1. Abstract The role of Suprathel, a synthetic skin substitute, for superficial and deep dermal burns in children was evaluated. 65 children (25 females, 40 males: mean age 4.9 years, (range 04 months to 11 years) with dermal burns were treated with Suprathel. Flame burns were 14 and 51 were scalds. The burns were superficial dermal (n= 16), mid-dermal (n=34) and deep dermal (n=15); the median %TBSA was 23.6% (range 08-45%). Suprathel was applied after debridement, followed by Vaseline gauze, dry gauze and crepe bandage. The outer dressings were changed every 4-5 days unless clinical problems indicated otherwise. Median healing time was 15 days (range 10-35 days). 20 patients took longer than 21 days to heal, of whom 13 were flame burns and developed hypertrophic scarring, which was strongly associated with wound infection. Healing time of superficial dermal and mid-dermal burns was not significantly different. Suprathel is an effective skin substitute for the treatment of superficial and deep dermal burns in children. The majority of burns in children are mixed depth, and Suprathel has the advantage that it may also be used to treat deep dermal burns. It behaves like a biological dressing but is not animal derived, so is acceptable to all religious and ethnic groups. Suprathel significantly reduced pain. Its easy handling and patient comfort was superior compared to other materials. The Suprathel membrane adhered rapidly to the wound thus protecting against infections and promoting wound healing. No allergic reactions were observed. The ability of the material to resorb ensured pain-free removal after complete healing of the wound. We observed that the material effectiveness contributes to the reduction of overall treatment costs. Further studies to evaluate the efficacy and cost effectiveness of Suprathel compared to other dressings in children are needed. 2. Keywords: <span style=font-size:10.0pt;font-family: times= new= roman,serif=> <span style=font-size:10.0pt;font-family: times= new= roman,serif=>Deep dermal burns; Suprathel; Synthetic skin substitute