Abstract
Background: Calretinin (calbindin) acts as calcium binding protein, it functions as a regulator of various physiological and pathological processes like phosphorylation of target proteins, extracellular matrix remodeling, cell proliferation, apoptosis and gene regulation. Hence, its assessment in odontogenic tumors like Ameloblastoma was carried out. To evaluate, assess, correlate and compare the Calretinin immune Aims and Objectives: positivity in tumors and cysts of odontogenic origin. The present study comprised of 6 Materials and Methods: 5 samples, fteen cases each of Dentigerous cysts, Odontogenic Keratocyst, Unicystic Ameloblastoma and 20 cases of Ameloblastoma. All the slides were stained immunohistochemically using Calretinin. The localization, staining intensity Results and Observation: and percentage of positivity for Calretinin showed a statistical signicant increase from DC to OKC to UA and Ameloblastoma which was 16.9, 31.9, 44.6, and 48.7 respectively. Stellate reticulum cells within Ameloblastoma showed intense immunostaining when compare with other tumors and cysts of odontogenic origin. calbindin can be used as diagnos Conclusion: tic marker in Conventional Ameloblastomas. It also helps to know the biological behavior of these tumors,
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