Current Art Research Articles

P-534. Similar Efficacy, Safety and CD4 T-cell Increase up to Week 96 Observed with Fostemsavir (FTR)-Based Regimens in the BRIGHTE Study and Dolutegravir (DTG)-Based Regimens in the VIKING-3 Study in Individuals with Multidrug-Resistant (MDR) HIV-1

Abstract Background Constructing suppressive regimens in individuals with MDR HIV-1 can be challenging. We assessed populations with limited ART options in the BRIGHTE study using FTR-based regimens and the VIKING-3 study using DTG-based regimens. Methods BRIGHTE was a phase 3 study (N=371; Randomized Cohort [RC], n=272; Non-randomized Cohort, n=99) in adults failing current ART (HIV-1 RNA > 400 c/mL) with ≤ 2 fully active approved ARVs. Participants (pts) with 1 or 2 active ARVs entered the RC and received open-label FTR + optimized background therapy (OBT) after an 8-day blinded placebo-controlled period. In the RC, the most common agent in initial OBT was DTG (84%), with 64% taking it twice daily (BID). VIKING-3 (n=183) was a single-arm open-label phase 3 study in adults with INI-resistant virus receiving DTG 50 mg BID + failing regimen (without raltegravir or elvitegravir) through Day 7, then the regimen was optimized with ≥ 1 fully active ARV and DTG continued. Virologic and immunologic response was analyzed by baseline (BL) demographics and characteristics. Results BRIGHTE pts were male (n=290, 78%), median age 48 years and White (n=259, 70%). Observed antiviral response in the RC was 81% (< 40 c/mL, n=128) and 88% (< 400 c/mL, n=140). Mean CD4 increase from BL was 204.7 cells/mm3, with BL mean CD4 count 152.5 cells/mm3. VIKING-3 pts were male (n=141, 77%), median age 48 years and 71% (n=130) White. Antiviral response observed in VIKING-3 was 84% (< 50 c/mL, n=101) and 93% (< 400 c/mL, n=111). Mean CD4 increase was 192 cells/mm3, with BL mean CD4 count 202 cells/mm3. Safety across study populations was as follows: BRIGHTE (RC), n=92 (34%) serious adverse events (AEs), n=57 (21%) drug-related AEs and n=7 (3%) AEs leading to withdrawal; VIKING-3, n=60 (33%) serious AEs, n=52 (28%) drug-related AEs and n=8 (4%) AEs leading to withdrawal. Conclusion Despite limited ARV options in individuals with MDR HIV-1, data demonstrate that over 96 weeks both DTG (BID) and FTR-based regimens provide robust viral suppression and CD4 T-cell improvement. Although differences in BL characteristics exist, immunosuppression was more profound in BRIGHTE pts. FTR and DTG were commonly used together in BRIGHTE, engaging different mechanisms of action. Data provide further support for effective ARVs for individuals living with MDR HIV-1. Disclosures Antonella Castagna, MD, Bristol-Myers Squibb: Advisor/Consultant|Gilead Sciences, Inc.: Advisor/Consultant|Gilead Sciences, Inc.: Grant/Research Support|Gilead Sciences, Inc.: Honoraria|Janssen: Advisor/Consultant|Janssen: Grant/Research Support|Janssen: Honoraria|Merck Sharp & Dohme: Advisor/Consultant|Merck Sharp & Dohme: Grant/Research Support|Merck Sharp & Dohme: Honoraria|ViiV Healthcare: Advisor/Consultant|ViiV Healthcare: Grant/Research Support|ViiV Healthcare: Honoraria Natalia Gregori, MD, GSK: Stocks/Bonds (Public Company)|ViiV Healthcare: employee Iacopo Marcon, PhD, GSK: Stocks/Bonds (Public Company)|ViiV Healthcare: employee Fangfang Du, MS in Statistics, GSK: Employee|GSK: Stocks/Bonds (Public Company) Bo Li, PhD, GSK: Employee Marcia Wang, PhD, GSK: Employee|GSK: Stocks/Bonds (Public Company) Alftan Dyson, PharmD, GSK: Stocks/Bonds (Public Company)|ViiV Healthcare: Employee Clifford B. Jones, BSc MSc MB ChB, GSK: Stocks/Bonds (Public Company)|ViiV Healthcare: Employee Manyu Prakash, PhD, GSK: Stocks/Bonds (Public Company)|ViiV Healthcare: employee Andrew Clark, MD, GSK: Stocks/Bonds (Public Company)|ViiV Healthcare: employee

Encountering the Obsolete Art: An Archaeological Gaze at the Contemporary Textile Tradition in India

Art is an essential glimpse into the history of humanity because it is often one of the few things to survive. It is a medium to express one’s feelings, which can tell us stories and relate the modes and beliefs of an era. Prehistoric art represents various aspects of the everyday life of early humans, including a diverse range of symbols and signs in multiple patterns. The present article explores how these ancient motifs can serve as the basis for decorating schemes for designers in the present fashion-oriented world. The modern generation is attracted to this pattern, and we have observed some novel design inventories that mimicked this type of artwork on their accessories. This article mainly analyses the contemporary fashion design trend in the last half-decade, which suggests the revival of such obsolete artwork in India. By correlating the past and present design motifs, the encounter of a common aesthetic sense emerged in this article, which shows a continuous artistic legacy from the yore to the present day. For this, the morphological analysis and comparative study of some current and ancient art motifs are also done. Although prehistoric art provides endless inspiration for designs as well as new ideas for art composition, we discuss the new avenues of inspiration in textiles using technology as well. Contemporary designers are also influenced by these fantastic artworks of our ancestors. So, it is necessary to show glimpses of the ancient art of India in modern fashion trends, which suggests innovation in designing practices inspired by the past.

창의성과 상상력 교육으로서 미술교육의 방향성

In this contemporary era, new perceptions and discussions are needed in all fields to look at the problems surrounding art, I believe, discussions on creativity and imagination are necessary above all else. If we look at art from the perspective of today, what is art can be defined? This can be dealt with focusing on questions such as what is the meaning of creativity and how creativity and imagination in art relate to education. This study deals with creativity in art education, especially in expression activities, focusing on the relationship with imagination. In order to explore the educational meaning of art that distinguishes art from other areas, especially when looking at the perspective of creativity in expression activities, it first requires a sense of purpose, that is, the ability to raise problems. It must also be conscious as a process of exploring and activities for material. And as a visualization of artistic illusion, it is necessary to be aware of the spatial ability to perceive the visual and spatial world with cognition and emotions, experiences and memories. as thinking ability to create abstract things such as visual and spatial ideas. As a perspective of creativity education, discussions and direction of art education should be raised in order to the current school art education.

Heavily treatment-experienced patients with HIV: are new mechanisms of action enough?

Antiretroviral (ARV) drug resistance poses a threat to ending the HIV epidemic. As the rates of integrase resistance continue to increase globally, the availability of options for HIV treatment becomes limited. Heavily treatment-experienced (HTE) people with HIV (PWH) are limited to two or fewer available fully active ARV classes and are more likely to have an AIDS-defining event. Appropriate identification and management of HTE PWH is crucial to improving patient outcomes and reducing the future spread of drug-resistant HIV. As treatment options become more limited owing to drug resistance, the availability of more potent drugs with a marked increase in virologic suppression is needed in the current ART era. The purpose of this narrative review is to review the identification of HTE PWH, novel mechanisms of resistance, and management of HTE PWH in resource-rich and resource-limited settings using novel ARVs and combination ART.

Clear enigmas and hidden meanings: the perpetuum mobile of the ‘machine of the world’ motif in recent interartistic activity in Brazil

Out of its European Renaissance origins in the writings of Dante and Camões, the metaphor of the machina mundi first came to the fore in Brazilian literature in the canonical poem by Carlos Drummond de Andrade: the quintessential work of Brazilian modernism in its broadest sense, “A Máquina do Mundo”. The aim of this article is to explore the multiple, shifting possibilities inherent in the complex literary-cultural motif of the ‘machine of the world’ in current Brazilian art and literature. The text begins by looking at the comic epic poem Por mares nunca dantes by Geraldo Carneiro, before focusing on the different creative practices and appropriations of a series of paradigmatic variations on the theme from the opening decades of the 21st century: hybridity and interdisciplinarity in the poems A máquina do mundo repensada by Haroldo de Campos and “A quarta parede” by Marco Lucchesi; and interartistic intersectionality and creative duality in Laura Vinci’s verbal-visual sculptural installation “A máquina do mundo”, and Nuno Ramos’s photo-illustrated poetry collection Junco. The aim of this exploration is to interpret each of the works within the discursive historical-cultural context of the motif, and to analyse critically its presence in these rewritten and reconceptualised forms.

Adaptive classification of artistic images using multi-scale convolutional neural networks.

The current art image classification methods have low recall and accuracy rate issues . To improve the classification performance of art images, a new adaptive classification method is designed employing multi-scale convolutional neural networks (CNNs). Firstly, the multi-scale Retinex algorithm with color recovery is used to complete the enhancement processing of art images. Then the extreme pixel ratio is utilized to evaluate the image quality and obtain the art image that can be analyzed. Afterward, edge detection technology is implemented to extract the key features in the image and use them as initial values of the item to be trained in the classification model. Finally, a multi-scale convolutional neural network (CNN) is constructed by using extended convolutions, and the characteristics of each level network are set. The decision fusion method based on maximum output probability is employed to calculate different subclassifies' probabilities and determine the final category of an input image to realize the art image adaptive classification. The experimental results show that the proposed method can effectively improve the recall rate and precision rate of art images and obtain reliable image classification results.

Comparative analysis of art therapy in education: China vs. foreign countries using CiteSpace

Comparative research on art therapy in education is limited, both in China and internationally. This study examines the potential of art therapy to transform art education, focusing on improving students' physical and mental health and aesthetic abilities, both in China and other countries. This study provides a comprehensive comparative analysis of art therapy in education within a visual context. Using bibliometric analysis of publications from the CNKI and WOS databases over the past 20 years, and the CiteSpace visualization tool, research hotspots and frontiers in art therapy within education were identified. Clustering research topics were explored, and the influence of art therapy on current art education was discussed. The study also predicts the future development trend of art therapy in both Chinese and international art education. Bibliometric analysis of CNKI and WOS databases, coupled with the CiteSpace visualization tool, facilitated the identification of key nodes in the keyword network, highlighting research hotspots and frontiers. The development of art therapy has shown an upward trend over the past two decades, particularly in the last ten years. Comparative analysis revealed ongoing progress of art therapy in both China and other countries, with untapped potential in China. Future trends indicate a complex upward trajectory, emphasizing the integration of localized art therapy methods and educational approaches. This comparative research paper explores art therapy in education, focusing on its potential to improve physical and mental health, as well as aesthetic abilities, in students from China and other countries. Using bibliometric analysis and the CiteSpace visualization tool, research hotspots and frontiers in art therapy within education were identified. The findings reveal a growing trend in art therapy over the past two decades, particularly in China. The study highlights untapped potential and predicts a complex upward trajectory, emphasizing the integration of localized art therapy methods and educational approaches. These insights contribute to the advancement of art education practices in China and internationally, underscoring the need for further exploration and integration of art therapy methods.

Seeing is believing: An Augmented Reality application for Palaeolithic rock art

By developing new recording methodologies, current rock art studies generate a large amount of graphic information about sites (tracings, photographs, three-dimensional reproductions) providing visibility of this fragile and little-known heritage, whose accessibility is often difficult or impossible for the general public. In addition, many rock art depictions are challenging to observe, due to the very nature of the artistic entities (fine engravings or faded paintings in karst environments or open-air sites with poor or changing light conditions), or to conservation problems derived from natural factors such as erosion and geological and biological processes, as well as from anthropic factors. These conditions make rock art depictions nearly indistinguishable in many places and on many objects today, except for experts. This difficulty of accessing and visualising rock art heritage, located in fragile environments and often challenging places such as caves or difficult-to-reach open-air sites, makes the information and knowledge generated by investigation of this heritage asset difficult to transfer to society in general, which is frequently unaware of the priceless value of this heritage. The present study proposes generating several mechanisms to transfer the results of research, restitution and documentation of rock art to society in general. An AR (Augmented Reality) application has been developed using LiDAR (Light Detection and Ranging) technology to address current challenges in implementing AR technologies in low-light environments. So far, this app has been developed in a Proof-of-Concept project at Spanish archaeological sites such as Hornos de la Peña (Cantabria), Domingo García (Segovia) and La Salud (Salamanca). This application will be particularly interesting for sites currently visited with or without a guide, allowing user interactivity and real-time reconstruction, for example, of the visibility of graphic motifs.

Review of Research on New Media Art in China from 2003 to 2022 - A Bibliometric Analysis Based on CiteSpace

With the enrichment of digital technology, new media art has become a hot topic in the current art field. However, the academic field lacks a comprehensive discussion on the development trend of new media art in China. To gain a clearer understanding of the development process of Chinese New Media Art, this research adopts the method of bibliometrics combined with CiteSpace Knowledge Map visualization software. Using 550 articles from the CSSCI Database for visualization knowledge map presentation, data analysis is conducted on the number of annual publications, academic institutions and authors, and bursting keywords. This presents the development history, evolution of hotspots, and future trends of Chinese New Media Art. The research found that the number of annual publications of Chinese new media art can be divided into four stages: slow growth from 2003 to 2006, rapid growth from 2007 to 2010, slow increase from 2011 to 2017, and fluctuating development from 2017 to 2022. Secondly, there is a low density of cooperation between authors and academic institutions, and no clear academic groups have been formed, with academic institutions mainly located in economically developed first-tier cities. It is predicted that "Virtual Reality, Artificial Intelligence, and Human-Computer Interaction" will become the future development directions of Chinese new media art research. It is hoped that this research can provide theoretical reference and data support for the future development of New Media Art in China.

Care ethics and contemporary art: Imagining and practising care

Feminist care ethicshas for some time guided contemporary artists and curators in their search for sustaining and sustainable practices in the current neoliberal backwash and climate crisis. With a focus on current Australian art in the context of recent care ethics scholarship, this article considers what contemporary art – in its processes as well as aesthetic outcomes – can offer in imagining and practising care for the human and more-than-human world. The article focuses on a series of exhibitions that comprised a key exploratory methodology of The Care Project: Feminism and art in neoliberal times (La Trobe University, 2019–2022). The exhibitions featured the work of regionally based artists. This accent on creative practices emerging from the experience of living in regional communities that are often on the frontline of climate change and social inequality offers unique perspectives on care ethics in practice.

P-114 The timing from post-insemination to blastocyst vitrification correlates with ploidy and gender

Abstract Study question Which morphology parameter of blastocysts has the strongest correlation with the euploid rate? Summary answer The vitrification times post-insemination and trophectoderm grade (TE) are more predictive parameters for euploid blastocysts, and female blastocysts require less time for vitrification. What is known already In current ART, the use of preimplantation genetic tests for aneuploidy (PGT-A) has increased by 2 to 25 percent in different countries. PGT-A analyses have helped patients achieve an increased pregnancy rate, choose the gender of the embryo and prevent miscarriages. Moreover, the potential for blastocyst euploid is strongly correlated with the developmental speed and morphology grades. However, for patients without PGT-A, the criteria for selecting transferred blastocysts are mostly based on morphology and the day of the blastocyst. Therefore, it is essential to clarify which parameter is more predictive of euploid embryos during elective FET cycles. Study design, size, duration This retrospective analysis included 713 blastocysts from 417 patients treated at the Ojinmed IVF Center, Mongolia, between May 2019 and June 2023. The morphology parameters (morphology grade, blastocyst formation time, vitrification time and inner diameter) were compared between the PGT-A results and the control results. Blastocyst quality was evaluated with the Gardner and Schoolcraft grading system, and the inner diameter of the blastocyst was measured. Participants/materials, setting, methods All patients underwent a clomiphene-based minimal ovarian stimulation protocol or drug-free natural cycle of IVF treatment. When the blastocyst diameter exceeded 160 μm, a trophectoderm (TE) biopsy was taken, and the blastocyst was immediately vitrified using the Cryotop method. The time of vitrification and formation of the blastocyst were recorded from the insemination. The patients were analyzed using high-resolution NGS PGT-A (10 Mb resolution for copy number variations and 30%-70% for mosaicism). Main results and the role of chance The PGT-A analysis reported euploid, aneuploid, and mosaic rates. Euploid, aneuploid, and mosaic rates were significantly correlated with blastocyst formation time (114.78 ± 4.49 h, 116.12 ± 6.42 h and 116.33 ± 6.87 h, p = 0.003) and vitrification blastocyst time (126.65 ± 9.8 h, 131.57 ± 10.8 h and 130.44 ± 11.19 h, p < 0.001), along with women’s age (34.9 ± 4.32, 38.14 ± 3.77, and 35.84 ± 4.5, p < 0.001). In logistic regression analysis, aneuploid rates were significantly lower in blastocysts with A and B grade of ICM (OR 0.36, CI 95% 0.24-0.32, p < 0.01 and OR 0.45, CI 95% 0.32-0.63, p < 0.01) and A and B grade of TE (OR 0.20, CI 95% 0.11-0.37, p < 0.01 and OR 0.20, CI 95% 0.25-0.48, p < 0.01) compared to C grades, respectively. The AUCs for prediction of euploid were maternal age 0.66 (95% CI 0.62-0.70), TE grade 0.64 (95% CI 0.57-0.64), blastocyst vitrification time 0.62 (95% CI 0.58-0.66), ICM grade 0.60 (95% CI 0.61-0.68), blastocyst formation time 0.55 (95% CI 0.51-0.59) and inner diameter 0.46 (95% CI 0.42-0.5). Although blastocyst vitrification time is correlated with blastocyst gender (female blastocyst 127.9 ± 10.25h vs male blastocyst 129.68 ± 10.84h, p = 0.02). Limitations, reasons for caution The results of the retrospective study are limited to data from a single IVF center and conventional incubators were used in this study. Wider implications of the findings These findings might help non PGT-A patients in deciding on embryo selection for transfer. The vitrification time and TE grade of blastocysts are strongly correlated with euploid rate than the ICM, inner diameter and formation time. Also, female blastocysts take less time to vitrification time than male blastocysts. Trial registration number *

미디어아트 전시에 대한 이용자 경험에 대한 연구

This study was designed to determine how the general public understands and accepts media art, which has recently emerged. Accordingly, this study conducted a survey to determine the level of awareness of the general public regarding current media art. Although there are various technical methodologies for practically implementing media art, it was confirmed that only a small number of production methods are accepted by the general public. In addition, media art-related exhibitions to be promoted in Korea are likely to have many popular themes that can be viewed with companions such as family and acquaintances, and the government, companies, and local governments can attract large-scale response or interest in specific events. The possibility of it being implemented in a certain way is also high. In this process, it is also believed that there is a high possibility that directing techniques that are easy to implement in a large format will be selectively selected. In this situation, it is judged that policy supplementation is necessary to ensure continuous development and diversity in the media arts field.

Genetic Variations in EIF2AK3 are Associated with Neurocognitive Impairment in People Living with HIV

Based on emerging evidence on the role for specific single-nucleotide variants (SNVs) in EIF2AK3 encoding the integrated stress response kinase PERK, in neurodegeneration, we assessed the association of EIF2AK3 SNVs with neurocognitive performance in people with HIV (PWH) using a candidate gene approach. This retrospective study included the CHARTER cohort participants, excluding those with severe neuropsychiatric comorbidities. Genome-wide data previously obtained for 1047 participants and targeted sequencing of 992 participants with available genomic DNA were utilized to interrogate the association of three noncoding and three coding EIF2AK3 SNVs with the continuous global deficit score (GDS) and global neurocognitive impairment (NCI; GDS ≥ 0.5) using univariable and multivariable methods, with demographic, disease-associated, and treatment characteristics as covariates. The cohort characteristics were as follows: median age, 43.1 years; females, 22.8%; European ancestry, 41%; median CD4 + T cell counts, 175/µL (nadir) and 428/µL (current). At first assessment, 70.5% used ART and 68.3% of these had plasma HIV RNA levels ≤ 200 copies/mL. All three noncoding EIF2AK3 SNVs were associated with GDS and NCI (all p < 0.05). Additionally, 30.9%, 30.9%, and 41.2% of participants had at least one risk allele for the coding SNVs rs1805165 (G), rs867529 (G), and rs13045 (A), respectively. Homozygosity for all three coding SNVs was associated with significantly worse GDS (p < 0.001) and more NCI (p < 0.001). By multivariable analysis, the rs13045 A risk allele, current ART use, and Beck Depression Inventory-II value > 13 were independently associated with GDS and NCI (p < 0.001) whereas the other two coding SNVs did not significantly correlate with GDS or NCI after including rs13045 in the model. The coding EIF2AK3 SNVs were associated with worse performance in executive functioning, motor functioning, learning, and verbal fluency. Coding and non-coding SNVs of EIF2AK3 were associated with global NC and domain-specific performance. The effects were small-to-medium in size but present in multivariable analyses, raising the possibility of specific SNVs in EIF2AK3 as an important component of genetic vulnerability to neurocognitive complications in PWH.Graphical

Resistance Mutation Patterns among HIV-1-Infected Children and Features of the Program for Prevention of Mother-to-Child Transmission in Vietnam's Central Highlands and Southern Regions, 2017-2021.

The Vietnam Ministry of Health (MOH) has intensified efforts in its aim to eliminate AIDS by 2030. Expanding the program for prevention of mother-to-child transmission (PMTCT) is a significant step towards achieving this goal. However, there are still HIV-exposed children who do not have access to PMTCT services, and some who have participated in the program but still contracted HIV. This study focused on assessing the prevalence and profile of HIV mutations among children under 18 months of age who had recently tested positive for HIV, while gaining insights into the implementation of early infant diagnostic (EID) tests. Between 2017 and 2021, 3.43% of 5854 collected dry blood spot (DBS) specimens from Vietnam's Central and Southern regions showed positive EID results. This study identified a high prevalence of resistance mutations in children, totaling 62.9% (95% CI: 53.5-72.3). The highest prevalence of mutations was observed for NNRTIs, with 57.1% (95% CI: 47.5-66.8). Common mutations included Y181C and K103N (NNRTI resistance), M184I/V (NRTI resistance), and no major mutations for PI. The percentage of children with any resistance mutation was significantly higher among those who received PMTCT interventions (69.2%; 95% CI: 50.5-92.6%) compared with those without PMTCT (45.0%; 95% CI: 26.7-71.1%) with χ2 = 6.06, p = 0.0138, and OR = 2.75 (95% CI: 1.13-6.74). Mutation profiles revealed that polymorphic mutations could be present regardless of whether PMTCT interventions were implemented or not. However, non-polymorphic drug resistance mutations were predominantly observed in children who received PMTCT measures. Regarding PMTCT program characteristics, this study highlights the issue of late access to HIV testing for both mothers and their infected children. Statistical differences were observed between PMTCT and non-PMTCT children. The proportion of late detection of HIV infection and breastfeeding rates were significantly higher among non-PMTCT children (p < 0.05). Comparative analysis between children with low viral load (≤200 copies/mL) and high viral load (>200 copies/mL) showed significant differences between the mothers' current ART regimens (p = 0.029) and the ARV prophylaxis regimen for children (p = 0.016). These findings emphasize the need for comprehensive surveillance to assess the effectiveness of the PMTCT program, including potential transmission of HIV drug-resistance mutations from mothers to children in Vietnam.

Cardiometabolic Differences in People Living with HIV Receiving Integrase Strand Transfer Inhibitors Compared to Non-nucleoside Reverse Transcriptase Inhibitors: Implications for Current ART Strategies.

In people living with HIV (PLHIV), integrase strand transfer inhibitors (INSTIs) are part of the first-line combination antiretroviral therapy (cART), while non-nucleoside reverse transcriptase inhibitor (NNRTI)-based regimens are alternatives. Distinct cART regimens may variably influence the risk for non-AIDS comorbidities. We aimed to compare the metabolome and lipidome of INSTI and NNRTI-based regimens. The 2000HIV study includes asymptomatic PLHIV (n = 1646) on long-term cART, separated into a discovery cohort with 730 INSTI and 617 NNRTI users, and a validation cohort encompassing 209 INSTI and 90 NNRTI users. Baseline plasma samples from INSTI and NNRTI users were compared using mass spectrometry-based untargeted metabolomic (n = 500) analysis. Perturbed metabolic pathways were identified using MetaboAnalyst software. Subsequently, nuclear magnetic resonance spectroscopy was used for targeted lipoprotein and lipid (n = 141) analysis. Metabolome homogeneity was observed between the different types of INSTI and NNRTI. In contrast, higher and lower levels of 59 and 45 metabolites, respectively, were found in the INSTI group compared to NNRTI users, of which 77.9% (81/104) had consistent directionality in the validation cohort. Annotated metabolites belonged mainly to 'lipid and lipid-like molecules', 'organic acids and derivatives' and 'organoheterocyclic compounds'. In pathway analysis, perturbed 'vitamin B1 (thiamin) metabolism', 'de novo fatty acid biosynthesis', 'bile acid biosynthesis' and 'pentose phosphate pathway' were detected, among others. Lipoprotein and lipid levels in NNRTIs were heterogeneous and could not be compared as a group. INSTIs compared to individual NNRTI types showed that HDL cholesterol was lower in INSTIs compared to nevirapine but higher in INSTIs compared to doravirine. In addition, LDL size was lower in INSTIs and nevirapine compared to doravirine. NNRTIs show more heterogeneous cardiometabolic effects than INSTIs, which hampers the comparison between these two classes of drugs. Targeted lipoproteomic and lipid NMR spectroscopy showed that INSTI use was associated with a more unfavorable lipid profile compared to nevirapine, which was shifted to a more favorable profile for INSTI when substituting nevirapine for doravirine, with evidently higher fold changes. The cardiovascular disease risk profile seems more favorable in INSTIs compared to NNRTIs in untargeted metabolomic analysis using mass-spectrometry.

Trends in the development of institutions and forms of artistic communication in modern St. Petersburg

The subject of the study is the works of contemporary St. Petersburg artists of different generations and creative trends, as well as the forms and features of their communication with each other and with the general as well as professional public. The trends of artistic communication in the city are determined by the activities of such institutions as art and non-art museums, art galleries and exhibition centers, which are a classic form of presentation of contemporary art; alternative venues such as creative spaces and art clusters. The field of attention also includes the attraction of St. Petersburg authors to the organization of small artistic associations, mainly art groups, for example, "Unconquered", "North-7", "Parasites", etc. In addition to works of art, theoretical works and reflections by researchers of contemporary art in St. Petersburg and the spaces of its public presentation are involved. The methodological basis is the analysis of the works of St. Petersburg masters of the beginning of the XXI century in the context of the development of urban institutions of artistic communication. The research is based on theoretical works devoted to the problem of artistic communication and trends in the current art process. Comparative-interpretative and typological methods are used to compare the works of artists and forms of artistic communication. The problem of artistic communication in the field of fine art in St. Petersburg is becoming the subject of a separate study. This area of city life is currently developing quite dynamically, as new art associations, curatorial practices and alternative classical platforms for the presentation of the work of authors belonging to different generations and art movements are emerging. Traditional museums and galleries, as well as creative spaces, art clusters and other often non-core institutions, such as libraries and cafes, are involved in this process. Against this background, the features of St. Petersburg artistic communication crystallize, which is characterized by a desire to organize communities, to fuse realistic traditions and current trends, to escapism and symbolism, as well as an interest in oriental themes and stylistics.

The Application Strategy of Graphic Combination in Primary Art Teaching

Graphic teaching is a teaching mode that guides teachers to combine images and words in the course of teaching. This teaching mode enables art teachers to explain the course content to students in a more intuitive way, deepen their understanding of what they have learned, and promote the improvement of art level and aesthetic ability. At the same time, it also helps to cultivate students' good study habits and achieve their all-round development. After consulting that no matter which version of the current primary school art textbooks are composed of text and picture typesetting. They complement each other and are closely linked to guide the learners. This is enough to explain an important feature of the combination of pictures and texts in art teaching, that is, teachers should pay attention to the combination of pictures and texts in teaching, especially in PPT courseware, and try to avoid all words or only pictures. This paper will discuss the essay and drawing diary and the combination of illustration and text in the form of graphic combination. This paper demonstrates the significance of graphic combination to the primary school art teaching and puts forward the application strategy of graphic combination in the primary school art teaching. Finally, the importance of graphic combination teaching to the overall development of students and the cultivation of social talents is emphasized again.

The art of Making Public: Mapping Networks of Art Mediation

ABSTRACT Current art mediation practices often show experimental forms of relating “art” and “public” and are navigating in non-linear ways at the intersection of art and education. In this paper we explore what these contemporary forms of art mediation may mean, both from a theoretical and from a practice-research perspective. We describe how the “educational turn in the arts’ facilitated unconventional and experimental art mediation practices: artists included educational practices more evidently as part of their artwork and education practices were more and more seen as spaces for critical cultural practice. But what do these contemporary art mediation processes mean in terms of engaged pedagogies and politics? How can we understand their positioning in the relation between culture and democracy? We propose an engaged research approach—“soft cartography”—to map practices of art mediation in urban networks. In this article we elaborate this research agenda in the case of Park Poétik, a Belgian example of art mediation practice. A soft cartography does not imply an exhaustive, objective mapping that nails down places, but rather investigates subjective motives and cultural dynamics and thereby starts from the perspectives of artists, mediators and citizens involved. This research approach allows us to explore how we can describe art mediation as public practices; as an enactment of a concern for “publicness” or an achievement of human togetherness in plurality. Finally we distillate a number of principles for soft cartography as an engaged research approach to map networks of art mediation.

Compliance of New Media Art Course in Chinese Middle School

Since the 21st century, with the rapid rise of the Internet, a variety of new media continue to appear, especially the rise of network media and electronic equipment, which has brought great changes to human information dissemination and communication, and made mankind enter a new era of information dissemination. In this era, in addition to using computers as a tool for art creation, art educators began to study the application of new media such as computers and networks in art classroom and teaching practice.In order to adapt to the development trend of international art education, China has added the content of new media art education in art curriculum standards, middle school art textbooks and middle school art courses. However, compared with the developed countries in the world, the current middle school new media art education in China generally has some problems, such as low attention, limited teaching content, lack of teacher training courses and so on. These problems have seriously affected the development of middle school new media art curriculum and teaching in China.Since the 2022 version of the art curriculum standard clearly puts forward the content of the new media art curriculum, the focus of this paper is how schools and teachers adapt to the curriculum standard and solve the difficulties encountered in the implementation of the new media art curriculum standard.

Lettering as an Artistic Activity to Integrate English Creative Learning with Hands-On Activity

The English language is challenging. Learning material is in its current state, and sometimes does not promote creativity. Students are looking for fun ways to learn the language. Lettering is one of current art activities that provides both creativity and fun. Applying lettering to the English language requires a module, to make it work. Keyword: English creative learning