Decrease In Blood Sugar Level Research Articles

The Positive Effect of The Forest Environment in The Ecotherapy Healing Forest Program on The Physical and Mental Health After COVID-19

This research is aimed at students who are currently experiencing excessive coursework and high emotional stress after COVID-19. Where if these conditions are not immediately addressed, it can cause mental illness. The Ecotherapy Healing Forest program offers several activities in it, such as relaxation programs to relieve stress, walks in the forest, and sensory elements to be given to the participants. In this study, 44 student participants were used from class 2018 – class 2021 at Kapuas Sintang University. Participants will be measured their blood sugar levels and oxygen saturation by medical personnel, and given the DASS 42 questionnaire to measure participants’ stress levels. Measurements will be accrued out 5 repetitions of the Ecotherapy Healing Forest program at different times. The results of this study revealed that there was a significant decrease in blood sugar levels, oxygen saturation and stress levels in the participants after participating in the Ecotherapy Healing Forest program. However, for smoking students, the Ecotherapy Healing Forest treatment does not have a significant effect on oxygen saturation values. Therefore, the authors propose Ecotherapy Healing Forest as a non-pharmacological intervention to relieve stress while improving physical health (blood sugar levels and oxygen saturation) for students.

Antidiabetic Activity of Manonjaya Snakefruit Skin Extract with Zebra Fish (Danio rerio) as Animal Model

This research aimed to determine the active fraction and profile of active compounds in Manonjaya sSnakefruit skin extract that can be used as antidiabetic and the antidiabetic activity using zebra fish. Manonjaya sSnakefruit skin was extracted by maceration using 70% ethanol and then fractionated using n-hexane, ethyl acetate and methanol. The ethyl acetate fraction showed the highest yield and total phenolic content as well as the strongest α-glucosidase inhibition with an inhibition percentage of 64.43%. The ethyl acetate fraction provided the most active spot as an α-glucosidase inhibitor. The profile of active compounds that act as antidiabetic compound is flavonoid from glycosylflavone and flavone groups. Antidiabetic activity using zebra fish was indicates that Manonjaya Snakefruit skin extract from ethanol extract and ethyl acetate fraction can decrease blood sugar level of zebra fish after induced with alloxan. The crude extract group had 54.51% lower sugar content than the induction group and 41.70% lower than the negative control. Meanwhile, the ethyl acetate fraction group had 65.10% lower sugar content than the induction group and 55.27% lower than the negative control.

Monitoring of Autoantibodies Following Autologous Hematopoietic Stem Cell Transplantation in 6 Children with Recently Diagnosed Type 1 Diabetes Mellitus.

BACKGROUND Bone marrow stem cells have been shown to be a promising therapeutic strategy for autoimmune diseases. This study aimed to assess the safety and efficacy of autologous hematopoietic stem cell (ABMSC) transplantation without immunoablation used to suppress the autoimmune reaction in 6 children with newly diagnosed autoimmune diabetes mellitus. We monitored the levels of islet cell antibodies (ICA), antibodies against islet antigen-related tyrosine phosphatase 2 (IA2), glutamic acid-decarboxylase (GAD) antibodies, and anti-insulin antibodies (AIA). MATERIAL AND METHODS Between 2018 and 2022, 6 children (age 6-10 years, average 8 years) recently diagnosed with type 1 diabetes mellitus with the presence of ICA, IA2, GAD, AIA and ketoacidosis, were treated with an ABMSC stimulated with Filgrastim, granulocyte colony-stimulating factor (G-CSF), 10 ug/kg/day for 4 days. Bone marrow was harvested on day 5, collected by puncture and identified as mononuclear cells >180×10⁶/kg, CD34+ >0.22%, and transplanted by intravenous (i.v.) infusion. Patients were monitored with ICA, IA2, GAD, AIA, C-peptide, blood glucose, and glycosylated hemoglobin A1c (HbA1C) 6 months after the procedure. RESULTS At 6-month follow-up, we observed a negative value of the ICA, which was previously positive (P<0.001). The IA2 (p=0.037) and GAD (P=0.377) antibodies decreased slowly but were significantly lower. AIA remained high. A decrease in blood glucose and HbA1C levels was observed (P<0.001). No complications occurred during follow-up. CONCLUSIONS Autologous hematopoietic stem cell transplantation without immunoablation was safe and effective in significantly decreasing the production and effect of autoantibodies against ICA, GAD, and IA2, as well as decreasing blood sugar levels and HbA1c.

THE EFFECT OF PROGRESSIVE MUSCLE RELAXATION ON REDUCING STRESS AND BLOOD SUGAR IN TYPE 2 DIABETES MELLITUS PATIENTS IN THE WORK AREA OF TANIWEL PUBLIC HEALTH CENTER

The main problems that often occur in people with Diabetes Mellitus (DM) are stress and an increase in blood sugar. Uncontrolled stress for a long time can lead to an increase in blood sugar levels, which can lead to various complications. One of the physical activities that can be done with relaxation is Progressive Muscle Relaxation (PMR) is an intervention that can be done in people with diabetes. The purpose of the study was to determine the effect of Progressive Muscle Relaxation (PMR) on increasing stress and blood sugar levels. The research design used a quasi-experimental approach with a pre-post-test control group design approach. The sample consisted of 36 respondents who were divided into 18 intervention groups and 18 control groups. The group was given a therapeutic intervention for 1 week with a duration of 2 times a day, namely in the morning and afternoon for 10-15 minutes. The instruments used are a glucometer, blood sugar level observation sheet, and Diabetes Distress Scale (DDS) questionnaire. Data analysis used the Wilcoxon test and Paired t-test to see pair data. Then for the research group, the data used the Man-Whitney Test. The results showed that there was a significant effect on decreasing blood pressure (p=0.013) and that there was an effect on decreasing blood sugar levels (p=0.034). Conclusion: Progressive Muscle Relaxation (PMR) affects reducing stress and blood sugar levels in Type 2 DM patients.

The Effect of Diabetes Self Management Education (DSME) with Audiovisu-al Media on Self-Care and Decreasing Blood Sugar Levels in Diabetes Melli-tus Patients Type II

Background: Diabetes mellitus (DM) is a metabolic disease characterized by hyperglycemia that occurs due to abnormal insulin secretion. Diabetes Self Management Education (DSME) is an important role in preventing or delaying complications in people with pre-diabetes and diabetes. Aim of study is to analize effect of Diabetes Self Management Education (DSME) with audiovisual media on self-care and decreasing blood sugar levels in diabetes mellitus patients type II&#x0D; Methods: Using a quasy experiment research design with control group design. Samples is 34 respondents (17 respondents in the control group and 17 respondents in the experimental group) that chosen randomly with odd and even way according to data patients DM. Self care measured by Summary of Diabetes Self-Care Activity (SDSCA) questionnaire, and blood sugar level measure with a glucometer. Intervention group given DSME for 14 days, and control group get treatment according to community standards. Bivariate analysis used the non-parametric Wilcoxon test and to see the difference between pre-test and post-test on the self-care variable and to see the differences between groups using the Mann-Whitney test. Analysis of bivariate test on blood sugar levels drop variables using parametric test Paired T-Test and to see the difference between groups using Independent T-Test test.&#x0D; Results: The results of the Wilcoxon test of self-care control group p=0.246 (p=&lt;0.05), so there is no effect, the experimental group p = 0.005 (p=&lt;0.05), so that concluded no effect. Mann-Whitney test results with personal care and experimental control group p=0.000 (p=&lt;0.05), so that there is a significant difference. Results of Paired T-Test blood sugar control group p = 0.812 (p =&lt;0.05), so there is no effect, the experimental group, p = 0.000 (p=&lt;0.05), so that concluded no effect. The results of the Independent T-Test blood sugar levels in the control and experimental groups p=0.020 (p=&lt;0.05), so there is a significant difference in effect.&#x0D; Conclusion: There is the influence of Diabetes Self-Management Education (DSME) The Audiovisual Media on self-care and decrease blood sugar levels in people with Type II DiabetsMellitus.

Antioxidant potential of gotu kola leaf extract (Centella asiatica (L.) Urban) as an alternative to antihyperglycemic herbal drinks

This study aims to determine the antihyperglycemic potential of Gotu kola leaf extract (Centella asiatica (L.) Urban as an alternative herbal drink in diabetic male white mice. This study was divided into four stages: extracting Gotu kola leaves using 96% ethanol as solvent, phytochemical screening, and testing antihyperglycemic activity. Male white mice were made diabetic by alloxan-induced. Mice were divided into five groups consisting of negative control (Aquadest), positive control (Glibenclamide 13 mg/Kg BW), dose 1 (200 mg Gotu kola extract/kg BW), dose 2 (400 mg Gotu kola extract/kg BW), dose 2 (400 mg Gotu kola extract/kg BW), 3 (600 mg Gotu kola extract/kg BW). The results of phytochemical screening showed that the Gotu kola leaf extract was positive for flavonoids and tannins. The analysis results on the Gotu kola leaf extract showed an IC50 value of 80.58 ppm, including strong antioxidant activity. The results of the antihyperglycemic activity test showed that diabetic male white mice were found to have decreased blood sugar levels on days 14 and 21 by respectively 24.3% and 41.6%; 25.4% and 42.3%; 37.8% and 55.3% after administration of Gotu kola leaf extract at P1, P2, and P3.

An Effect Of Methanol Extract Sunkist Orange Peel (Citrus Sinensis (L.) Osbeck) On Blood Sugar And Cholesterol Levels Wistar Rats (Rattus Norvegicus) Induced By Aloxan

Insulin resistance is a condition with damage to target organs that generally respond to the activity of the hormone insulin. About 10% of the population in big cities in Indonesia suffer from insulin resistance. At the cellular level, insulin resistance can result from damage to the pre-receptor, receptor, or post-receptor. The most common cause of insulin resistance is post-receptor damage, namely disruption and damage to insulin signaling pathways. To find out that the methanol extract of Sunkist orange peel can reduce blood sugar levels in Wistar rats. This research uses the experimental laboratory method in vivo with the chosen research design form, namely True Experimental Pre Test and Post Test Control. The Kruskal Wallis test showed that the Sunkist Orange Peel Methanol Extract resulted in a significant decrease in blood sugar levels of Wistar rats with a p-value &lt;0.05, and also the Anova test showed that the Sunkist Orange Peel Methanol Extract resulted in a decrease in blood sugar levels of Wistar rats, which is significant with p-value &lt;0.05. All doses tested affect lowering blood sugar levels, namely, 300 mg/kg BW, 450 mg/kg BW, and 600 mg/kg BW.

In Vivo study of Antidiabetic Activity from Ethanol Extract of Clitoria ternatea L. Flower

Background: Clitoria ternatea L. or telang flower is a plant whose all parts have benefits for the human body. The benefits of telang flower include antioxidant, antidiabetic, antiobesity, anticancer, anti-inflammatory, antibiotic and hepatoprotective agent. Clitoria ternatea L. flower as an antidiabetic treatment works by increasing insulin secretion, inhibiting the formation of advanced glucose end products, as well as inhibiting the work of enzymes involved in the production of glucose in the blood. In this study using an experimental method, using 25 mice which were divided into 5 groups. The negative control group (aquadest), the positive control group (glibenclamide 5 mg), and the three groups with variations in the dose of 96% ethanol extract of telang flower 200, 400, 600 mg/kg BW. The results: The results showed that the negative control group did not experience a decrease in blood sugar levels; the positive control group by giving glibenclamide 5 mg experienced a decrease in blood sugar levels of up to 48.6 mg/dl. In 200 mg dose extract; 400; 600 mg of tested animals showed a decrease in blood sugar up to 48.2 mg/dl, 31.2 mg/dl, 43 mg/dl respectively. The conclusion: Based on the data obtained, it was then analyzed statistically using the One Way ANOVA test, resulting in a significant value &lt;0.05, then the Kruskal-Wallis Test was carried out. It could be concluded that there was a significant difference in decreasing blood sugar levels. Different dose of Clitoria ternatea L. extract gives a significant effect on reducing blood sugar levels.&#x0D; Keywords: Antidiabetic, Extract, Clitoria ternatea L., Flower

The Effect of Petai (Parkia Speciosa Hassk) Seed Extract and Glimepiride on Blood Sugar Levels Of Alloxan-Induced Mice (Mus Musculus)

Diabetes mellitus is a metabolic disease characterized by hyperglycemia as a result of insulin deficiency in the body, ineffective insulin function, or both. Glimepiride is a third generation of oral hypoglycemic drug (OHO) that has a lower risk of hypoglycemia and weight gain compared to the first generation of sulfonylurea. Petai plant (Parkia speciosa Hassk) is one of the medicinal plants that has been known to be efficacious as antioxidant and anti-diabetic. This study aimed to discover the effect of administering the seeds of petai (Parkia speciosa Hassk) on blood glucose levels in mice induced by alloxan. This experimental study used 42 mice divided into 5 groups, they were K- (a standard diet), K+ (alloxan 175 mg/kgBB), control treatments P1 and P2 with doses of 300 mg/kgBB and 400 mg/kgBB of petai seed extract, and control treatment P3 with Glimepiride 0.0026/20g. This research was conducted at Pharmacology Laboratory of the Faculty of Pharmacy and Biochemistry of the Faculty of Medicine, Andalas University. Blood sugar levels were measured by the colorimetric method using vitalab micro spectrophotometer (Microlab 300). The results of the Kruskal-Wallis test on the blood sugar levels of mice with the administration of petai seed extract at a dose of 300mg/KgBB with a mean decrease in blood sugar levels of 85.48±5.32 mg/dl and on the blood sugar levels of mice with the administration of Glimepiride 0.0026mg/20gBB with a mean decrease in blood sugar levels of 88.73±9.95 mg/dl for 7 days did not show a statistically significant difference in the Post Hoc Test with Mann-Whitney (p = 0.423) with a mean difference of reduction of 3.25mg/dl. The conclusion of this study is that the petai seed extract has the same effective effect as Glimepiride to reduce blood sugar levels in alloxan-induced mice.

The purpose of the text is the effectiveness/benefits of dragon fruit and guava fruit that can lower blood glucose levels in type 2 Diabetes Mellitus patients

Introduction: Diabetes mellitus (DM) is a serious chronic degenerative disease caused by insufficient insulin hormone, or the body’s ineffective use of the insulin produced, with clinical symptoms such as polyphagia, polydipsia, polyuria, weight loss, and weakness accompanied by blood sugar levels ≥ 200 mg/dL and fasting blood sugar ≥ 126 mg/dL. Material and Method: This was a quantitative study with a quasi-experimental design. Results: Most of the respondents were female (70%) either in the treatment group or (60%) in the comparison group and had an average age between 45 and 59 years (50%). The average decrease in blood sugar level was 69.40 mg/dL. Red guava (NAMBUIRA) showed an effect on the blood sugar levels in type 2 DM patients at Talang Ratu Palembang Public Health Center (P = 0.000). Conclusion: NAMBUIRA pudding contains antioxidants and is rich in fiber and had an effect on reducing blood sugar levels in patients with type 2 DM at Talang Ratu Public Health Center of Palembang.

Microscopic analysis of Trichosanthes dioica

One of the most nutrient-dense cucurbit vegetables is the pointed gourd (Trichosanthes dioica Roxb.), which enjoys a prized spot in the Indian market during the warm and wet months. It is a perennial crop that is quite popular because it is available for eight months out of the year (February–September). It has certain medical effects due to its high protein and vitamin A content, and there are numerous studies about its involvement in decreasing blood sugar levels. In this paper, an effort was made to examine the microscopic characteristics of Trichosanthes dioica. Leaf exhibited uniceriate glandular epidermis with a single cellular head. Spongy parenchymatous cells, collenchymatous cells, pericycle, phloem, and xylem were all present after the epidermis. The Xylem vessels were spiral and reticulate. The collenchymatous cells' inside. The existence of uniseriate multicellular trichomes was shown by powder microscopy. crystal sheath oil globules, anomocytic stomata, liginified spiral arteries, and epidermis cells. The powders were subjected to various reagent treatments during the powder analysis, and various colours were visible to the naked eye and under UV light. There was quantitative microscopy. Vein termination and vein islet averages were 13.6 and 12, respectively. The upper and lower epidermis of the leaf had average stomatal counts of 12.5 and 16.33, respectively. The upper and lower epidermis of the leaf had average stomatal indices of 22.87 and 24.62, respectively. Data from these studies were helpful for evaluating the raw materials used in the manufacturing of herbal medicines and for anatomical research.

Optimasi Dan Identifikasi Fitokimia Serta Uji Efek Hipoglikemik Kombinasi Ekstrak Daun Dandang Gendis (Clinacanthus nutans) Dan Ekstrak Ciplukan (Physalis angulata L.) Secara In Vitro

Diabetes mellitus is a metabolic disease characterized by hyperglicemic. Dandang Gendis (Clinacanthus nutans) and Ciplukan (Physalis angulata L.) are plants which recognized as blood glucose controller. The study aims to determine the effectiveness of the combination of the two extracts in decreasing blood sugar levels in vitro. The leaves of dandang gendis and ciplukan were extracted with various solvents (hot water, cold water, 96% ethanol, 75% ethanol, 50% ethanol and 30% ethanol were used as solvents), then tested the quality of the simplicia and extract, then the phytochemical test of each extract, after that the hypoglycemic activity of each extract was tested, made several variations of the dose, then tested the antidiabetic activity of the combination extract, calculated percent protection and percent effectiveness of single extract and a combination of leaf extract of dandang gendis (Clinacanthus nutans) and ciplukan (Physalis angulata L).The results showed that inhibition of the α-amylase enzyme by extracts of Dandang Gendis, Ciplukan and their combinations included the combination of EE96% 10 mg (1:1) of 1.25 ppm; Combination of EE96% 10mg (1:2) of 6.340 ppm; Combination of EE96% 10mg (2:1) of 5.808 ppm; The combination of EE96% 10mg (2:2) was 7.115 ppm and the IC50 acarbose value was 4.23 ppm. Dandang Gendis extract, Ciplukan and their combination had α-amylase inhibitory activity which was not significantly different between the extract and the control Acarbose. Inhibition of α-amylase enzyme activity could be influenced by metabolites and total phenolic extracts of Gendis, Ciplukan and their combinations.

IbM PADA ANAK SEKOLAH DASAR DENGAN STATUS GIZI KURANG

Breakfast or breakfast provides an important meaning for everyone to start the activity throughout the day. This activity is carried out until nine in the morning. Breakfast should be able to meet 15% to 30% of the total daily nutritional needs. Breakfast is expected to be able to realize a healthy, active and intelligent life (Hardinsyah, 2013). School-age children require good and sufficient intake of nutrients for activities, especially during breakfast (Susyani et al., 2014). In addition to adequate and balanced nutritional content, menu choices must be practical and varied from various types of food ingredients (Ministry of Health, 2013). Breakfast is beneficial for good school attendance, nutrient intake, academic achievement, fitness and a healthy weight (Hardinsyah; Perdana, 2013). Meanwhile, the impact of not eating breakfast on children has been shown to have an effect on academic achievement at school (Muchtar et al., 2011). There are various reasons why children skip breakfast, namely, long distance to school, late getting up in the morning, not in taste, not used to or afraid of being late for school (Mardiana, et al, 2013; Irianto in Ristiana, 2009). The habit of not eating breakfast results in a decrease in blood sugar levels (hypoglycemia) so that the energy supply decreases, if this happens continuously it causes the body to tremble, get tired quickly and decrease motivation to learn (Wardoyo; Mahmudiono, 2013). According to Hardinsyah (2012) in Briawan, et al (2013), it is recorded that 20%-40% of Indonesian children do not eat breakfast every day. Hardinsyah and Aries (2012), stated that 44.6% of school-age children consume low-quality breakfast, which is below 15% of the daily nutritional adequacy. Lack of knowledge about the importance of eating breakfast in children is one of the factors that cause children to ignore breakfast (Notoatmodjo, 2012). Nutrition education needs to be given in order to achieve health behavior (Healthy Behavior). Based on the above background, it is necessary to provide counseling and examples of providing breakfast for school children.

IDF21-0564 The Use of a Digital Self-Care Platform in The Control of Diabetes in People With Diabetes During the COVID-19 Pandemic

Background: People living with diabetes are at a high risk of suffering poor outcomes after being infected with COVID-19. In the early months of the pandemic in Nigeria, there was a dearth of face-to-face opportunities for people with diabetes to receive care and education on managing their condition. mDoc is a digital health social enterprise which provides virtual self-care support to people living with regular and chronic health conditions including diabetes through our CompleteHealth™ platform. This is a digital health platform where members, once registered, can monitor and track their health. This presentation describes how virtual self-care support was provided to members with diabetes during the pandemic. Aim: To examine how providing virtual self-care support during the COVID-19 pandemic to people living with diabetes is a viable method of helping them manage their condition. Method: A retrospective study was conducted with 88 members with diabetes registered onto the mDoc CompleteHealth™ platform between March 2020 and June 2021. Members were provided with self-care support through the mDoc’s virtual omni-channel support system: weekly messages were sent via WhatsApp and the CompleteHealth™ chat to members and the coach-led multidisciplinary care teams (including a nutritionist and fitness coach) called members to provide lifestyle modifications on diet and exercise as well as self-care education on diabetes management. The members were also encouraged to check their blood glucose levels regularly and adhere to their prescribed medications. The blood glucose levels of the members were collected through the CompleteHealth™ platform where members log in health metrics either by themselves or through their health coach. Members also received information on the COVID-19 prevention protocols and where to get vaccinated when COVID-19 vaccine rollout began in Nigeria. Results: The average age of members with diabetes registered on the CompleteHealth™ platform over the study period was 58 years old with 35.3% being men and 64.7% being women. Of the 88 members who received this virtual support, with multiple FBG values, 78 (88.6%) showed an improvement in their control of their blood sugar levels, with the average value for their FBG falling from 163.2 mg/dL at baseline to 133.6 mg/dL by June 2021. These members also saw their average weekly exercise duration increase from 59.3 minutes per week to 72.7 minutes per week. Discussion: We saw a decrease in blood sugar levels in a majority of members that received weekly virtual support from a health coach-led multidisciplinary care team over the 15 months that the self-care support was provided. This intervention helps people manage diabetes from afar, which is important as self-care has become an increasingly essential part of the global healthcare system, especially due to the limited access to face-to-face doctor consultations during the COVID-19 pandemic. We believe that empowering people with the self-efficacy they need to take care of themselves can lead to better control of their chronic disease which will eventually lead to better health outcomes.

Phytochemical screening and antidiabetic activities test of ethanol extract from Syzygium cumini L. seeds in male Wistar rats induced by alloxan

Introduction: The ethanol extract of the jamblang fruit seed (Syzygium cumini L.) is known to have an antidiabetic effect and this is further confirmed by the high intensity of its α-amylase inhibitory effect. Aim: The purpose of this study was to determine the antidiabetic activity of jamblang fruit seed extract in reducing blood sugar levels. Method: Phytochemical screening was carried out on the ethanol extract from jamblang fruit seeds. Twenty-eight male wistar rats were given alloxan to induce diabetes. The rats were divided into four groups: normal control, negative control (CMC-Na), positive control (Glibenclamide), and a group that was given ethanol extract of jamblang seeds. Measurement of blood glucose levels was carried out on day 0 and day 15. Results: The phytochemical screening results show that the ethanolic extract of jamblang fruit seeds (Syzygium cumini L.) contains alkaloids, flavonoids, saponins, tannins, and polyphenols, as well as steroids and triterpenoids. The group being treated with ethanol extract from jamblang seeds showed decreased blood sugar levels on day 15, indicating the antidiabetic effectiveness of the extract. Conclusion: Ethanol extract from jamblang seeds (Syzygium cumini) contains alkaloids, flavonoids, saponins, tannins, polyphenols, steroids, and triterpenoids; and is able to reduce blood glucose levels of male wistar rats induced with alloxan.

THE DIFFERENCE OF THE DECREASE BLOOD SUGAR LEVEL THROUGH AEROBIC EXERCISE AND RESISTANCE EXERCISE IN PREDIABETES PATIENTS

Prediabetic is a situation where the person’s blood sugar level is above normal but has not fully categorized as Diabetes Mellitus. The decrease of blood sugar level in prediabetes patients can be done in various methods, such as Aerobic Exercise and Resistance Exercise. This study aims to investigate the difference of the decrease blood sugar level through Aerobic Exercise and Resistance Exercise in prediabetes patients. Experimental with pre test and post test two group design is used in this study. It was conducted in Tonja sub-distict, North Denpasar in January until March 2020. The research sample is 24 people, where 21 is woman and 3 man which are randomly divided into 2 experimental groups. Experimental Group I was given Aerobic Exercise and experimental group II was given Resistance Exercise. Glucometer is used as a measurement tool in this study. Based on the result of paired t-test, there is a decrease in blood sugar level in Experimental Group I, which the average before intervention is 146,58±21,33mg/dL into 126,42±21,03mg/dL after intervention and obtained p=0,001(&lt;0,05). In Experimental Group II, the blood sugar level is decreased, where the average before intervention is 142,33±16,71mg/dL and after intervention is 121,83±20,83mg/dL and p=0,001(&lt;0,05). There is no significant difference in the decrease of blood sugar level between two groups with p=0,948(&gt;0,05). The conclusion is both Aerobic Exercise and Resistance Exercise have a good effect in decreasing blood sugar level.&#x0D; Keywords: Aerobic Exercise; Resistance Exercise; Prediabetes; Blood Sugar

PROVISION OF CINNAMON BARK ETHANOL EXTRACT (Cinnamomum burmanii Blume) LOWER BLOOD SUGAR LEVELS HYPERGLYCEMIC WISTAR RATS

Cinnamon plant (Cinnamomum burmanii Blume) is a tall plant that contains secondary metabolites and is widely consumed by the community for generations which is used as a medicinal ingredient. The part of the cinnamon plant that is widely used by the community is the bark. Cinnamon bark extraction was carried out by maceration method in 96% ethanol followed by evaporation until a thick extract was formed. Furthermore, characterization was carried out and applied to hyperglycemic wistar rats by observing the decrease in blood sugar levels. The results showed that the moisture content was 9.62% and the yield was 14.74% and the phytochemical test showed that the cinnamon bark extract was positive for polyphenols and flavonoids. Cinnamon bark extract was able to reduce blood sugar levels of hyperglycemic wistar rats to reach normal which was observed from the third day after being injected with alloxan until the seventeenth day.

Pendampingan Pasien Obesitas dan Diabetes Mellitus Era Pandemi Covid-19

This activity aims to provide community service with the One Student One Family (OSOF) scheme. The activity was carried out to improve the quality of patients with obesity and Diabetes mellitus (DM) in Family A (families with problems with non-communicable diseases or PTM) in Bantul, Yogyakarta during the Covid-19 pandemic. The methods used in this service are education, mentoring, monitoring, and evaluating consumption patterns, physical activity, measuring weight, and checking blood sugar levels. In addition, the commitment of patients and family members is initiated to achieve a good quality of life. The results of this service activity indicate that mentoring impacts improving the quality of life of patients in the form of improving diet, exercise habits/physical activity, weight loss of 1.1 kg in 2 weeks, and decreasing blood sugar levels by 116 mg/DL. In addition, there is a patient's commitment to implementing a healthy lifestyle vigorously in the long term to produce better results. Family members also expressed a commitment to continuously provide motivation, support, and an environment to improve the patient's quality of life. This proves that the OSOF program has succeeded in having a positive impact on the target.

Penatalaksanaan Kadar Gula Darah Tikus Putih (Rattus norvegicus) Model Diabetes Mellitus Tipe 2 Menggunakan Rebusan Umbi Yakon (Smallanthus sonchifolius)

The world health organization recommends the use of traditional medicines for chronic and degenerative diseases in maintaining health and helping to improve their safety and efficacy. The Yakon (SS) tubers contain FOS (Fructooligosaccharides) as a lowering of blood sugar levels. The purpose of this study was to determine blood sugar levels after treatment with boiled Yakon tubers (SS). This type of research is an experimental design with a pre-post test with a control-group design. The independent variable is the boiled water of Yakon tubers, the dependent variable is blood sugar levels. The samples were divided into 2 groups: the treatment group of boiled Yakon tuber (Smallanthus s) dose 1 (350 mg/kg/BW) and dose 2 (700 mg/kg/BW), the control group. Each group consisted of 6 rats. Mice were conditioned to hyperglycemia by being given a high-glucose diet for 9 weeks. Blood sugar measurement using Gluco-D, data analysis used is Paired Sample T-Test, Independent, Sample T-Test, and One Way Anova. The results showed that treatment dose 1 experienced an average decrease in blood sugar levels by 158.5 mg/dl (p 0.004) and dose 2 by 161.17 mg/dl (p 0.001). The results of the study were the control group and treatment 1 (Sig.2-tailed) = .000 (0.05) and the control group with treatment 2 (Sig.2-tailed) = .000 (0.05) While the comparison results showed that there was a difference between the control group with treatment group 1, and control group with treatment 2 respectively (Sig.2-tailed)=0.000, =0.05. The results of this study indicate that there is an effect of boiled water from Yakon tubers. The Yakon tuber boiled water can be implemented as an alternative in the management of blood sugar in conditions of diabetes mellitus.

Spiritual Spiritual Therapy (Dhikr) can Decrease Blood Sugar Levels in Diabetes Mellitus Patients in the Intensive Care Unit (ICU): A Study Literature

Diabetes Mellitus is a metabolic disorder of the distribution of glucose that cannot produce and utilize the hormone insulin optimally so that it can cause an increase in blood glucose levels that exceed normal limits. Dhikr therapy can provide a relaxing effect and calm the soul which can affect the production of the hormone cortisol so that it can reduce blood glucose levels. The purpose of the study was to determine spiritual dhikr therapy to reduce blood sugar levels in diabetes mellitus patients in the Intensive Care Unit Room. This research is a literature review research by analyzing and comparing several articles through searches on journal sites such as Google Scholar and PubMed using the keywords Spiritual therapy of dhikr, blood sugar, diabetes mellitus and in 2016-2021. The result of this literature review is that spiritual remembrance therapy is efficient to reduce blood sugar levels in diabetes mellitus patients who are treated in the Intensive Care Unit. The conclusion of this study is that Spiritual dhikr therapy is a form of intervention that can be carried out by families or nurses as stimulation to patients who can help reduce blood sugar levels in patients with diabetes mellitus. Based on the results, it can be found that the spiritual dhikr therapy intervention can effectively reduce blood sugar levels in patients and it is recommended for type 2 DM patients to use spiritual therapies such as dhikr to lower blood sugar levels.