Current Density Reconstruction Research Articles

Optimized current-density reconstruction from wide-field quantum diamond magnetic field maps

Optimized current-density reconstruction from wide-field quantum diamond magnetic field maps

Cross-Modal Reorganization From Both Visual and Somatosensory Modalities in Cochlear Implanted Children and Its Relationship to Speech Perception.

We hypothesized that children with cochlear implants (CIs) who demonstrate cross-modal reorganization by vision also demonstrate cross-modal reorganization by somatosensation and that these processes are interrelated and impact speech perception. Cross-modal reorganization, which occurs when a deprived sensory modality's cortical resources are recruited by other intact modalities, has been proposed as a source of variability underlying speech perception in deaf children with CIs. Visual and somatosensory cross-modal reorganization of auditory cortex have been documented separately in CI children, but reorganization in these modalities has not been documented within the same subjects. Our goal was to examine the relationship between cross-modal reorganization from both visual and somatosensory modalities within a single group of CI children. We analyzed high-density electroencephalogram responses to visual and somatosensory stimuli and current density reconstruction of brain activity sources. Speech perception in noise testing was performed. Current density reconstruction patterns were analyzed within the entire subject group and across groups of CI children exhibiting good versus poor speech perception. Positive correlations between visual and somatosensory cross-modal reorganization suggested that neuroplasticity in different sensory systems may be interrelated. Furthermore, CI children with good speech perception did not show recruitment of frontal or auditory cortices during visual processing, unlike CI children with poor speech perception. Our results reflect changes in cortical resource allocation in pediatric CI users. Cross-modal recruitment of auditory and frontal cortices by vision, and cross-modal reorganization of auditory cortex by somatosensation, may underlie variability in speech and language outcomes in CI children.

Magnetic Resonance Current Density Imaging (MR-CDI).

Current density imaging (CDI) was developed with the aim of determining the three-dimensional distribution of externally applied electric current pathways inside a conductive medium, using measurements of magnetic flux density [Formula: see text] data. While the B field may be measurable using instruments such as a magnetometer, in magnetic resonance current density imaging (MR-CDI), an MRI scanner is used to measure the magnetic flux density data induced by current flow. In MR-CDI, the object must be rotated inside the MRI machine to find all three components of the B-field, as only the component of B parallel to the magnet main magnetic field can be measured. In principle, once the all three components of the B field have been obtained from an MR imaging experiment, the current density distribution [Formula: see text] can be reconstructed from Ampere's law [Formula: see text]. However, the need to rotate the object within the MRI scanner limits the usability of this technique. To overcome this problem, researchers have investigated the current density reconstruction problem using only one component of the magnetic flux density Bq, where q = x, y, z. In this chapter, we discuss numerical algorithms developed to reconstruct the distribution of J information from the measured B-field.

The Influence of the Head Model Conductor on the Source Localization of Auditory Evoked Potentials.

The accuracy of EEG source analysis reconstruction improves when a realistic head volume conductor is modeled. In this study we investigated how the progressively more complex head representations influence the spatial localization of auditory-evoked potentials (AEPs). Fourteen young-adult participants with normal hearing performed the AEP task. Individualized head models were obtained from structural MRI and diffusion-weighted imaging scans collected in a separate session. AEPs were elicited by 1kHz and 4kHz tone bursts during a passive-listening tetanizing paradigm. We compared the amplitude of the N1 and P2 components before and after 4min of tetanic-stimulation with 1kHz sounds. Current density reconstruction values of both components were investigated in the primary auditory cortex and adjacent areas. Furthermore, we compared the signal topography and magnitude obtained with 10 different head models on the EEG forward solution. Starting from the simplest model (scalp, skull, brain), we investigated the influence of modeling the CSF, distinguishing between GM and WM conductors, and including anisotropic WM values. We localized the activity of AEPs within the primary auditory cortex, but not in adjacent areas. The inclusion of the CSF compartment had the strongest influence on the source reconstruction, whereas white matter anisotropy led to a smaller improvement. We conclude that individualized realistic head models provide the best solution for the forward solution when modeling the CSF conductor.

Individual versus task differences in slow potential generators.

Average slow potentials (SPs) can be computed from any voluntary task, minimally involving attention to anticipated stimuli. Their topography when recorded by large electrode arrays even during simple tasks is complex, multifocal, and its generators appear to be equally multifocal and highly variable across subjects. Various sources of noise of course contaminate such averages and must contribute to the topographic complexity. Here, we report a study in which the non-averaged SP band (0 to 1Hz) was analyzed by independent components (ICA), from 256 channel recordings of 18 subjects, during four task conditions (resting, visual attention, CPT, and Stroop). We intended to verify whether the replicable SP generators (between two separate day sessions) modeled as current density reconstruction on structural MRI sets were individual-specific, and if putative task-related differences were systematic across subjects. Typically, 3 ICA components (out of 10) explained SPs in each task and subject, and their combined generators were highly variable across subjects: although some occipito-temporal and medial temporal areas contained generators in most subjects; the overall patterns were obviously variable, with no single area common to all 18 subjects. Linear regression modeling to compare combined generators (from all ICA components) between tasks and sessions showed significantly higher correlations between the four tasks than between sessions for each task. Moreover, it was clear that no common task-specific areas could be seen across subjects. Those results represent one more instance in which individual case analyses favor the hypothesis of individual-specific patterns of cortical activity, regardless of task conditions. We discuss this hypothesis with respect to results from the beta band, from individual-case fMRI studies, and its corroboration by functional neurosurgery and the neuropsychology of focal lesions.

Widespread Reductions of Spontaneous Neurophysiological Activity in Leber's Disease-An Application of EEG Source Current Density Reconstruction.

Leber’s hereditary optic neuropathy (LHON) is a rare, maternally inherited genetic disease caused by a mutation of mitochondrial DNA. Classical descriptions have highlighted structural abnormalities in various parts of patients’ optic tracts; however, current studies have proved that changes also affect many cortical and subcortical structures, not only these belonging to the visual system. This study aimed at improving our understanding of neurophysiological impairments in LHON. First of all, we wanted to know if there were any differences between the health control and LHON subjects in the whole-brain source electroencephalography (EEG) analysis. Second, we wanted to investigate the associations between the observed results and some selected aspects of Leber’s disease’s clinical picture. To meet these goals, 20 LHON patients and 20 age-matched healthy control (HC) subjects were examined. To investigate the electrophysiological differences between the HC and LHON groups, a quantitative analysis of the whole-brain current source density was performed. The signal analysis method was based on scalp EEG data and an inverse solution method called low-resolution brain electromagnetic tomography (eLORETA). In comparison with the healthy subjects, LHON participants showed significantly decreased neuronal activity in the alpha and gamma bands; more specifically, in the alpha band, the decrease was mainly found in the occipital lobes and secondary visual cortex, whereas, in the gamma band, the reduced activity occurred in multiple cortical areas. Additionally, a correlation was found between the alpha band activity of the right secondary visual cortex and the averaged thickness of the right retinal nerve fiber layer in the LHON participants. Our study suggests that LHON is associated with widespread cortical de-activation, rather than simply abnormalities of structures constituting the visual system.

Improved Current Density and Magnetization Reconstruction Through Vector Magnetic Field Measurements

Stray magnetic fields contain significant information about the electronic and magnetic properties of condensed matter systems. For two-dimensional (2D) systems, stray field measurements can even allow full determination of the source quantity. For instance, a 2D map of the stray magnetic field can be uniquely transformed into the 2D current density that gave rise to the field and, under some conditions, into the equivalent 2D magnetisation. However, implementing these transformations typically requires truncation of the initial data and involves singularities that may introduce errors, artefacts, and amplify noise. Here we investigate the possibility of mitigating these issues through vector measurements. For each scenario (current reconstruction and magnetisation reconstruction) the different possible reconstruction pathways are analysed and their performances compared. In particular, we find that the simultaneous measurement of both in-plane components ($B_x$ and $B_y$) enables near-ideal reconstruction of the current density, without singularity or truncation artefacts, which constitutes a significant improvement over reconstruction based on a single component (e.g. $B_z$). On the other hand, for magnetisation reconstruction, a single measurement of the out-of-plane field ($B_z$) is generally the best choice, regardless of the magnetisation direction. We verify these findings experimentally using nitrogen-vacancy magnetometry in the case of a 2D current density and a 2D magnet with perpendicular magnetisation.

Frontal Cortical Modulation of Temporal Visual Cross-Modal Re-organization in Adults with Hearing Loss.

Recent research has demonstrated frontal cortical involvement to co-occur with visual re-organization, suggestive of top-down modulation of cross-modal mechanisms. However, it is unclear whether top-down modulation of visual re-organization takes place in mild hearing loss, or is dependent upon greater degrees of hearing loss severity. Thus, the purpose of this study was to determine if frontal top-down modulation of visual cross-modal re-organization increased across hearing loss severity. We recorded visual evoked potentials (VEPs) in response to apparent motion stimuli in 17 adults with mild-moderate hearing loss using 128-channel high-density electroencephalography (EEG). Current density reconstructions (CDRs) were generated using sLORETA to visualize VEP generators in both groups. VEP latency and amplitude in frontal regions of interest (ROIs) were compared between groups and correlated with auditory behavioral measures. Activation of frontal networks in response to visual stimulation increased across mild to moderate hearing loss, with simultaneous activation of the temporal cortex. In addition, group differences in VEP latency and amplitude correlated with auditory behavioral measures. Overall, these findings support the hypothesis that frontal top-down modulation of visual cross-modal re-organization is dependent upon hearing loss severity.

Sensory Inhibition Is Related to Variable Speech Perception in Noise in Adults With Normal Hearing.

Purpose Speech perception in noise (SPiN) varies widely in individuals with normal hearing, which may be attributed to factors that are not reflected in the audiogram, such as inhibition. However, inhibition is involved at both sensory and cognitive stages of auditory perception, and while inhibition at the cognitive level has been shown to be a significant factor in SPiN processes, it is unknown whether sensory inhibition may also contribute to SPiN variability. Therefore, the goal of this study was to evaluate sensory inhibition in adults with normal hearing and mild SPiN impairment. Method Cortical auditory evoked potentials (CAEPs) were recorded in 49 adults via high-density electroencephalography using an auditory gating paradigm. Participants were categorized according to a median signal-to-noise ratio (SNR) loss of 1.5 dB: typical SNR loss ≤ 1.5 dB (n = 32), mild SNR loss > 1.5 dB (n = 17). CAEP gating responses were compared and correlated with SNR loss and extended high-frequency thresholds. Current density reconstructions were performed to qualitatively observe underlying cortical inhibitory networks in each group. Results In comparison to adults with typical SPiN ability, adults with mild SPiN impairment showed an absence of the gating response. A CAEP gating component (P2) reflected decreased sensory inhibition and correlated with increased SNR loss. Extended high-frequency thresholds were also found to correlate with SNR loss, but not gating function. An atypical cortical inhibitory network was observed in the mild SNR loss group, with reduced frontal and absent prefrontal activation. Conclusion Sensory inhibition appears to be atypical and related to SPiN deficits in adults with mild impairment. In addition, cortical inhibitory networks appear to be incomplete, with a possible compensatory parietal network. Further research is needed to delineate between types or levels of central inhibitory mechanisms and their contribution to SPiN processes.

Evaluating the Performance of Ultra-Low-Field MRI for in-vivo 3D Current Density Imaging of the Human Head

Magnetic fields associated with currents flowing in tissue can be measured non-invasively by means of zero-field-encoded ultra-low-field magnetic resonance imaging (ULF MRI) enabling current density imaging (CDI) and possibly conductivity mapping of human head tissues. Since currents applied to a human are limited by safety regulations and only a small fraction of the current passes through the relatively high-resistive skull, a sufficient signal-to-noise ratio (SNR) may be difficult to obtain when using this method. In this work, we study the relationship between the image SNR and the SNR of the field reconstructions from zero-field-encoded data. We evaluate these results for two existing ULF MRI scanners, one ultra-sensitive single-channel system and one whole-head multi-channel system, by simulating sequences necessary for current-density reconstruction. We also derive realistic current-density and magnetic-field estimates from finite-element-method simulations based on a three-compartment head model. We found that existing ULF-MRI systems reach sufficient SNR to detect intra-cranial current distributions with statistical uncertainty below 10%. However, they also reveal that image artifacts influence the reconstruction quality. Further, our simulations indicate that current-density reconstruction in the scalp requires a resolution less than 5 mm and demonstrate that the necessary sensitivity coverage can be accomplished by multi-channel devices.

Auditory Gating in Hearing Loss

Sensory gating is a measure used to evaluate inhibitory deficits underlying neurological disorders. However, the effects of hearing loss (HL), thought to decrease inhibition, remain unknown on gating function. The goal of this study was to investigate gating performance in HL. This was a prospective, cross-sectional study with independent group comparison and correlational design. Eleven adults (mean age/standard deviation = 47.546 ± 7.967 years) with normal hearing (NH) and 11 adults (mean age/standard deviation = 56.273 ± 13.871 years) with mild-moderate high-frequency HL. Cortical auditory evoked potentials (CAEPs) were recorded in response to tonal pairs via high-density electroencephalography. The CAEP response to the second tone in the pair (S2) was compared with the response to the first tone in the pair (S1) within groups. Amplitude gating indices were compared between groups and correlated with auditory behavioral measures. Current density reconstructions were performed to estimate cortical gating generators. Amplitude gating indices were decreased and correlated with elevated auditory thresholds. Gating generators in temporal, frontal, and prefrontal regions were localized in the NH group, while HL gating was localized in mainly temporal and parietal areas. Reduced inhibition may be associated with compensatory cortical gating networks in HL and should be considered when utilizing gating in clinical populations.

Development and testing of implanted carbon electrodes for electromagnetic field mapping during neuromodulation.

Deep brain stimulation electrodes composed of carbon fibers were tested as a means of administering and imaging magnetic resonance electrical impedance tomography (MREIT) currents. Artifacts and heating properties of custom carbon-fiber deep brain stimulation (DBS) electrodes were compared with those produced with standard DBS electrodes. Electrodes were constructed from multiple strands of 7-μm carbon-fiber stock. The insulated carbon electrodes were matched to DBS electrode diameter and contact areas. Images of DBS and carbon electrodes were collected with and without current flow and were compared in terms of artifact and thermal effects in phantoms or tissue samples in 7T imaging conditions. Effects on magnetic flux density and current density distributions were also assessed. Carbon electrodes produced magnitude artifacts with smaller FWHM values compared to the magnitude artifacts around DBS electrodes in spin echo and gradient echo imaging protocols. DBS electrodes appeared 269% larger than actual size in gradient echo images, in sharp contrast to the negligible artifact observed in diameter-matched carbon electrodes. As expected, larger temperature changes were observed near DBS electrodes during extended RF excitations compared with carbon electrodes in the same phantom. Magnitudes and distribution of magnetic flux density and current density reconstructions were comparable for carbon and DBS electrodes. Carbon electrodes may offer a safer, MR-compatible method for administering neuromodulation currents. Use of carbon-fiber electrodes should allow imaging of structures close to electrodes, potentially allowing better targeting, electrode position revision, and the facilitation of functional imaging near electrodes during neuromodulation.

Focal cortical hypermetabolism in atypical benign rolandic epilepsy

ObjectiveAtypical benign rolandic epilepsy (BRE) is an underrecognized and poorly understood manifestation of a common epileptic syndrome. Most consider it a focal epileptic encephalopathy in which frequent, interictal, centrotemporal spikes lead to negative motor seizures and interfere with motor and sometimes speech and cognitive abilities. We observed focal cortical hypermetabolism on PET in three children with atypical BRE and investigated the spatial and temporal relationship with their centrotemporal spikes. MethodsEEG, MRI and PET were performed clinically in three children with atypical BRE. The frequency and source localization of centrotemporal spikes was determined and compared with the location of maximal metabolic activity on PET. ResultsCortical hypermetabolism on thresholded PET t-maps and current density reconstructions of centrotemporal spikes overlapped in each child, in the central sulcus region, the distances between the "centers of maxima" being 2 cm or less. Hypermetabolism was not due to recent seizures or frequent centrotemporal spikes at the time of FDG uptake. SignificanceThe findings suggest that localized, increased cortical activity, in the region of the EEG focus, underlies the negative clinical manifestations of atypical BRE. Similar findings are reported in the broader group of epileptic encephalopathies associated with electrical status epilepticus in sleep.

Somatosensory Cross-Modal Reorganization in Children With Cochlear Implants

Deprived of sensory input, as in deafness, the brain tends to reorganize. Cross-modal reorganization occurs when cortices associated with deficient sensory modalities are recruited by other, intact senses for processing of the latter’s sensory input. Studies have shown that this type of reorganization may affect outcomes when sensory stimulation is later introduced via intervention devices. One such device is the cochlear implant (CI). Hundreds of thousands of CIs have been fitted on people with hearing impairment worldwide, many of them children. Factors such as age of implantation have proven useful in predicting speech perception outcome with these devices in children. However, a portion of the variance in speech understanding ability remains unexplained. It is possible that the degree of cross-modal reorganization may explain additional variability in listening outcomes. Thus, the current study aimed to examine possible somatosensory cross-modal reorganization of the auditory cortices. To this end we used high density EEG to record cortical responses to vibrotactile stimuli in children with normal hearing (NH) and those with CIs. We first investigated cortical somatosensory evoked potentials (CSEP) in NH children, in order to establish normal patterns of CSEP waveform morphology and sources of cortical activity. We then compared CSEP waveforms and estimations of cortical sources between NH children and those with CIs to assess the degree of somatosensory cross-modal reorganization. Results showed that NH children showed expected patterns of CSEP and current density reconstructions, such that postcentral cortices were activated contralaterally to the side of stimulation. Participants with CIs also showed this pattern of activity. However, in addition, they showed activation of auditory cortical areas in response to somatosensory stimulation. Additionally, certain CSEP waveform components were significantly earlier in the CI group than the children with NH. These results are taken as evidence of cross-modal reorganization by the somatosensory modality in children with CIs. Speech perception in noise scores were negatively associated with CSEP waveform components latencies in the CI group, suggesting that the degree of cross-modal reorganization is related to speech perception outcomes. These findings may have implications for clinical rehabilitation in children with cochlear implants.

Fault Identification on a Fuel Cell by 3-D Current Density Reconstruction From External Magnetic Field Measurements

An original approach of fuel cell diagnosis is presented. It is based on the solving of an inverse linear problem linking the magnetic field signature outside of the fuel cell to the current density distribution inside. The searched solution is a linear combination of conservative current distribution obtained by a set of electrokinetic problems solved by a finite face element method. As the problem is ill-posed, the solution is stabilized using a truncated singular value decomposition. The approach is validated to reconstruct a 3-D current density distribution in a stack simulator and in a fuel cell stack operating in the laboratory conditions.

Application of Whitney elements for the reconstruction of electric arc current density in low-voltage circuit breakers

Purpose This paper aims to present the mathematical formulations of a magnetic inverse problem for the electric arc current density reconstruction in a simplified arc chamber of a low-voltage circuit breaker. Design/methodology/approach Considering that electric arc current density is a zero divergence vector field, the inverse problem can be solved in Whitney space W2 in terms of electric current density J with the zero divergence condition as a constraint or can be solved in Whitney space W1 in terms of electric vector potential T where the zero divergence condition naturally holds. Moreover, the tree gauging condition is applied to ensure a unique solution when solving for the vector potential in space W1. Tikhonov regularization is used to treat the ill-posedness of the inverse problem complemented with L-curve method for the selection of regularization parameters. A common mode approach is proposed, which solves for the reduced electric vector potential representing the internal current loops instead of solving for the total electric vector potential. The proposed inversion approaches are numerically tested starting from simulated magnetic field values. Findings With the common mode approach, the reconstruction of current density is significantly improved for both formulations using face elements in space W2 and using edge elements in space W1. When solving the inverse problem in space W1, the choice of the regularization operator has a key role to obtain a good reconstruction, where the discrete curl operator is a good option. The standard Tikhonov regularization obtains a good reconstruction with J-formulation, but fails in the case of T-formulation. The use of edge elements requires a tree-cotree gauging to ensure the uniqueness of T. Moreover, additional efforts have to be taken to find an optimal regularization operator and an optimal tree when using edge elements. In conclusion, the J-formulation is to be preferred. Originality/value The proposed approaches are able to reconstruct the three-dimensional electric arc current density from its magnetic field in a non-intrusive manner. The formulations enable us to incorporate a priori knowledge of the unknown current density into the solution of the inverse problem, including the zero divergence condition and the boundary conditions. A common mode approach is proposed, which can significantly improve the current density reconstruction.

First-Order Induced Current Density Imaging and Electrical Properties Tomography in MRI

In this paper, we present an efficient dedicated electrical properties tomography (EPT) algorithm (called first-order current density EPT ) that exploits the particular radio frequency field structure, which is present in the midplane of a birdcage coil, to reconstruct conductivity and permittivity maps in this plane from $\hat{B}_1^+$ data. The algorithm consists of a current density and an electrical properties step. In the current density reconstruction step, the induced currents in the midplane are determined by acting with a specific first-order differentiation operator on the $\hat{B}_1^+$ data. In the electrical properties step, we first determine the electric field strength by solving a particular integral equation, and subsequently determine conductivity and permittivity maps from the constitutive relations. The performance of the algorithm is illustrated by presenting reconstructions of a human brain model based on simulated (noise corrupted) data and of a known phantom model based on experimental data. The method manages to reconstruct conductivity profiles without model related boundary artifacts and is also more robust to noise because only first-order differencing of the data is required as opposed to second-order data differencing in Helmholtz-based approaches. Moreover, reconstructions can be performed in less than a second, allowing for essentially real-time electrical properties mapping.

EEG source reconstruction evidence for the noun-verb neural dissociation along semantic dimensions

One of the long-standing issues in neurolinguistic research is about the neural basis of word representation, concerning whether grammatical classification or semantic difference causes the neural dissociation of brain activity patterns when processing different word categories, especially nouns and verbs. To disentangle this puzzle, four orthogonalized word categories in Chinese: unambiguous nouns (UN), unambiguous verbs (UV), ambiguous words with noun-biased semantics (AN), and ambiguous words with verb-biased semantics (AV) were adopted in an auditory task for recording electroencephalographic (EEG) signals from 128 electrodes on the scalps of twenty-two subjects. With the advanced current density reconstruction (CDR) algorithm and the constraint of standardized low-resolution electromagnetic tomography, the spatiotemporal brain dynamics of word processing were explored with the results that in multiple time periods including P1 (60–90ms), N1 (100–140ms), P200 (150–250ms) and N400 (350–450ms), noun–verb dissociation over the parietal-occipital and frontal-central cortices appeared not only between the UN-UV grammatical classes but also between the grammatically identical but semantically different AN-AV pairs. The apparent semantic dissociation within one grammatical class strongly suggests that the semantic difference rather than grammatical classification could be interpreted as the origin of the noun–verb neural dissociation. Our results also revealed that semantic dissociation occurs from an early stage and repeats in multiple phases, thus supporting a functionally hierarchical word processing mechanism.

The Relation between Infant Covert Orienting, Sustained Attention and Brain Activity.

This study used measures of event-related potentials (ERPs) and cortical source analysis to examine the effect of covert orienting and sustained attention on 3- and 4.5-month-old infants' brain activity in a spatial cueing paradigm. Cortical source analysis was conducted with current density reconstruction using realistic head models created from age-appropriate infant MRIs. The validity effect was found in the P1 ERP component that was greater for valid than neutral trials in the electrodes contralateral to the visual targets when the stimulus onset asynchrony (SOA) was short. Cortical source analysis revealed greater current density amplitude around the P1 peak latency in the contralateral inferior occipital and ventral temporal regions for valid than neutral and invalid trials. The processing cost effect was found in the N1 ERP component that was greater for neutral than invalid trials in the short SOA condition. This processing cost effect was also shown in the current density amplitude around the N1 peak latency in the contralateral inferior and middle occipital and middle and superior temporal regions. Infant sustained attention was found to modulate infants' brain responses in covert orienting by enhancing the P1 ERP responses and current density amplitude in their cortical sources during sustained attention. These findings suggest that the neural mechanisms that underpin covert orienting already exist in 3- to 4.5-month-old, and they could be facilitated by infant sustained attention.

Distinct Visual Evoked Potential Morphological Patterns for Apparent Motion Processing in School-Aged Children.

Measures of visual cortical development in children demonstrate high variability and inconsistency throughout the literature. This is partly due to the specificity of the visual system in processing certain features. It may then be advantageous to activate multiple cortical pathways in order to observe maturation of coinciding networks. Visual stimuli eliciting the percept of apparent motion and shape change is designed to simultaneously activate both dorsal and ventral visual streams. However, research has shown that such stimuli also elicit variable visual evoked potential (VEP) morphology in children. The aim of this study was to describe developmental changes in VEPs, including morphological patterns, and underlying visual cortical generators, elicited by apparent motion and shape change in school-aged children. Forty-one typically developing children underwent high-density EEG recordings in response to a continuously morphing, radially modulated, circle-star grating. VEPs were then compared across the age groups of 5–7, 8–10, and 11–15 years according to latency and amplitude. Current density reconstructions (CDR) were performed on VEP data in order to observe activated cortical regions. It was found that two distinct VEP morphological patterns occurred in each age group. However, there were no major developmental differences between the age groups according to each pattern. CDR further demonstrated consistent visual generators across age and pattern. These results describe two novel VEP morphological patterns in typically developing children, but with similar underlying cortical sources. The importance of these morphological patterns is discussed in terms of future studies and the investigation of a relationship to visual cognitive performance.