Introduction. Over the past decades, scientists have been studying questions about the phenomenal similarity of the nervous and immune systems, as systems that ensure an adequate response of the body to environmental changes, the impact of production factors.
 The study aims to assess the phenotypic composition of lymphocytes, cytokines and the level of constant potential of the brain in patients with vibration disease (VD) due to the impact of local vibration.
 Materials and methods. The authors have conducted a neuro-immunological examination of 26 men with vibration disease formed when exposed to local vibration. The comparison group consisted of 15 men who were not exposed to vibration in their professional activities. The authors determined cytokine status indicators (IL-2, IL-4, IL-8, INF-γ) in serum by a solid-phase enzyme immunosorbent method. Registration of DC-potential level was carried out using the neuro-energy mapping method.
 Results. We have established a relationship between the increased content of CD3+, CD4+, CD8+, CD95+ and IL-8 immunocompetent cells with an increase in DC-potential level in the frontal (central, right and left hemispheres), central cortical, right-left parietal parts of the brain. The researchers also established a relationship between a reduced content of CD20+, INF-γ and increased levels of DC-potential level in the right and left temporal, left parietal lobes of the brain in patients with VD from local vibration.
 Limitations. The disadvantage of this work is the small groups of employees.
 Conclusion. The revealed correlations of the content of immunological indicators with an increase of DC-potential level in various parts of the brain in the examined patients may indicate that the formation of vibrational pathology is accompanied by both shifts in peripheral cellular immunity and violations of the hemeostatic stability of intercentral relations in the cerebral cortex, which may be a sign of the neuroinflammatory process and the development of cytotoxic reactions.
 Ethics. The study was conducted in compliance with Ethical standards in accordance with the Helsinki Declaration of the World Medical Association.