Objective: To evaluate the shear bond strength and the adhesive remnant index (ARI) of an orthodontic resin after in vitro pH cycling and topical fluoride application. Methods: Edgewise brackets were bonded with TransbondTM XT resin on the buccal of 40 bovine incisors. The teeth were divided in 4 groups (n=10): G1: pre cycling group (immediate shearing); G2: pos cycling group (pH cycling in the absence of fluoride); G3: experimental group with single topical application of neutral fluoride gel (2% NaF) before pH cycling; G4: experimental group with three daily applications of fluoride dentifrice (MFP 1500 ppmF) during pH cycling. Shear bond strength and ARI were evaluated after 14 days of pH cycling (acid saliva, pH 4.5). Shear bond strength data were analyzed by ANOVA and Tukey’s test while the Man-Whitney and Kruskal-Wallis were used for analysis of ARI data using a 95% confidence interval (p 0.05) in the shear bond strength among the groups. For the ARI analysis, 100% of the specimens of G1, G2 and G4, and 60% of G3 were scored 1, while 40% of the specimens of G3 were scored 2. There was statistically significant difference (p=0.029) between G1 and G3; G2 and G3; G3 and G4. Conclusion: Topical fluoride application concomitant to pH cycling did not exert influence on the shear bond strength of TransbondTM XT resin, but the use of neutral fluoride gel indicated a reduction in the risks of tooth fracture on debonding of orthodontic brackets, according to the ARI characteristics.