Cystic Teratoma Of Ovary Research Articles

Is It Necessary to Perform Surgical Staging in Patientswith Giant Immature Ovarian Teratomas MimickingMature Cystic Teratoma at Frozen Section

Giant mature teratomas (>20 cm in diameters) sometimes may contain malignant immature elements or tissues. These small foci of immature tissues could be missed at frozen section resulting inadequate initial surgical intervention. There is no large series in the literature either showing the accuracy of frozen section on huge ovarian teratomas or concerning the adequate surgical approach at the initial surgery for giant immature teratomas diagnosed as mature cystic teratomas at frozen section in patients with elevated tumor markers. We presented a case with unilateral giant immature ovarian teratoma and peritoneal gliomatosis which diagnosed as mature cystic teratoma at frozen section. Although elevated tumor markers (CA-125, AFP, CA-19,9 CEA, and lactate dehydrogenase), ascites and peritoneal implants were suggested malignant disease, staging surgery was not performed due to the benign report of frozen section. Since the patients having peritoneal implants of mature glial tissue have an excellent prognosis regardless of the grade of the ovarian teratomas, it may be suggested that surgical staging at the initial operation may not be performed in patients with giant immature teratoma diagnosed as mature teratoma at frozen section despite to the elevated tumor markers, presence of ascites or mature peritoneal implants. seems that using it in infertile patients has beneficial effects.

皮膚有棘細胞癌と鑑別を要した卵巣成熟嚢胞奇形腫によるSister Mary Joseph’s Noduleの1例

皮膚有棘細胞癌と鑑別を要した卵巣成熟嚢胞奇形腫によるSister Mary Joseph’s Noduleの1例

A huge dermoid cyst with thrombocytosis and preoperative intraperitoneal rupture: An unusual presentation

Benign cystic ovarian teratoma is the most common ovarian neoplasm accounting for 10-25% of ovarian tumors.They affect women of all age and particularly women of reproductive age group.They may present with a variety of symptoms ranging from being asymptomatic to pain abdomen, dysmenorrhea, pelvic pain, nausea, vomiting, fever, anorexia, loss of weight and shortness of breath. The complications associated with benign cystic teratoma are torsion (16%), malignant degeneration (2%), rupture (1-2%), and infection (1%). Its spontaneous or iatrogenic intraperitoneal rupture is associated with chemical peritonitis. A dermoid cyst has been associated with thrombocytosis in 30% of the cases.Hereby we present a case of huge ovarian dermoid cyst associated with thrombocytosis and spontaneous preoperative rupture with chemical peritonitis.

Primary malignant melanoma arising in a cystic teratoma

The malignant transformation of a cystic teratoma is a rare event, occurring in about 0.2% to 1.8%. Primary malignant melanoma arising from the ovary is extremely rare. A primary melanoma in an ovarian cystic teratoma originates most frequently at the dermoepidermal junction, similar to a cutaneous melanoma. Though there are no standard adjuvant regimens for the treatment of primary malignant melanoma of the ovary. We present another case report of malignant melanoma developing in cystic teratoma.

Benign Cytic Teratoma of Ovary Perforating into the Urinary Bladder: A Rare Case

Benign cystic ovarian teratoma is the most common ovarian neoplasm accounting for 10–25 % of ovarian tumors. Complications of cystic teratomas include torsion (16 %), malignant degeneration (2 %), infection (1 %), and rupture (1 %). It can rupture into the bladder, small bowel, rectum, sigmoid colon, vagina, abdominal wall, and peritoneal cavity. We report a case of ovarian dermoid perforating into the bladder and with a queer presentation with a tuft of hair projecting through the urethra while micturating.

An Over-View of Tuberculosis of Female Genital Tract With Reference To Experience in a Medical College in Rural Set-Up in West Bengal: A Retrospective Two Year Study

Aim: To determine frequency of female genital tract (FGT) tuberculosis (TB) in the gynecological biopsies received in the Department of pathology of a peripheral medical college. Methods: This is a retrospective study conducted in the Department of Pathology of Burdwan Medical College & Hospital. Histopathological records of two year (2008-2010) were retrieved and searched for the cases of female genital tract TB. Relevant histopathological findings and clinical data were recorded and analyzed. Results: There were 1537 cases of gynecological biopsy and 9 cases were diagnosed as FGT tuberculosis based on histopathological and clinical findings. Ovarian benign cystic teratoma was seen in one case along with ipsilateral tuberculous salpingitis, one case showed B/L ovarian tuberculosis with involvement of both the tubes. Bilateral fallopian tubes were involved in 2 cases and endometrial tuberculosis was diagnosed in 5 cases with 1 case showing simultaneous involvement of the cervix. In one case omental biopsy received along with tubal specimen showed tuberculous granulomas. Conclusion: FGT tuberculosis was usually seen in age 16-28 years and constituted 0.59% of total gynecological cases. Fallopian tubes, ovaries and endometrium and cervix were affected with the involvement of peritoneum or omentum, commonest being tuberculous endometritis. Histopathology, in association with clinical findings still remains gold standard for the diagnosis of FGT tuberculosis in our country despite advancement in diagnostic modalities; however, incidental histological detection in clinically unanticipated cases is not an uncommon event. DOI: http://dx.doi.org/10.3329/bjms.v11i3.11719 Bangladesh Journal of Medical Science Vol. 11 No. 03 July’12

嚢胞内に多数の“floating balls”を有する卵巣成熟嚢胞性奇形腫の1例

嚢胞内に多数の“floating balls”を有する卵巣成熟嚢胞性奇形腫の1例

Massive ovarian cystic teratomas diagnosed at a rural Nepal camp

This case report presents the findings of significantly large sized (> 8 cm) symptomatic unilateral cystic teratomas in two perimenopausal patients in remote Nepal.Ovarian dermoid cysts consist of cystic, solid and fat tissue. Traditionally, cells differentiate along the various germ lines, essentially recapitulating various body tissues. The characteristic sonographic features include a dermoid plug, dermoid mesh, a fat‐fluid level and the “tip of the iceberg” sign.The presence of two or more of these typical features confidently supports an ultrasound‐based diagnosis of ovarian dermoid cyst.The presence of intratumoral hair, teeth, fat, and skin tissue revealed at surgery confirmed the initial ultrasound based diagnosis.

Tejido prostático en teratoma quístico maduro del ovario: Caso clínico

Male accessory sexual glands arising in ovarian cystic teratoma are exceedingly rare. We report a 56-year-old female subjected to an ovariohysterectomy due to a left ovarian mass. The pathological study of the surgical piece revealed a tumor composed of different mature tissue elements and well defined nodules of benign prostatic tissue.

Prostatic tissue in a mature cystic teratoma of the ovary: report of one case

Male accessory sexual glands arising in ovarian cystic teratoma are exceedingly rare. We report a 56-year-old female subjected to an ovariohysterectomy due to a left ovarian mass. The pathological study of the surgical piece revealed a tumor composed of different mature tissue elements and well defined nodules of benign prostatic tissue.

Malignant Transformation of a Mature Cystic Ovarian Teratoma into Thyroid Carcinoma, Mucinous Adenocarcinoma, and Strumal Carcinoid: A Case Report and Literature Review

Malignant transformation of a mature cystic teratoma (MCT) is an infrequent, often asymptomatic event. We report the first example of a struma ovarii with a focus of follicular variant of papillary thyroid carcinoma (a), mucinous adenocarcinoma (b), and strumal carcinoid tumor (c)—all three arising in one mature cystic teratoma of the ovary. From our reviews, we found limited data to guide management when these malignant foci occur within an MCT. Consideration should be given to thyroidectomy followed by total-body scanning and serum studies for foci of thyroid carcinoma and adjuvant therapy with thyroidectomy and radioablation if residual disease is identified (a). Additionally, extrapolating from data for mucinous adenocarcinomas, consideration could be given to adjuvant chemotherapy after appropriate staging (b). Strumal carcinoid tumors should be treated as tumors of low malignant potential. Observation is appropriate if after complete staging, no invasive implants are noted (c).

Conservative surgery in the management of a benign ovarian cystic teratoma presenting as a rectal mass: a case report

Ovarian cystic teratomas constitute 10-15% of all ovarian tumours and are the most common ovarian neoplasms found in adolescence and during pregnancy. Nevertheless, ovarian cystic teratomas have also been described in patients aged 1-91 years. We report an unusual case of a benign ovarian cystic teratoma presenting as a rectal mass that was managed surgically using radical resection by a multidisciplinary team. This case report highlights the importance of preoperative investigations including colonoscopy and radiological investigations. A dedicated pelvic radiologist/pathologist and the involvement of a multidisciplinary team at the time of initial diagnosis and a gynaecologist and colorectal surgeon at the time of surgery will lead to an accurate diagnosis and the most appropriate treatment. Although rare, erosion of an ovarian dermoid into the rectum should be considered in young women who have an atypical presentation and are found to have a lesion in the rectum with biopsies indicating benign pathology.

Sebaceous adenoma arising within an ovarian mature cystic teratoma in Muir-Torre syndrome

This is the first reported case of a sebaceous adenoma arising within an ovarian mature cystic teratoma in a patient with Muir-Torre syndrome. The pathologic findings and a literature review are presented, including the importance and possible benefits of an early diagnosis of Muir-Torre syndrome. It is proposed that the presence of a sebaceous adenoma in an ovarian cystic teratoma may serve as a useful trigger to consider further history and investigations, with the goal of identifying an important genetic cancer predisposition syndrome.

Struma ovarii in breast cancer

We described a case of benign struma ovarii associated to bilateral mature cystic ovarian teratoma in an asymptomatic post-menopausal woman with breast cancer. The patient synchronously underwent surgical treatment of breast and ovarian tumors.

A novel approach identifies new differentially methylated regions (DMRs) associated with imprinted genes

Imprinted genes are critical for normal human growth and neurodevelopment. They are characterized by differentially methylated regions (DMRs) of DNA that confer parent of origin-specific transcription. We developed a new strategy to identify imprinted gene-associated DMRs. Using genome-wide methylation profiling of sodium bisulfite modified DNA from normal human tissues of biparental origin, candidate DMRs were identified by selecting CpGs with methylation levels consistent with putative allelic differential methylation. In parallel, the methylation profiles of tissues of uniparental origin, i.e., paternally-derived androgenetic complete hydatidiform moles (AnCHMs), and maternally-derived mature cystic ovarian teratoma (MCT), were examined and then used to identify CpGs with parent of origin-specific DNA methylation. With this approach, we found known DMRs associated with imprinted genomic regions as well as new DMRs for known imprinted genes, NAP1L5 and ZNF597, and novel candidate imprinted genes. The paternally methylated DMR for one candidate, AXL, a receptor tyrosine kinase, was also validated in experiments with mouse embryos that demonstrated Axl was expressed preferentially from the maternal allele in a DNA methylation-dependent manner.

Primary Malignant Melanoma Arising in an Ovarian Mature Cystic Teratoma - A Case Report and Literature Review -

Malignant melanoma involving the ovary is uncommon. Most of the reported ovarian malignant melanomas are metastatic, and only 44 cases are primary. Teratoid elements must be identified in the ovary for the diagnosis of primary malignant melanoma because ovaries normally do not contain melaninproducing cells. However, it is challenging to assess the primary site of ovarian malignant melanoma because it is almost always found in an advanced state, replacing entire ovarian structures, and this makes it difficult to determine whether the lesion is a primary ovarian melanoma. Mature cystic teratoma is the most common benign germ cell tumor of the ovary, and it constitutes 15-25% of ovarian tumors overall. A wide variety of malignant tumors may arise within a mature cystic teratoma, including squamous cell carcinoma (75%), adenocarcinoma (7%), undifferentiated carcinoma, basal cell carcinoma, and various sarcomas (7%). Malignant melanoma arising from mature cystic teratoma has also been reported, but it is very rare. Here, we report on an uncommon case of primary malignant melanoma arising from a mature ovarian cystic teratoma with multiple metastatic lesions.

Hashimoto's disease in a bilateral benign cystic ovarian teratoma: a case report

A wide array of tissues derived from all the three germinal layers is seen in ovarian teratomas. Among these, thyroid tissue is present in 10% cases of all mature cystic teratomas. We report this case of Hashimoto's thyroiditis in a clinically euthyroid patient who tested positive for antithyroid peroxidase antibodies in spite of normal thyroid hormone profile. While the histological features of several disorders of thyroid tissue may be discovered, Hashimoto's thyroiditis is extremely rare finding in ovarian teratomas.

OLIGODENDROGLIOMA ARISING IN A MATURE CYSTIC OVARIAN TERATOMA IN A CHILD

In childhood mature cystic teratomas are the most common type of ovarian germ cell tumors. Tumors of neuroepithelial origin are extremely rare in mature teratomas. To the authors’ knowledge, this is the first case report oligodendroglioma arising in a mature cystic ovarian teratoma in children. A 13-year-old girl presented with a history of pelvic pain for 2 months. An ultrasound examination showed a monolateral multicystic, calcific ovarian mass, measuring approximately 6 × 5 cm, arising in the left over and adnexia, suggesting a teratoma. An exploratorative laparotomy and ooferectomy were performed. On histopatological examination, various samples from cystic areas had mature tissues from all 3 germ cell layers, including skin, bone, bronchial structures, and cerebellum. Sections from solid areas showed uniform population of monotonous, rounded cells with indistinct cytoplasm and having perinuclear halo (fried-egg appearance) on a fibrillary, neuropilic background. Microcalcifications as calcospherites were noted in the stroma. Based on the typical morphological features, the cased was diagnosed as mature cystic teratoma with low-grade oligodendroglioma. To the authors’ knowledge, there are a few reports in the literature of an oligodendroglioma arising in an ovarian teratoma in adults and this presented patient is the first case in childhood.

Huge Mediastinal Cystic Tumor Penetrating the Sternum

We report a very rare case of a huge anterior mediastinal tumor penetrating the sternum that was diagnosed in a 59-year-old woman. The tumor was completely resected en bloc with the manubrium sterni, and the chest wall defect was closed with a pectoralis major muscle flap. Histologic examination of the cystic mass revealed the diagnosis of a benign mediastinal cystic tumor, most likely a benign cystic mature teratoma.

Mature and immature ovarian teratomas: US, CT and MR imaging features [in French

Mature cystic ovarian teratomas, also called dermoid cysts, are one of the most frequent ovarian tumors of younger female patients and are suggested when a fat-containing cystic tumor is identified on imaging. However, the presence of fat is not pathognomonic for dermoid cyst, and it may also be identified in immature teratomas, whose prognosis and treatment are different. Some imaging features are helpful to differentiate between both, rumors, including the presence of enhancement on CT and MRI. Knowledge of the imaging features of these tumors allows for a confident diagnosis to be made in most cases. A few rate and less typical imaging features should also be recognized.