Abstract The composite fuselage panel is a crucial component in large civil aircraft, necessitating higher detection rates and efficiency. Phased array ultrasonic testing can enhance the efficiency and defect detection rate; however, it is essential to consider the structural characteristics of the fuselage to ensure reliable identification of design defects. Based on the material properties, structural features, and defect detection requirements of composite fuselage panels, a test block reflecting their characteristics was designed and fabricated with various prefabricated defects. Ultrasonic phased array method was employed for a series of testing parameter optimization experiments and defect detectability analysis. The detected flaws were quantitatively analyzed and compared with those obtained using conventional ultrasonic automatic scanning techniques to validate the effectiveness of the developed ultrasonic phased array method. The feasibility of utilizing phased array ultrasonics for nondestructive evaluation of wide-body airliner composite fuselage panels is confirmed.