Cystic Hyperplasia Research Articles

Hiperplasia endometrial cística em ouriço-pigmeu-africano (Atelerix albiventris) – relato de caso

A 2 year old female african pygmy hedgehog (Atelerix albiventris) was presented at a private clinic with persistent hematuria. Abdominal ultrasound identified suggestive changes of uterus enlargement, indicating its surgical removal. Anesthesia was accomplished with isoflurane via chamber induction and was maintained via mask. Ovariohysterectomy was performed and tissue fragments were submitted to histopathologic evaluation. For postoperative treatment, meloxicam, enrofloxacin and dipyrone were used. Microscopy revealed moderate uterine squamous metaplasia, cystic endometrial pseudocarcinomatous hyperplasia (CEH), and moderate uterine adenomyosis. The knowledge of these animals’ reproduction morphophysiology is essential, not only by the demand as pets in the clinical routine, as well as in the advances of comparative pathology.

Cystic lymphoid hyperplasia in the larynx: serendipity in clinical practice

Cystic lymphoid hyperplasia in the larynx: serendipity in clinical practice

Frequency and morphology of benign histopathological lesions in total abdominal hysterectomy specimens.

Hysterectomy is one of the most frequently performed gynecological procedure all over the globe undertaken for varying indications, to effectively cure many gynaecological conditions. Histopathological analysis of the hysterectomy specimens should be undertaken for justification of procedure and diagnostic purposes. Objectives: To determine the frequency and morphology of different benign histopathological lesions in total abdominal hysterectomy specimens. Study Design: Descriptive cross-sectional study. Setting: Department of Pathology Fatima Jinnah Medical College. Period: From Jan 2015 to June 2015. Material & Methods: The gross and histopathological findings of uterus and cervix in one hundred Total Abdominal hysterectomy specimens were studied. Non-probability, purposive sampling was done. Total abdominal hysterectomy specimens with or without salpingoophorectomy of patients aged between 20 to 70 years were included. While Total abdominal hysterectomy done in mentally retarded patients and for malignancies were excluded. Patient’s data, presenting complaints and preoperative diagnosis was recorded on predesigned proforma. SPSS version 17 was used as an analytical tool. Results: Age of the patients ranged from 30-55 years with 72% between 41-50 years. The microscopic examination of the cervix revealed features of chronic cervicitis in 75% cases. The commonest neoplastic lesion was leiomyoma present in 66% of cases. Myometrium revealed foci of adenomyosis in 21% cases. Endometrial histology showed hyperplasia in 25% of cases(simple hyperplasia 20%, cystic hyperplasia 4% and complex hyperplasia 1%), hormonal imbalance in 21%, pressure atrophy in 11%, atrophic endometrium in 6% , cystic atrophy in 2% while acute and chronic endometritis in 1% and 2% of cases respectively. Conclusion: The commonest cervical lesion was chronic cervicitis (75%). The commonest benign neoplastic lesion was leiomyoma, present in 66% of cases. Other common pathologies on histology were hyperplasia in 25% of cases, adenomyosis and hormonal imbalance in 21 % of cases each, pressure atrophy in 11%, atrophic endometrium in 6% while endometritis (acute & chronic ) in 3% of cases mainly. Histopathological examination of hysterectomy specimens helps to detect the exact cause and underlined pathology.

Cutaneous apocrine cystomatosis in three slaughter-aged pigs.

Apocrine cystomatosis is a rare condition characterized by clusters of cystically dilated sweat glands or other specialized apocrine glands. Cystic dilation of cutaneous sweat glands has been described in humans, dogs, and cats, but not in pigs, to our knowledge. We describe herein linear, brown, colloid-filled cavities < 1 cm diameter within the subcutaneous fat of the entire dorsal region of carcasses of three 6-mo-old pigs. These incidental findings were detected during meat inspection in 3 different slaughterhouses in Catalonia, Spain. Histopathology revealed multiple cystic cavities lined by flattened glandular epithelium, filled with proteinaceous material, and corresponding to cystic hyperplasia of sweat glands.

Simultaneous intrathyroidal parathyroid adenomas and multifocal papillary thyroid carcinoma in a patient with kidney transplantation: a case report

BackgroundPersistent hyperparathyroidism after kidney transplantation has been associated with adverse outcomes. Parathyroidectomy is the definitive treatment approach, but the success of parathyroidectomy relies on the accurate preoperative localization of the culprit parathyroid lesions. Simultaneous intrathyroidal parathyroid adenomas and multifocal papillary thyroid carcinoma present important diagnostic challenges. Here, we describe a patient with kidney transplantation who underwent successful surgery after being evaluated with functional and structural imaging.Case presentationA 53-year-old man presented with potentially malignant multifocal thyroid nodules by ultrasonography 2 years after kidney transplantation. The patient had hypercalcaemia and persistent hyperparathyroidism. Thyroid papillary carcinoma was confirmed in the left thyroid nodules by fine-needle aspiration biopsy. The right superior thyroid hypoechoic nodule was 1.2 cm in size and showed marked uptake of the tracer 99mTcO4-sestamibi during single-photon emission computed tomography/computed tomography (SPECT/CT); additionally, a cystic parathyroid lesion without tracer uptake was present behind the left superior pole of the thyroid. The histological examination demonstrated the coexistence of right intrathyroidal parathyroid adenomas, left cystic parathyroid nodular hyperplasia and multifocal papillary thyroid carcinoma. At the 6-month follow-up, the serum calcium levels were within the normal range, and the patient’s kidney function remained stable.ConclusionsSimultaneous intrathyroidal parathyroid adenomas and multifocal papillary thyroid carcinoma in a patient with kidney transplantation is a rare clinical scenario. Physicians must be aware that the combination of functional (SPECT/CT) and structural (ultrasonography) imaging is highly successful in diagnosing patients with coexistent intrathyroidal parathyroid adenomas and papillary thyroid carcinoma.

A histomorphological pattern analysis in endometrial biopsies of infertile woman

Introduction: Infertility is an agonising problem to many couples, giving them a sense of hopelessness. The hormonal alterations gives rise to various histological patterns in endometrium. Aims and Objective: To know the various morphological patterns of endometrium in females presenting with infertility (primary/secondary) Materials and Methods: A cross-sectional study in which 237 cases of endometrial biopsies were reviewed along with clinical data, in infertile woman (primary/secondary) from January 2016 to December 2018. The results were analysed and interpreted. Results: Of the 237 biopsies, 196 cases (82.7%) were of primary infertility and 41 cases (17.3%) of secondary infertility. Overall mean age was 28.3 years. The most common endometrial pattern was secretory phase (35.86%) followed by proliferative phase (30.8%). Disordered proliferative phase was seen in 17.7% cases. There were 23 cases of simple cystic hyperplasia and one case of complex hyperplasia. 5 cases each of polyp and tuberculous endometritis were diagnosed and two coincidental cases of endometrial carcinoma. One case was reported as Arias-Stella reaction. Conclusion: Secretory phase of endometrium was the most common morphological pattern which suggests that despite of ovulation there could be other causes that might have led to this ailment. This study also proposes that endometrial biopsies can be used as a primary diagnostic tool especially in cases of unexplained infertility that could be due to tuberculosis or polyps. Keywords: Endometrial biopsy, Infertility, Tuberculous endometritis.

Can constant light exposure affect the thyroid gland in prepubertal male albino rats? Histological and ultrastructural study.

Through scientific literature, there is evidence that light affects thyroid function in human, mice and rabbits. Constant light and sleep deprivation is also used as a form of human torture, as it has impact on cognitive performances. The present work was conducted to study the effect of constant light for short and long periods on the thyroid gland in the prepubertal male albino rats. A total of 30 prepubertal male albino rats were used. The rats separated into three groups: group I (control); group II were those rats put under steady encompassing light (24 h/day, light intensity of 600 lux) for 4 weeks; and group III were the rats maintained in constant light for 3 months. The rat thyroid gland was subjected to histological and ultrastructural examination. The rats exposed to light for long durations showed disturbed architecture; the follicles exhibited back to back arrangement (signs of hypertrophy with hyperplasia), lined by multiple layers of follicular cells or were lined by vacuolated cells. Few thyroid follicles exhibited cystic hyperplasia. Congested blood capillaries were demonstrated between the follicles. It can be concluded that the short-term exposure to constant light for 1 month had no apparent effect on thyroid gland tissues while longer exposure to light for 3 months had detrimental effects on the thyroid gland structure of male albino rats.

Invasive cystic hypersecretory carcinoma of the breast: a rare variant of breast cancer: a case report and review of the literature

BackgroundCystic hypersecretory carcinoma is a rare subtype of breast cancer. It is a member of cystic hypersecretory lesions, which include a series of pathological disease lineages: cystic hypersecretory hyperplasia (CHH), CHH with atypia, cystic hypersecretory carcinoma (CHC) and invasive CHC. It was found that most cystic hypersecretion lesions were in situ carcinoma, and only 19 cases of invasive cystic hypersecretion carcinoma were reported.Case presentationWe are reporting a case of a 63-year-old female who had a lump in her left breast for 3 years. A modified radical mastectomy was done and morphological diagnosis of invasive CHC with axillary node metastasis was made.ConclusionsOwing to a smaller number of reported cases, little is known about the biological behavior, prognosis and molecular study of cystic hypersecretion lesions. Therefore, more cases with follow-up data are needed to reveal the biological behavior of this rare tumor.

Clinico-pathological evaluation and etiological stratification of chronic AUB patients based on PALM-COEIN classification: A prospective study in tertiary care center of Nalgonda District

Context: Abnormal uterine bleeding (AUB) is a common crippling gynaecological condition with vast financial implications. A structured approach for establishing the cause using the FIGO defined PALM-COEIN (Polyp, Adenomyosis, Leiomyoma, Malignancy (and hyperplasia), Coagulopathy, Ovulatory disorders, Endometrial, Iatrogenic and Not otherwise classified) classification system will facilitate accurate diagnosis and inform treatment options. Aims and objectives: 1. Clinico-pathological evaluation of patients presenting with chronic AUB. 2. Etiological stratification of patients with chronic AUB in accordance to PALM-COEIN Classification.3. To determine frequency of various uterine histopathological findings and their associated etiologies in the population of Nalgonda district. Settings and Design:The present study was a cross-sectional prospective study conducted at the Department of pathology and Department of Obstetrics and Gynecology, Kamineni Institute of Medical Sciences, Narketpalli over a period of 2 years starting from June 2016 to June 2018. Methods and Material: The study population included 188 cases of Chronic AUB. Specimens analysed were: 1. endometrial biopsy obtained by dilatation and curettage. 2. Hysteroscopy guided biopsy 3. Hysterectomy specimens. Histopathological evaluation of specimens was done and reported in accordance with PALM-COEIN classification. Results: The commonest Age group involved was perimenopausal group (41-50) constituting (39.4%). Multiparous women most commonly presented with AUB accounting for 44.1% of all cases. Menorrhagia is the most common clinical presentation in reproductive age group (50.6%) and perimenopausal women (39.2%). Post-menopausal bleeding (36.0%) is commonest presentation in Post- menopausal age-group of AUB patients. Proliferative endometrium is the most common histological finding in reproductive age group (44.9%) and perimenopausal women (33.8%). Leiomyomas are the most common presentation is Post-menopausal women (32%). 4 Patients in the Post-menopausal Age group presented with Endometrioid Adenocarcinoma. According to PALM-COEIN classification AUB-E is the most common etiologic factor across all age groups. Non-structural causes account for 54.8% of AUB cases and among 45.2% of structural causes, Simple cystic hyperplasia is the most common histological finding. Conclusions: AUB is a common and debilitating condition with high direct and indirect costs. Histopathological evaluation is the gold standard tool in the evaluation of the patients with Chronic AUB. A structured approach to establishing the cause using the FIGO PALM-COEIN classification system will facilitate accurate diagnosis and inform treatment options.

Endometrial polyp with chronic endometritis in an African pygmy hedgehog (Atalerix albiventris) – a case report

An African pygmy hedgehog (Atalerix albiventris) (APH) was admitted to the clinic with a history of vaginal bleeding. Examination showed poor clinical status of the patient based on haemogram values. The ultrasound showed an enlarged uterus filled with an anechoic content without the presence of free abdominal fluid. Ovariohysterectomy was performed under general inhalation anaesthesia. Histopathology examination was performed on tissue samples of the uterus with the final diagnosis of an endometrial polyp with endometrial cystic hyperplasia and chronic endometritis. In regard to the diagnostic findings, therapeutic option and postoperative care performed in this case, it is important to emphasize the fact that an early diagnosis of a reproductive disease contributes to proper treatment and a positive outcome. The endometrial polyp with cystic endometrial hyperplasia and chronic endometritis should be added to the list of differential diagnoses in cases where neoplasia of the reproductive system is suspected in an APH.

Stromal immunoglobulin κC expression is associated with initiation of breast cancer in TA2 mice and human breast cancer.

The initiation of spontaneous breast cancer (SBC) in Tientsin Albino 2 (TA2) mice is related to mouse mammary tumor virus (MMTV) infection, and MMTV amplification is hormonally regulated. To explore the insertion site of MMTVLTR in TA2 mouse genome, reverse PCR and nested PCR were used to amplify the unknown sequence on both sides of the MMTV‐LTRSAG gene in SBC and normal breast tissue of TA2 mice. Furthermore, the clinicopathological significance of the insertion site was evaluated in 43 samples of normal breast tissue, 46 samples of breast cystic hyperplasia, 54 samples of ductal carcinoma in situ, 142 samples of primary breast cancer and 47 samples of lymph node metastatic breast cancer by RNA in situ hybridization. We confirmed that the insertion site of the MMTV‐LTRSAG gene was located between Igκv2‐112 and Igκv14‐111 in chromosome 6 of TA2 mouse. IG κC was localized in the stromal cells of TA2 mouse with SBC and in human breast cancer tissues. Tumor cells were negative for IG κC in RNA in situ hybridization. The positive staining index of IG κC in stromal cells was the highest in lymph node metastatic breast cancer, followed by primary breast cancer, ductal carcinoma in situ, and breast cystic hyperplasia. Furthermore, the positive staining index of IG κC was related to the expression of ER, PR, HER2 and Ki‐67. Our findings showed that stromal IG κC expression was associated with the initiation of SBC in TA2 mice. IG κC may be a high‐risk factor for the initiation and progression of human breast cancer.

Standing thyroidectomy in 10 horses.

To describe a surgical technique for thyroidectomy in horses with thyroid neoplasia under standing sedation and local anesthesia. Retrospective study. Client-owned horses (n = 10). Medical records of horses with a history of thyroid enlargement were included in the study if thyroid gland enlargement was treated surgically via hemi- or bilateral thyroidectomy, with the horse standing and sedated. Data derived from follow-up clinical examination, performance level, recurrence, and cosmetic outcome were evaluated. Thyroid enlargement was unilateral in 8 and bilateral in 2 horses. Histopathological findings included adenomas (5/10), adenocarcinomas (2/10), cystic hyperplasia (2/10), and C-cell adenoma (1/10). No major complications were encountered during or after surgery. All horses resumed their previous level of exercise within 6 weeks. Recurrence was diagnosed in 1 horse, 7 months after excision, and a second surgery was required. Recurrent laryngeal nerve neuropathy and seroma formation subsequent to surgery were not recorded in any of the cases. Thyroidectomy can safely be performed with the horse standing and sedated with local anesthesia. Performing standing thyroidectomy does not increase intraoperative or postoperative complications and could be considered for horses with thyroid enlargement amenable to surgery.

Fundamentos y Consideraciones de la Patología Endometrial Canina

El estudio de las patologías reproductivas es de importancia para el adecuado abordaje clínico y médico. El objetivo del presente artículo fue realizar una investigación bibliográfica sobre los fundamentos y consideraciones de la patología endometrial canina, con énfasis en la hiperplasia endometrial quística y la piometra, buscando sostener o refutar el concepto arraigado o dogma, acerca de la condicionalidad existente entre ellas, el cual ha sido denominado complejo hiperplasia endometrial quística-piometra. De acuerdo a le evidencia analizada, se puede señalar que en la perra existen dos tipos de lesiones uterinas comunes que pueden ser de presentación independiente: alteraciones del crecimiento (hiperplasia) y alteraciones inflamatorias/infecciosas (endometritis-piometra). En la etiopatogenia de ambas entidades el rol de la progesterona, en tanto generadora de cambios celulares y moleculares en el epitelio uterino, resulta indiscutible.

Clinical profile and triggering factors for acquired, bilateral nevus of Ota-like macules

Background: Acquired, bilateral nevus of Ota-like macules (ABNOM) is one of the most common dermal melanocytoses. Although there are some literatures on ABNOM, its clinical features and etiopathogenetic factors have not been fully understood.Objective: To determine the prevalence and characteristics of ABNOM among the Chinese patients.Methods: A survey was carried out using the clinical examination and a questionnaire on 3212 first-time outpatients in our dermatology department, and 102 cases of ABNOM were subsequently enrolled.Results: The outpatient prevalence of ABNOM was 3.18%, and the age of the onset was 27.2 years on average. They all presented as speckled macules on the face alone or coexisted with patchy lesions (17.7%) or a band-like pigmentation (1.0%). Unprecedentedly, we found the zygomatic arch, the infraorbital, the cheek and the parotid region can be involved, and 52.0% cases had sclera pigmentation. ABNOM commonly coexisted with the pigmented fungiform papillae of the tongue, the melasma, the acne, prementstrual syndrome (female) and breast cystic hyperplasia (female) with the rates of 33.3%, 20.6%, 26.5%, 47.0% and 43.0% separately. Triggering factors’ investigation disclosed screen irradiation (47.1%), pregnancy (32.0%), cosmetics (29.4%), sensitive skin (22.6%), and positive family histories (21.6%) were highly related.Conclusions: Our study confirms that ABNOM is a relatively common disorder among adult Chinese’s outpatients. It is commonly distributed over the malar, lateral forehead and temple’s areas. The sclera pigmentation is another common finding that is overlooked in previous research. ABNOM is concomitant with melasma and some other disorders. Excessive sun exposure, hormonal disturbances and hereditary susceptibility are the main potential triggering factors of ABNOM.

Biological relevance of effects following chronic administration of octamethylcyclotetrasiloxane (D4) in Fischer 344 rats

Octamethylcyclotetrasiloxane (D4) is a cyclic siloxane primarily used as a monomer or intermediate in the production of silicone polymers resulting in potential exposure of workers, and potential low level inhalation or dermal exposure for consumers and the general public. Following a two-year inhalation toxicity study with D4 in rats, increases in uterine endometrial cystic hyperplasia and adenomas were observed at the highest concentration of D4 administered (700ppm). No other neoplasms were increased with D4 treatment. In addition, chronic inhalation exposure of rats to D4 induced changes in relative liver and kidney weights, and produced a chronic nephropathy.This manuscript examines the biological relevance and possible modes of action for the effects observed in the F344 rat following chronic inhalation exposure to D4. D4 is not genotoxic and appears to exert its effects through a nongenotoxic mode of action. An alteration in the estrous cycle in the aging F344 rat was the most likely mode of action for the observed uterine effects following chronic inhalation exposure. Data support the conclusion that D4 acts indirectly via a dopamine-like mechanism leading to alteration of the pituitary control of the estrous cycle in aging F344 rats with a decrease in progesterone and an increase in the estrogen/progesterone ratio most likely induced by a decrease in prolactin concentration. D4 also inhibited the pre-ovulatory LH surge causing a delay in ovulation, persistent follicles and thus a prolonged exposure to elevated estrogen in the adult Sprague Dawely rat. A lengthening of the estrous cycle in the F344 rat with an increase in endogenous estrogen was also induced by D4 inhalation. Although the mode of action responsible for induction of uterine adenomas in the female F344 rat has not been clearly confirmed, the subtlety of effects on the effects of D4 on cyclicity may prevent further assessment and definition of the mode of action. The occurrence of uterine endometrial adenoma in the rat is not relevant for human risk characterization because (1) there are differences in ovulatory cycle regulation in rats compared to humans, (2) cystic hyperplasia without atypia in women is not a cancer precursor, and (3) there is no endometrial lesion in women that is directly analogous to endometrial adenoma in the rat. The effects of D4 on liver are due to a phenobarbital-like mechanism that results in induction of cytochrome P450 and other enzymes of xenobiotic biotransformation. The liver effects are adaptive and not adverse. Kidney findings included chonic progressive nephropathy, a rat lesion that has no counterpart in the human and that should not be used in human risk assessment.

Retraction Note to: Improving the diagnosis, treatment, and biology patterns of feline mammary intraepithelial lesions: a potential model for human breast masses with evidence from epidemiologic and cytohistopathologic studies.

In this study, the frequency of different types of mammary masses and their relationship with cytohistopathologic changes was investigated and data on history, macroscopic description, clinical examination and treatment were collected. To determine the prevalence and types of cytohistopathologic changes, mammary glands from 12 female cats were evaluated. The mean age of cats at the time of diagnosis was 11.5 ± 1.9 years (range 4–14 years), the mean gross size of the masses was 3.1 ± 2.4 cm, 4/12 (33.3 %) masses were ≤3.0 cm in diameter, and the maximum diameter of the largest mass had a median of 5 cm, with a range of diameter of 6 × 5 × 4 cm. Moreover, the preferential localization of mammary masses was the abdominal lobes (%50) and thoracic lobes (%33.3), and inguinal lobes (%16.7 of cases). Furthermore, two cases of the inguinal masses affected the caudo-inguinal lobe, six cases caudo-abdominal lobe, and thoracic masses were found in four cases. Eventually, six cases (%50) of masses were found in the right mammary lobes and six cases (%50) in the left mammary lobes. The majority of the masses revealed elastic (%50 of cases), hard (%25 of cases), or soft (%25 of cases) consistency. In the present study, according to the criteria of the veterinary and the medical WHO classification system, of the 12 cats with the cytohistopathological features of six (50 %) cases qualified abscess, 3 (25 %) cases as cystic hyperplasia and 3 (25 %) cases were called situ carcinoma. Whereas, all hyperplastic lesions (case nos. 7–9 and ranging in size from, 1 to >4 cm3) and carcinomas in situ lesions (case nos. 10–12 and ranging in size from, 1 to >3 cm3) were found incidentally upon routine cytohistology. Other lesions were observed grossly and removed either at surgery (case nos. 1–6). Finally, the cats were treated with unilateral lumpectomy (3 cases) and also, nine (75 %) cases had subsequent drainage, 3 (25 %) of which showed cystic hyperplasia and 6 (50 %) showed abscess on subsequent histopathological evaluation. Therefore, a correct diagnosis must be established quickly, and treatment must be instituted rapidly when alteration is noted in the mammary glands.

Decoding Intratumoral Heterogeneity of Breast Cancer by Multiparametric In Vivo Imaging: A Translational Study.

Differential diagnosis and therapy of heterogeneous breast tumors poses a major clinical challenge. To address the need for a comprehensive, noninvasive strategy to define the molecular and functional profiles of tumors in vivo, we investigated a novel combination of metabolic PET and diffusion-weighted (DW)-MRI in the polyoma virus middle T antigen transgenic mouse model of breast cancer. The implementation of a voxelwise analysis for the clustering of intra- and intertumoral heterogeneity in this model resulted in a multiparametric profile based on [(18)F]Fluorodeoxyglucose ([(18)F]FDG)-PET and DW-MRI, which identified three distinct tumor phenotypes in vivo, including solid acinar, and solid nodular malignancies as well as cystic hyperplasia. To evaluate the feasibility of this approach for clinical use, we examined estrogen receptor-positive and progesterone receptor-positive breast tumors from five patient cases using DW-MRI and [(18)F]FDG-PET in a simultaneous PET/MRI system. The postsurgical in vivo PET/MRI data were correlated to whole-slide histology using the latter traditional diagnostic standard to define phenotype. By this approach, we showed how molecular, structural (microscopic, anatomic), and functional information could be simultaneously obtained noninvasively to identify precancerous and malignant subtypes within heterogeneous tumors. Combined with an automatized analysis, our results suggest that multiparametric molecular and functional imaging may be capable of providing comprehensive tumor profiling for noninvasive cancer diagnostics. Cancer Res; 76(18); 5512-22. ©2016 AACR.

Histopathological analysis of endometrial biopsies in dysfunctional uterine bleeding

Background: It is estimated that 9-30% of women of reproductive age suffer from menorrhagia. Because most cases are associated with anovulatory menstrual cycles, adolescent and perimenopausal women are particularly vulnerable to this particular condition. The aim of this study was to evaluate the histopathological pattern of endometrial biopsy from patients presenting with dysfunctional uterine bleeding.Materials and Methods: This is a cross-sectional observational study done in Nobel Medical College, Biratnagar, Nepal for a period of three years from June 2012 to June 2015. All the patients presenting with dysfunctional uterine bleeding and who underwent endometrial biopsy were included in this study. Distribution of various histopathological patterns was observed in the different age groups.Results: A total of 300 cases were included in my study. The commonest pattern in these patients was proliferative endometrium 61 (%). The commonest pathology was simple cystic hyperplasia (13.3%). Other patterns identified were secretory endometrium, chronic endometritis and pill endometrium. Malignant lesion comprised of 8 (2.7%) of patients and the majority was in &gt;50 years followed by in between 41-50 years of age. Atrophic endometrium was the commonest finding in post menopausal bleeding, comprising of 11 cases (3.6%), followed by endometrial carcinoma of 8 cases (2.7%).Conclusion: As observed from the study, there is an age specific association of endometrial bleeding, with highest incidence in perimenopausal age group. Hence, dilatation and curettage is helpful for diagnosis, to assess therapeutic response and to know the pathological incidence of organic lesions in cases of dysfunctional uterine bleeding.

Histomorphometric study of the canine prostate during ageing and in cases of benign prostate hyperplasia

Abstract Introduction: The aim of the study was to examine the percentage volume of epithelium, acini, and interstitial collagen in the nonhyperplastic canine prostate and in cases of epithelial and epithelial cystic hyperplasia. Material and Methods: A histomorphometric study of 39 prostates was performed using computer image analysis. Results: The highest percentage volume of epithelium was found in cases of epithelial hyperplasia (47.8 %) and epithelial cystic hyperplasia was the correlate for acini (48.97 %). Epithelium decreased with dogs’ age (P &lt; 0.01), whereas acini increased (P &lt; 0.01). Interstitial collagen varied only insignificantly across age groups, but collagen was higher (12.1 %) in the nonhyperplastic prostates. With age cystic formation progressed in the canine prostate, the percentage volume of epithelium decreased and that of acini increased, but this same parameter in prostatic collagen did not change distinctly. The epithelium percentage volume increased in cases of epithelial hyperplasia but the cystic variant caused an increase in acinar volume. Conclusion: As dogs age, cystic formation progresses in the prostate, therefore the volume of epithelium decreases and that of acini increases. The volume of prostatic collagen did not change distinctly with age, and was higher in normal prostates than in both epithelial and epithelial cystic hyperplastic glands.

Bulky Uterus and Multiparity are Important Contributing Factors for Dysfunctional Uterine Bleeding among Bangladeshi Women

Background: Dysfunctional uterine bleeding (DUB) is irregular uterine bleeding that occurs in the absence of recognizable pelvic pathology, general medical disease, or pregnancy. It reflects a disruption in the normal cyclic pattern of ovulatory hormonal stimulation to the endometrial lining. About 1–2% of women with improperly managed anovulatory bleeding eventually may develop endometrial cancer but determinants behind the disease are largely unknown.Objective: The present study aimed to find out the determinants of dysfunctional uterine bleeding.Materials and Methods: In this cross-sectional study 50 patients of dysfunctional uterine bleeding (DUB) were recruited from different tertiary hospitals in Dhaka city. Clinical parameters have been recorded using a predesigned questionnaire and analyzed using SPSS for Windows version 16.0 and Microsoft Office Excel.Results: In the studied patients, about 38% were suffering from type 2 diabetes mellitus, 12% from obesity and 18% from hypertension. Almost all the patients (96%) were suffering from anemia. Histological findings have shown that endometrium of 63% patients were in proliferative phase, about 16% were in secretory phase and 11% patients were with cystic hyperplasia. Ultrasonographic results have shown that about 72% of the patients had bulky uterus. Ninety two percent patients carried more than two pregnancies, and 40% patients carried &gt;5 pregnancies.Conclusion: Bulky uterus and multiple pregnancies may be associated with dysfunctional uterine bleeding in Bangladeshi women.J Enam Med Col 2016; 6(1): 23-27