3D bioprinting has opened numerous avenues in the medical field, particularly advancing biomedical techniques for administration of drugs, fabrication of prostheses, surgical operations and restoration of damaged body parts. In this review we discuss the principles of 3D bioprinting, its applications, advantages over traditional methods, recent advancements and the future prospects of automation within the field.. The review also delves into the creation of more physiologically relevant tissue models for drug screening and toxicity testing. Finally, we also explore more recent advancements showcasing the impact of printing in space, integration of artificial intelligence (AI), and development of 4D bioprinting. Expressing current limitations and challenges, the review underscores the potential of 3D bioprinting in personalized medicine.