It is necessary to extract and recognize the cloud regions presented in imagery to generate satellite imagery as analysis-ready data (ARD). In this manuscript, we proposed a new deep learning model to detect cloud areas in very-high-resolution (VHR) satellite imagery by fusing two deep learning architectures. The proposed UNet3+ model with a hybrid Swin Transformer and EfficientNet (UNet3+STE) was based on the structure of UNet3+, with the encoder sequentially combining EfficientNet based on mobile inverted bottleneck convolution (MBConv) and the Swin Transformer. By sequentially utilizing convolutional neural networks (CNNs) and transformer layers, the proposed algorithm aimed to extract the local and global information of cloud regions effectively. In addition, the decoder used MBConv to restore the spatial information of the feature map extracted by the encoder and adopted the deep supervision strategy of UNet3+ to enhance the model’s performance. The proposed model was trained using the open dataset derived from KOMPSAT-3 and 3A satellite imagery and conducted a comparative evaluation with the state-of-the-art (SOTA) methods on fourteen test datasets at the product level. The experimental results confirmed that the proposed UNet3+STE model outperformed the SOTA methods and demonstrated the most stable precision, recall, and F1 score values with fewer parameters and lower complexity.