by local or systemic conditions. A case of 10 year-old, Malay girl with unknown underlying medical illness, presented with delayed eruption of maxillary permanent right central incisor. The case history revealed frequent dental abscess around age of 5, followed by dental extraction under local anaesthesia. The clinical examination showed the presence of unerupted tooth 11, elongated but encapsulated with gingiva mimicking a ‘pinky’ tooth. A minimal gingivectomy was carried out to remove the mucosal barrier under topical anaesthesia and tooth 11 erupted completely 2 weeks later without the need for further treatment. This distinct aesthetic problem that affected the child’s self-confidence, can be overcome if was referred earlier. Surgical intervention has produced fast and good outcome for this kind of DTE.

Oral Manifestations in Pediatric Patients with Coeliac Disease - A Review Article.

Background:Coeliac disease is a chronic enteropathy that remains a challenge for the clinician, due to its atypical manifestations and etiopathogenic complexity.Objective:This article intends to describe the oral characteristics of Coeliac Disease in children in order to facilitate their management in the dental office.Methods:A review of the literature was performed electronically in PubMed (PubMed Central, and MEDLINE) for articles published in English from 2000 to April of 2017. The article is also based on the authors' clinical experience with children with coeliac disease. The searched keywords were “coeliac disease “,”oral manifestations “, “dental enamel defects”, “recurrent aphthous stomatitis” and “oral aphthous ulcers”.Results:There are some oral manifestations which are strictly related to coeliac disease: dental enamel defects, recurrent aphthous stomatitis, delayed tooth eruption, multiple caries, angular cheilitis, atrophic glossitis, dry mouth and burning tongue.Conclusion:The complete knowledge of the oral manifestations of coeliac disease can trigger an effective change in the quality of life of the patients with this disease.

OSTEOPETROSIS, A RARE CONDITION - REPORT CASE

Osteopetrosis comprises a heterogeneous group of inherited skeletal disorder characterized by a marked increase in bone density, by altering the normal function of osteoclasts and the consequent defect in bone resorption and remodeling. It can be described in 2 main forms: autosomal recessive malignant infantile osteopetrosis and benign autosomal dominant osteopetrosis. There may be some oral complications such as delayed tooth eruption, missing teeth, malformed teeth, enamel hypoplasia, disturbances in dentinogenesis, prone to decay, periodontal defects in membrane protrusion and presence of odontomas. The aim of this study is to report a case of a 2-year-old male patient, which was brought by the responsible to our service of Stomatology with asymmetry and facial deformities complaints. The patient was already in medical care, bringing skull magnetic resonance showing changes consistent with the diagnosis of osteopetrosis. He underwent bone marrow transplantation and is under clinical follow-up.

Thyroid Function during Early Life and Dental Development

Children with low levels of thyroid hormones (hypothyroidism) have delayed tooth eruption, enamel hypoplasia, micrognathia, and anterior open bite, whereas children with hyperthyroidism may suffer from accelerated tooth eruption, maxillary, and mandibular osteoporosis. However, it is still unknown whether thyroid function variations within the normal or subclinical range also have an impact on hard dental tissues in healthy children. The objective of this study was, therefore, to investigate the association between thyroid function from the fetal period until early childhood and dental development at school age. This study is embedded in the Generation R Study, a population-based cohort study established in Rotterdam, the Netherlands. Maternal thyroid function (thyroid-stimulating hormone [TSH], free thyroxine [FT4], and thyroid peroxidase antibody [TPOAb] concentrations) was measured during early pregnancy, and thyroid function of the offspring (TSH and FT4) was measured in cord blood at birth and in early childhood (6 y). Dental development was assessed from panoramic radiographs of children of school-going age (9 y). In total, 2,387 to 2,706 subjects were available for the multivariable linear regression analysis, depending on the point in time of thyroid function measurement. There was an inverse association between cord blood and early childhood TSH concentrations with dental development, with a –0.06 lower standard deviation (SD) per 1 mU/L of TSH (95% confidence interval [CI], –0.11 to –0.01) and a –0.06 lower SD per 1 mU/L of TSH (95% CI, –0.11 to 0.00), respectively. There was no association between the maternal thyroid function during pregnancy and the dental development score of the child. However, TPOAb-positive mothers had children with a –0.20 SD (adjusted 95% CI, –0.35 to –0.04) lower dental development score compared with TPOAb-negative mothers. The findings of this study suggest that the thyroid hormone is involved in the maturation of teeth from the early stages of life onward.

The Sirt6 gene: Does it play a role in tooth development?

Dental Mesenchymal Cells (DMCs) are known to play a role in tooth development as well as in the repair and regeneration of dental tissue. A large number of signaling molecules regulate the proliferation and differentiation of DMC, though the underlying mechanisms are still not fully understood. Sirtuin-6 (SIRT6), a key regulator of aging, can exert an impact on embryonic stem cell (ESC) differentiation. The experimental deletion of Sirt6 in mouse bone marrow cells has been found to have an inhibiting impact on the bone mineral density and the osteogenic differentiation of these cells. The possible role of Sirt6 in tooth development, however, has at present remained largely unexplored. In the present study, we found that SIRT6 had no effect on tooth development before birth. However, Sirt6 gene deletion in knockout mice did have two post-natal impacts: a delay in tooth eruption and sluggishness in the development of dental roots. We propose an explanation of the possible molecular basis of the changes observed in Sirt6-/- mice. SIRT6 is expressed in mouse odontoblasts. Sirt6 deletion enhanced the proliferation of DMCs, as well as their capacity for adipogenic differentiation. On the other hand, it inhibited their capacity for in vitro osteogenic/chondrogenic differentiation. Further studies suggested that other factors may mediate the role of Sirt6 in odontogenesis. These include the nuclear factor kappa B (NF-κB), p38 mitogen-activated protein kinase (p38-MAPK), extracellular regulated MAP kinase (ERK) pathways and the mitochondrial energy. We demonstrated that Sirt6 plays a role in tooth root formation and confirmed that SIRT6 is necessary for DMC differentiation as well as for the development of the tooth root and for eventual tooth eruption. These results establish a new link between SIRT6 and tooth development.

Effects of pamidronate administration on tooth eruption and mandibular growth in new born rats.

Bisphosphonates are commonly used drugs in pediatric patients in the treatment of osteoporotic diseases and various types of cancers. The purpose of this study was to evaluate the effects of pamidronate administration on mandibular growth and tooth eruption in new born rats. Forty Sprague Dawley rats were included in the study and divided into four groups as; 14th day pamidronate group, 30th day pamidronate group, 14th day control group and 30th day control group. Pamidronate groups were daily injected with 1.25 µg/g pamidronate disodium subcutaneously whereas control groups were injected with sterile saline. Eruption levels of lower incisor and molar teeth were assessed macroscopically. Mandibular growth was assessed by measuring reference points in cone beam tomography. Histological and histomorphometric examinations were performed under light microscope to evaluate tooth morphology and number of osteoclasts. Retardation in mandibular growth, decrease in number of osteoclasts, delay in tooth eruption, degeneration in both tooth morphology and structure were observed in the pamidronate groups compared to control groups. Pamidronate administration during growth and development stage may adversely affect tooth eruption and mandibular growth in new born rats.

Orthodontic management of delayed permanent tooth eruption and a case report of hyper-IgE syndrome

This article aims to look at the treatment and management of patients presenting with delayed tooth eruption of the permanent dentition. We describe the case of a 17-year-old girl who presented having been diagnosed with Hyper-IgE syndrome. The patient was positive for the STAT-3 gene and presented with a history of some classic Hyper-IgE features. There was a history of multiple skin abscesses and she was on long-term antibiotics. She presented in the mixed dentition with multiple retained deciduous teeth and a full complement of unerupted and fully formed permanent teeth. This article will describe features of this syndrome and discuss management strategies for patients presenting with delayed eruption. Clinical Relevance: This case study highlights the difficulties in managing patients who present with retained primary dentition at an older age. It also presents a rare case presentation of a patient with Hyper-IgE.