Objectives: The effect of art painting in reducing stress, anxiety and depression in dentists was sought in this study. Method: Initially the list of artists who were also dentists was obtained from art societies; the names of those with artistic activity were found. We examined 80 dentists (two groups: case and controls, 40 each) from the viewpoint of stress, depression and anxiety. We visited these dentists, collected data relevant to their artistic activity and some demographic data including: age, gender, marital status, engagement in a field of specialty, existence of a stressed and depressed person in the family or history of a tragic event (divorce, death of a family member) in life. Then, a sample was taken from the non-artist group. These two groups were examined using a DASS-42 questionnaire and then the data was statistically assessed by the Mann-Whitney U -test and Chi-Square test. Results: There was a significant difference between the two groups of dentists. Among dentists who had artistic activity (painting), 32 persons (80%) had no stress, 40 (100%) had no depression and 40 (100%) had no anxiety. However, among dentists who did not have artistic activity (painting), 7 (17.5%) had no stress, 10 (25%) had no depression and 17 (42.5%) had no anxiety. Conclusions: Disregarding confounding variables, in this study dentist who did not have artistic activity, had more stress, anxiety and depression than dentists who engage in artistic activity (painting).