Decrease In Body Fat Percentage Research Articles

Effects of Different Intensity Exercise on the Patients of Oxidative Stress Factors and Glycemic Control Type 2 Diabetes Mellitus

This study’s major purpose was to examine the impact of two various exercise intensities on glucagon-like peptide-1 and endoplasmic reticulum stress in teenagers with type 2 diabetes. Twenty teenagers with T2DM were recruited in the trial and randomly assigned to one of two groups: HIT (n = 10) or LIT (n = 10). At a heart rate of less than 45 percent, the low-intensity intense exercise group participated in aerobic activity training. Interval training with a heart rate reserve of at least 80% was used by the high-intensity intermittent training group. Both groups had the same weekly energy expenditure (1,200 kcal/week). The nositol required enzyme 1 and X-box binding protein-1 improved in both groups, but the difference in improvement between the two groups was not statistically significant. High-intensity interval training led to a significant decrease in body fat percentage among participants. After 12 weeks, the C-peptide levels had risen and varied considerably between the two groups. According to the homeostasis model assessment, there were significant differences between the groups in fasting glucose and insulin resistance, and leptin levels reduced after 12 weeks. The 12-week rise in glucagon-like peptide-1 was different across the groups. In teenagers with type 2 diabetes mellitus, high-intensity intermittent exercise training may enhance glycemic management, physical body composition, glucagon-like peptide-1, and endoplasmic reticulum stress.

The effect of proprioceptive training on technical soccer skills in female soccer

Development of perceptual-cognitive motor skills is a crucial factor influencing soccer training and competition. The aim of the study was to examine the effects of neuromuscular coordination, proprioceptive and balance exercises on physiological attributes and technical skills in female soccer. Female soccer players competing in Greek A Division (N = 48) were assigned to intervention (N1 = 24) and control groups (N2 = 24). The Proprioceptive Training Intervention Program (PTIP) lasted approximately 20 min and was implemented five times per week for 16 weeks. It was hypothesized that the PTIP in addition to a regular training programme would significantly affect female soccer player perceptual-cognitive-motor capability as it was estimated with physiological attributes ([Formula: see text]O2max and agility) and motor performance soccer technical skills (juggling, heading, shooting, passing, and dribbling). All performance variables were measured prior and after the 16-weeks PTIP. Groups by Measures (2 × 2) ANOVAs with repeated measures on the second factor revealed that the intervention group decreased percent body fat and improved [Formula: see text]O2max and all technical skills in comparison to the control group after the PTIP ( p < 0.05). The findings demonstrate the beneficial role of a proprioceptive training programme on both physiological attributes and technical skills in female soccer. Practical implications include the application of the intervention programme for monitoring and developing soccer players while also the use of the assessment tests to evaluate players.

Yoga Exercise Intervention Improves Balance Control and Prevents Falls in Seniors Aged 65.

IntroductionBody balance control represents a key factor preventing falls and subsequent injuries in seniors aged 65+. Intervention based on yoga exercises seem to be effective in improving balance.ObjectiveThe objective is to analyse and compare changes in static, dynamic, and total balance scores, changes in body composition and social indices as effects of yoga-based intervention.MethodsA total of 500 participants (234 men aged 74.5 SD±7.74 and 266 women aged 76.9 SD±7.23) were assessed using the Tinetti Balance Assessment Tool, the InBody 230 bioimpedance body composition analyser, and the SF-36 Health Survey, applied to pre and post-testing. The experimental group (n=262; 122 males; 140 females) underwent a four-week yoga-based intervention, 30 minutes daily, while the control group (n=238; 112 males; 126 females) underwent its usual daily programme at senior homes or centres. The ANOVA model, consisting of the Group, Stage, Subject and Group × Stage interaction factors, was used for data evaluation.ResultsIntervention led to improvements in the static, dynamic and total balance scores in the experimental group compared to the control group. The results of SF-36 showed positive changes in the psychosocial aspects of health, such as promoting of calmness and happiness in male seniors and reducing fatigue, nervousness and depression in female seniors. The post-intervention decrease in body fat percentage and increase in muscle mass in seniors is discussed.ConclusionsThe four-week yoga-based intervention had positive effects on the static, dynamic and total balance scores, body composition and social status.

Effects of different exercise programs on cardiorespiratory fitness and body composition in college students

Background/ObjectivesThe cardiorespiratory fitness (CRF) of college students is showing a downward trend, this study aimed to explore the effects of three exercise programs on CRF and body composition indicators in college students. MethodsA total of 50 non-smoking, healthy and physically inactive students were recruited from campus in Beijing, China, and randomly assigned to 4 groups: low-intensity continuous training with blood flow restriction (LICT-BFR, n = 13), moderate-intensity continuous training (MICT, n = 13), high-intensity interval training (HIIT, n = 12), and no exercise control (n = 12), the intervention continued for 8 weeks. Body composition and aerobic capacity were measured before and after the intervention. ResultsExercise groups reached significant improvements in maximal oxygen uptake (VO2max, p < 0.01) and a decrease in body fat percentage (p < 0.05) comparing to the control group. The fat mass and visceral fat area reduced significantly (p < 0.05) with a muscle mass growth (p < 0.05) in the LICT-BFR and MICT groups comparing to the control group. Changes of fat and muscle mass were trivial in the HIIT group (p = 0.842, p = 0.247). ConclusionAll three exercise programs can improve the CRF of college students, with LICT-BFR has the most profound effects, and MICT is more beneficial for body composition improvement than other programs. From an overall perspective, LICT-BFR should be the ideal choice, however, due to limited equipment, college students can choose MICT or HIIT according to their situations.

Physical activity program using active video games with sedentary adolescents

Objective: the aim of our study was to assess the effect of a physical activity that uses active video games in body composition, physical fitness, cardiovascular and biochemical parameters with sedentary adolescents. Methods: a non-controlled clinical trial design with a convenience sample of adolescents, separately, from ages ten to 17, of both genders. The intervention protocol consisted of physical activity with active video games (AVG), lasting two months, in 24 sessions, evolving into three levels (basic, intermediate and advanced) according to the maximum heart rate of the individuals. The adolescents’ body composition, physical fitness, cardiovascular and biochemical parameters were assessed. Data analysis was performed with a 95% confidence interval. Results: among the 14 adolescents that completed the physical training, we observed a improvement of muscle resistance (Δ= 8.26; p= 0.02) and decrease in post-exercise heart rate and systolic blood pressure (p&lt; 0.01). However, were found a non-significant decrease in body fat percentage (Δ= -3.83; p= 0.24) and strength (Δ= 4.26; p= 0.57). A high level of satisfaction with the proposed activity was identified. Conclusion: a physical activity program based on AVG can reduce cardiovascular risk factors and improve muscle resistance in sedentary adolescents.

Effect of body weight training plus low carbohydrate diet versus running plus low carbohydrate diet on body fat percentage changes in overweight and obese young man

This study aims to determine the effect of body weight training combined with a low carbohydrate diet and running combined with a low carbohydrate diet on reducing body fat percentage in overweight and obese young man. The research used pretest posttest group design experimental method. The sample consisted of 30 young man divided into two groups that had been strictly selected. Their body fat percentage was measured before and after the research program. The result was analyzed through paired sample t-test at a significance level of α 0.05 and the average difference test (independent sample t-test posttest) to get a better result. This study shows that body weight training combined with a low carbohydrate diet and running combined with a low carbohydrate diet have a significant effect on decreasing body fat percentage, but running combined with a low carbohydrate diet is better at reducing body fat percentage compared with body weight training combined with a low carbohydrate diet. Overweight and obese young man can apply body weight training combined with a low carbohydrate diet or run combined with a low carbohydrate diet to reduce body fat percentage, but to get the results of a reduction in body fat percentage running and low carbohydrate diets is more recommended.

Gestational and lactational exposure to BPA, but not BPS, negatively impacts trabecular microarchitecture and cortical geometry in adult male offspring

Bisphenol-A (BPA) and bisphenol-S (BPS) are endocrine disrupting chemicals (EDCs) found primarily in plastics. Estrogen is a primary hormonal regulator of skeletal growth and development; however, the impact of gestational BPA or BPS exposure on skeletal health of offspring remains relatively unknown. Here, adult female mice were randomized into three treatment groups: 200 μg BPA/kg BW (BPA), 200 μg BPS/kg BW (BPS) or control (CON). Animals were then further randomized to exercising (EX) or sedentary (SED) groups. Treatment continued through mating, gestation, and lactation. One male offspring from each dam (n = 6–8/group) was assessed at 16 weeks of age to evaluate effects of EDC exposure on the adult skeleton. Cortical geometry of the mid-diaphysis and trabecular microarchitecture of the distal femur were assessed via micro-CT. Biomechanical strength and mineral apposition rate of the femoral diaphysis were assessed via three-point bending and dynamic histomorphometry, respectively. Two-factor ANOVA or ANCOVA were used to determine the effects of maternal EX and BPA or BPS on trabecular and cortical bone outcomes. Maternal EX led to a significant decrease in body fat percentage and bone stiffness, independent of EDC exposure. Offspring exposed to BPA had significantly lower trabecular bone volume, trabecular number, connectivity density, cortical thickness, and greater trabecular spacing compared to BPS or CON animals. In conclusion, gestational BPA, but not BPS, exposure negatively impacted trabecular microarchitecture and cortical geometry in adult male offspring. If these findings translate to humans, this could have significant public health impacts on expecting women or those seeking to become pregnant.

Effect of High-Intensity Interval Resistance Training on Appendicular Skeletal Muscle Mass Index Measured by Bioelectric Impedance Analysis in Sarcopenic Elderly Women

Background: Aging is an inevitable physiological process leading to a progressive decrease in muscle mass and function, which is called sarcopenia. Correspondingly, this study aimed to investigate the effect of High-Intensity Interval Resistance Training (HIIRT) on certain sarcopenia-related factors in elderly women. Methods: This was a quasi-experimental study in which thirty elderly women aged 60 to 70 years, from April to September 2020, volunteered to participate and were randomly assigned to the experimental (n=15) and control (n=15) groups. Body Mass Index (BMI), Appendicular Skeletal Muscle Mass (ASM), Appendicular Skeletal Muscle Mass Index (ASMI), and body fat percentage were measured using bioelectric impedance analysis; handgrip strength was measured via Jamar dynamometer; walking speed was measured employing six-meter walking test (6MWT); IGF-1 level (μg/L) was measured with Mediagnost kit (Germany) and serum myostatin level (ng/L) was measured using ELISA kit from R&D Company (USA) via Enzyme-Linked Immuno Sorbent Assay )ELISA( method in two stages: pre-test (week 0) and post-test (end of week 8). Independent t-test was subsequently utilized to assess the research variables through SPSS software version 23 at 0.05 level of significance. Results: The results indicated a significant decrease in body fat percentage (1.05±0.79, p <0.001) and Myostatin (MSTN) (87.25±82.38, p <0.01) and a significant increase in handgrip strength (-08.58±4.50, p <0.001), ASM (-4.91±0.28, p <0.001), ASMI (-0.19±0.11, p <0.001), and 6MWT (-0.42±0.26, p <0.001) in the experimental group compared to the control. There was also an increase in IGF-1 (-0.83±2.90, P=0.88), yet it was not significant. Conclusion: The major components indicative of sarcopenia were improved through High-Intensity Interval Resistance Training. Therefore, HIIRT appeared to be one of the most important coping strategies for reduction of muscle mass and strength in older women. We could thus conclude that it is necessary for the elderly to do this type of training.

Differential Effects of Resistance- and Endurance-Based Exercise Programs on Muscular Fitness, Body Composition, and Cardiovascular Variables in Young Adult Women: Contextualizing the Efficacy of Self-Selected Exercise Modalities.

There is an evident lack of research simultaneously investigating endurance training (ET) and resistance training (RT) with regard to their potential influence on fitness and health status in young women. This study aimed to determine the effects of RT and ET three times a week over an eight-week period on anthropometric/body composition indices, blood pressure (BP), and muscular fitness in apparently healthy young women who participated in a self-preferred program. The sample of participants comprised 57 young healthy women (23.9 ± 3.08 years, 165.5 ± 5.8 cm, 66.8 ± 7.2 kg) divided into ET (n = 18), RT (n = 19), and non-exercising (C) (n = 20) groups. The variables consisted of anthropometric/body composition indices (body mass, BMI, body fat, and lean body mass), muscular fitness variables (lower body strength, upper body strength, abdominal strength, dynamometric force, and flexibility), and cardiovascular parameters (resting heart rate and systolic and diastolic BP). A pre- and post-testing design, with factorial analysis of variance for repeated measurements (ANOVA: Group × Measurement), including a consecutive post hoc test, was applied. The ANOVA indicated a similar improvement in body composition (increase in lean body mass and decrease in body fat percentage), resting heart rate, and flexibility in both of the exercise groups, with no significant changes in the C group. RT improved the participants’ strength and force capacities to a greater extent than ET. BP showed a trend of improvement in both of the training groups, but without statistically significant pre- to post-changes. Correlation analysis calculated with variables of pre- to post-differences (VDs) indicated poor associations between VDs, indicating relative independence of the obtained effects for the different variables in each training group. Although this investigation comprised apparently healthy young women, numerous positive changes indicated the efficacy of both programs in a relatively short period of time. While the participants in this study self-selected training programs, the evidenced positive effects can be at least partially related to this fact.

Pengaruh pemberian jelly mengandung glukomanan porang (Amorphophalus oncophyllus) dan inulin sebagai makanan selingan terhadap berat badan, IMT, lemak tubuh, kadar kolesterol total, dan trigliserida pada orang dewasa obesitas

Effect of jelly containing of porang (Amorphophalus oncophyllus) glucomannan and inulin as a snack to the body weight, BMI, body fat, total cholesterol, and triglyceride levels in obese adultBackground: Obesity is a major risk factor for noncommunicable diseases, especially cardiovascular disease. Porang glucomannan and inulin are water-soluble fibers that have been widely studied for their health benefits. Jelly products that contain both types of fiber are expected to have the ability to support the diet program in adults with obese nutritional status. Objective: To determine the effect of giving jelly containing a combination of glucomannan porang and inulin on body weight, BMI, body fat, total cholesterol, and triglyceride levels in obese adults.Methods: This research is a randomized controlled trial using a pre and post-test design. A total of 55 subjects who live in the Special Region of Yogyakarta, participated in the study until the end of 8 weeks. Subjects were divided into 3 groups; 18 people in the group who were given jelly containing glucomannan porang and inulin (porang-inulin jelly group), 17 people in the group who were given placebo jelly (placebo jelly group), and 20 people in the negative control group who did not get jelly (negative control group). All subjects received a low-calorie diet intervention of 1,500 kcal in the first month and 1,200 kcal in the second month. Results: There was a significant reduction in body weight and BMI (p&lt;0.05) in all groups, but there was no difference in the effect between the porang–inulin jelly group and the other groups (p&gt;0.05). Clinically, there was a significant decrease in body fat percentage in the porang-inulin jelly group, in subjects with the category of an excess fat percent (-0.90 ± 0.49%) and obesity (-1.48 ± 0.83%). A significant decrease in fat percentage also occurred in the porang-inulin jelly group, both in male subjects (-1.42 ± 0.50%) and female (-1.15 ± 0.82%), while in the placebo jelly group and negative control, the decrease did not occur in all categories and genders. There was an increase in total cholesterol levels in the negative control group (p&lt;0.05) after the study (+7.45 ± 13.18 mg/dL). In the porang-inulin jelly group, the increase in cholesterol levels did not occur significantly either in general or based on clinical categories and gender. Conclusion: Consumption of porang-inulin jelly may support weight loss programs, BMI, percent body fat, and inhibit the increase of total cholesterol and triglyceride levels in adults with obese nutritional status.

Body Mass and Body Composition Changes over 7 Years in a Male Professional Rugby Union Team

The purpose of this study was to investigate longitudinal body mass and body composition changes in one professional rugby union team (n=123), (i) according to position [forwards (n=58) versus backs (n=65)], analysis of players with 6 consecutive seasons of DXA scans (n=21) and, (iii) to examine differences by playing status [academy and international], over 7 years. Players [mean age: 26.8 y, body mass index: 28.9+kg.m2] received DXA scans at fourtime points within each year. A modest (but non-significant) increase in mean total mass (0.8 kg) for professional players was reflected by increased lean mass and reduced body fat mass. At all-time points, forwards had a significantly greater total mass, lean mass and body fat percentage compared to backs (p<0.05). Academy players demonstrated increased total and lean mass and decreased body fat percentage over the first 3 years of senior rugby, although this was not significant. Senior and academy international players had greater lean mass and lower body fat percentage (p<0.05) than non-international counterparts. Despite modest increases in total mass; reflected by increased lean mass and reduced fat mass, no significant changes in body mass or body composition, irrespective of playing position were apparent over 7 years.

Effect of different interval training protocols on adiposity indicators in overweight-obese children and adolescents: a systematic review and meta-analysis

ABSTRACT The present meta-analysis verified the impact of different protocols of high-intensity interval training (HIIT) on indicators of adiposity in overweight and obese children and adolescents. Searches were performed in the databases: PubMed, ScienceDirect, SPORTDiscus, LILACS and SciELO. Were included studies without caloric restriction that aimed to verify the effect of HIIT interventions on the adiposity indicators in overweight children and adolescents published until December 2018. The PEDro scale was used to assess the risk of bias. The meta-analysis was conducted in the Revman software using standardized mean difference (SMD) data and 95% confidence intervals (CI). Seventeen studies were selected, which involved 289 children and adolescents with overweight and obesity. HIIT interventions (mean=11.7±5.9 weeks) produced significant decreases in body fat percentage (SMD=-0.65; CI=-1.07, -0.23) and waist circumference (SMD=-0.34; CI=-0.49, -0.18). Also, major relative risk of decrease in body fat percentage were observed in favour to protocols with work/recovery interval ratios of 1:1 and 2:1. HIIT protocols with ratios (work/recovery intervals) 1:1 and 2:1 promote significant reductions in fat percentage and waist circumference in overweight and obese children, independently of the total work time.

Influences of Ketogenic Diet on Body Fat Percentage, Respiratory Exchange Rate, and Total Cholesterol in Athletes: A Systematic Review and Meta-Analysis.

(1) Background: The purpose of the current meta-analysis was to investigate any positive or negative effects of ketogenic diets in athletes and provide an assessment of the size of these effects. (2) Methods: Databases were used to select relevant studies up to January 2021 regarding the effects of ketogenic diets in athletes. Inclusion criteria were as follows: data before and after ketogenic diet use, being randomized controlled trials and presenting ketogenic diets and assessments of ketone status. Study subjects were required to be professional athletes. Review studies, pilot studies, and studies in which non-athletes were included were excluded from this meta-analysis. The outcome effect sizes in these selected studies were calculated by using the standardized mean difference statistic. (3) Results: Eight studies were selected for this meta-analysis. Athletes who consumed the ketogenic diet had reduced body fat percentages, respiratory exchange rates, and increased total cholesterol compared to athletes who did not consume this diet. However, body mass index, cardiorespiratory fitness, heart rate, HDL cholesterol, glucose level, and insulin level were unaffected by the diet. (4) Conclusions: Ketogenic diets had a beneficial effect by decreasing body fat percentage, but athletes with high total cholesterol level need to be monitored when instituting a ketogenic diet. Our study sample size was limited; therefore, additional studies may be needed to confirm the current findings. Further studies need to be conducted on changes in LDL cholesterol, HDL cholesterol, total cholesterol and ratio of LDL to HDL cholesterol.

Efficiency of an mHealth App and Chest-Wearable Remote Exercise Monitoring Intervention in Patients With Type 2 Diabetes: A Prospective, Multicenter Randomized Controlled Trial.

BackgroundExercise has been recommended as a cornerstone for diabetes management. Supervised exercise is more efficient than unsupervised exercise but is less convenient and accessible.ObjectiveWe aimed to determine the efficiency of exercise using a fitness app and heart rate band to remotely monitor patients with type 2 diabetes in comparison with that of traditional exercise.MethodsPatients with type 2 diabetes without severe complications or comorbidities were recruited to participate in this multicenter randomized controlled trial and were allocated to either the intervention or control group (1:1 ratio). Participants in both groups were asked to engage in moderate to vigorous physical activity for at least 150 minutes per week; each participant was prescribed individualized exercises. Participants in the intervention group were asked to follow exercise videos on the app and to wear a chest band; heart rate, exercise duration, and exercise intensity were recorded by the app. Participants in the control group self-reported exercise intensity and duration. Cardiopulmonary endurance, body composition, blood glucose level, and insulin level were assessed before and after a 3-month exercise program.ResultsOf the 101 participants who were enrolled, the majority of them (85/101, 84.2%) completed the study. Both groups had similar baseline characteristics, with the exception that participants in the intervention group were slightly younger and less likely to have hypertension. Self-reported exercise duration was longer than app-recorded exercise duration (control: mean 214 minutes/week; intervention: mean 193 minutes/week); in addition, a higher proportion of participants in the control group (29/41, 71%) than in the intervention group (18/44, 41%) met the 150-minute target for moderate to vigorous physical activity. However, compared with the control group, the intervention group had a larger increase in cardiopulmonary endurance (mean difference –2.0 bpm [beats per minute] vs 1.0 bpm; P=.02) and a larger decrease in body fat percentage (mean difference –1.8% vs –0.8%; P=.01). There was no difference in hemoglobin A1c level reduction between the two groups, yet more participants in the intervention group stopped taking their antidiabetic drugs or had their dosages lowered by an endocrinologist, compared with those in the control group. There were no serious adverse events in either group.ConclusionsThis was the first randomized controlled trial in China, to our knowledge, to test the efficiency of exercise using a fitness app and heart rate band to remotely monitor prescribed exercise in patients with type 2 diabetes. The findings of our study suggest that exercise programs may be more efficient if participants are remotely monitored with an app and heart rate band than if participants are not monitored.Trial RegistrationChinese Clinical Trial Register ChiCTR1800015963; http://www.chictr.org.cn/showprojen.aspx?proj=27080

The Effect of Selected Pilates Exercises on Balance, Blood Pressure, and Body Composition of Inactive Healthy Elderly Women

Background and Aim: Aging is a process during which most of the body’s physiological functions are gradually weakened and disrupted. This study aimed to investigate the effect of 8 weeks of selected Pilates exercises on balance, body composition, and blood pressure in healthy older women. Materials and Methods: This randomized quasi-experimental study with the pre-test, posttest design was performed on 20 inactive older women with a Mean±SD age of 62±2.5 years, Mean±SD height of 160.6±4.51 cm, and Mean±SD weight of 67.70±4.60 kg. The participants were randomly divided into experimental (n=10) and control (n=10) groups. The experimental group participated in the Pilates program for 8 weeks, 3 sessions per week. During this period, the control group did not participate in any training program. The studied variables in the training group were evaluated at the beginning and after 8 weeks of the program. Finally, the results of pre-test and post-test exercises of both groups were compared. The Kolmogorov-Smirnov test was used to ensure the normality of the data and paired t test and analysis of variance was used to analyze intra-group and inter-group findings, respectively. The significance level was set as less than 0.05. Results: Eight weeks of Pilates training significantly increased static (P=0.04) and dynamic (P=0.0001) balance and significantly decreased body fat percentage (P=0.001) in older women. However, the results showed that Pilates exercises had no significant effect on blood pressure and waist to hip ratio in older women (P≥0.05). Conclusion: Pilates exercises can improve balance and reduce the percentage of body fat in older women, and it is a suitable and inexpensive alternative or complementary treatment to improve balance and reduce falls. However, more studies are needed on the effect of this type of exercise on other indicators of elderly health.

The effect of two types of combined training on bio-motor ability adaptations in sedentary females.

The purpose of this study was to compare the effects of combined training of high-volume/low intensity vs. low volume/high intensity on different bio-motor adaptations in sedentary women. Thirty sedentary healthy females (mean age, 22.1±3.3 years), were randomly assigned into: control group (CG; N.=10), High-Volume/low-intensity training group (HV; N.=10); or high-intensity/low-volume training group (HI; N.=10). Training protocols were performed for 8 weeks, on three non-consecutive days a week. Post-intervention, there were significant main effects of time and a group by time interaction for all body composition and performance variables (P≤0.001), while no significant differences were found for changes in maximum heart rate. Pairwise comparisons revealed significant decreases in body fat percentage and speed test in HV and HI (P≤0.001) after intervention, while anaerobic power significantly increased in HV and HI (P≤0.001). The rating of perceived exertion (RPE) was significantly superior in HI than HV (P≤0.05). Additionally, there were significant main effects of time and a group by time interaction for all one-repetition maximum tests (P≤0.001). Combined interval training and resistance training were effective for improving bio-motor parameters in sedentary young women. HV training produced less RPE than HI training, which may potentially increase adherence to training protocols post-intervention.

Neuromuscular Blockade Correlates with Hormones and Body Composition in Acromegaly.

Tumor resection is the first-line therapy for acromegaly patients. In some cases, unsatisfactory intraoperative neuromuscular blockades (NMBs) lead to failed operations. The purpose of this study was to investigate and quantify the NMB status of acromegaly patients and explore the relationship between NMB status and hormone levels and body composition. Twenty patients with untreated acromegaly and seventeen patients with nonfunctioning pituitary adenomas as controls were enrolled in this study. NMB was assessed using the train-of-four (TOF) technique with TOF-Watch® SX. The onset time of NMB, deep neuromuscular blockade duration (DNMBD), and clinical neuromuscular blockade duration (CNMBD) were monitored. We found a significantly longer onset time (110.25 ± 54.90 vs. 75.00 ± 27.56, s, p=0.017), shorter DNMBD (21.99 ± 5.67 vs. 34.96 ± 11.04, min, p < 0.001), and shorter CNMBD (33.26 ± 8.09 vs. 46.21 ± 10.89, min, p < 0.001) in acromegaly patients compared with the controls. DNMBD and CNMBD decreased in patients with decreasing body fat percentage and increasing growth hormone (GH) level, insulin-like growth factor 1 (IGF-1) level, and GH and IGF-1 burden. The onset time increased with increasing IGF-1 level and GH and IGF-1 burden. Taken together, a unique NMB status was identified in acromegaly patients with the following characteristics: prolonged onset time and shortened DNMBD and CNMBD. Changes in the levels and burdens of GH and IGF-1 and body composition were linearly correlated with intraoperative NMB in acromegaly patients.

Combination of resistance and aerobic exercise for six months improves bone mass and physical function in HIV infected individuals: A randomized controlled trial.

To evaluate the effect of combined resistance and aerobic training (RT+AT) on regional bone mineral density (BMD) and physical performance in people living with HIV (PLWH). Forty PLWH (20 men and 20 women) were randomized into RT+AT group (n=20; age = 38.3 ± 4.9) or non-exercise control group (n=20; age = 37.9 ± 5.1). The RT+AT group was required to perform a nonlinear periodized resistance training program targeting large muscle groups followed by 20 min aerobic exercise at 65-80% of maximal heart rate. Participants in RT+AT performed three supervised sessions per week for 6-months, whereas participants in the control group were instructed to continue with their current lifestyle habits. The primary outcome was bone mineral density (lumbar spine (L2-L4), femoral neck, and distal 1/3 radius). Secondary outcomes included physical function, anthropometry, inflammatory markers, and growth factors. The RT+AT group demonstrated a significant increase in BMD at follow-up for the Lumbar spine (L2-L4), femoral neck, and 1/3 radius (all, P <.05), and There were no gender differences in the training response between men and women for any of the BMD regions. Similar findings were also observed for lean body mass, IGF1and Adiponectin (P<.001). We observed a decrease in percent body fat, fat mass, IL-6, TNF-α, and myostatin in the RT+AT group (P<.001). Finally, there was a significant increase in handgrip strength and gait speed for both women and men in the RT+AT group (P <.001). A combination of resistance and aerobic training appears to be a feasible and effective means for counteracting bone loss and improving various inflammatory markers, physical function, and growth hormones in PLWH.

Effects of small-sided recreational team handball training on mechanical muscle function, body composition and bone mineralization in untrained young adults-A randomized controlled trial.

Prolonged physical inactivity in young adults may lead to deficiencies in musculoskeletal fitness, and thus a need exists to develop physical activity and exercise programmes that are effective of increasing musculoskeletal fitness. The aim of this study, therefore, was to investigate the effects of small-sided team handball training on lower limb muscle strength, postural balance and body composition in young adults. Twenty-six men and twenty-eight women were stratified for peak oxygen uptake (VO2peak) and body fat percentage and randomly allocated to either 12 wks of small-sided recreational team handball training (THG: 14 men and 14 women, age 24.1±2.6 yrs (mean±SD), VO2peak 39.8±5.9 ml/kg/min and body fat percentage 32.7±8.7%) or serving as non-exercising controls (CON: 12 men and 14 women, age 24.8±3.1 yrs, VO2peak 39.7±5.0 ml/kg/min, body fat percentage 31.7±9.7%). THG trained on average 1.8 times/week for 12 wks. At 0 and 12 wks, lower limb muscle strength, rate of force development (RFD), vertical jump height and power, postural balance, body composition and muscle biopsies were assessed. No training effects were observed for maximal isokinetic or isometric knee extensor strength, maximal vertical jump height or take-off power, fibre type distribution or capillarization. Late phase (RFD) increased (+7.4%, p<0.05) and postural sway excursion length was improved after training (-9%, p<0.05) in THG with no difference from CON (p>0.05). Further, THG demonstrated a decrease in body fat percentage (-3.7%) accompanied by increases in whole-body fat free mass (FFM) (+2.2%), leg FFM (+2.5%), total bone mineral content (BMC) (+1.1%), leg BMC (+1.2%), total hip bone mineral density (+1.6%) and hip T-score (+50%) which differed from CON (all p<0.05). In conclusion, recreational small-sided team handball training appears to effectively improve rapid force capacity, postural balance, lean and fat body mass and bone health in previously untrained young adults. The study was registered at ClinicalTrials.gov (NCT04247724).ClinicalTrials.gov ID number: NCT04247724

Abstract 13631: Improving Cardiac Rehabilitation Attendance Through an Appointment-based Approach

Introduction: Cardiac rehabilitation (CR) is the pillar of secondary prevention for patients with cardiovascular disease (CVD). Despite its effectiveness, there remain systemic issues with adherence to in-clinic CR sessions, with the median number of CR sessions completed nationwide being 26 (out of a total of 36 sessions). We evaluated pre-post health outcomes for patients participating in a patient-driven appointment-based CR program, reasons for discharge, as well as predictors of total CR sessions attended. Methods: We utilized data from the Yale New-Haven Health (YNHH) CR program over a 6-year period (2012-2017). Data was collected on patient demographics, socio-economic status, and clinical characteristics. We evaluated CR outcomes with paired T-tests and conducted logistic regression analysis to determine predictors of CR adherence and completion. Results: A total of 2,135 patients were enrolled in CR from 2012 to 2017 (27.9% women, mean age 65±12 years). Patients completed a median of 30 sessions out of a total of 36. The primary reason for discharge was completion of all 36 sessions of CR (46.4%). The appointment-based CR program resulted in significant improvements in physical health outcomes (Table) , with matched-subject improvements of 1.42 METs increase, 0.32 kg/m 2 decrease in BMI and a 1.88% decrease in body fat percentage (P&lt;0.001). Patients also demonstrated improvements in blood pressure control, lipid profiles and diabetes management. Logistic regression modeling found that patient-specific medical factors, such as self-reported levels of stress and physical activity were predictive of CR completion. Conclusion: We demonstrated that an appointment-based CR program led to an increase in the median number of CR sessions completed versus the nationwide average, and produced significant improvements in health outcomes. Appointment-based CR could aid in optimizing the dose-response benefit of CR for patients with CVD.