Modern seismic resistant structures need to be designed in order to withstand frequent earthquakes without significant damages and to remain safe, even though a certain amount of structural damage is accepted in case of rare seismic events.In this paper an innovative typology is proposed for MR-Frames aiming at the ambitious goal of free from damage (FFD) structures. At local scale, the innovation is constituted by the use of beam-to-column connections equipped with friction pads, so that the dissipative zones are constituted by damping devices located at the beam ends. In addition, friction dampers are also located at the column base to assure damage prevention even when a global mechanism is completely developed. Moreover, at global scale the prevention of column hinging, required to obtain FFD structures, can be assured provided that a rigorous design methodology based on the theorems of plastic collapse is applied aiming to guarantee the desired energy dissipation mechanism.The seismic performances of a MR-Frame with beam-to-column joints and column-base connections equipped with friction dampers are herein investigated by means of non-linear dynamic analyses carried out with the aim to assess the fulfillment of the design goal, i.e. the development of free from damage structures.