Dangerous Liaisons Research Articles

“Dangerous liaisons”: Heightened intra-limbic connectivity during subliminal cocaine cues is a relapse-vulnerable endophenotype

“Dangerous liaisons”: Heightened intra-limbic connectivity during subliminal cocaine cues is a relapse-vulnerable endophenotype

Dangerous liaisons: doctors-in-training and the pharmaceutical industry.

Interaction between doctors and the pharmaceutical industry is long-standing and ingrained in modern practice. Doctors-in-training are at a vulnerable stage of their careers, both in requiring knowledge and forming lasting relationships. There is evidence that limiting contact between industry and junior doctors has a positive effect on subsequent clinical behaviour. Currently in Australia, there is no limitation on pharmaceutical representatives approaching doctors-in-training, and the majority of education sessions are sponsored by pharmaceutical companies. This purposefully creates a sense of reciprocity, which may have adverse long-term consequences on attitudes, behaviours and patient care. Several guidelines exist that may assist junior doctors in navigating these potential interactions, most notably the Royal Australasian College of Physicians' own Guidelines for Ethical Relationships between Physicians and Industry. Despite this, there is no reflection of its importance or necessity within subspecialty curricula. This should be rectified, to the benefit of both the profession and public.

Dangerous Liaisons: The Burden of Food Allergy Self-management in College

Dangerous Liaisons: The Burden of Food Allergy Self-management in College

Book Review: Dangerous Liaisons: The Marriages and Divorces of Marxism and Feminism

Book Review: Dangerous Liaisons: The Marriages and Divorces of Marxism and Feminism

Dangerous Liaisons: Working Women and Sexual Justice in the American Civil War

The American Civil War drew thousands of white and black women into paid and unpaid work for the Union and Confederate armies. While the armies provided some women with a reliable income, their very proximity also represented a dangerous liaison that drew them into closer contact with Union troops that rendered them vulnerable to sexual assault. By 1865, more than four hundred Union soldiers had been court-martialed for sexual crimes against white and black women and girls. At the war’s onset, the Union’s judge advocate corps, which tried soldiers for violations of the articles of war, was ill-prepared to adjudicate sexual crimes. By the war’s end, however, an ethic of sexual justice emerged from Union military courts to provide women with a means of redressing their wartime sexual violation.

Immune Network, the Dangerous Liaisons in Pain: A Short Review

Introduction: Pain has increasingly become an important health problem. However, few doctors at primary health care are qualified to treat it. Recent researches also suggest that neurons are not the only ones involved in the establishment and maintenance of pain. This short review was conceived to collect some information on the contribution of immune system to the pathogenesis of pain and also to shed light to other mechanisms connected to this process. Development: Inflammation at the damaged site generates a cascade of events that produce innate immune cells concentration and activation; as well as production of pro-inflammatory cytokines, hormonal factors and neurotrophic activators of glial cells, which in turn perturb synaptic transmission. This entire complex induces pain persistence. Concluding remarks: The recognized commitment of immune, endocrine and nervous cells in pathological changes related with pain is crucial to offer new and satisfactory approaches to solve this problem. Integral modulation of these agents would contribute to new effective alternatives in the handling of pain.

The golden wave: culture and politics after Sri Lanka's tsunami disaster

Introduction: Political Ethnography of Disaster Wijitha's Story 1. That day: Chaos and Solidarity Dr. Priyanka's Story 2. Deaths: Fate and Vulnerability Pradeep and Manoj's Story 3. Short-term Camps: Chaos and the Crafting of Order Sumendra's Story 4. Housing: Temporary Shelters, Permanent Homes, and the Buffer Zone Lalitha's Story 5. Dangerous Liaisons: The Power, Peril, and Politics of Mediating between Donors and Recipients Jagath's Story 6. Business Recovery: Tourism and Construction Dayawansa's Story 7. Reconstructing Class: Discourse on Theft, Loot, Cheating, and Gifts Fazmina's Story 8. The Politics of Corruption: Accusations and Rebuttals Tharindu's Story 9. Citizenship and Ethnicity: The Tsunami and the Civil War Conclusion

Rilpivirine resistance and the dangerous liaisons with substitutions at position 184 among patients infected with HIV-1: analysis from a national drug-resistance database (ARCA).

Rilpivirine (RPV) is a novel NNRTI with a mutational pattern different from first-generation drugs of the same class: 16 resistance-associated mutations (RAM) are listed, but the combination E138K + M184I seems to be the most important. Aims of the present study were to evaluate the prevalence of these RAMs in Italian HIV-1 infected patients and to assess if previous drug history could represent a risk to develop RPV-related RAMs. The analysis was performed using the ARCA database, which contains data on resistance and therapy from subjects throughout Italy. Prevalence of RPV-associated and first-generation NNRTI-associated RAMs was evaluated. Linear regression model, odds ratio and 95% Confidence Interval were used to assess factors associated with the development of RPV RAMs, substitutions at position 184 and their combinations. A total of 8,067 tests were selected within the database. In Italian HIV-positive HAART-naïve patients, prevalence of the main RAMs for RPV is low except for E138A (present in 5.1% of subjects). The combination E138K + M184I is absent in both naïve and experienced subjects. A previous exposure to NVP might increase the risk to develop RPV-associated RAMs. TDF, EFV, and possibly FTC may predispose to the selection for M184I. Among Italian patients the susceptibility to RPV is widespread since some severe substitutions (e.g., E138K are rare), whereas issues exist for others (i.e., E138A, Y181C) which are more frequent. Appropriate use of RPV within a therapeutic sequencing might be controversial.

Dangerous Liaisons between Beta-Amyloid and Cholinergic Neurotransmission

The review examines the multifaceted interactions between cholinergic transmission and beta-amyloid suggesting a continuum in the action of the peptide that at low concentrations (picomolar-low nanomolar) may directly stimulate nicotinic cholinergic receptor while desensitizing them at increasing concentrations (high nanomolar-low micromolar). In addition high beta-amyloid concentrations may reduce the synaptic release of several neurotransmitters, including glutamate, aspartate, GABA, glycine and dopamine, when the release is elicited through cholinergic stimulation but not following depolarization. The effect of beta-amyloid has been observed both in vitro and in vivo in at least three different brain areas (nucleus accumbens, striatum, hippocampus) suggesting that the peptide may exert some general effects even if not all the brain areas have been evaluated. In turn the activation of cholinergic receptors may affect the amyloid precursor protein processing diverting the metabolism toward non-amyloidogenic products. These actions, dissociated from those described in the case of high beta-amyloid concentrations leading to neurotoxic oligomers, may participate to cause dysfunctions in the neurotransmitter activity, in turn leading, at least from a theoretical point of view, to early neuropsychiatric disturbances in the disease. Complexively these observations underscore novel relationships between two main players in Alzheimer's disease pathogenesis that are beta-amyloid and cholinergic transmission. Also emerges the inherent difficulty of targeting beta-amyloid in a context in which the peptide exerts several actions beyond neurotoxicity.

Dangerous liaisons, fatal women: The fear and fantasy of soccer wives and girlfriends in Spain

Critical feminist analysis has produced much important work on women in the gender regime of men’s sport. The protagonists of these studies have been mostly female athletes, fans, managers and journalists. This article focuses on yet another female persona in men’s sport: the lover. Complementing research that identifies wives and girlfriends (WAGs) as helpmates who fulfill traditional auxiliary roles to their athlete partners, this article presents another sexual persona through the Spanish soccer scene: femmes fatales or ‘fatal women’. Through fantasy narratives, these WAGs are constructed as ‘dangerous destabilizers’ that threaten elite male sport performance through their sexuality. The presence of female fans, athletes and professionals in men’s sport has often provoked redressive actions such as techniques of sexualization, the denial of authentic female fandom and expertise, or the prescription of gender-appropriate behaviors and aspirations. Complementing critical feminist research on these mechanisms, and with an attempt to gain a wider perspective of female presence in men’s sport, this article explores the often contradictory reactions to ‘fatal women’: demonization, fetishization, the pathologization of sex and the proliferation of erotic fantasies.

Dangerous liaisons: flirtations between oncogenic BRAF and GRP78 in drug-resistant melanomas

BRAF mutations in aggressive melanomas result in kinase activation. BRAF inhibitors reduce BRAF(V600E) tumors, but rapid resistance follows. In this issue of the JCI, Ma and colleagues report that vemurafenib activates ER stress and autophagy in BRAF(V600E) melanoma cells, through sequestration of the ER chaperone GRP78 by the mutant BRAF and subsequent PERK activation. In preclinical studies, treating vemurafenib-resistant melanoma with a combination of vemurafenib and an autophagy inhibitor reduced tumor load. Further work is needed to establish clinical relevance of this resistance mechanism and demonstrate efficacy of autophagy and kinase inhibitor combinations in melanoma treatment.

Dangerous Politics, Dangerous Liaisons: Love and Terror among Jewish Women Radicals in Czarist Russia

Pendant les années 1870 et 1880, les femmes juives sont très représentées dans les mouvements de gauche qui ont émergé en Russie. Dans cet article, nous explorons les origines sociales, les expériences de vie, et les motivations des femmes attirées par la politique socialiste à cette époque. Nous portons une attention particulière à la mixité sociale parmi les militants, et établissons un modèle de romances judéo-nobles qui figure aussi dans les salons dans d’autres époques et villes. Quatre notes biographiques approfondissent ce que nous pouvons apprendre des statistiques. Les femmes mises en exergue sont Gesia Gelfman, Anna Kuliscioff, Anna Epshtein et Rosalie Idelson.

A análise do discurso diante de estranhos espelhos: visualidade e (inter)discursividade na pintura

Este artigo intenciona compreender a dimensão discursiva das pinturas por meio da análise do discurso ancorada em Michel Foucault. Recorta-se a figura do espelho em pinturas canônicas com vistas a observar seu funcionamento discursivo enquanto elemento do enunciado artístico visual. Apresenta três partes: a primeira, que determina o lugar ocupado pelo discurso estético nos trabalhos de Michel Pêcheux e de Michel Foucault; a segunda, que se concentra na análise de três pinturas europeias, a saber, As meninas, de Velásquez; Um bar em Folies-Bergère, de Manet; e As ligações perigosas, de Magritte; e a terceira parte, que discute a intersecção entre visualidade e interdiscursividade a partir (a) das reflexões de M. Foucault acerca do discurso estético e (b) da figura do espelho presente nessas pinturas.

Dangerous Liaisons between Detergents and Membrane Proteins. The Case of Mitochondrial Uncoupling Protein 2

The extraction of membrane proteins from their native environment by detergents is central to their biophysical characterization. Recent studies have emphasized that detergents may perturb the structure locally and modify the dynamics of membrane proteins. However, it remains challenging to determine whether these perturbations are negligible or could be responsible for misfolded conformations, altering the protein's function. In this work, we propose an original strategy combining functional studies and molecular simulations to address the physiological relevance of membrane protein structures obtained in the presence of detergents. We apply our strategy to a structure of isoform 2 of an uncoupling protein (UCP2) binding an inhibitor recently obtained in dodecylphosphocholine detergent micelles. Although this structure shares common traits with the ADP/ATP carrier, a member of the same protein family, its functional and biological significance remains to be addressed. In the present investigation, we demonstrate how dodecylphosphocholine severely alters the structure as well as the function of UCPs. The proposed original strategy opens new vistas for probing the physiological relevance of three-dimensional structures of membrane proteins obtained in non-native environments.

Concentrated intimacies

The author analyses the showcase of Slovenian theatre, which took place as part of the 2012 Maribor Theatre Festival (Borštnikovo srečanje). The text is a short critical reflection on the performances that were shown in the showcase: The feast, or The story of a savoury corpse …, The Fisherman and His Soul, The Trial, or the Woeful Story of Joseph K., Three Sisters, Tristan and Isolde, Who Is Next?, Dangerous Liaisons and The Conference of the Birds. With no ambition to sum up the state of affairs in Slovenian theatre on the basis of these performances, the author nevertheless establishes that Slovenian theatre with its aesthetics remains very diverse, and that it is marked by strong directorial personalities, high-quality actors and good production conditions. This allows it to maintain its leading position in the region; however, it remains to be seen how the serious financial crisis will affect its future.

Dangerous liaisons between interleukin-6 cytokine and toll-like receptor families: A potent combination in inflammation and cancer

The potent pro-inflammatory actions of members of the interleukin (IL)-6 cytokine and toll-like receptor (TLR) families have been implicated in numerous inflammatory disorders, as well as inflammation-associated cancers. It is fast becoming apparent that a hallmark of many such inflammatory-related diseases is the overlapping deregulated expression of members of each family, and the consequent augmented activation of shared signaling pathways. Here, we review the molecular basis by which the IL-6 cytokine and TLR family signaling networks are regulated, and integrate recent advances exploring the intimate cross-regulation of these two families which may provide the foundation for the future development of therapeutics to target chronic inflammation-associated diseases, including cancer.

Dangerous Liaisons? Governments, companies and Internet governance

Dangerous Liaisons? Governments, companies and Internet governance

The Graphic canon: from the epic of Gilgamesh to Shakespeare to Dangerous liaisons

The Graphic canon: from the epic of Gilgamesh to Shakespeare to Dangerous liaisons

Erratum: Dangerous liaisons: molecular basis for a syndemic relationship between Kaposi's sarcoma and P. falciparum malaria

[This corrects the article on p. 35 in vol. 4, PMID: 23487416.].

Alfred Hitchcock, Creator and Creation: Fictionalizing the “Master of Suspense”

january–february 2013 • 9 photo : hbo films W hen I first heard that actor Toby Jones was to play the role of Alfred Hitchcock in The Girl, an HBO movie, I wondered what curse had been placed on him. In 2006 he had appeared brilliantly in Infamous as Truman Capote. However, in fall 2005, Capote was released starring Philip Seymour Hoffman in the title role, and whether Jones was, as some critics asserted, better at the impersonation became irrelevant. Now Toby Jones was playing Hitchcock in the same year that Anthony Hopkins plays him in Hitchcock. The Girl, however, was aired before Hitchcock , so perhaps there is truth in the general rule that whoever gets there first wins, as when Hollywood inexplicably released two versions of Choderlos de Laclos’s Les Liaisons Dangereuses. Dangerous Liaisons with Glenn Close and John Malkovich (1988) cost $14 million and grossed almost $35 million, while Valmont with Annette Bening and Colin Firth (1989) cost $33 million and grossed just over $1.1 million.1 We can assume, however, that one version of the two is likely to be better than the other, and The Girl is so appalling, it is hard to imagine Hitchcock is worse. Experiencing two portrayals of the same character in a short period of time almost always means that the viewer or reader will be comparing them as the drama develops and, because of this, will have difficulty suspending disbelief on the second occasion. The emotional reaction to the second portrayal will be muted, Alfred Hitchcock, Creator and Creation Fictionalizing the “Master of Suspense” Crime&Mystery international j. madison davis Toby Jones as Alfred Hitchcock in the HBO film The Girl. 10 World Literature Today and therefore it won’t seem as convincing . To see Dick Powell play Philip Marlowe in Murder, My Sweet (1944, based on Farewell, My Lovely) and then Robert Mitchum in the same story (1975) invites comparison, of course, but the usual gap in time between seeing them allows a normal viewer to experience each interpretation on its own terms. Similarly, when a character is based on a historical person, the problem doesn’t manifest itself unless the personality and appearance of the person is still alive in the audience’s imagination. A biopic can be quite effective, whether it is Abel Gance’s Napoleon or Steven Spielberg’s Lincoln. We have certain notions about historical characters— Napoleon was very short (not true), Lincoln was tall (true)—but we don’t feel we know them personally. The details don’t make an interpretation seem ridiculous. Abraham Lincoln, Vampire Hunter is way over the sacrilege line for me, but apparently not for many. Characters we “know,” however, inevitably invite distracting comparisons . Hollywood and television have done many productions based on mass-media celebrities. Some, such as George “Superman” Reeves played by Ben Affleck (Hollywoodland) or the many Al Capones don’t have a sharp enough identity to make us reject the portrayal on the basis of either appearance or personality. However, actors playing Clark Gable, Humphrey Bogart, or Elvis face a daunting task in anything other than parody. Theresemblancetoacelebritymay be remarkable, as when Julianne Moore played Sarah Palin in Game Change, but doing an imitation turns the actor into an animatronic puppet. One of last year’s more critically acclaimed films, My Week with Marilyn, achieved just the right balance with the Marilyn Monroe character. Michelle Williams resembled Monroe enough, caught her mannerisms enough, and yet she seemed like a human being. Kenneth Branagh playing Laurence Olivier caught almost nothing of him and came across like Wallander lost in the wrong movie. Perhaps the most remarkable example of a star playing a star was Faye Dunaway’s turn as Joan Crawford in Mommie Dearest. In this instance, the perception of Crawford was damaged forever, and Dunaway’s career was almost ruined because whatever role she took reminded people of the Mommie Crawford. Hitchcock is another of those celebrities that people seem to think they “know,” because he carefully constructed and cultivated his image. His television show, Alfred Hitchcock Presents, mostly chose quality stories of a particular type rather than using original scripts. Henry Slesar had the most stories...