Degli Studi Research Articles

Luigi Pasinetti 1930–2023

Journal Article LUIGI PASINETTI 1930–2023 Get access Murray Milgate, Murray Milgate Queens’ College, University of Cambridge Search for other works by this author on: Oxford Academic Google Scholar John Eatwell, John Eatwell Queens’ College, University of Cambridge Search for other works by this author on: Oxford Academic Google Scholar Giancarlo de Vivo Giancarlo de Vivo Università degli Studi di Napoli Search for other works by this author on: Oxford Academic Google Scholar Contributions to Political Economy, bzad008, https://doi.org/10.1093/cpe/bzad008 Published: 02 May 2023 Article history Accepted: 06 April 2022 Published: 02 May 2023

The intertwined epidemics of HIV and COVID-19 - emerging data and responses.

aDivision of HIV, Infectious Diseases, and Global Medicine; Department of Medicine; University of California, San Francisco (UCSF), USA bIII Division of Infectious Diseases, Department of Biomedical and Clinical Sciences (DIBIC), Luigi Sacco University Hospital, University of Milan, Italy Correspondence to Agostino Riva, and Monica Gandhi, MD, Universita degli Studi di Milano, Milano, Italy. E-mail: [email protected]; [email protected]

Spatial decrease in muscle activation induced by acute passive static stretching: a possible neuromuscular compartmentalization of the gastrocnemius muscle

Recently, spatial adaptation of muscle excitability during sustained muscle voluntary contractions (MVC) up to fatigue has been reported, suggesting a functional muscle compartmentalization. Acute passive stretching (PS) can induce a reduction in surface electromyography (sEMG) amplitude; however, it is not clear whether PS may decrease motor-unit activity heterogeneously, similar to what occurs with fatigue. Therefore, the aim of the study was to evaluate possible heterogeneity in muscle activation following PS intervention in the gastrocnemius muscle. Thirty healthy men (age: 24±2 yrs., stature: 1.78±0.07 m, body mass: 77±6 kg) underwent a 5-min PS intervention (5 x 45s-on/15s-off cycles). Before (PRE), immediately after (POST) and after 5 (POST5) and 10 min (POST10), participants performed MVCs of the plantar-flexor muscles. Spatial muscle activation was recorded by means of high-density sEMG (HD-sEMG) in the gastrocnemius medialis and lateralis of the stretched and of the contralateral, non-stretched limb. The HD-sEMG root mean square (RMS) and its centroid were calculated. During stretching, the fascicle length and pennation angle (ultrasound approach) were measured for the proximal and distal portion of both muscles, together with the perceived level of discomfort (0-10 visual analogue scale). HD-sEMG RMS was reduced in POST, POST5 and POST10 in both gastrocnemius medialis (p<0.05 in all) and lateralis (p<0.05 in all) of the stretched limb, while the centroid shifted toward a more caudal direction (p<0.05). Interestingly, the same behaviour was found in the contralateral limb in POST for both muscles (both p<0.05). No differences were found in control. During stretching, no differences were found in fascicle length and pennation angle between the proximal and distal portion, whereas a higher discomfort was perceived in the distal portion of both muscles (p<0.05 in all). The uneven spatial decrease in muscle activation following acute PS suggests differences in neuromuscular organization of the gastrocnemius muscle. Possibly, a different discomfort perception between the proximal and distal portion could have induced a different inhibitory effect. The study was funded by a grant of the Universitnà degli Studi di Milano This is the full abstract presented at the American Physiology Summit 2023 meeting and is only available in HTML format. There are no additional versions or additional content available for this abstract. Physiology was not involved in the peer review process.

Axial Postural Abnormalities in Parkinsonism: Gaps in Predictors, Pathophysiology, and Management.

Axial Postural Abnormalities in Parkinsonism: Gaps in Predictors, Pathophysiology, and Management.

The ‘Deluge’ of 25 October 1822 in Genoa, Italy

The ‘Deluge’ of 25 October 1822 in Genoa, Italy

5613386 CELEBRATING THE SICKLE CELL DISEASE WORLD DAY ON JUNE 19TH AFTER TWO YEARS OF PANDEMIC: MY LIFE WITH SCD, PATIENTS’ PERSPECTIVE

Jackeline Elizabeth Maran1, Marina Perdibon1, Ilaria Baido1, Michel Nkongne Gyslene2, Fabrizio Canonici2, Vania Munaretto3-4, Giulia Reggiani3-4, Alessandra Biffi3-4, Laura Sainati4, Raffaella Colombatti3-4 1Fondazione Città della Speranza Onlus 2Associazione Malattia Drepanocitica 3Dipartimento della Salute della Donna e del Bambino, Università degli Studi di Padova Background: After two years of COVID in which activities were reduced due to the pandemic and each one’s life was affected by restrictions and limitations, the Sickle Cell Disease (SCD) Association in Padova teamed up with the Sickle Cell Group at the Pediatric Hematology Oncology and Bone Marrow Transplant Unit to celebrate the Sickle Cell Disease world day by organizing an online meeting with children/youths and their families. Theme of the meeting was: “My Life with SCD: poems, pictures and writings express our view on disease and care”. Aims: One of the goals of this meeting was to create an opportunity for individuals with SCD to meet and have a constructive discussion with each other about the disease and express their feelings after two years of pandemic. Methods: One month before the meeting children, teenager and parents were asked to sharer with the organizing team any drawing, painting, poem, writing, that they felt could express their feelings or experience of the disease itself or how it affected their life, or their experience in the hospital. The materials received were organized in a power point presentation and At the meeting, families were able to see a PowerPoint presentation with the poems, drawings, writings. Each author had the choice to personally share their production or have it read out loud by a member of the team. Free time to comment or share experiences was given. Results: 20 children, teenagers and parents participated. Countries of origin (Nigeria, Ghana, Congo, Albania, Italy), religious background (catholic, muslim, no religion, other) were different as well as disease genotype (HbSS, HbSC, HbSB°), severity or treatment received (Hydroxyurea, transfusion, Hematopoietic stem cell transplantation -HSCT, none). Drawings and writings regarded experience with the disease (mechanism of action, admissions), feelings experienced (fear, hope, light at the end of the tunnel), aspirations (sports) and gratitude (to the social and medical team, to parents) (Figure 1). Surprisingly, families who had a child having undergone HSCT, reported on the need and importance to talk about this experience for years after the event and made a request of a support goup. Finally, all families underlined the need to meet again soon to discuss together issues related to personal experience with SCD, even via web. of discussion with each other and with the drepanocytosis group; and that throug the online telematics platform it is still possible to involve all families, listening and trying to comfort them on doubts and perplexities about the disease, In conclusion, it can be said that after two years of pandemic, in our setting, online meeting can help patients and families reconnect with each other and activities can be planned to aid experiences and feelings. Patients’ associations and Health Care Teams can collaborate in this area.Figure 1:: Poems and drawings on “My Life with Sickle Cell Disease” by children, teenagers and parents from the Associazione Malattia Drepanocitica

The oldest case of lymphoma? Insights from a XIII century fresco.

A fresco painted by an unknown artist in the mid XIII century and displayed in the “Gothic Hall” of the Four Crowned Saints' seclusion cloister in Rome (left panel) is interesting not only for its undisputed beauty, but also for a possible clinical enigma that can be seen on careful examination. The fresco shows a young woman with a readily detectable swollen area (roughly of walnut size) in the right cervical part of her neck (shown in higher magnification in the right panel). In the absence of other clinical information, our (independently reached) interpretation is that this may represent an early (perhaps the earliest) example of a lymphoma shown in a painting. Based on strict semeiotic principles, the size of the lymph node is sufficient to rule out, at least at a first glance, underlying infectious diseases such as mononucleosis or toxoplasmosis, which do not usually cause lymphadenopathy of that size. Similarly, chronic lymphatic leukemia may be excluded since it affects predominantly older patients. Yersinia pestis (the gram-negative coccobacillus causing plague or bubonic plague) infection is unlikely for at least two reasons: (a) the skin overlaying the swollen lymph node does not appear to be erythematous; (b) the plague pandemic, called “the black death”, arose in Crimea and then reached Europe in 1346,1 about a century after the fresco was painted. Mycobacterium tuberculosis may be suspected in this case since it typically involves latero-cervical region (i.e. cervical lymphadenitis also referred to as scrofula). However, a tuberculosis origin is unlikely in the woman in this painting since it gives rise to an early erythema of the overlaying skin,2, 3 which in this painting is lacking. These simple clinical considerations lead us to believe that the most probable cause of the swollen lymph node of this young woman painted in the mid XIII century is a lymphoma, and that this fresco is the earliest representation of such disease. Open Access Funding provided by Universita degli Studi di Ferrara within the CRUI-CARE Agreement.

The strange route of an umbilical venous catheter

Journal of Paediatrics and Child HealthVolume 59, Issue 3 p. 593-594 Case ImagesOpen Access The strange route of an umbilical venous catheter First published: 28 March 2023 https://doi.org/10.1111/jpc.1_16038AboutSectionsPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Answer The pattern was confirmed by echographic evaluation showing the catheter reaching the heart through the whole inferior vena cava (Fig. 2) without evidence of ductus venosus patency. The umbilical venous catheter passed through the right internal iliac vein (IIV) and then arrived to the heart passing through the inferior vena cava bypassing the liver. The patient had no other cardiovascular abnormalities on clinical and imaging evaluations. Fig. 2Open in figure viewerPowerPoint Ultrasound showing the catheter reaching the heart passing through the whole inferior vena cava. This is a rare case of extrahepatic insertion of the umbilical vein in the right IIV, different to the previously reported cases of insertion in the left IIV1-4 or umbilical vein bifurcation, with a suggested origin consequent to a resorption in early fetal life of both umbilical veins rather than only the right one.1 This anomaly has possible prenatal diagnosis3 and syndromic associations.1 A consent for image publication was obtained from the child's parents. Acknowledgement Open Access Funding provided by Universita degli Studi di Padova within the CRUI-CARE Agreement. References 1Currarino G, Stannard MW, Kolni H. Umbilical vein draining into the inferior vena cava via the internal iliac vein, bypassing the liver. Pediatr. Radiol. 1991; 21: 265– 6. 2Fliegel CP, Nars PW. Aberrant umbilical vein. Pediatr. Radiol. 1984; 14: 55– 6. 3Gorincour G, Droullé P, Guibaud L. Prenatal diagnosis of umbilicoportosystemic shunts: Report of 11 cases and review of the literature. AJR Am. J. Roentgenol. 2005; 184: 163– 8. 4Leonidas JC, Fellows RA. Congenital absence of the ductus venosus: With direct connection between the umbilical vein and the distal inferior vena cava. AJR Am. J. Roentgenol. 1976; 126: 892– 5. Volume59, Issue3March 2023Pages 593-594 FiguresReferencesRelatedInformation

Cochlear Implantation in Intralabyrinthine Schwannoma: Case Series and Systematic Review of the Literature

Intralabyrinthine schwannomas (ILS) are rare benign tumours arising from the peripheral branches of the cochlear or vestibular nerves in the membranous labyrinth, intracochlear schwannomas being the most frequent ones. When hearing is no longer feasible on the affected side, surgical removal along with simultaneous cochlear implantation can be proposed to the patient. We hereby present a systematic review of the literature on the topic, as well as two original cases from our centre (Ospedale Università degli Studi di Padova). Cochlear implantation in intracochlear schwannomas is feasible, with overall satisfactory hearing outcomes in accordance with the evidence found in the literature.

Redefining Bradykinesia.

Redefining Bradykinesia.

Mutant NPM1: Nuclear export and the mechanism of leukemogenesis.

Mutant NPM1: Nuclear export and the mechanism of leukemogenesis.

Peer Review Statement

All papers published in this volume have been reviewed through processes administered by the Editors. Reviews were conducted by expert referees to the professional and scientific standards expected of a proceedings journal published by IOP Publishing Publishing.• Type of peer review: Single Anonymous• Conference submission management system: Morressier• Number of submissions received: 48• Number of submissions sent for review: 48• Number of submissions accepted: 46• Acceptance Rate (Submissions Accepted / Submissions Received × 100): 95.8• Average number of reviews per paper: 1• Total number of reviewers involved: 18• Contact person for queries: Name: Laura Valore Email: laura.valore@na.infn.it Affiliation: Università degli Studi di Napoli Federico II

Industrial PhD: My way to go?

Sara Puglioli earned her MSc in medicinal chemistry and pharmaceutical technologies at the Università degli Studi di Firenze in 2020. Sara moved to Basel for a 9-month opportunity in industry, where she worked as a research associate at SpiroChem. At SpiroChem, she designed, planned, and performed custom multi-step syntheses. Sara moved to Zürich in 2021 to start her industrial doctoral studies (jointly with IUSS Pavia) at Philochem, a Swiss-Italian company founded by ETH Prof. Dario Neri with his brothers Duccio and Giovanni. Her PhD project focuses on DNA-encoded chemical libraries and the application of this technology in the discovery of novel tumor-targeting ligands.

Shining a Spotlight on Photochemistry

Shining a Spotlight on Photochemistry

ChemSystemsChem – On the Up and Up

<i>ChemSystemsChem</i> – On the Up and Up

A Reader and Reading in ‘Long’ Eighteenth-Century Russia

[Rev. of: Reading Russia. A History of Reading in Modern Russia. Volume 1. Edited by Damiano Rebecchini and Raffaella Vassena. Milano: Università degli Studi di Milano, 2020] The first volume of the collective monograph “Reading Russia. The History of Reading in Modern Russia”, is focused on the ‘long’ eighteenth century. It includes a preface by D. Rebecchini and R. Wassena to the entire three-volume edition and eight chapters written by famous researchers of Russian culture, literature and history. In the first chapters, D. Waugh considers the history of reading in the pre-Petrine period, G. Marker problematizes key issues of studying the history of reading in eighteenth-century Russia, K. Ospovat traces the dynamics of reading policy from Peter I to Elizabeth I. R. Bodin discusses the main changes in the reading habits in the second half of the century, A. Zorin demonstrates the «revolutionary» changes among the nobility due to the sentimentalism literature, E. Kislova researches the reading habits of the educated clergy, and B. Grigoryan studies the reader's image development in the Russian magazines of 1760–1830-ies. S. Franklin's chapter discusses the urban graphosphere in three different centuries: from the triumphal arches of Peter the Great, through the commercial signs of the mid-nineteenth century, he arrives at the inscriptions of the Soviet city. Overall, like the entire publication, the reviewed volume is the first major study of the history of reading in Russia, covering a long period and summarizing results of individual studies.

Peer Review Statement

All papers published in this volume have been reviewed through processes administered by the Editors. Reviews were conducted by expert referees to the professional and scientific standards expected of a proceedings journal published by IOP Publishing Publishing.• Type of peer review: Single Anonymous• Conference submission management system: Morressier• Number of submissions received: 19• Number of submissions sent for review: 19• Number of submissions accepted: 19• Acceptance Rate (Submissions Accepted / Submissions Received × 100): 100• Average number of reviews per paper: 1.263157894736842• Total number of reviewers involved: 15• Contact person for queries: Name: Livio Gianfrani Email: livio.gianfrani@unicampania.it Affiliation: Università degli Studi della Campania Luigi Vanvitelli - Dipartimento di Matematica e Fisica

The Life in the Scroll: Medieval Notaries as Mediators in the Trial, in Wills and in Contracts

The essay brings together the results of two researches carried out within the project: Limen, Languages of Notarial Mediation between the Middle Ages and the Modern Age, presented in July 2019 at the Extraordinary Call for Interdepartmental Projects of the University of Milan and considered worthy of funding with the recognition of the Seal of excellence in 2020. In the two interventions previously published in italian language (L’attività di mediazione del notaio nella Summa di Rolandino in Mediazione Notarile. Forme e linguaggi tra Medioevo ed Età Moderna, a cura di Alessandra Bassani, Marta Mangini e Fabrizio Pagnoni, Quaderni degli Studi di Storia Medievale e di Diplomatica VI, Milano Pearson 2022 e Notaio mediatore: la distanza fra la vita e la pergamena in Giustizia, istituzioni e notai tra i secoli XII e XVII in una prospettiva europea. In ricordo di Dino Puncuh, a cura di Denise Bezzina - Marta Calleri - Marta Luigina Mangini - Valentina Ruzzin, Notariorum Itinera Varia 6, Società Ligure di Storia Patria, Genova 2022) the Author used the hermeneutic tool of the ‘function’ of mediation to connect the results of the historical-legal research with those equally in-depth of the historians of society, institutions and the economy. Thus the medieval notary’s activity emerges from the examination of testimonial depositions, mortis causa deeds and contracts of writing and discipleship: the notary was protagonist of the institutional, social and economic life of the medieval municipality and also a spiritual and family mediator in his customers’ most intimate and personal life.

Open for All at ChemElectroChem

Open for All at <i>ChemElectroChem</i>

Designing a Master Course on Architectures for Big Data: A Collaboration between University and Industry

We describe a collaboration between Marelli and Università degli Studi di Milano that allowed the latter to add a course on «Architectures for Big Data» in its Master programme of Computer Science, with the aim of providing a teaching approach characterized by an intertwined exposition of discipline, methodology and practical tools. We were motivated by the need of filling, at least in part, the gap between the expectation of employers and the competences acquired by students. Indeed, several big-data-related tools and patterns of widespread use in working environments are seldom taught in the academic context. The course also allowed to expose students to company-related processes and topics. So far, the course has been taught for two editions, and a third one is currently ongoing. Using both a quantitative and a qualitative approach, we show that students appreciated this new form of learning activities, in terms of enrollments, exam marks, and activated external theses. We also exploited the received feedback in order to slightly modify the content and the structure of the course.