This paper describes an intelligent closed-loop deep brain stimulation modulation platform with multi-sensor information input feedback, adaptive, interactive, and high integration. This platform has 16 channels of data acquisition channels and 4 channels of stimulation channels. Four channels of the acquisition channel are used for intracranial LFPs acquisition, and 12 channels are used for acquisition of extracranial signals (EEG, ECG and EMG). The output waveform of stimulation channels is a configurable and arbitrary waveform. The stimulation voltage is in constant voltage mode, the stimulation voltage range is -5 V ∼ +5 V, and the impedance range of the stimulation load is 500 Ω ∼ 5 KΩ. This study achieved simultaneously the stimulation at the recording, which effectively reduces the influence of the stimulation artifacts on the recorded signal. The platform constructs multi-information closed-loop deep brain stimulation for Parkinson's disease from three aspects: motor behavior signal feedback, extracranial electrical signal feedback, and deep brain field potential signal feedback. A modular portable and universal closed-loop neuromodulation research platform has been formed. This study completed the acquisition and recording and adaptive closed-loop algorithm and stimulation function, effectively eliminating the stimulus artifacts, adapting to wide dynamic range brain impedance, and enhancing the stability of stimulus output. It has the characteristics of compact structure, small size, low power consumption and stable operation.