Degree Of Disorder Research Articles

The Optimization of Pair Distribution Functions for the Evaluation of the Degree of Disorder and Physical Stability in Amorphous Solids.

The amorphous form of poorly soluble drugs is physically unstable and prone to crystallization, resulting in decreased solubility and bioavailability. However, the conventional accelerated stability test for amorphous drugs is time-consuming and inaccurate. Therefore, there is an urgent need to develop rapid and accurate stability assessment technology. This study used the antitumor drug nilotinib free base as a model drug. The degree of disorder and physical stability in the amorphous form was assessed by applying the pair distribution function (PDF) and principal component analysis (PCA) methods based on powder X-ray diffraction (PXRD) data. Specifically, the assessment conditions, such as the PDF interatomic distance range, PXRD detector type, and PXRD diffraction angle range were also optimized. The results showed that more reliable PCA data could be obtained when the PDF interatomic distance range was 0-15 Å. When the PXRD detector was a semiconductor-type detector, the PDF data obtained were more accurate than other detectors. When the PXRD diffraction angle range was 5-40°, the intermolecular arrangement of the amorphous drugs could be accurately predicted. Finally, the accelerated stability test also showed that under the above-optimized conditions, this method could accurately and rapidly assess the degree of disorder and physical stability in the amorphous form of drugs, which has obvious advantages compared with the accelerated stability test.

Optimizing the synthesis of ZnFe2O4 through chemical and physical methods: effects of the synthesis route on the phase purity, inversion, and magnetic properties of spinel zinc ferrite

In this work, ZnFe2O4 ferrites were prepared by chemical (coprecipitation) and ceramic (ball-milling) methods. The effects of the synthesis route on the phase purity, crystallinity, particle size distribution, and magnetic properties were investigated to identify the most appropriate conditions for the synthesis of high-quality ferrites. The samples were examined by x-ray diffraction, scanning electron microscopy, thermal gravimetric analysis, Fourier transform infrared spectroscopy, vibrating sample magnetometry, and Mössbauer spectroscopy. The XRD patterns revealed that a high-purity spinel phase was obtained by coprecipitation at pH ≥ 7 by calcining the pristine powder at T ≥ 900 °C, whereas a single spinel phase was obtained at T ≥ 700 °C in the ball-milling method. The crystallite size of the spinel phase exhibited general increasing trends with the increase of the pH value under the same heat-treatment conditions and with the increase of the calcination temperature. Additionally, the mean physical particle size exhibited an increasing trend with the increase of the calcination temperature. The VSM measurements revealed a noticeable degree of inversion in the spinel ferrites prepared by coprecipitation (exhibiting the highest degree at pH = 10) and an insignificant degree of inversion in the spinel ferrites prepared by the ceramic method. However, calcining the powder exhibiting the highest degree of inversion (prepared by coprecipitation at pH = 10) at 1100 °C resulted in ordering the zinc ions at tetrahedral sites of the spinel structure. Mössbauer spectra for representative zinc ferrite samples prepared by the two methods revealed a major central doublet (with a small magnetic sextet corresponding to the α-Fe2O3 phase in the sample at pH = 7). The hyperfine parameters of the doublet observed in the Mössbauer spectra of the samples, and the corresponding magnetization behavior revealed a higher degree of ionic disorder in the spinel ferrite prepared by coprecipitation.

Effect of growth conditions on magnetization reversal and magnetic anisotropy in Co2Fe0.5Ti0.5Si quaternary Heusler alloy thin films

Ferromagnetic resonance and magneto-optic Kerr effect (MOKE) techniques are employed to unravel the nature of ‘in-plane’ (IP) magnetic anisotropy and magnetization reversal (MR) processes in magnetron-sputtered 100 nm Co2Fe0.5Ti0.5Si (CFTS) thin films, deposited (and subsequently annealed) at different substrate temperatures (Ts) ranging from 200 °C to 550 °C. By varying TS, the CFTS films are produced with different amounts of anti-site (AS) atomic disorder. Irrespective of the degree of AS disorder, the IP uniaxial magnetic anisotropy (UMA) is prevalent in all the CFTS films. The TS450 and TS500 films, deposited at T S = 450 °C and 500 °C, stand out as they have (i) the least AS disorder, (ii) lowest value (α = 0.0055) of the Gilbert damping constant, (iii) high saturation magnetization ( ≅770 G ) at 300 K, (iv) UMA energy density as high as ≅1.6×104erg/cc at 120 K dropping to ≅1.0×104erg/cc at 300 K, (v) spin-wave stiffness ( D ) at T = 0 K, D0≅175 meVÅ2 and, as in other CFTS films, the electron–magnon interaction is primarily responsible for the thermal renormalization of D . Furthermore, in the TS450 and TS500 films, MOKE hysteresis loops at various angles ( ψH ) that the field makes with the easy axis in the film plane, reveals two mutually exclusive UMAs, UMA1≫UMA2 , with easy axes perpendicular to each other. By contrast, only a single UMA is observed in all the remaining films. When ψH=0∘ , MOKE domain images reveal that, consistent with the uniaxial nature of magnetic anisotropy, an abrupt reversal of magnetization is accompanied by the formation of 180° domains. When ψH = 90°, due to the presence of two UMAs in TS450 and TS500 films, following the field reversal, first the reverse domains nucleate and then grow at the expense of the fundamental domains through field-induced domain wall motion.

Prevalence and correlates of mental disorders among Chinese overseas students during the COVID-19: A multi-regional cross-sectional analysis.

The global impact of the COVID-19 pandemic extends beyond physical health, significantly affecting mental health. Chinese overseas students are particularly susceptible to the adverse psychological effects of the pandemic. Understanding the prevalence and correlates of mental disorders in this population is essential for developing targeted interventions and support systems. Employing a snowball sampling technique, this study recruited Chinese overseas students from diverse regions. The 50-item Self-evaluation Table was utilized to assess the presence of mental disorders. Descriptive statistics, including percentages, 95% confidence intervals, means, and standard deviations, characterized the survey population. The chi-square test identified disparities among categorical variables, while logistic regression explored risk factors for mental disorders among Chinese overseas students. Out of the total sample size of 10,864 Chinese overseas students, a staggering 7,090 (65.4%) met the diagnostic criteria for mental disorders. Furthermore, the degree of mental disorder varied significantly across different regions (p < 0.001), education levels (p < 0.05), the duration of anti-epidemic measures (p < 0.05), and age (p < 0.05), while no significant differences were observed in terms of gender (p > 0.05). Several risk factors contributing to the mental disorder burden among Chinese overseas students during the pandemic were identified, including the seriousness of the epidemic in their residential area, the apprehension of getting infected, anxieties regarding academic performance, the infection control policies implemented by the host government, preventive measures taken locally to counter the epidemic, and challenges encountered in returning to their home country. Given the significant challenges in mental health faced by Chinese overseas students during the COVID-19 crisis, addressing their specific needs and implementing tailored measures is imperative. Future public health emergencies should consider the potential mental disorders and disease risks faced by Chinese overseas students. By providing comprehensive support and targeted interventions, policymakers, educational institutions, and healthcare providers can help mitigate the adverse psychological effects and promote the well-being of this vulnerable population.

Tribology performance of diamond-like carbon films on polyether-ether-ketone surfaces

Diamond-like carbon films were deposited on the polymer PEEK surface using a magnetron sputtering system. Experiments were conducted under varying rotational friction speed conditions. Special attention was devoted to assessing the surface condition of spherical spots post-friction experiments. Optical microscopy, friction tester, Raman spectroscopy, XPS analysis, and atomic force microscopy were employed to examine film surface morphology, atomic bonding structure, and surface roughness. The results indicate that thin film wear trace exhibits a graphitization trend that increases and then decreases, peaking around 350 rpm (0.11 m/s). Conversely, for spherical spots, the graphitization pattern is the opposite, suggesting a higher degree of disorder in the transferred film on these spots. XPS analysis reveals multiple chemical bonding structures between carbon and oxygen elements on the spherical spots. Notably, under the optical microscope, spherical spots exhibit clear directional alignment, which is absent on the film surface. This study introduces an innovative approach for producing diamond-like carbon films with lubricating and anti-wear properties. It also provides guidance for designing high-performance polymer tribo-systems in industrial applications.

Structural Properties of Amorphous Vanadium Pentoxide Under Compression

Structural properties of amorphous vanadium pentoxide (V2O­5) under compression investigated by molecular dynamics simulation. The simulated amorphous V2O5 is composed of basic structural units of type VO5, VO6 at low-pressure and VO6, VO7 at high-pressure. These basic structural units connected by vertex-, edge- and face- shared links to form a structural network. The random distribution of atom and void clusters leading to a high degree of disorder in the V2O5 structure. Under compression, the fraction of average vertex-, edge- and face- shared links increased strongly. The number of VCs and VTs also increases as the large voids are divided into smaller voids. Our results also elucidated the decreasing of cross-section and increasing of length in VTs are main causes for increasing ion conductivity of the amorphous V2O5.

Air-mediated phosphoric acid activation strategy for preparation of oxygenated functional groups rich activated carbon for capacitive deionization

Atmosphere during H3PO4 activation is vital to the texture structure and surface-interface properties of activated carbon (AC), but the researches are way out of sufficiency. In this work, it is found that the air in the H3PO4 activation process is not only conducive to the introduction of more-oxidized oxygenated functional groups on ACs, but also beneficial to the formation of micropores rather than mesopores. Besides, as the air content increases in H3PO4 activation, the ACs’ ash, phosphorous content and conductivity reduce, but their wettability, disorder degree and defect number increase. In addition, the potential of zero charge of the as-prepared ACs is positively correlated with the O-CO content, which show a pattern of first increasing and then decreasing with the increase of air content. Benefit from the improved hydrophilicity, electrolyte-affinity, additional adsorption sites for sodium ions, the optimal AC exhibits excellent salt adsorption capacity of 12.08 mg g−1 and good cycling stability at 1.0 V in single-pass capacitive deionization. This work not only establishes a novel and effective method for regulating the texture structure and surface properties of ACs, but also provides promising cathode candidates for capacitive deionization application.

Interface Nuclei in the Y-Ag-Zn System: Three Chemical Pressure-Templated Phases with Lamellar Mg2Zn11- and CaPd5+x-Type Domains.

The interface nucleus approach was recently presented as a framework for understanding and predicting the emergence of modular intermetallic phases, i.e., complex structures derived from the assembly of units from simpler parent structures. Here, we present the synthesis and crystal structures of three new modular intermetallics in the Y-Ag-Zn system that support this strategy: YAg2.79Zn2.80 (I), YAg2.44Zn3.17 (II), and YAg2.71Zn2.71 (III). Each of these structures is derived from an intergrowth of slabs of the Mg2Zn11 and CaPd5+x types, with the chief differences being in the thickness and degree of disorder within the CaPd5+x-type domains. The merging of the parent structure domains is facilitated by their sharing a common geometrical unit, a double hexagonal antiprism. The use of this motif as an interface nucleus mirrors its role in another family of structures: an intergrowth series combining the CaCu5 and Laves phase structure types, as in the PuNi3-type phase YNi3. However, there is a key difference between the two series. While in the CaCu5/Laves intergrowths, the interface between the parent structures arises perpendicular to the interface nucleus's unique (hexagonal) axis, in the Mg2Zn11/CaPd5+x-type intergrowths revealed here, the interfaces run parallel to this axis. Using CP analysis of the Mg2Zn11/CaPd5+x-type parent structures, we trace this behavior to the different directions of high-CP compatibility of the interface nuclei in the Mg2Zn11/CaPd5+x and CaCu5/Laves structure type pairs. In this way, the Y(Ag/Zn)5+x phases highlight the role that interface nuclei play in directing the domain morphologies of modular intermetallic phases.

Neuropsychological and psychometric parameters in the patients with duodenal ulcer depending on Helicobacter pylori presence

Neuropsychological and psychometric parameters in the patients with duodenal ulcer depending on Helicobacter pylori presence

Disorder effects on flatbands in moiré superlattices.

Plenty of exotic phenomena in moiré superlattices arise from the emergence of flatbands, but their significance could be diminished by structural disorders that will significantly alter flatbands. Thus, unveiling the effects of disorder on moiré flatbands is crucial. In this work, we explore the disorder effects on two sets of flatbands in silicon-based mismatched moiré superlattices, where the level of disorder is controlled by varying the magnitude of random perturbations of the locations of silicon strips. The results reveal that, after ensemble averaging, the average spectral positions of the four flatbands exhibit stability despite variations in the degree of disorder. However, the δ-like density of states (DOS) related to flatbands in the perfect superlattice evolves into a finite-width envelope of high DOS. By increasing the level of disorder, the width of the DOS envelope increases accordingly. Particularly, we observe a fascinating contrast: the width of bandgap flatbands saturates after initial growth, while the width of dispersive-band-crossed flatbands exhibits a linear increase versus the disorder. This unveils fundamental differences in how flatbands respond to structural imperfections, offering crucial insights into their perturbation characteristics within moiré superlattices. Our work offers new perspectives on flatbands in partially disordered moiré superlattices.

Low-temperature electrical conductivity of ion-beam irradiated Bi–Sb films

Bismuth-antimony alloys are among the most studied topological insulators and also have very promising thermoelectric properties. In addition, in the amorphous state they exhibit superconductivity with critical temperatures in the range 6.0–6.4 K. In this work, we have prepared and studied different polycrystalline films of Bi100–xSbx (x = 0, 5, 10, 15), and we have induced, through ion beam irradiation, significant damage in their internal structure with the aim of amorphizing the material. Specifically, we have irradiated Bi ions in the 10–30 MeV range, exploiting the capabilities of a 5 MV ion beam accelerator of tandem type. We have characterized the Bi–Sb films before and after irradiation from a morphological and structural point of view and measured their electrical resistivity from room temperature to near 2 K, to evaluate the influence of the preparation method and degree of disorder. We have found that the studied Bi–Sb system always behaves as a small energy gap semiconductor that follows the empirical Meyer–Neldel rule, which correlates the conductivity prefactor with the exponential value of the energy gap.

Dynamic Simulation Analysis of Aviation Gear Transmission Based on Rough Tooth Surface

In order to explore the influence of tooth surface microstructure on the dynamics of aviation gear transmission, this paper describes the profile of aviation gear considering rough surface based on fractal theory. With the help of the established gear fractal contact model, the dynamic parameters such as time-varying friction coefficient, time-varying meshing stiffness and transmission error of rough tooth surface are characterized. The nonlinear dynamic model of aviation gear is established to solve the dynamic response of smooth and rough tooth surface. The dynamic meshing force, dynamic friction force, vibration time domain and frequency domain diagram are obtained, and the corresponding experiments are carried out. The simulation and experimental results show that the fluctuation range of the dynamic simulation results of aviation gear transmission based on rough tooth surface will be larger, and it has a certain degree of disorder, which is closer to the experimental results.

Mental Health Disorders in Healthcare Workers Exposed to COVID-19, Mashhad, Iran: A Cross-sectional Study

Background: Healthcare workers (HCWs) who are directly involved in the management of patients with SARS-CoV-2 infection are at higher risk of psychological disorders. Objective: In this study, we evaluated the risk factors related to mental health disorders in HCWs active in the management of the COVID-19 pandemic in Mashhad, Iran. Methods: This was a cross-sectional investigation performed between April 2020 and May 2020 at five referral centers in Mashhad, Iran. Patient Health Questionnaire (PHQ-9), 7-item Generalized Anxiety Disorder scale (GAD-7), Insomnia Severity Index (ISI), Impact of Event Scale–Revised (IESR), and VAS (for fear from COVID-19) to assess depression, anxiety, insomnia, distress and fear related to COVID-19 were filled. Risk factors were evaluated by the regression model. Results: Mean ± SD age of participants was 33.84 ± 7.03 years. Most were females (64.2%). Of 360 participants, 252 had some degree of an anxiety disorder (70%), 63.8% had depression, 55.8% had insomnia, and 72.8% had distress. Work experiences (OR: 0.94, 95% CI = 0.901- 0.983, p = 0.007), exposure to COVID-19 patients (OR: 2.54, 95% CI = 1.37-4.69, p &lt; 0.001), and job status (OR: 1.40, 95% CI = 1.19 -1.54, p &lt; 0.001) were significant predictors of anxiety. Age (OR: 1.15, 95% CI = 1.05-1.27, p = 0.002), exposure to COVID-19 patients (OR: 1.95, 95% CI = 1.04-3.64, p = 0.037), work experience (OR: 0.86, 95% CI = 0.78-0.93, p &lt; 0.001), having children (OR: 0.58, 95% CI = 0.39- 0.87, p = 0.008), and being infected with COVID-19 (OR: 9.95, 95% CI = 1.92-51.64, p &lt; 0.001) were the significant independent factors for depression in participants. Conclusion: COVID-19 could significantly affect HCWs mental health status, specifically depression. By targeting these predictors, health policymakers can reduce the burden of psychological disorders in HCWs.

High Potential Electrochemical Synthesis of Thermally Reduced Graphene Nanomaterial

In this study, we provide electrochemical techniques for synthesizing thermally reduced graphene nanomaterial that have high potential, low defects, cost-effectiveness, and ecological sustainability. The electrochemical exfoliation is carried out by employing a 195 W DC (voltage = 60[Formula: see text]V and current = 3.25 A) power source at a maximum electrolyte temperature of about 92.5∘C within the aqueous suspension of 2[Formula: see text]M of sulfuric acid (H2SO[Formula: see text]. Thereafter, the synthesized nanomaterial was treated in the weak piranha [combination of sulfuric acid and hydrogen peroxide (H2O[Formula: see text]] solution using an electrochemical technique inside the water bath sonicator at 80∘C. X-ray diffraction (XRD) analysis shows the peak of diffraction to the (002) plane of the reduced graphene oxide (RGO) samples emerges at around 2[Formula: see text] and 26.56∘ with an interplanar distance of 3.40 Å and 3.54 Å. According to the XRD data, after the high-temperature thermal reduction phase, the structure of the crystals and interplanar separation were recovered. The size of the crystallite of RGO produced under H2SO4 conditions was discovered to be greater than the crystallite size of graphene oxide produced under piranha solution conditions. The Raman analysis results show that the degree of disorder of the graphene synthesized within the H2O2 was higher than in comparison to the graphene synthesized in H2SO4. Field emission scanning electron microscopy (FE-SEM) results show that graphene synthesized in the presence of H2O2 has a thin and porous microstructure in comparison to H2SO4 with no significant effect on the presence of the availability of the C/O ratio. The atomic force microscopy (AFM) analysis indicates that the surface roughness of the graphene synthesized in the H2O2 was higher than that of the H2SO4. The Fourier transform infrared spectroscopy (FT-IR spectroscopy) analytical results show that the majority of the functional groups have been eliminated within the samples.

Complementary Feeding Practices and Weaning Practices in Morocco: A Systematic Review and Meta-Analysis

Introduction: Complementary feeding represents a crucial phase in an infant's developmental journey. Inadequate implementation, marked by an imbalance in both quantity and quality, can lead to varying degrees of nutritional disorders, whether from excess or deficiency. Study Objectives and Methods: Conducted from December 2023 to February 2024, this research aims to assess the weaning age and the age of initiating dietary diversification among Moroccan infants. Additionally, it seeks to scrutinize specific nutritional practices and behaviors within the Moroccan infant population. Our methodology involved an extensive bibliographic search using databases such as PubMed, Science Direct, Scopus, and Google Scholar, focusing on research conducted in Morocco from 2005 to 2020. Variables examined include the prevalence of breastfeeding at six months, the age of weaning, the commencement of dietary diversification at six months, and the prevalence of advice from healthcare professionals, particularly nursing experts, provided to Moroccan mothers. Results and Discussion: Complementary feeding practices in Morocco navigate the intersection of maternal nutritional beliefs and a plethora of infant feeding concepts, resulting in a complex landscape. The crucial role of medical and nursing personnel in conveying appropriate information and advice to Moroccan mothers is highlighted. Conclusion: Complementary feeding is a pivotal milestone in infant nutrition, necessitating adjustments and updates in Moroccan practices. The active involvement of medical and nursing personnel is essential to ensure optimal weight development and prevent infant nutritional disorders. Impact and Contribution of Patient or Public: Emphasizing the importance of the results in positively influencing infant feeding practices in Morocco, with a focus on the crucial role played by medical and nursing personnel in promoting infant health.

A Method for Measuring Spatial Information of Area Maps Considering the Diversity of Node–Edge and Gestalt Principles

Existing methods for measuring the spatial information of area maps fail to take into account the diversity of adjacency relations and the heterogeneity of adjacency distances among area objects, resulting in insufficient measurement information. This article proposes a method for measuring area map information that considers the diversity of the node–edge and Gestalt principles. Firstly, this method utilizes the adjacency relations between the Voronoi diagram of area objects to construct an adjacency graph that characterizes the spatial distribution of area objects in area maps. This adjacency graph serves as the information representation of area maps. Secondly, the method selects four characteristic indicators, namely geometric information, node degree, adjacency distance, and adjacency strength, to represent the diversity of nodes and edges in the graph that affect spatial information. Finally, nodes in the adjacency graph are taken as the basic units, and the spatial information of area maps is comprehensively calculated by integrating the four characteristics that represent spatial information. To verify the validity and rationality of the proposed method, a dataset of continuously simplified area maps and a dataset of artificially simulated degrees of randomness were designed to evaluate the performance of the existing method and the method proposed in this paper. The results indicate that the correlation between the measurement results obtained by the method proposed in this paper and the degree of disorder is as high as 0.94, outperforming the existing representative methods. Additionally, the correlation between the measurement results of this method and the degree of simplification reaches 1, indicating that the variation range of the measured values is more consistent with the cognitive assumptions based on artificial simulations compared to the existing methods. The experimental results show that the method proposed in this paper is an effective metric approach for representing spatial information in area maps.

Absolute Structures of a Mirror Pair of Infinite Na(H2O)4 + -Connected ε-Keggin-Al13 Species.

The absolute structures of a pair of infinite Na(H2O)4+-connected ε-Keggin-Al13 species (Na-ε-K-Al13) that were inversion structures and mirror images of each other were determined. Single crystals obtained by adding A2SO4 (A = Li, Na, K, Rb, or Cs) solution to NaOH-hydrolyzed AlCl3 solution were subjected to X-ray structure analyses. The statistical results for 36 single crystals showed that all the crystals had almost the same unit cell parameter, belonged to the same F4̅3m space group, and possessed the same structural formula [Na(H2O)4AlO4Al12(OH)24(H2O)12](SO4)4·10H2O. However, the crystals had two inverse absolute structures (denoted A and B), which had a crystallization ratio of 1:1. From Li+ to Cs+, with increasing volume of the cation coexisting in the mother solution, the degree of disorder of the four H2O molecules in the Na(H2O)4+ hydrated ion continuously decreased; they became ordered when the cation was Cs+. Absolute structures A and B are the first two infinite aluminum polycations connected by statistically occupied [(Na1/4)4(H2O)4]+ hydrated ions. The three-dimensional structure of the infinite Na-ε-K-Al13 species can be regarded as the assembly of finite ε-K-Al13 species linked by [(Na1/4)4(H2O)4]+ in a 1:1 ratio. In this assembly, each [(Na1/4)4(H2O)4]+ is connected to four ε-K-Al13 and each ε-K-Al13 is also connected to four [(Na1/4)4(H2O)4]+ in tetrahedral orientations to form a continuous rigid framework structure, which has an inverse spatial orientation between absolute structure A and B. This discovery clarifies that the ε-K-Al13 (or ε-K-GaAl12) species in Na[MO4Al12(OH)24(H2O)12](XO4)4·nH2O (M = Al, Ga; X = S, Se; n = 10-20) exists as discrete groups and deepens understanding of the formation and evolution process of polyaluminum species in forcibly hydrolyzed aluminum salt solution. The reason why Na+ statistically occupies the four sites was examined, and a formation and evolution mechanism of the infinite Na-ε-K-Al13 species was proposed.

Risk Coupling Assessment of Vehicle Scheduling for Shipyard in a Complicated Road Environment

Vehicle scheduling at shipyards can involve delays due to numerous risk factors encountered in the complicated shipyard road environment. This paper studies the problems of risk coupling in shipyard vehicle scheduling based on the risk matrix approach, considering the complicated road environment, assessing the degrees of coupling and disorder. Based on safety-engineering theory and comprehensive analysis of the road environment, four key criteria are identified, vehicles, the road environment, the working environment, and humans, including 12 factors and their specific contents. The degree of coupling between various combinations of risk criteria is quantitatively determined utilizing the N-K model. Additionally, the degree of disorder in the risk criteria is assessed based on information entropy theory. The model’s correction coefficients are determined through comparative analysis of experimental data. By integrating the degree of coupling and disorder, delays caused by different combinations of risk criteria in scheduling tasks are computed. The quantitative evaluation model enables accurate appraisal of risk events during shipyard vehicle scheduling. The model provides a valuable managerial tool to analyze delays caused when specific risk criteria are met and to compare these delays to the potential impact on time resulting from adjusting vehicle scheduling plans. This research has significant implications for enhancing vehicle distribution efficiency in shipyards.

Dodecyl creatine ester therapy: from promise to reality

Pathogenic variants in SLC6A8, the gene which encodes creatine transporter SLC6A8, prevent creatine uptake in the brain and result in a variable degree of intellectual disability, behavioral disorders (e.g., autism spectrum disorder), epilepsy, and severe speech and language delay. There are no treatments to improve neurodevelopmental outcomes for creatine transporter deficiency (CTD). In this spotlight, we summarize recent advances in innovative molecules to treat CTD, with a focus on dodecyl creatine ester, the most promising drug candidate.

Study of Optical Rogue Waves in Two-Dimensional Disordered Lattices

We probed the impact of both the degree of disorder and nonlinearity on rogue waves (RWs) in two-dimensional disordered lattices. Our results unveiled that an increase in the disorder level under linear conditions heightened the probability of RW occurrence and simultaneously contracted the “long tail”. Interestingly, with the introduction of nonlinearity, this “long tail” became shorter compared with linear conditions. Nevertheless, in the context of disordered media, RW occurrence probability demonstrated relative stability—a distinct deviation from its conduct within homogeneous media.