Current Era Research Articles

MODERNIDADE LÍQUIDA E AS DIFERENTES GERAÇÕES

The text discusses the challenges faced by education in the current era, highlighting the individualized search for knowledge through technological resources. Under the influence of individualism and social regression, technology gains prominence in educational discussions. Access to information via the internet is considered a form of democratization, but the mere availability of information does not constitute education. The school is asked to position itself as a technology guide, recognizing the need for innovation to meet the demands of students. The search for autonomy, a crucial path to liberation, is intrinsically linked to the concept of humanizing education. This approach highlights the importance of dialogue as an essential foundation for acquiring knowledge. Bibliographic research covers secondary sources, seeking new approaches. The objective is to analyze Bauman’s “Liquid Modernity” and the perspectives of different generations, exploring how education should adapt to modernity and the characteristics of the current generation, and how institutions and teachers should respond to this reality.

Molecular similarity: Theory, applications, and perspectives

Molecular similarity pervades much of our understanding and rationalization of chemistry. This has become particularly evident in the current data-intensive era of chemical research, with similarity measures serving as the backbone of many Machine Learning (ML) supervised and unsupervised procedures. Here, we present a discussion on the role of molecular similarity in drug design, chemical space exploration, chemical “art” generation, molecular representations, and many more. We also discuss more recent topics in molecular similarity, like the ability to efficiently compare large molecular libraries.

Unveiling the anticancer potential of novel spirooxindole-tethered pyrazolopyridine derivatives

In the current medical era, human health is confronted with various challenges, with cancer being a prominent concern. Therefore, enhancing the therapeutic arsenal for cancer with a constant influx of novel molecules that selectively target tumor cells while displaying minimal toxicity toward normal cells is imperative. This study delves into the antiproliferative and EGFR kinase inhibitory activities of newly reported spirooxindole-pyrazolo[3,4-b]pyridine derivatives 8a-h and 10a-h. The inhibitory effects on the growth of human cancer cell lines A-549 (lung carcinoma), Panc-1 (pancreatic carcinoma), and A-431 (skin epidermoid carcinoma) were evaluated, and the SAR has been clarified through analysis. With IC50 values in the single-digit micromolar range, compounds 8b, 8d, 10a-b, and 10d were shown to be the most effective antiproliferative candidates against the studied cancer cell lines. They also exerted negligible cytotoxicity (with selectivity scores between 8.63 and 30.02) against the human lung MRC5 cell line. Additionally, we investigated the potential inhibitory action of compounds 8b, 8d, 10a-b, and 10d on EGFR and VEGFR-2. 10a was this investigation’s most effective EGFR inhibitor, with an IC50 value of 0.54 μM. Ultimately, the molecular docking analysis of congener 10a highlighted its effective suppression of EGFR by examining its binding mode and docking score compared to Erlotinib. These findings underscore the potential of spirooxindole-pyrazolo[3,4-b]pyridine derivatives as promising anticancer agents targeting EGFR kinase.

The Utilization of Interactive Multimedia in Improving Vocabulary Knowledge of High School Students

In the current digital era, English education is becoming increasingly important. By integrating English language learning with digital learning media, it is hoped to create a more dynamic and student-centered learning environment. The goal is to facilitate students in achieving the set learning objectives. This research focuses on evaluating the effectiveness of interactive multimedia in improving English vocabulary comprehension in English subjects at the junior high school level. The research method employed is an experiment with a quasi-experimental design, involving pre and posttests in both control and experimental classes. The sample consists of 32 students from class VIII B (experimental group) and 32 students from class VIII C (control group) in SMPN 1 Jatisrono, selected using cluster random sampling from various classes. The experimental group receives treatment through learning activities using interactive multimedia, while the control group does not use interactive multimedia in the learning process. Data collection is conducted through attitude scale questionnaires filled out by junior high school students. The research findings indicate that the use of interactive multimedia significantly influences the improvement of students' English vocabulary comprehension. This is evidenced by the significant increase in students' English vocabulary knowledge after undergoing learning with interactive multimedia. Interactive multimedia is considered effective in influencing students' comprehension and helping them achieve learning objectives. Thus, interactive multimedia can be considered a suitable learning medium for English subjects at the junior high school level. The use of technology in such learning is crucial to keep up with the times and ensure that students have skills relevant to current global needs. This underscores the importance of integrating technology into education to create more effective and engaging learning experiences for students.

Examining Transformational Leadership: A Thematic and Bibliometric Literature Review

In the current era of digitalization, companies across all sectors are undergoing swift and significant transformations. Transformational leadership is receiving increased scholarly attention due to its distinct traits that differentiate it from conventional leadership methods. This study aims to assess the efficacy and theoretical underpinnings of transformative leadership. In order to accomplish this objective, the present study undertakes a thorough and methodical examination of 3195 scientific articles pertaining to transformative leadership. This inquiry employs the SPAR-4-SLR procedure and utilizes several bibliometric analytic methods such as performance analysis and science mapping. The study incorporates many approaches such as content analysis, keyword co-occurrence analysis, and bibliographic coupling. This study provides an analysis of performance measures, such as publishing and citation patterns, notable publications and authors, and the prevailing concepts and subjects within the intellectual framework of the area. Additionally, the study offers recommendations for future research in this area. Hence, there is a need for research on the concept of "green intellectual capital". Additionally, it can be worth contemplating a particular domain that holds the possibility for transformative leadership.

PERAN E-WALLET DALAM PENGAMBILAN KEPUTUSAN YANG EFISIEN

This rapid technological progress has made many changes, such as in the current era, developments have made many changes in carrying out transactions such as digital wallets (e-wallets). This e-wallet has many advantages in making it easier for us to save money, carry out transactions and manage our daily finances digitally via smartphone in a practical and time efficient way to use it. The aim is to analyze the role of e-wallets which will influence efficient financial decisions among students of the 4th semester accounting study program at Widya Mandala Catholic University Surabaya 2024. The method used in this research is qualitative using respondents as data collectors. The total population of the objects we studied was 97 respondents, then we used the Slovin formula where the results of our calculations found that the number of respondents we had to research was 78 respondents. By compiling 5 questions, they were used as research objects. The results of the analysis show that e-wallets make financial management easier by recording all transactions in a position where of course e-wallets will provide efficiency in financial recording so that respondents or users don't have to bother recalculating their money manually. However, there are still some privacy issues and even fraud in certain circles which can be a point of view for all e-wallet companies to be able to anticipate this. The convenience and comfort provided by digital payments via e-wallet is present and felt by consumers when carrying out transactions and this can be a source of satisfaction for users. There are also shortcomings such as respondents not feeling any change in behavior because respondents have not felt any change in behavior due to lack of access or understanding of technology, to a preference for traditional payment methods

Pelatihan Internet of Things (IoT) di SMA Negeri 1 Donorojo dalam Rangka Program Kerja KKN UNISNU Jepara

In the Industrial Revolution 4.0 era began to enter the virtual realm through connectivity between humans, machines, and data spread in various places and known as the Internet of Things (IoT) where the technology is needed in the current era. Internet of Things (IoT) is a technology that connects physical devices, vehicles, household appliances, and various other items. The Community Service Method used is offline training. The results of this Community Service are 30 participants who participated in the training with initially there were only 4 participants who understood the concept and application of IoT to 29 participants with a percentage of 86.2%, followed by participants' interest in the IoT field from 3 participants to 28 participants with a percentage of 89.2%, and activeness in question and answer sessions and discussions from 5 participants to 30 participants with a percentage of 83.3%.

Kinematics of human hand and robotics applications

Human kinematics is very vital to robotics study as it plays a major role in robotic development and advancement. The importance of robotics study and applications in this current era cannot be over emphasized. This paper looks at the human hand kinematics, taking cognizance of the important elements of joint types and number of joints in the human arm, with emphasis on the degree of freedom for mobility purposes. It has highlighted the multi-various capabilities of the human hand and also indicated the limitations, thus throwing more light on the possibility of maximizing these limitations and improving on the mobility and capabilities of the human hand, where new tasks and functions can be defined and robots designed and directed to carry out such functions so as to improve the productivity of its applications in various areas of Engineering. In the light of the above a new direction of research in new tasks definitions and functions are clearly opened.

Integration of Team Performance, Emotional Intelligence, and Human Resource Management Practices: A Systematic Review

In this article, we will discuss how to combine team performance with emotional intelligence and use human resource management practices in an increasingly competitive globalization situation. Research data was collected through trusted journal databases such as Scopus and Google Scholar to ensure broad and relevant literature coverage. You can search for literature using Publish or Perish (POP) applications and enter keywords relevant to the research subject. In order to gain a more holistic understanding of the research subject, data collection involved combined methods using quantitative and qualitative analysis. In the current era of globalization, the level of productivity and sustainability of an organization can be improved through teams that work effectively, have good emotional intelligence skills, and implement optimal human resource management practices. The importance of this Research is highly visible in increasing understanding of the relationship between these factors and how they affect business today

Syringe services program staff and participant perspectives on changing drug consumption behaviors in response to xylazine adulteration

BackgroundXylazine is an increasingly common adulterant in the North American unregulated drug supply that is associated with adverse health outcomes (e.g., skin infections, overdose). However, there are significant knowledge gaps regarding how xylazine was initially identified and how syringe services program (SSP) staff and clients (people who use drugs) responded to its emergence.MethodsFrom June–July 2023, we conducted qualitative interviews with medical (e.g., clinicians) and frontline SSP staff (e.g., outreach workers) and adult clients with a history of injection drug use at a Miami-based SSP. Inductive memos identified emergent codes; thematic analysis involving team consensus established final themes.ResultsFrom interviews with SSP staff (n = 8) and clients (n = 17), xylazine emergence was identified at different times, in various ways. Initially, during summer 2022, clients identified a “tranquilizer-like substance” that worsened sedation and withdrawal and caused wounds. SSP medical staff later identified this adulterant as xylazine by treating new medical cases and through diverse information-sharing networks that included professional societies and news sources; however, frontline SSP staff and clients needed additional educational resources about xylazine and its side effects. With limited guidance on how to reduce harm from xylazine, SSP clients altered their drug consumption routes, reduced drug use, and relied on peers’ experiences with the drug supply to protect themselves. Some individuals also reported preferring xylazine-adulterated opioids and increasing their drug use, including the use of stimulants to avoid over sedation.ConclusionsXylazine’s emergence characterizes the current era of unprecedented shifts in the unregulated drug supply. We found that xylazine spurred important behavioral changes among people who use drugs (e.g., transitioning from injecting to smoking). Incorporating these experiences into early drug warning surveillance systems and scaling up drug-checking services and safer smoking supply distribution could help mitigate significant health harms caused by xylazine and other emergent adulterants.

Counterproductive work behavior reviewed by organizational culture in millennial employees

Purpose: Counterproductive work behavior is deviant behavior carried out by individuals that causes losses to the company and its members. One of the generations working as employees in the current era is the millennial generation or commonly known as generation Y. This research aims to examine the influence of organizational culture on counterproductive work behavior among millennial employees. Method: This research method is quantitative using a research instrument in the form of a questionnaire using a Likert scale. In this study, the researcher determined using a cluster sampling technique to obtain a sample of 130 respondents from six companies. The analytical tests used are Confirmatory Factor Analysis (CFA) and multiple regression. Result: The results of the multiple linear regression test show that there is a significant influence on organizational culture variables (innovation and risk taking, attention to detail), results orientation, people orientation, team orientation, aggressiveness, stability) on counterproductive work behavior among millennial employees. Organizational culture has a significant influence on counterproductive work behavior, namely innovation and risk taking variables have a positive influence and contribute 11.4%, then results orientation has a negative influence and contributes 56.5%, then people orientation has a negative influence and contributes 23 .1%. %. Team orientation also has a positive influence and contributes 14.3%, while aggressiveness has a positive influence and contributes 20.9%, while other variables that have no influence on counterproductive work behavior are the variables attention to detail and stability. Conclusion: In the future this research can become a reference for further research by paying attention to other variables such as personality, job characteristics, work group characteristics, and organizational injustice.

The Influence of Brand Experience, Brand Trust, and Perceived Value on Brand Loyalty of Maybelline Products in Surabaya

The current era of technological advancement has significantly changed various aspects of human life, including behavior patterns and lifestyles. Lifestyle changes that were initially cosmetic and used only on special occasions have now become daily necessities, leading to diverse demands for cosmetics and intense competition. This situation presents both opportunities and challenges for cosmetic companies. This study aims to determine how brand experience, brand trust, and perceived value affect brand loyalty of Maybelline products in Surabaya.The research method employed is quantitative research, with a sample size of 102 respondents who filled the sample criteria. Sampling was conducted using the Purposive Sampling technique, with the criteria being female, Maybelline product user, having made at least two purchases, and residing in Surabaya. Data analysis in this study utilized SEM-PLS. The results indicate that Brand Experience, Trust, and Perceived Value positively influence Brand Loyalty towards Maybelline products in Surabaya. The research method employed is quantitative research, with a sample size of 102 respondents who filled the sample criteria. Sampling was conducted using the Purposive Sampling technique, with the criteria being female, Maybelline product user, having made at least two purchases, and residing in Surabaya. Data analysis in this study utilized SEM-PLS. The results indicate that Brand Experience, Trust, and Perceived Value positively influence Brand Loyalty towards Maybelline products in Surabaya.

Optimalisasi Manajemen Barang Tenggat Waktu dan Lelang pada Penggadaian Yapusa

Pegadaian Yapusa Bangil is a financial institution that provides pawn services to the public. Along with the development of technology and the demands of operational efficiency, the goods management and auction process at Pegadaian Yapusa is still carried out manually, which has the potential to cause errors, delays, and a lack of transparency. This research aims to design and develop an item management application that can control the entry and exit of goods and set deadlines for goods to be auctioned automatically. This application is designed to improve operational efficiency and reduce potential errors in managing goods at Pegadaian Yapusa. The main features of this app include accurate item recording and automatic notifications for items that are close to the deadline. The research methods used in development include interviews, observations, and literature studies to collect relevant data and information. The results of this study show that the application of goods management can help increase productivity and efficiency in the management of goods at Pegadaian Yapusa. In addition, this application also contributes to the development of theories and concepts in the fields of technology, business, and management. With this application, it is hoped that Pegadaian Yapusa can compete in the current digital era and provide better services to the community

Classification of Indonesia False News Detection Using Bertopic and Indobert

In the current global era, the development of technology and information is very rapid, so it is very easy to get information/news from the internet. Because of the ease of getting this information, there is a lot of circulating fake news (hoaxes), the news is not filtered so anyone can spread news that is not clear in content. This can lower a person's credibility in the professional world, cause division, threaten physical and mental health, and can also result in material losses. Based on this, to stop the spread of hoaxes is to detect them as early as possible and block them. This detection can use deep learning methods which are also one of the architectures of transformers, namely a combination of BERTopic which is used to find important words from the news narrative, then the words are combined into the narrative and classified using Indo Bidirectional Encoder Representation from Transformer (IndoBERT). For experiments, the author uses a dataset taken from the kaggle.com website entitled Indonesia False News (HOAX) dataset. This study uses a learning rate of 1e-5, a batch size of 16 and using 5 epochs so that the f1-Score results are 92% for validation data and 91% for testing data.

ANALISIS FAKTOR YANG MEMPENGARUHI KEPUTUSAN PEMBELIAN DENGAN KUALITAS PELAYAN PADA TOKO SAMPOERNA DI SITUBONDO SEBAGAI VARIABEL MODERASI

With the development in the current era of technology which is increasingly modern, it will make many businesses experience a high increase and progress, one of which is the development of the retail business. The purpose of this study was to analyze Product Prices, Location, Service Quality in influencing Purchasing Decisions at Sampoerna Stores in Situbondo. This research is explanatory research. The population in this study were consumers of Sampoerna Stores. The sampling technique was determined by simple random sampling. Data analysis and hypothesis testing in this study used the Structural Equation Model-Partial Least Square (PLS-SEM). The results of hypothesis testing using the Smart PLS 3.0 application, show that Price has a positive but insignificant effect on Purchasing Decisions, Location has a positive and significant effect on Purchasing Decisions, Price moderated by service quality has a positive but insignificant effect, Location moderated by service quality has a negative but insignificant effect.

Does digital global value chain participation reduce energy resilience? Evidence from 49 countries worldwide

The digital global value chains (DGVCs) embody the two major characteristics of the current era: globalization and digitalization. The DGVCs has a major impact on global economic development, but few studies have explored its impact on the energy system. We divide digital global value chain participation (DGVCP) into forward digital global value chain participation (FDGVCP) and backward digital global value chain participation (BDGVCP) and analyze their effect on energy resilience by employing panel data from 49 countries from 2007 to 2019. Our benchmark regression results provide empirical evidence of the negative effects of DGVCP, showing that FDGVCP and BDGVCP reduce energy resilience. Moreover, the negative impact of FDGVCP and BDGVCP is stronger in a transparent institutional environment. The results remain robust after causal identification. The mechanism analysis results show that FDGVCP and BDGVCP influence energy resilience through the scale channel, structure channel, and technology channel. Our research reveals that the DGVCs have a negative impact on energy resilience, contrasting with the conclusions of previous mainstream studies. Our findings underscore some important implications for avoiding the negative effects of DGVCs and enhancing energy resilience.

Unravelling the Key Ingredients of Employability Skills for Surveyor Graduates: A Systematic Literature Review

The surveying profession has proven its value in the current era of development, as it offers services that generate, enhance, preserve, and protect valuable property and assets. Despite increasing attention, surveying education seems to be falling behind in meeting the demands of the construction industry by producing graduates with essential employability skills. Only a few studies have attempted to review the employability skills expected by employers from surveyor graduates. Therefore, this systematic review aims to identify essential elements of employability skills for surveyor graduates. The preparation of this review follows the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analysis) review method. A total of 25 related studies were obtained from three databases: Scopus, ScienceDirect, and Google Scholar. The findings revealed that the most crucial employability skills expected from surveyor graduates are communication skills (functional work skills), leadership skills (functional work skills), teamwork skills (functional work skills), critical thinking skills (cognitive skills), and emotional intelligence (personal and entrepreneurial skills). Surveying education should consider incorporating these identified skill sets into their curriculum and training modules to ensure the employability and readiness of graduates for the workforce.

A Review of the Regulatory Challenges of Personalized Medicine.

Personalized medicine integrates genomics with clinical and familial histories, revolutionizing healthcare by tailoring treatments to individual patient characteristics. At its core, pharmacogenomics enables the customization of medication prescriptions based on genetic profiles, enhancing drug efficacy and safety. This precision medicine approach addresses disease diagnosis, prevention, and treatment, offering targeted therapies for conditions like autoimmune disorders, rheumatoid arthritis, and neoplastic conditions. Examples of pharmacogenomics and personalized medicine include treatment for certain conditions like blood clotting disorders (warfarin (blood thinner), genetic variability, acute lymphoblastic leukemia (ALL), and thiopurine methyltransferase (TPMT) testing) in leukemia treatment. Historically, personalized medicine has evolved from Hippocrates' humoral theories to modern molecular diagnostics. The shift from cellular to molecular-level investigations has led to the current post-genomic era, emphasizing the four chemical components of DNA in understanding and treating disorders. This evolution enhances our ability to predict disease susceptibility, treatment response, and potential adverse reactions, demanding advancements in privacy laws, payment systems, regulatory standards, and education. Personalized healthcare optimizes treatment by considering genetic, environmental, and lifestyle factors, reducing adverse reactions, and improving patient satisfaction. It drives genomic and biotechnological research, fostering the development of targeted therapies and diagnostic tools, and streamlining drug development. Applications in lung cancer, renal carcinoma, and rheumatoid arthritis (RA) illustrate the efficacy of personalized medicine. Targeted therapies, such as tyrosine kinase inhibitors (TKIs) and monoclonal antibodies (mAbs), show significant success in lung cancer. Biomarkers guide renal carcinoma treatments, while gene expression profiles predict rheumatoid arthritis outcomes with tumor necrosis factor-alpha (TNF-α) blockers. The US FDA's increasing approvals of personalized treatments underscore its commitment to precision medicine. However, regulatory challenges persist, necessitating clear processes and policies. Ethical considerations, including equitable access and privacy, are critical for responsible implementation. The FDA's increasing approvals of personalized treatments highlight its commitment to advancing precision medicine, yet regulatory challenges remain, requiring the development of clear processes and policies to manage innovation safely. While these hurdles are being addressed through evolving guidelines and collaborative efforts, ethical considerations, including equitable access and privacy, are critical for responsible implementation. Early examples, such as warfarin and imatinib, demonstrate the role of genetic information in guiding treatment, illustrating the potential of personalized medicine to optimize healthcare outcomes.

Analysis of Aliyun-based serverless on MapReduce efficiency

In the context of the current era of big data, traditional Hadoop and cluster-based MapReduce frameworks are unable to meet the demands of modern research. This paper presents a MapReduce framework based on the AliCloud Serverless platform, which has been developed with the objective of optimizing word frequency counting in large-scale English texts. Leveraging AliCloud's dynamic resource allocation and elastic scaling, we have created an efficient and flexible text data processing system. This paper details the design and implementation of the Map and Reduce phases and analyses the impact of vCPU and memory specifications, as well as parallel resource allocation on system performance. Experimental results show that increasing vCPU specifications significantly improves processing capacity and execution efficiency. While the impact of memory specifications is relatively minor, it can positively influence performance in specific scenarios. Parallel processing markedly enhances system performance. Experiments on "Harry Potter and the Sorcerer's Stone" validate the framework's performance across various configurations. This study offers valuable insights for the design and optimization of serverless-based MapReduce frameworks, as well as suggesting future enhancements. These include the implementation of advanced parallel computing strategies, improved error handling, and refined data preprocessing, which collectively aim to boost system performance and stability.

Analisis Pelaksanaan Elektronik Government Sebagai Upaya Mewujudkan Tata Kelola Pemerintahan Yang Baik (Good Governance)

In the current era of digitalization and modernization, the development of information technology (IT), especially computer technology and internet networks is increasingly rapid, one way that can be used by the government to realize good governance. Based on the Presidential Instruction of the Republic of Indonesia Number 3 of 2003 concerning National Policy and Strategy for the Development of E-Government and also the Regional Regulation of the Province of West Nusa Tenggara Number 3 of 2018 concerning Electronic System-Based Government Governance, government agencies should implement electronic-based government services and administration. The purpose of the study was to determine how the implementation of electronic government is as an effort to realize good governance in the Social Service of West Nusa Tenggara Province, and to determine what factors influence the implementation of electronic government as an effort to realize good governance in the Social Service of West Nusa Tenggara Province. The type of research used is a qualitative descriptive research type. Based on the results of the study and discussion, it can be concluded that: (1). Of the three forms of implementation of the theory of electronic government implementation forms according to Indirajit, namely publish, interact and transact, only 2 forms are applied, namely publish and interact, while the third form, namely the transact form, is not applied by the NTB social service.