Daily Basis Research Articles

Effects of temperature variation on yield and quality of field crickets (<i>Gryllus bimaculatus</i>) and black soldier flies (<i>Hermetia illucens</i>)

Insect rearing provides an affordable alternative source of animal nutrition for most small-scale farmers. However, current rearing technology with uncontrolled environmental conditions suppresses insect yields, leading to low adoption of insect production. The objective of this study was to assess the effect of temperature variation, using an adaptive control structure, on the yield of field crickets (Gryllus bimaculatus) and black soldier fly larvae (Hermetia illucens). Temperature values of 25°C, 27°C, and 30°C constant relative humidity of 50%, and constant air speed of 3 m/s were adopted for the study. Throughout the study, weighing of the insect wet yield was done on a daily basis for larvae and after three days for cricket pinheads. Black soldier fly larvae and adult crickets were harvested at the ages of two weeks and six weeks, respectively, and oven dried at 105°C for 24 hours for subsequent analysis of proteins. Results indicated that black soldier fly larvae reared at 25°C, 27°C, and 30°C had a maximum mean wet yield of 0.216 ± 0.022 g, 0.234 ± 0.019 g, and 0.248 ± 0.016 g, respectively, at the age of two weeks. Similarly, crickets reared at 25°C, 27°C, and 30°C had a mean yield of 0.807 ± 0.167 g, 0.933 ± 0.102 g, and 1.306 ± 0.254 g at the age of six weeks. Dried cricket reared at 25°C, 27°C, and 30°C had 25.566 ± 0.012%, 46.811 ± 0.647%, and 58.216 ± 1.510% protein, respectively. Contrary to this, black soldier flies reared at 25°C, 27°C, and 30°C yielded 42.655 ± 1.732%, 47.121 ± 0.015%, and 62.536 ± 0.014%, respectively. Larval yield recorded significant different yields (f = 4.935, p = 0.03), whereas crickets failed to record significant different yields (f = 0.777, p = 0.388) under different temperature levels. A higher temperature regime yielded higher body mass and protein turnover. The findings of this study boost the future prospects of insects as food and feed for enhancing food and nutrition security.

Interactivity on Participatory Artworks. A Case Study of Long Life Laboratory

Contemporary art is a signifier for the occurance of the melting back aspect of melting back aspects of the arts with other non art disciplinesn in the art world as well as the creative industry. The collapse of hierarchies between high art and low art is the discourse in the West also influenced the development of art in Indonesia. This allows also many works popping up to a hybrid combination between pure art and design as applied art. Nowadays people believe the participatory art can be developed as the styled identity of Indonesia contemporary arts because of the collective spirit of commonly called ‘paguyuban’ it ussualy bring. There is a place called Jatiwangi Art Factory who developed an art movements by running a kind of community based methods to build their village out of economical bankruptcy. A similar approach was elaborated by a couple of Jakarta urban artist namely Irwan Ahmett and Tita Salina. They often work with the society in daily basis to criticize the Jakarta social problems. Departing from the above observation, this paper made to dissect the authos’s works entitled “Long Life Laboratory” which had been exhibited at the Bazaar Art Jakarta 2016 in Pacific Place Mall by measuring the level of interactivity on this kind work of participatory art. A Qualitative method is used also to read this visual form associated with the theory of relational aesthetic, a thinking of a French art critic Nicolas Bourriard

A Resource-Based View on Individual Absorption in the Context of Multiple Team Memberships

Knowledge work—frequently characterized as nonroutine and complex—requires individuals to be deeply engrossed with or “absorbed” in their work. Notwithstanding, organizations tend to put knowledge workers in multiple teams, undermining their ability to achieve the level of absorption required to realize their full potential. We examine how knowledge workers who are operating in multiple team contexts navigate competing demands on their time on a daily basis. Based on conservation of resources theory, we posit that the time devoted to the focal team—that is, the primary team in which knowledge workers are most actively involved—fosters absorption. However, this positive relationship is moderated by the number of different team contexts and problem-solving demands that knowledge workers experience daily, as together, these contextual conditions block optimal resource utilization. To test our hypotheses, we apply hierarchical linear modelling to experience-sampling data from 140 knowledge workers surveyed over 10 consecutive working days. Our findings support the hypothesized model, suggesting that daily involvement in multiple team contexts hinders full absorption, especially if daily problem-solving demands are high. Our insights emphasize the importance of the role and potential cost of multiple team membership (MTM) for understanding knowledge workers’ optimal functioning.

Home care for COVID-19 positive cases: suitability of the residential setting and ability of cases to adhere to the required preventive measures

IntroductionWith the upsurge of COVID-19 cases, Lebanese hospitals were overburdened and hospital care was prioritized for COVID-19 patients with the highest probability of poor outcomes. This paper aimed to assess the suitability of residential settings for home isolation and to explore the patient’s ability to adhere to the required precautions measures.MethodsAll COVID-19 cases reported between February, 21 and the end of June 2020 and who had mild or moderate symptoms, were contacted via phone calls by a healthcare professional to fill out a standardized questionnaire developed to assess the suitability of the residential setting for home care. Inpatient cases were required, before their discharge from the hospitals, to sign consent related to their adherence to the mandatory precautionary measures. They were also asked to complete, on daily basis, the symptoms monitoring log form. A referral system to health facilities was established to manage cases with worsening health status. A collaborative framework to address violations of home isolation rules was also put in place.ResultsOf the 600 cases assessed, 44.7% of them were isolated in a living building apartment (67.2%) with one entrance (85.5%) including four to eight rooms (71%). Around one-quarter of patients have children (< 5 years) and 75% of them were living with elderly people. Most of the patients confirmed the availability of a well-ventilated single room (96.2%) and a separate bathroom (80.17%). As for infrastructure, more than 90% of patients confirmed the availability of drinking and tank water, heating facilities, electricity, and safe trash elimination. Similarly, more than 90% of them had access to personal hygiene items, disinfectants, and personal protective equipment. The bulk of homes care were rated as easily reachable. As for awareness and ability to self-serving, 94.5% of patients were knowledgeable about the required preventive measures, able to serve themselves and to adhere to the isolation requirements as well. Only 51.8% of them had access to psychological support.ConclusionProper assessment of the residential setting for home care of COVID-19 cases combined with close monitoring of the adherence of patients to the required precaution measures are highly needed for limiting the spread of infection within the household and the community.

Mental Health of Nursing Professionals in Brazil

Mental health is described as emotional balance and the ability to deal with life’s challenges. However, in the work environment, the use of new technologies, competitiveness and ambitious goals can harm the mental health of nursing professionals. This study aims to refl ect on the consequences of a fragile mental health of nursing professionals in Brazil. The methodology was based on an integrative research of the literature, of a qualitative nature, for this, a search was carried out in the Latin American and Caribbean Literature database in Health Sciences, with only seven relevant articles being selected on the consequences of impaired mental health. to nursing professionals. The results highlighted the importance of addressing the mental health of nursing professionals, since they deal with situations of stress and suff ering on a daily basis.

Research on pricing and replenishment decision of vegetable and fruit commodities-Based on nonlinear programming model and ARIMA time series forecasting

Due to the timeliness of vegetable and fruit sales, supermarkets generally supplement each product on a daily basis based on the past sales and demand of each product according to the specific situation. In order to make replenishment and pricing decisions for vegetables and fruits in commercial supermarkets, this paper considers cost, sales volume, supply and demand relationship and loss factors under profit maximization based on cost plus pricing method. Sales volume, cost plus pricing functions are defined, and seasonal ARMIA model is used for forecasting. The sales profit function and constraint conditions are established, and the nonlinear programming model is constructed to solve the problem to obtain the profit maximization scheme.

Spatiotemporal deformation characteristics of Outang landslide and identification of triggering factors using data mining

Since the impoundment of Three Gorges Reservoir (TGR) in 2003, numerous slopes have experienced noticeable movement or destabilization owing to reservoir level changes and seasonal rainfall. One case is the Outang landslide, a large-scale and active landslide, on the south bank of the Yangtze River. The latest monitoring data and site investigations available are analyzed to establish spatial and temporal landslide deformation characteristics. Data mining technology, including the two-step clustering and Apriori algorithm, is then used to identify the dominant triggers of landslide movement. In the data mining process, the two-step clustering method clusters the candidate triggers and displacement rate into several groups, and the Apriori algorithm generates correlation criteria for the cause-and-effect. The analysis considers multiple locations of the landslide and incorporates two types of time scales: long-term deformation on a monthly basis and short-term deformation on a daily basis. This analysis shows that the deformations of the Outang landslide are driven by both rainfall and reservoir water while its deformation varies spatiotemporally mainly due to the difference in local responses to hydrological factors. The data mining results reveal different dominant triggering factors depending on the monitoring frequency: the monthly and bi-monthly cumulative rainfall control the monthly deformation, and the 10-d cumulative rainfall and the 5-d cumulative drop of water level in the reservoir dominate the daily deformation of the landslide. It is concluded that the spatiotemporal deformation pattern and data mining rules associated with precipitation and reservoir water level have the potential to be broadly implemented for improving landslide prevention and control in the dam reservoirs and other landslide-prone areas.

Comparison of the study performance of dental students in different subfields of neuroanatomy at the Charité - Universitätsmedizin Berlin and evaluation of the neuroanatomy course in the fourth preclinical semester

IntroductionThe dentist's main working area is the head and neck region, which is innervated by the cranial nerves. On a daily basis, dentists must administer local anaesthesia to ensure pain-free treatment and differentiate between dental pain and neuropathies to avoid mistreatment. Therefore, neuroanatomical training, especially on the cranial nerves, is of immense importance for clinical practice. In order to adopt the curriculum, it is essential to constantly evaluate the quality of the training and to investigate whether there is a correlation between the students' performance and the relevance of the subfields to their work. Material and methodsTo address this issue, the results of MC exams in the neuroanatomy course for dental students at Charité-Universitätsmedizin Berlin from winter semester 2014/2015 to winter semester 2019/2020 were analysed. Each question was assigned to a specific subfield of neuroanatomy. We then compared cranial nerves and cranial nerve nuclei (clinically relevant) with the remaining subfields (clinically less/not relevant) to investigate whether students performed better in anatomy subfields that are more aligned with the clinical practice of a dentist. We also conducted an anonymous survey (n=201) of the dental students. ResultsFrom winter semester 2014/2015 to winter semester 2019/2020, students performed significantly (***, p< 0.001) better on the clinically relevant questions of the MC examination than on the less/not clinically relevant questions. However, when looking at each of the eleven semesters separately, only three semesters actually performed significantly better on the clinically relevant questions. Our survey also showed that students perceived the subfield of cranial nerves and cranial nerve nuclei to be the most relevant and studied it more intensively out of their own interest. DiscussionThe study showed that students perceived the subfield of cranial nerves and cranial nerve nuclei to be the most relevant. However, there was no direct correlation between student performance and clinically relevant questions. Using student performance alone as an indicator of relevance is not optimal, as factors such as motivation to learn can have a significant impact. ConclusionGreater clinical relevance influences what students learn more intensively out of their own interest, but does not influence the results of the MC examination in favour of the subspecialty. Based on the available evidence, it is recommended that the structure of the neuroanatomy course be reconsidered.

Assessment of possible biomedical applications of green synthesized TiO2NPs-an in-vitro approach

Biomedical applications for various types of nanoparticles are emerging on a daily basis. Hence this research was performed to evaluate the antifungal (Aspergillus sp., Alternaria sp., Trichophyton sp., Candida sp., and Penicillium sp.), cytotoxicity (MCF10A cell lines), and antioxidant (DPPH) potential of Coleus aromaticus mediated and pre-characterized TiO2NPs were studied with respective standard methodology. Interestingly, the TiO2NPs exhibited significant antifungal activity on pathogenic fungal strains like Alternaria sp., Aspergillus sp. (31 ± 1.4), Penicillium sp. (31 ± 1.9) Trichophyton sp. (27 ± 2.1), and Candida sp. (26 ± 2.3) at high concentration (250 μg mL−1). However, the considerable levels of zone of inhibitions on fungal pathogens were recorded at 100 μg mL−1 of TiO2NPs as well as it was considerably greater than positive control. It also demonstrated dose based anti-inflammatory and antidiabetic activities. The plant-mediated TiO2NPs demonstrated a maximum DPPH scavenging efficiency of 91% at a dosage of 250 μg mL−1, comparable to the positive control's 94%. Furthermore, TiO2NPs at 100 μg mL−1 concentration did not cause cytotoxicity in MCF10A cell lines. At higher concentrations (250 μg mL−1), the nanoparticles showed the lowest cytotoxicity (17%). These findings suggest that C. aromaticus-mediated TiO2NPs have significant biomedical applications. However, in-vivo studies are needed to learn more about their (C. aromaticus-mediated TiO2NPs) potential biomedical applications.

Analysis and Health Risk Assessment of Heavy Metals in Bakery Products Sold in the Local Market of Rajshahi City, Bangladesh

All age groups are fond of bakery items, although middle-class and lower-class people in Bangladesh are especially prominent. However, this food product's ingredients, manufacturing process, and packaging all have the potential for heavy metal contamination. As a result, the mean concentrations of Cr, Mn, Cu, Ni, Cd and Pb in 18 different brands of local bakery items, while others were from well-known brands readily available in Rajshahi City, were evaluated using an atomic absorption spectrometer. The concentrations of Cr, Mn, Cu, Ni, Cd, and Pb were 0.34–1.66, 0.29–1.70, 0.19–1.27, ND–7.04, ND–0.38, and ND–1.33 mg/kg, respectively. The order of the metal content was Ni&gt; Mn&gt; Cr&gt; Pb&gt; Cu&gt; Cd, with their polluted values. According to the results, some cereals and cereal-based food product samples included levels of Ni, Pb, &amp; Cd that were greater than the permissible range recommended by the World Health Organization. Fewer samples typically exceed the acceptable limit than all of them. The metals' estimated daily intake levels did not exceed the permitted intake thresholds. On the other hand, the amounts of healthy nutritive metals like Mn and Cu that were ingested from that foodstuff were relatively small and barely met the daily demands for these nutrients. As a whole, the heavy metals' estimated target hazard quotients were &lt; 1, indicating that people who regularly use these goods on a daily basis shouldn't have any health concerns.

Epidemiological and cost analysis of burned patients in Iran

IntroductionConsidering the financial support provided by insurance and the government for burn patients in Iran, and recognizing the substantial economic impact associated with their treatment, there is a pressing need to delve into the epidemiology of these patients and analyze the related costs. This study aims to explore the epidemiological aspects and hospitalization costs of burn patients specifically within the burn ward of Imam Reza 68-bed Hospital in Mashhad, a regional center of referral in the eastern part of the country. MethodsData had extracted from the electronic data collection system, which is used on a daily basis in the hospital. We included patients with a primary or secondary diagnosis of burns, code T20.0-T32.9 and T95 according to the International Classification of Diseases ICD-10. Ultimately, 1151 patients were included in the study. We analyzed 1151 burn cases in terms of patients’ age at the time of the event, gender, type of burn (Chemical, scalds, flame, electrical and contact burns), anatomical location of the burn (head and neck, upper limb, lower limb, multiple regions and part unspecified), burn etiology, burn degree (I, II, III), total burn surface area (%TBSA), Inpatient ward, expenditure ($), burn mortality rate and length of hospitalization. The age group was divided into seven groups by the 10 years intervals. Statistical analysis of the data was performed using SPSS-16 and Excel software. Results1151 patients were included in the study. High-risk groups are pediatric up to nine (0–9) years. According to age, we found that most cases were children, respectively, 25% (291) cases. Men accounted for 743 cases (65%), women for 408 (35%). Major causes of severe burn injury were flame burns (49%) and scalds (43%). Unspecified was the most common burn location (40%), followed by the multiple regions (23%) and upper limb (11%). In cases of head and neck burns, the financial burden on the patient is elevated compared to other types of burns due to increased expenses for medications, disposable medical instruments, and hoteling. The main items for the burned patients are hoteling (38% of total costs), surgeon (24%), medicine (16%), and medical consumables (6%). The per capita expenditure was $9,365 ± $8,100 in pediatrics and $11,179 ± $10,180 in adults Conclusions: Most cases of death were related to burn in multiple areas of the body and then trunk burn (30% and 19%, respectively) and no death was observed in patients with hand and wrist burn. Burns can be incredibly severe and life-threatening, especially when they affect multiple areas of the body, such as the trunk and any burn injury is still a serious matter. It's important to prioritize fire safety and take precautions to prevent such accidents from happening.

Axillary Lymphadenectomy: Safe Dissection Through a Correct Technique.

The primary treatment of breast cancer in sentinel-positive ganglia includes axillary lymphatic nodal dissection. The LAD (lymphatic axillary dissection) has decreased in overall numbers but due to the increasing incidence of breast cancer, it is practised on a daily basis, even though there is a myriad of complications such as numbness of the upper limb and chest wall, movement restriction of the upper limb, and chronic painwhich appear due to trauma to the nerves which pass through the axilla. However, the utility in the overall survival or DFS (disease-free survival) of the patient is unquestionable. In our study, through the dissection of cadavers, we exposed the vital structures and theanatomical relations of this region. We aimed to offer a map or technique for the surgeon to followto decrease the overall morbidity of this procedure.

Epigenetic mechanisms of particulate matter exposure: air pollution and hazards on human health.

Environmental pollution nowadays has not only a direct correlation with human health changes but a direct social impact. Epidemiological studies have evidenced the increased damage to human health on a daily basis because of damage to the ecological niche. Rapid urban growth and industrialized societies importantly compromise air quality, which can be assessed by a notable accumulation of air pollutants in both the gas and the particle phases. Of them, particulate matter (PM) represents a highly complex mixture of organic and inorganic compounds of the most variable size, composition, and origin. PM being one of the most complex environmental pollutants, its accumulation also varies in a temporal and spatial manner, which challenges current analytical techniques used to investigate PM interactions. Nevertheless, the characterization of the chemical composition of PM is a reliable indicator of the composition of the atmosphere, the quality of breathed air in urbanized societies, industrial zones and consequently gives support for pertinent measures to avoid serious health damage. Epigenomic damage is one of the most promising biological mechanisms of air pollution-derived carcinogenesis. Therefore, this review aims to highlight the implication of PM exposure in diverse molecular mechanisms driving human diseases by altered epigenetic regulation. The presented findings in the context of pan-organic cancer, fibrosis, neurodegeneration and metabolic diseases may provide valuable insights into the toxicity effects of PM components at the epigenomic level and may serve as biomarkers of early detection for novel targeted therapies.

Unsupervised clustering of bitcoin transactions

Since its inception in 2009, Bitcoin has become and is currently the most successful and widely used cryptocurrency. It introduced blockchain technology, which allows transactions that transfer funds between users to take place online, in an immutable manner. No real-world identities are needed or stored in the blockchain. At the same time, all transactions are publicly available and auditable, making Bitcoin a pseudo-anonymous ledger of transactions. The volume of transactions that are broadcast on a daily basis is considerably large. We propose a set of features that can be extracted from transaction data. Using this, we apply a data processing pipeline to ultimately cluster transactions via a k-means clustering algorithm, according to the transaction properties. Finally, according to these properties, we are able to characterize these clusters and the transactions they include. Our work mainly differentiates from previous studies in that it applies an unsupervised learning method to cluster transactions instead of addresses. Using the novel features we introduce, our work classifies transactions in multiple clusters, while previous studies only attempt binary classification. Results indicate that most transactions fall into a cluster that can be described as common user transactions. Other clusters include transactions made by online exchanges and lending services, those relating to mining activities as well as smaller clusters, one of which contains possibly illicit or fraudulent transactions. We evaluated our results against an online database of addresses that belong to known actors, such as online exchanges, and found that our results generally agree with them, which enhances the validity of our methods.

Sugar Alcohol: A Comparison of Xylitol and Sorbitol in Food Application

Sugar is commonly used on a daily basis but, consuming excessive sugar can lead to various health issues such as diabetes, cardiovascular, and respiratory illnesses. As a result, the food industry has been manufacturing artificial sweeteners in order to reduce the risk of disease development. This research aims to compare the roles of xylitol and sorbitol based on their chemical value, as well as the benefits and drawbacks of their use in food applications. Sugar alcohols are mostly employed as thickeners and sweeteners and are additionally referred to as bulk sweeteners. Xylitol is typically found in fruits, vegetables, and hardwood trees. Furthermore, when compared to sucrose, xylitol includes similar tastes and sweeteners, though insulin is not required during metabolism. Additionally, it is used in healthcare products such as toothpaste and mouthwash due to its ability to prevent tooth decay. Similarly, sorbitol can be found in fruits and vegetables and is frequently employed as a sweetener, texture enhancer, and moisture maintainer. Nevertheless, xylitol and sorbitol may have their own set of advantages and disadvantages. It has been found that xylitol has a wide range of potential health benefits, including lower blood glucose and insulin response, and less sweetness intensity than sucrose. However, a drawback of ingesting xylitol is that it provides low-GI energy, making it unsuitable for people with low glucose levels, and it has a lower laxation threshold. Sorbitol also provides health benefits as it supplies calories and has a low glycemic index.

Obesity as a Predisposing Genetic Factor for Development of Pediatric Hypertension in Calabar Municipality, Cross River State, Nigeria

Aims: The study aimed to assess the prevalence of obesity in children, and to evaluate obesity as a risk factor of hypertension among children obtaining treatment at the University of Calabar teaching hospital.&#x0D; Study Design: the study adopted a descriptive cross-sectional survey design involving children between 3 and 18years attending pediatrics clinic at the University of Calabar teaching hospital was used to achieve the objectives of the study.&#x0D; Place and Duration of Study: Study was conducted at the University of Calabar teaching hospital Calabar, Cross River state, southern Nigeria between May 2023 and November 2023.&#x0D; Methodology: data collection was carried out using the following instruments; (a) Semi-structured questionnaire; for anthropometric measurements (the anthropometric measurements were used to determine MBI of respondents) (b) Weighing balance and measuring tape; for measuring the weight and height of respondents in kilogram (kg) and metre (m) respectively (c) Digital blood pressure monitor; for measurement of respondents’ blood pressure. Data was collected with the help of the research assistants on a daily basis for 6 weeks from the pediatric unit of the hospital with two research assistants administering the questionnaire while the other took and recorded anthropometric measurements.&#x0D; Results: BMI percentile of 53 (39.13%) respondents was 95th percentile and above, followed by 35(25.36%) at 5th percentile, 28(20.29%) below 5th percentile, and 22(15.94%) at 85th percentile. 43(31.16%) respondents had elevated blood pressure of 120-129 mm Hg(systolic) and less than 80 mm Hg (diastolic) were recorded for 22(15.94%) and 25(18.12%) respondents respectively. 48(34.78%) respondents had blood pressure higher than 130/80 mm Hg indicative of hypertension.&#x0D; Conclusion: BP above 130/80 mm Hg indicated a positive correlation between childhood obesity and pediatric high blood pressure.

Development of an application in the healthcare area using the Design Science Research methodology

Purpose: Pressure injuries are serious health problems and are considered to be one of the biggest challenges that health services face on a daily basis, especially nurses. In addition to the impact on institutions, such as increased treatment costs and length of stay, pressure injuries also have a major impact on patients' lives. Method: The method used was the Research Methodology in Design Sciences, this methodology is used to accurately describe the development of an innovation from the elaboration of the initial index to the communication of results. Results: The development of a mobile platform application that performs the appropriate classification of pressure injuries and has a support system for the correct choice of coverage, can provide safer and consequently quality health care. Conclusion: At the moment we live with the increase in people's longevity and consequently the increase in chronic diseases, this app can improve the quality of life of the population and also qualify health care, through correct information and easy accessibility and usability.

Myricetin induces M2 macrophage polarization to alleviate renal tubulointerstitial fibrosis in diabetic nephropathy via PI3K/Akt pathway.

Development of end-stage renal disease is predominantly attributed to diabetic nephropathy (DN). Previous studies have indicated that myricetin possesses the potential to mitigate the pathological alterations observed in renal tissue. Nevertheless, the precise molecular mechanism through which myricetin influences the progression of DN remains uncertain. To investigate the effects of myricetin on DN and explore its potential therapeutic mechanism. Db/db mice were administered myricetin intragastrically on a daily basis at doses of 50 mg/kg or 100 mg/kg for a duration of 12 wk. Subsequently, blood and urine indexes were assessed, along with examination of renal tissue pathology. Kidney morphology and fibrosis were evaluated using various staining techniques including hematoxylin and eosin, periodic acid-Schiff, Masson's trichrome, and Sirius-red. Additionally, high-glucose culturing was conducted on the RAW 264.7 cell line, treated with 25 mM myricetin or co-administered with the PI3K/Akt inhibitor LY294002 for a period of 24 h. In both in vivo and in vitro settings, quantification of inflammation factor levels was conducted using western blotting, real-time qPCR and ELISA. In db/db mice, administration of myricetin led to a mitigating effect on DN-induced renal dysfunction and fibrosis. Notably, we observed a significant reduction in expressions of the kidney injury markers kidney injury molecule-1 and neutrophil gelatinase associated lipocalin, along with a decrease in expressions of inflammatory cytokine-related factors. Furthermore, myricetin treatment effectively inhibited the up-regulation of tumor necrosis factor-alpha, interleukin-6, and interluekin-1β induced by high glucose in RAW 264.7 cells. Additionally, myricetin modulated the M1-type polarization of the RAW 264.7 cells. Molecular docking and bioinformatic analyses revealed Akt as the target of myricetin. The protective effect of myricetin was nullified upon blocking the polarization of RAW 264.7 via inhibition of PI3K/Akt activation using LY294002. This study demonstrated that myricetin effectively mitigates kidney injury in DN mice through the regulation of macrophage polarization via the PI3K/Akt signaling pathway.

Adding behavior traits to select for heat tolerance in dairy cattle

The increase in periods of heat waves leads to an increase in heat stress events in dairy cattle leading to welfare issues, production losses, and health issues. However, the low frequency of milk recording data makes genetic evaluation for heat tolerance still a challenge. A possible solution could be to add behavior data captured through sensors which are recorded permanently, mostly reported on a daily basis. The objective of this study was to evaluate the potential gain of adding behavior traits as proxies for genetic evaluation of heat tolerance. Behavior traits including activity time (ACT), rumination time (RUM), and eating time (EAT) were recorded for 453 Holstein cows equipped with SenseHub (Allflex Livestock Intelligence) collars from October 2019 to July 2022 in 6 herd located in the Walloon Region of Belgium. A multitrait reaction norm model based on separate temperature and humidity index (THI) thresholds was used. Results showed that behavior traits present not only interesting characteristics for genetic evaluation of heat tolerance but also for heat stress detection in farms. Indeed, sensors allow recording of behavior for all events of heat stress in lactating and nonlactating animals. Moderate heritability values were also found for the behavior traits (0.14 for ACT, 0.19 for RUM, and 0.12 for EAT), and a high ratio between the general and thermotolerance additive genetic variances was obtained. In addition, positive correlations of thermotolerance for ACT and EAT with thermotolerance for milk production (fat- and protein-corrected milk: 0.45 and 0.28, respectively) and negative genetic correlations of thermotolerance for ACT with somatic cells (somatic cell score: −0.39) were estimated. The genetic correlation matrix allows us to explain a high part of the variation for the reaction to heat stress of 2 economic traits (fat- and protein-corrected milk: 59% and somatic cell score: 31%) based on behavior data. Based on these results, behavior traits could be used to assess heat stress in nonlactating cattle for which the number of genetic evaluations for heat tolerance is still limited.

Organising and managing digital platform renewal: The role of framing and overflowing

AbstractRenewing digital platforms is increasingly vital to ensure organisational performance and competitiveness. Managing such renewal is challenging, however, because it requires organisations to remove their exiting digital platform while at the same time building on the practises that depend on it in order to implement a new platform. Unfortunately, the literature offers little guidance on how to launch and manage this inherently complex process. Against this backdrop, we conducted a three‐year case study of how a local government organisation organised and managed the renewal of its digital platform, which 4000 health professionals in eldercare use on a daily basis. We use two concepts—framing and overflowing—to reflect the complexity of the process and to describe how it unfolded. Initially, managers used persuasive language to carefully frame a vision of the change and prepare platform users for the renewal process. Despite these framing efforts, however, unexpected events led to overflow situations in which events rendered the framing untenable and threatened successful renewal. This, in turn, led to a decision to postpone the new platform's go‐live date. While the postponement did defuse the situation, new overflows emerged, and management was forced to initiate further framing activities to move the platform renewal forward. Based on our insights into these events and extant literature, we present a conceptual model of framing and overflowing in organising and managing digital platform renewal that unpacks how framing–overflowing dynamics play out over time in response to the complexity of the process.