Cyst Of Odontogenic Origin Research Articles

EVALUATION OF CALRETININ EXPRESSION IN ODONTOGENIC CYSTS AND TUMORS - AN IMMUNOHISTOCHEMICAL STUDY

Background: Calretinin (calbindin) acts as calcium binding protein, it functions as a regulator of various physiological and pathological processes like phosphorylation of target proteins, extracellular matrix remodeling, cell proliferation, apoptosis and gene regulation. Hence, its assessment in odontogenic tumors like Ameloblastoma was carried out. To evaluate, assess, correlate and compare the Calretinin immune Aims and Objectives: positivity in tumors and cysts of odontogenic origin. The present study comprised of 6 Materials and Methods: 5 samples, fteen cases each of Dentigerous cysts, Odontogenic Keratocyst, Unicystic Ameloblastoma and 20 cases of Ameloblastoma. All the slides were stained immunohistochemically using Calretinin. The localization, staining intensity Results and Observation: and percentage of positivity for Calretinin showed a statistical signicant increase from DC to OKC to UA and Ameloblastoma which was 16.9, 31.9, 44.6, and 48.7 respectively. Stellate reticulum cells within Ameloblastoma showed intense immunostaining when compare with other tumors and cysts of odontogenic origin. calbindin can be used as diagnos Conclusion: tic marker in Conventional Ameloblastomas. It also helps to know the biological behavior of these tumors,

Conservative management of an extensive odontogenic keratocyst in the anterior region of a pediatric patient’s jaw

Odontogenic keratocysts (OKCs) are now considered benign cysts of odontogenic origin that are characterized by an aggressive behavior with a relatively high recurrence rate, particularly when OKCs are associated with syndromes. Its histological appearance is characteristic with the presence of an epithelial lining parakeratinized showing a corrugated surface, together with a number of architectural features of the epithelium as a thickness of six to eight layers and the presence of columns, palisade basal cell. Radiographically, the lesion is often unilocular radiolucent surrounded by margins smooth or jagged edges with sclerotic. OKCs are more frequently in the third decade of life. This article reports a case of a young patient with exuberant OKC on unusual anterior mandibular site underwent treatment that involved a 48-month period of decompression, followed by enucleation of the residual cyst. Preserving important structures of the bone and soft tissue decompression is a method with low morbidity. In addition, according to the literature, decompression has a success rate at least as high as the one of most aggressive treatments.

CONDYLE SALIVARY GLAND DEFECT (STAFNE DEFECT) MIMICKING AN ODONTOGENIC CYST

Stafne bone defect consists of an asymptomatic, anatomic condition of uncertain origin and rare evolvement, often discovered at random in routine radiographic examinations. It is usually consisted on mandibular salivary gland inclusion as a developmental anomaly represented by a bone concavity usually containing submandibular gland tissue. A 39-year-old woman presented a hypodense lesion in the condyle of the left side of the jaw, discovered randomly. Because of the fact that the lesion mimics a cyst of odontogenic origin, excisional biopsy and later histopathologic analysis were performed. The histologic slices revealed the presence of ectopic serous salivary glands located in the head of the left condyle, characterizing a Stafne defect. Faced with this diagnosis, the conduct was the patient´s periodic follow-up.

IMMUNOHISTOCHEMICAL DISTRIBUTION OF THE SIBLINGS IN AMELOBLASTOMA AND ODONTOGENIC KERATOCYST

Objective Ameloblastomas are benign but aggressive neoplasms of the jaw. The odontogenic keratocysts (OKC) are aggressive jaw cysts of odontogenic origin. A recent WHO classification designated OKC as a neoplasm but a current edition re-designated it as a cyst. The small integrin-binding ligand n-linked glycoproteins (SIBLINGs) are a family of molecules that some epithelial neoplasms use in furthering their progression. Members of the SIBLING family are bone sialoprotein (BSP), dentin matrix protein1 (DMP1), dentin sialophosphoprotein (DSPP), matrix extracellular phosphoglycoprotein (MEPE), and osteopontin (OPN). The objective of this study was to compare the expression of the SIBLINGs in ameloblastomas and odontogenic keratocysts. Findings Using immunohistochemistry, with appropriate controls, 49 cases of ameloblastomas and 35 cases of OKCs were screened for the expression of all five SIBLINGs in a retrospective study on archived paraffin sections. Immunoreactivity was scored as positive if > 10% of tumor/cyst cells stained for a SIBLING and negative if Conclusion While all members of the SIBLINGs are expressed in ameloblastomas and OKCs, DSPP expression in OKCs is significantly higher than in ameloblsatomas, whereas, MEPE expression in OKCs is considerably lower than in ameloblastomas. The differences in the expression of DSPP and MEPE between ameloblastomas and OKCs may indicate differences in the degree of aggressive behaviors.

Glandular odontogenic cyst of posterior maxilla: A rare entity

Introduction: Glandular odontogenic cyst (GOc) is uncommon jaw cyst of odontogenic origin with unpredictable and potentially aggressive behavior. It is a rare developmental cyst with relatively low frequency of just 0.012–0.03%. Very limited cases of GOc have been reported in literature since it was first described by Gardner et al. in 1988. GOc is found to occur in fifth decade of life and the most common site of occurrence is mandible, especially the mandibular anterior region with slight predilection for males. However, its occurrence in the maxillary posterior region of a 23-year-old female with associated symptoms of pain is quite rare. case report: this case report presents one such rare case of GOc in right maxillary region of a 23-year-old female who was primarily diagnosed as a radicular cyst. Later, due to recurrence of the lesion, patient had to undergo enucleation and partial resection of posterior maxilla, and after a comprehensive histopathological analysis, it

Management of an impacted inverted mesiodens associated with a large circumferential type of dentigerous cyst: A rare case report with one-year follow-up

Introduction: A dentigerous cyst is a developmental cyst of odontogenic origin, which apparently develops by accumulation of fluid between the reduced enamel epithelium and the tooth crown of an unerupted tooth, with consequent expansion of tooth follicle. It may be associated with crown of unerupted teeth, odontomas, or supernumerary teeth. Ninety-five percent of dentigerous cysts are associated with permanent dentition whereas only 5% are with supernumerary teeth.

Expression of Osteopontin in Selected Benign and Malignant Salivary Gland Neoplasms

phy. Measurement of serum PSA/KLK 3 is useful to aid in detection of early prostate cancer, as well as to assess progression of disease. This study aims to evaluate common neoplasms & cysts of odontogenic origin including the lateral periodontal cyst, dentigerous cyst, keratocystic odontogenic tumour (KOT) and ameloblastoma for the presence of KLK 3. Subsequently, we wish to investigate the role of KLK 3 in the pathogenesis and progression of these neoplasms. Materials and Methods: Archived paraffin embedded samples from the division of oral pathology at the Western University of Canada were obtained, cut and assessed for the presence of KLK 3 using a standard immunostaining technique, utilizing a polyclonal antibody for KLK 3. Sixty (n 60) lesions were investigated including lateral periodontal cysts (n 9), dentigerous cysts (n 10), keratocystic odontogenic tumours (n 11) and ameloblastomas (n 11) as well as nasopalatine duct cysts (n 9, non-odontogenic cystic control) and odontomas (n 10, neoplasm control). Analysis of immunostaining was performed utilizing a scoring system assessing staining intensity as well as proportion of cells stained. These scores were combined to yield a total score for each sample examined. Epithelial staining, was examined and scored. Data was analyzed using the Kruskal-Wallis, as well as Dunn’s multiple comparison test. Results: Kruskal-Wallis analysis shows a significant difference in staining intensity of KLK 3 between the groups of lesions evaluated (p 0.004). There is a significant difference in expression of KLK 3 when comparing the odontoma to KOT (p 0.05) and odontoma to ameloblastoma (p 0.01). Positive staining for KLK 3 was also observed in the lateral periodontal cyst, dentigerous cyst and nasopalatine duct cyst, however no significant differences were noted when comparing these other types of lesions. Conclusion: For the first time, KLK 3 has been identified in odontogenic tissues. KLK 3 is present in significantly greater amounts in benign neoplasms of odontogenic origin, the ameloblastoma and KOT, when compared to the odontogenic hamartoma. KLK 3 is expressed in odontogenic neoplasms including the lateral periodontal cyst, dentigerous cyst, and odontomas. Positive identification of this biomarker may prove to be a diagnostic avenue for early detection and treatment of these locally destructive diseases.

Multiple Odontogenic Keratocysts

ABSTRACTOdontogenic keratocyst is a cyst of odontogenic origin that exhibits a keratinized epithelial lining. Odontogenic keratocyst has been the topic of numerous investigators and is known for its potentially aggressive behavior and significant rate of recurrences.1OKC cyst often occurs as a solitary lesion at the angle of the mandible, however in some instances, multiple such cysts may occur in association with a syndrome called “Nevoid basal cell syndrome”.1These patients have propensity to develop multiple neoplasm including basal cell carcinoma and medulloblastoma. Hence early diagnosis and treatment is of utmost importance in reducing the severity of long-term sequelae of this syndrome. Here we present a case of multiple odontogenic keratocysts with nevi and narrowed ribs which has profound relevance to specialist in Oral Medicine and Radiology and Oral and Maxillofacial Surgery.

Bilateral Odontogenic Keratocyst - A Case Report

The odontogenic keratocyst is a cyst of odontogenic origin that exhibits a keratinised epithelial lining. Odontogenic keratocyst has been the topic of numerous investigators and is known for its potentially aggressive behavior and significant rate of recurrence. This cyst often occurs as a solitary lesion in the angle of the mandible, however in some, multiple such cysts may occur in association with a syndrome called Nevoid basal cell syndrome. Here we report a case of a bilateral odontogenic keratocyst in a 60 yr old male patient, wherein multiple cysts were present but, without any other associated manifestations.