PARKINSON'S DISEASE - A REVIEW OF DIAGNOSTIC METHODS AND MODERN THERAPIES

Abstract

Parkinson's disease (PD) is a chronic, neurodegenerative disease belonging to the group of alpha-synucleinopathies. It is associated with the loss of dopaminergic neurons and is characterized by the presence of Lewy bodies. The diagnosis of PD is mainly based on the clinical picture. The basis of therapy are dopaminergic drugs, and the doses of drugs, as well as the frequency of their administration, should be increased along with the progression of the disease, which, however, is associated with an increase in side effects. We are still looking for new solutions that will make the therapy optimal and tailored to each patient. Currently, methods such as deep brain stimulation are becoming more and more available. New technologies such as PD-watch, hydrogel, Parkinson's gloves, STAT-ON TM or gene therapy bring hope to patients struggling with this disease on a daily basis. The aim of our work was to provide an overview of modern treatment methods and to provide the reader with basic information about Parkinson's disease. The information we used in this work comes from a critical review of the Pubmed literature, as well as specialized medical literature. Methods:We analyzed scientific publications containing information on Parkinson's disease, current treatment data. We also searched for modern diagnostic methods and information on Parkinson's disease treatment options. We have collected the data and summarized it in this article. Conclusion: Currently available therapies provide good control of motor symptoms, but do not modify the development of Parkinson's disease. However, the development of technology and medicine allows us to think that in the future the fate of patients with this disease will change, and new solutions will bring positive results.