Current State Of Research Research Articles

The Hallmarks of Endometriosis.

A heuristic tool called "the hallmarks of cancer" helps to reduce the enormous complexity of cancer phenotypes and genotypes to a preliminary set of guiding principles. Other aspects of cancer have surfaced as possible improvements in our understanding of the disease's mechanisms. Endometriosis is a gynecological disease condition negatively impacting the quality of life of many women. To date, there is no curative treatment for endometriosis. Therapy is aimed at treating the symptoms using hormone therapy, pain therapy and complementary therapy. Chronic pain and overlapping pain syndromes and illnesses can also be treated with multimodal pain therapy and psychosomatic therapy. Endometriosis is, however, a chronic and complex entity which, in this regard, resembles cancer. The present work investigates the hallmarks of endometriosis with a view to summarizing the current research status and paving new ways for future research projects.

ANTICANCER IMMUNOGENIC POTENTIAL OF ONCOLYTIC PEPTIDES: RECENT ADVANCES AND NEW PROSPECTS

Oncolytic peptides are derived from natural host defense peptides/antimicrobial peptides produced in a wide variety of life forms. Over the past two decades, they have attracted much attention in both basic research and clinical applications. Oncolytic peptides were expected to act primarily on tumor cells and also trigger the immunogenic cell death. Their ability in the tumor microenvironment remodeling and potentiating the anticancer immunity has long been ignored. Despite the promising results, clinical application of oncolytic peptides is still hindered by their unsatisfactory bioactivity and toxicity to normal cells. To ensure safer therapy, various approaches are being developed. The idea of the Ukrainian research group was to equip peptide molecules with a "molecular photoswitch" — a diarylethene fragment capable of photoisomerization, allowing for the localized photoactivation of peptides within tumors reducing side effects. Such oncolytic peptides that may induce the membrane lysis-mediated cancer cell death and subsequent anticancer immune responses in combination with the low toxicity to normal cells have provided a new paradigm for cancer therapy. This review gives an overview of the broad effects and perspectives of oncolytic peptides in anticancer immunity highlighting the potential issues related to the use of oncolytic peptides in cancer immunotherapy. We summarize the current status of research on peptide-based tumor immunotherapy in combination with other therapies including immune checkpoint inhibitors, chemotherapy, and targeted therapy.

Proposal and Analysis of "Ternary" Model of Sensitization for Proton Therapy

In order to improve the biological effect of proton therapy, the authors first propose a new method of boron-based proton-enhanced radiotherapy in a " ternary " radiotherapy mode, based on the existing sensitizing effect of proton radiotherapy: i.e, Boron-based mediators (11B and 10B) induce the proton-hydrogen-boron fusion reaction of the low-energy protons arriving at the Bragg peak region of the tumor target area (p+11B→3α) and thermal neutron capture (10B+n→7Li3+(0.84 MeV)+4He2+(1.47 MeV)+(0.477 MeV)), which release low-energy α-particles with high LETs to enhance the biological effect of proton dose in the target area, thus improve the clinical effect of proton therapy. Then, the advantages and disadvantages of the "ternary" model were analyzed from the theoretical basis and current research status, and finally, the "ternary" model is summarized and prospected.

스마트건설을 통한 건설산업의 전환

The purpose of this study is to identify the current status of smart construction technology, relevant domestic and foreign research, market trends, and practical application. The development direction of domestic smart construction technology is also investigated. For the analysis of the overseas smart construction industry, VOS viewer was used to generate information on the relationship of and trends in overseas smart construction studies through keyword correlation analysis and clustering. The construction industry is facing various challenges such as the need to improve productivity and the need to address key issues including shortage and aging of specialized workforce, increasing number of old buildings, and changes in the environment. To resolve these issues, the industry is actively introducing smart construction technologies such as BIM, AI, VR, AR, and robots. It is also important to develop smart construction technology as a high-value-added business, especially when the future of the real estate construction industry is taken into account. This can be achieved by taking advantage of the company’s active technological development and the government's supportive policies towards smart construction.

Ecosystem service research in the dry subtropics: Current state, temporal changes and drivers of regional variability

Dry subtropical (DST) regions that share similar climatic and topographic conditions exhibit today significant disparities in population density, agricultural intensity, wealth and cultural values. In addition, they are also facing increasing pressures on their natural resources. These attributes collectively shape individuals' varying dependence on natural resources and may influence their perception of ecosystem services (ES). In this study, we conducted a systematic literature review, focusing on the DST regions, to address two main questions: 1) What is the current state, temporal trends and regional variability in scientific research on ES and 2) What are the potential drivers of the variability in ES research? Amongst the 471 publications found in our review, 53% focused on provisioning services, followed nearly equally by cultural (33%) and regulating (30%) services. Only 13% addressed more than one ES category and approximately 33% mentioned economic valuation. Our study reveals that research on ES in the dry subtropics experienced a significant increase from 2005 onwards. Approximately 45% of the publications included the term 'ecosystem service' and its frequency has risen substantially over time. Most publications primarily focus on African dry subtropics (over 60%), followed by South and North American ones. Publications from southern Asia and NE Australia were more scarce. Importantly, we found no clear relationship between the number of publications, publication density or representativeness and the variables used as indicators of human pressure (e.g. population density). Consequently, research efforts in the DST regions appear to be influenced by a diverse range of financial and institutional constraints, international research agendas, as well as the personal interests of researchers, contributing to the idiosyncratic nature of this field.

Microbial dysbiosis in systemic lupus erythematosus: a scientometric study.

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease. Mounting evidence suggests microbiota dysbiosis augment autoimmune response. This study aims to provide a systematic overview of this research field in SLE through a bibliometric analysis. We conducted a comprehensive search and retrieval of literature related to microbial researches in SLE from the Web of Science Core Collection (WOSCC) database. The retrieved articles were subjected to bibliometric analysis using VOSviewer and Bibliometricx to explore annual publication output, collaborative patterns, research hotspots, current research status, and emerging trends. In this study, we conducted a comprehensive analysis of 218 research articles and 118 review articles. The quantity of publications rises annually, notably surging in 2015 and 2018. The United States and China emerged as the leading contributors in microbial research of SLE. Mashhad University of Medical Sciences had the highest publication outputs among the institutions. Frontiers in Immunology published the most papers. Luo XM and Margolles A were the most prolific and highly cited contributors among individual authors. Microbial research in SLE primarily focused on changes in microbial composition, particularly gut microbiota, as well as the mechanisms and practical applications in SLE. Recent trends emphasize "metabolites," "metabolomics," "fatty acids," "T cells," "lactobacillus," and "dietary supplementation," indicating a growing emphasis on microbial metabolism and interventions in SLE. This study provides a thorough analysis of the research landscape concerning microbiota in SLE. The microbial research in SLE mainly focused on three aspects: microbial dysbiosis, mechanism studies and translational studies (microbiota-based therapeutics). It identifies current research trends and focal points, offering valuable guidance for scholars in the field.

Research progress and future trends of early-onset gastric cancer

Early onset gastric cancer (EOGC), defined as gastric cancer occurring at a younger age. Early-onset gastric cancer tends to be poorly differentiated and highly malignant. Genetic material and environmental exposure factors may be the main causes of early occurrence of gastric cancer. Prolonging the survival and improving the quality of life of patients with early-onset gastric cancer is our main research goal in the future. This article aims to elaborate on the current research status and progress of EOGC in terms of its clinicopathological characteristics, molecular genetics, microecological environment, prediction methods, treatment plans, and prognosis, while also exploring potential avenues for future research.

The detection of unconventional quantum oscillations in insulating 2D materials

In strongly correlated quantum materials, electrons behave in ways that often extend beyond the confines of conventional Fermi-liquid theory. Interesting results include the observation of low-temperature metallic behavior in systems that are highly resistive. Here we provide an overview of experiments in which insulators exhibit characteristics of a metal such as the Shubnikov–de Haas-like quantum oscillations, focusing on recent findings in the correlated insulating states of two-dimensional WTe2. We discuss the status of current research, clarify the debates and challenges in interpreting the experiments, rule out extrinsic explanations and discuss promising future directions.

Synaptic device-based neuromorphic computing in artificial intelligence

The application of synaptic device-based neuromorphic computing in artificial intelligence is an emerging research field aimed at simulating the structure and function of the human brain and realizing high-efficiency, low-power, and adaptive intelligent computing. This paper reviews the principles, growth and challenges of neuromorphic devices based on synapses computing and its applications and perspectives in artificial intelligence fields like an image processing as well as natural language processing. The paper first introduces the basic concepts, properties and classification of synaptic devices, as well as the basic framework and algorithms of neuromorphic computing. Then, the paper analyzes the advantages and difficulties of neuromorphic computing based on synaptic devices, including the preparation, testing, modelling and integration of the devices, as well as the systems architecture, programming and optimization. Then, this paper gives examples of the applications and effects of synaptic device-based neuromorphic computing in artificial intelligence fields such as image processing and natural language processing, including image denoising, image segmentation, image recognition, text classification, text summarization, and text generation. Finally, this paper summarizes the current research status and future synaptic device-based neuromorphic computing trends. It puts forward some research directions and suggestions to promote the development and innovation in this field.

BIBLIOMETRIC REVIEW OF RESEARCH ON GREEN BUILDING ASSESSMENT METHOD BY CITESPACE AND HISTCITE

Numerous qualitative review studies have been conducted to enhance the understanding of current research status of green buildings (GBs). Green building assessment methods (GBAMs) are crucial to the development of GBs and relevant research works has received wide attention. However, there are very few reviews to quantitively explore these studies. Therefore, this paper aims to systematically review literatures on GBAMs, and visually analyzes them through CiteSpace and HistCite. The article identified the most influential journals, contributors, representative institutions and regions. The knowledge bases of this area focus on “triple bottom line”, “indicator”, “building design”, “life cycle costing”, “life cycle sustainability assessment”, “tropical climate”, “building information modelling” and “Chinese green building label”. Through citation analysis, “updating existing GBAMs by scheme comparison”, “updating existing GBAMs by GB case analysis”, “establishment of new GBAMs” and “incorporation of BIM in GBAMs” were found as the main research themes. “Design”, “LCA”, “model”, “energy”, “management”, “residential buildings” and “office buildings” are high-frequency keywords. Future research directions were finally proposed as “more investigation on the other types of GBs”, “incorporation of cost-related criteria”, “enhancing health-related indicators” and“integrating with BIM technology”. The results could provide a useful reference to industry practitioners and scholars interested in GBAMs.

Visualization analysis of research frontiers and trends in the treatment of sciatic nerve injury.

To visualize and analyze the literature related to sciatic nerve injury treatment from January 2019 to December 2023, and summarize the current status, hotspots, and development trends of research in this field. Using CiteSpace and VOSviewer software, we searched the Web of Science database for literature related to the treatment of sciatic nerve injury. Then we analyzed and plotted visualization maps to show the number of publications, countries, institutions, authors, keywords, references, and journals. A total of 2,653 articles were included in the English database. The annual number of publications exceeded 230, and the citation frequency increased yearly. The United States and China were identified as high-influence nations in this field. Nantong University was the leading institution in terms of close cooperation among institutions. The authors Wang Yu had the highest number of publications and were highly influential in this field. Keyword analysis and reference Burst revealed a research focus on nerve regeneration and neuropathic pain, which involve regenerative medicine and neural tissue engineering. Chronic pain resulting from sciatic nerve injury often manifests alongside anxiety, depression, cognitive-behavioral disorders, and other issues. Interventions such as stem cells, electrical stimulation, electroacupuncture, total joint replacement, pharmacological interventions, gene therapy, nerve conduits, chitosan scaffolds, and exercise promote nerve repair and alleviate pain. Schwann cells have been the focus of much attention in nerve repair and regeneration. Improving the outcome of sciatic nerve injury is a current research challenge and focus in this field. Based on keyword Burst, nerve conduits and grafts may become a potential research hotspot in the treatment of sciatic nerve injury. This visual analysis summarizes research trends and developments of sciatic nerve injury treatment and predicts potential research frontiers and hot directions.

A decade of insight: bibliometric analysis of gut microbiota's role in osteoporosis (2014-2024).

Osteoporosis represents a profound challenge to public health, underscoring the critical need to dissect its complex etiology and identify viable targets for intervention. Within this context, the gut microbiota has emerged as a focal point of research due to its profound influence on bone metabolism. Despite this growing interest, the literature has yet to see a bibliometric study addressing the gut microbiota's contribution to both the development and management of osteoporosis. This study aims to fill this gap through an exhaustive bibliometric analysis. Our objective is to uncover current research hotspots, delineate key themes, and identify future research trends. In doing so, we hope to provide direction for future studies and the development of innovative treatment methods. Relevant publications in this field were retrieved from the Web of Science Core Collection database. We used VOSviewer, CiteSpace, an online analysis platform and the R package "Bibliometrix" for bibliometric analysis. A total of 529 publications (including 351 articles and 178 reviews) from 61 countries, 881 institutions, were included in this study. China leads in publication volume and boast the highest cumulative citation. Shanghai Jiao Tong University and Southern Medical University are the leading research institutions in this field. Nutrients contributed the largest number of articles, and J Bone Miner Res is the most co-cited journal. Of the 3,166 scholars who participated in the study, Ohlsson C had the largest number of articles. Li YJ is the most co-cited author. "Probiotics" and "inflammation" are the keywords in the research. This is the first bibliometric analysis of gut microbiota in osteoporosis. We explored current research status in recent years and identified frontiers and hot spots in this research field. We investigate the impact of gut microbiome dysregulation and its associated inflammation on OP progression, a topic that has garnered international research interest in recent years. Additionally, our study delves into the potential of fecal microbiota transplantation or specific dietary interventions as promising avenues for future research, which can provide reference for the researchers who focus on this research filed.

The impact of climate change on vehicle engineering and countermeasures

With the increasingly severe climate change, the field of vehicle engineering is facing numerous challenges and opportunities. This article aims to analyze the impact of climate change on vehicle engineering and propose corresponding strategies. Firstly, the research background and significance are introduced, and the current research status both domestically and internationally is analyzed. Following that, a comprehensive analysis is conducted on the impact of climate change on vehicle engineering, including the influence of current climate change on the development of vehicle engineering, the impact of low-carbon transportation on the development of vehicle engineering, and the influence of climate change on vehicle safety. Then, the role of vehicle engineering in responding to climate change is discussed in detail. Finally, development strategies for vehicle engineering are proposed, including the development of new energy vehicles, improvement of autonomous driving technology, and optimization of transportation policies. This study explains the impact of climate change on vehicle engineering and proposes strategies for long-term development.

A bibliometric analysis of interstitial cells of Cajal research.

The significance of interstitial cells of Cajal (ICC) in the gastrointestinal tract has garnered increasing attention. In recent years, approximately 80 articles on ICC have been published annually in various journals. However, no bibliometric study has specifically focused on the literature related to ICC. Therefore, we conducted a comprehensive bibliometric analysis of ICC to reveal dynamic scientific developments, assisting researchers in exploring hotspots and emerging trends while gaining a global perspective. We conducted a literature search in the Web of Science Core Collection (WoSCC) from January 1, 2013, to December 31, 2023, to identify relevant literature on ICC. We employed bibliometric software, namely VOSviewer and CiteSpace, to analyze various aspects including annual publication output, collaborations, research hotspots, current status, and development trends in this domain. A total of 891 English papers were published in 359 journals by 928 institutions from 57 countries/regions. According to the keyword analysis of the literature, researchers mainly focused on "c-Kit," "expression," "smooth muscle," and "nitric oxide" related to ICC over the past 11 years. However, with "SIP syncytium," "ANO1," "enteric neurons," "gastrointestinal stromal tumors (GIST)," and "functional dyspepsia (FD)," there has been a growing interest in the relationship between ANO1, SIP syncytium, and ICC, as well as the role of ICC in the treatment of GIST and FD. Bibliometric analysis has revealed the current status of ICC research. The association between ANO1, SIP syncytium, enteric neurons and ICC, as well as the role of ICC in the treatment of GIST versus FD has become the focus of current research. However, further research and collaboration on a global scale are still needed. Our analysis is particularly valuable to researchers in gastroenterology, oncology, and cell biology, providing insights that can guide future research directions.

Research Progress on the Basic Pharmacodynamic Substance and Mechanism of <i>Citri Sarcodactylis Fructus</i> in Relieving Anxiety

Anxiety disorder resulting from the interaction of psychological factors-caused anxiety and mood disorder symptoms is one of the clinical mental diseases. Excessive worry, nervousness and fear often bring about several negative outcomes, and seriously impact the physical, mental, and social functioning of patients. What’s worse, with poor treatment, anxiety disorder may develop into mental illnesses such as depression and schizophrenia. The treatment of anxiety has mainly recourse to drug therapy and psychotherapy; however, Western drug therapy represented by 5-hydroxytryptamine reuptake inhibitor often causes evident adverse effects, including nausea and constipation, as well as poor long-term medication compliance of patients. Citri Sarcodactylis Fructus can sooth the liver and regulate qi, which can be applied to alleviate anxiety disorder as an ancillary drug. Modern pharmacological research revealed that bergamot volatile oil, also known as bergamot essential oil (BEO), is the main active chemical component of Citri Sarcodactylis Fructus for anti-anxiety. BEO has been confirmed to exert an anti-anxiety effect through modulating neuronendocrine-immune network, including immunoregulation, suppression of hyperactive hypothalamic-pituitary-adrenal (HPA) axis, enhancement of function of hypothalamic-pituitary-thyroid (HPT) axis, modulation of neurotransmitter, and promotion of neurotrophic effect. The study discusses the current research status regarding the application of Citri Sarcodactylis Fructus for anti-anxiety in recent years, and deeply probes into the mechanism of Citri Sarcodactylis Fructus playing an anti-anxiety role via neuronendocrine-immune network, in an effort to provide references to clinical treatment of anxiety disorder and new ideas for developing drugs targeting anxiety disorders.

Application of extra- and intracochlear electrocochleography during and after cochlear implantation

Electrocochleography (ECochG) represents apromising approach for monitoring cochlear function during cochlear implantation and for investigating the causes of residual cochlear function loss after implantation. This paper provides an overview of the current research and application status of ECochG, both during and after cochlear implantation. Intraoperative ECochG can be conducted either via the implant itself or an extracochlear measuring electrode. Postoperative ECochG recordings are also feasible via the implant. Various studies have demonstrated that asignificant decrease in ECochG amplitude during electrode insertion correlates with an increased risk of losing residual cochlear function, with critical cochlear events occurring primarily towards the end of the insertion. Postoperative data suggest that the loss of cochlear function mainly occurs in the early postoperative phase. Future research directions include the automation and objectification of signal analysis, as well as amore in-depth investigation into the underlying mechanisms of these signal changes.

Partner violence in healthcare settings on breastfeeding mothers: a scientometric analysis

Background Partner violence is a significant issue affecting women’s health, particularly their breastfeeding practices in healthcare settings. Despite a considerable body of research on this topic, there is a need for a systematic overview of the existing literature to explore its thematic and structural developments. Methods This scientometric analysis covers a period of 45 years (1977-2022) and identifies 415 peer-reviewed articles published in English before 2023 from the Scopus database. The articles were included if they engaged with themes related to partner violence, healthcare settings, breastfeeding, and mothers, using predefined search terms and filters. Bibliometric data were decoded and visualized using VOSviewer and RStudio to analyze and visualize the scientific dialogue, trends, patterns, and networks in the literature regarding partner violence and its impact on breastfeeding mothers in healthcare settings. Results The study revealed a concentrated exploration of themes related to violence, healthcare provision, mental health, and women’s reproductive health. The co-occurrence network and thematic mapping illuminated seven pivotal clusters, revealing a complex narrative of interconnected research areas. Niche and emerging themes such as “Depression,” “HIV,” and “Covid-19” were identified, highlighting the evolving landscape of the research domain. Conclusions This analysis provides a panoramic overview of the existing literature, revealing intricate thematic structures and collaboration networks within the research on partner violence and breastfeeding mothers in healthcare settings. The study not only sheds light on the historical and current states of research but also pinpoints potential future directions, thereby assisting scholars and policymakers in navigating and prioritizing subsequent investigative endeavors.

Evolution and global research trends of immunity in diabetic nephropathy: a bibliometric and visual analysis from 2004 to 2023

BackgroundDiabetic nephropathy (DN) is the leading cause of end-stage renal disease, with an increasing prevalence worldwide, but its pathomechanisms remain incompletely understood. Accumulating evidence suggests that immunity plays an important role in the development of DN. Many papers have been published in the field over the last 20 years, but there has been no bibliometric review of the research hotspots and trends in the field. This study aimed to assess the current research status and future trends of the link between immune and DN using bibliometric analysis.MethodsPublications on the association between immunity and DN from 2004 to 2023 were retrieved from the Web of Science Core Collection database and screened according to inclusion criteria. VOSviewer and CiteSpace software were employed to visualize research trends and hotspots in the field. Data including author, institution, country, journal, reference, and keyword were analyzed.ResultsUltimately 1246 publications meeting the criteria were included in the bibliometric analysis, involving 838 articles (84.96%) and 408 reviews (15.04%). The literature covered 81 countries and regions, 1751 institutions, and 6584 authors. The top 2 countries in terms of the number of publications were China (435) and the United States (318), and they collaborated most frequently. The United States had the highest number of citations for published papers (18,161), far exceeding the other countries. England had 38 publications but had the highest average number of citations (92.32). The University of California system was the most prolific institution (25 papers, 1062 citations, 42.48 citations per paper). Frontiers in Immunology was the most prolific journal in the field (30 papers). The most cited journal was Kidney International (863 citations). The analysis of keywords and references showed that inflammation, ferroptosis, and lipid metabolism may be future research hotspots in this field.ConclusionsThe number of publications related to immunity and DN has increased annually over the past 20 years, with a significant increase in the last 3 years especially. Our results identified research hotspots and trends in the field. These findings provide valuable perspectives for future research, enhancing our understanding of the immune-related mechanisms of DN and exploring potential therapeutic strategies.

Analysis of hot spots and trends in rolling bearing fault diagnosis research based on scientific knowledge mapping

As a key component of mechanical equipment, real-time monitoring and diagnosis of rolling bearings play a critical role in ensuring the stable operation of equipment and the safety of operators. In order to present the current status and trends of fault diagnosis research on rolling bearings more intuitively, the scientific knowledge mapping was used to visualize and analyze the relevant literature in the article. The results show that the number of publications in this area of research has grown significantly in recent years, with China, India, the United States, and England having contributed significantly. The journals such as MECHANICAL SYSTEMS AND SIGNAL PROCESSING, MEASUREMENT, and JOURNAL OF SOUND AND VIBRATION have played an important role in disseminating cutting-edge technologies in this field. In addition, the exploration of modern methods based on data-driven and artificial intelligence, as well as their application to real-world problems, are gradually becoming the focus of research. Through summarising and analysing, the application of modern data processing techniques, the development of more efficient and practical intelligent fault diagnosis techniques, and the close integration of laboratory research and practical applications will become future research trends.

Evolutionary trends and research hotspots in electrochemical machining: A bibliometric analysis from 2010 to 2023

Electrochemical Machining has played an important role in solving manufacturing scenarios with difficult-to-machine materials, complex shapes, special requirements, and many other aspects. To systematically grasp the evolutionary trends, current status, and hotspots of research in the field of Electrochemical Machining, data analysis and mining of literature big data in the field of Electrochemical Machining from 2010 to 2023 were conducted, and graph visualization analysis was carried out. The research results indicate that: 1) Electrochemical Machining is highly valued by research institutions in various countries, with steady growth in research results and relatively high funding for research projects. China is in a leading position in terms of the number of papers and funding;2) A certain degree of cooperation has been formed globally around the research of Electrochemical Machining, and the cooperation between research institutions has obvious regional characteristics; 3) The research level of Electrochemical Machining has gradually deepened from theoretical research to interdisciplinary application research in materials science, energy, engineering, technology, and other fields. Research on machine learning based Electrochemical Machining has received increasing attention, and artificial neural networks have achieved new results in processing optimization applications. Artificial intelligence is the key technology and cutting-edge direction in the next stage of Electrochemical Machining research.