Current Applications Research Articles

Variations in isoprenoid tetraether lipids through the water column of the Western Pacific Ocean: Implications for sedimentary TEX86 records

The TetraEther indeX of 86 carbon atoms (TEX86) is widely used as a proxy to reconstruct past sea surface temperatures. Most current applications of TEX86 are primarily based on analyzing the composition of isoprenoid glycerol dialkyl glycerol tetraethers (isoGDGTs) that comprise TEX86 in sediments, with the assumption that the sedimentary isoGDGTs are mainly derived from the surface mixed layer. Here we report on the variations in the isoGDGT distribution, archaeal abundance and community through the water column of the Western Pacific Ocean, directly testing the export depth of isoGDGTs and constraining the temperature records of TEX86. Our data show that maximum isoGDGT concentrations occurred in subsurface waters (150–200 m) with maximum archaeal abundances. The ratio between isoGDGTs bearing 2 vs. 3 cyclopentane moieties, i.e. [2/3] ratio, increased with depth, which is likely related to the shift of the archaeal community from Ca. Nitrosopelagicus-dominance to norank_f__Nitrosopumilaceae-dominance. Models based on the [2/3] ratios in the water column predicted an average export depth of isoGDGTs to sediments of around 150–200 m, consistent with the robust relationship between the compiled sedimentary TEX86 and the annual mean subsurface temperature. Taken together, our findings support that TEX86 records subsurface rather than surface temperatures in the open ocean.

Guideline-directed medical therapy in heart failure patients with reduced ejection fraction in Palestine: Retrospective clinical audit study

ObjectivesTo assess the characteristics of patients with heart failure with reduced ejection fraction (HFrEF) and heart failure with mid-range ejection fraction (HFmrEF), as well as the current application of guideline-directed medical therapy (GDMT) in Palestine. MethodsThis retrospective cohort study involved a population of heart failure (HF) patients who visited cardiology clinics at An-Najah National University Hospital and the National Hospital, Palestine. The primary outcome measures of interest were the proportions of patients prescribed guideline-based cardiovascular medications (GBCMs), such as angiotensin-converting enzyme inhibitors (ACEIs)/angiotensin II receptor blockers (ARBs), β-blockers, and mineralocorticoid receptor antagonists (MRAs), and the corresponding optimized doses at ≥ 50 % of targets and the reasons underlying the non-prescription of GDMT. ResultsA total of 70.5%, 56.6%, and 88.6% of patients were on ACEIs/ARBs, MRAs, and β-blockers, respectively. Of all patients, 38.7% were on the triple GDMT regimen. ConclusionLess than half the patients received the triple combination treatment. Age, diabetes mellitus, chronic renal disease, and admission to the hospital for HF all had significant independent relationships with the reduced utilization and inadequate dosage of GDMT.

Current clinical applications of Cerenkov luminescence for intraoperative molecular imaging.

Cerenkov luminescence imaging (CLI) is a new emerging technology that can be used for optical imaging ofapproved radiotracers, both in a preclinical, and even more recently, in a clinical context with rapid imaging times,low costs, and detection in real-time (Grootendorst et al. Clin Transl Imaging 4(5):353-66, 2016); Wang et al.Photonics 9(6):390, 2022). This brief review provides an overview of clinical applications of CLI with a focuson intraoperative margin assessment (IMA) to address shortcomings and provide insight for future work in thisapplication. A literature review was performed using PubMed using the search words Cerenkov luminescence imaging (CLI),intraoperative margin assessment (IMA), and image-guided surgery. Articles were selected based on title, abstract,content, and application. Original research was summarized to examine advantages and limitations of CLI compared to other modalities forIMA. The characteristics of Cerenkov luminescence (CL) are defined, and results from relevant clinical trials arediscussed. Prospects of ongoing clinical trials are reviewed, along with technological advancements related to CLI. CLI is a proven method for molecular imaging and shows feasibility for determining intraoperative margins if futurework involves establishing quantitative approaches for attenuation and scattering, depth analysis, and radiationsafety for CLI at a larger scale.

Research on the Decision-Making Method for the Passive Design Parameters of Zero Energy Houses in Severe Cold Regions Based on Decision Trees

As the field of zero energy building design and research continues to progress, the use of data analysis methods is on the rise. These methods are applied to create assessment criteria, compare performance, and aid in design decision making. Decision trees, as a data-driven approach, offer interpretability and predictability, assisting designers in summarizing their design experience and serving as a foundation for design references. However, the current application of decision tree methods in the zero energy house sector primarily focuses on HVAC systems, lacking a comprehensive exploration from an architectural design perspective. Therefore, this study presents an empirical method for building and applying models based on decision trees, using zero energy house cases in severely cold regions of China as samples. Through an analysis of the interactions among various passive design parameters and the use of EnergyPlus for performance simulations, a decision tree model is established. This model aids in determining the recommended combinations of passive design parameters that meet the criteria of low energy consumption. Moreover, feature weighting highlights the most influential passive design parameters on building energy consumption, including the length of the architectural gestalt plane, the roof shape, and the ground thermal resistance. This research provides valuable methods and guidance for the design and construction of zero energy houses in severely cold regions of China.

Clinical Applications of "In-Hospital" 3D Printing in Hip Surgery: A Systematic Narrative Review.

Introduction: Interest in 3D printing for orthopedic surgery has been increasing since its progressive adoption in most of the hospitals around the world. The aim of the study is to describe all the current applications of 3D printing in patients undergoing hip surgery of any type at the present time. Materials and Methods: We conducted a systematic narrative review of publications indexed in MedLine through the search engine PubMed, with the following parameters: 3D printing AND (orthopedics OR traumatology) NOT tissue engineering NOT scaffold NOT in vitro and deadline 31 July 2023. After reading the abstracts of the articles, papers were selected according to the following criteria: full text in English or Spanish and content related to hip surgery. Those publications involving experimental studies (in vitro or with anatomical specimens) or 3D printing outside of hospital facilities as well as 3D-printed commercial implants were excluded. Results are presented as a reference guide classified by disease, including the used software and the steps required for the development of the idea. Results: We found a total of 27 indications for in-house 3D printing for hip surgery, which are described in the article. Conclusions: There are many surgical applications of 3D printing in hip surgery, most of them based on CT images. Most of the publications lack evidence, and further randomized studies should be encouraged to assess the advantages of these indications.

Survey of Blood Flow Restriction Training Applications in Sports Medicine and Performance Practice Across North America.

Abstract Colapietro, MA, Lee, JZ, and Vairo, GL. Survey of blood flow restriction training applications in sports medicine and performance practice across North America. J Strength Cond Res 38(5): 856–863, 2024—This study profiled current clinical applications of blood flow restriction (BFR) training and observed side effects by surveying active sports medicine and performance personnel across North America. An online survey consisting of questions derived from a related position statement was distributed through professional organizations, email listservs, and social media. Personnel with experience applying or prescribing BFR training with permanent residence within the United States or Canada were eligible to participate. Variables captured included demographics (profession, practice setting), BFR equipment, treatment parameters, observed side effects, and personal perceptions regarding BFR training. An alpha level of p < 0.05 determined significance. A convenience sample included 72 clinicians with 67 being from the United States. Athletic trainers (n = 35) and physical therapists (n = 30) primarily participated. Chi-square test of independence indicated that a higher proportion of physical therapists (90.3%) report receiving formal education in BFR training compared with athletic trainers (65.7%) ( = 4.1, p = 0.043). Parameters varied between respondents for exercise prescription and occlusion settings. Respondents primarily followed position statement recommendations with individualized pressure selections for resistance (80.9%) and aerobic (84.8%) BFR modes. Side effects reported included delayed onset muscle soreness (66.2%), inability to continue because of pain (28%), and numbness (22.5%). Personal perceptions between athletic trainers and physical therapists were compared using independent t-tests. Physical therapists indicated higher confidence in safety (difference = 0.37 ± 0.32, p = 0.026), understanding recommendations (difference = 0.47 ± 0.37, p = 0.011), and theoretical principles (difference = 0.80 ± 0.53, p = 0.004). Despite variation in BFR parameters used, sports medicine personnel demonstrate compliance with position statement recommendations and report mild side effects.

Designing and Testing an IoT Low-Cost PPP-RTK Augmented GNSS Location Device.

Nowadays, the availability of affordable multi-constellation multi-frequency receivers has broadened access to accurate positioning. The abundance of satellite signals coupled with the implementation of ground- and satellite-based correction services has unlocked the potential for achieving real-time centimetre-level positioning with low-cost instrumentation. Most of the current and future applications cannot exploit well-consolidated satellite positioning techniques such as Network Real Time Kinematic (RTK) and Precise Point Positioning (PPP); the former is inapplicable for large user bases due to the necessity of a two-way communication link between the user and the NRTK service provider, while the latter necessitates long convergence times that are not in keeping with kinematic application. In this context, the hybrid PPP-RTK technique has emerged as a potential solution to meet the demand for real-time, low-cost, accurate, and precise positioning. This paper presents an Internet of Things (IoT) GNSS device developed with low-cost hardware; it leverages a commercial PPP-RTK correction service which delivers corrections via IP. The main target is to obtain both horizontal and vertical decimetre-level accuracies in urban kinematic tests, along with other requisites such as solution availability and the provision of connection ports for interfacing an IoT network. A vehicle-borne kinematic test has been conducted to evaluate the device performance. The results show that (i) the IoT device can deliver horizontal and vertical positioning solutions at decimetre-level accuracy with the targeted solution availability, and (ii) the provided IoT ports are feasible for gathering the position solutions over an internet connection.

Artificial Intelligence in Heart Failure: Friend or Foe?

In recent times, there have been notable changes in cardiovascular medicine, propelled by the swift advancements in artificial intelligence (AI). The present work provides an overview of the current applications and challenges of AI in the field of heart failure. It emphasizes the "garbage in, garbage out" issue, where AI systems can produce inaccurate results with skewed data. The discussion covers issues in heart failure diagnostic algorithms, particularly discrepancies between existing models. Concerns about the reliance on the left ventricular ejection fraction (LVEF) for classification and treatment are highlighted, showcasing differences in current scientific perceptions. This review also delves into challenges in implementing AI, including variable considerations and biases in training data. It underscores the limitations of current AI models in real-world scenarios and the difficulty in interpreting their predictions, contributing to limited physician trust in AI-based models. The overarching suggestion is that AI can be a valuable tool in clinicians' hands for treating heart failure patients, as far as existing medical inaccuracies have been addressed before integrating AI into these frameworks.

Application of Single-Cell Sequencing Technology in Research on Colorectal Cancer.

Colorectal cancer (CRC) is the third most prevalent and second most lethal cancer globally, with gene mutations and tumor metastasis contributing to its poor prognosis. Single-cell sequencing technology enables high-throughput analysis of the genome, transcriptome, and epigenetic landscapes at the single-cell level. It offers significant insights into analyzing the tumor immune microenvironment, detecting tumor heterogeneity, exploring metastasis mechanisms, and monitoring circulating tumor cells (CTCs). This article provides a brief overview of the technical procedure and data processing involved in single-cell sequencing. It also reviews the current applications of single-cell sequencing in CRC research, aiming to enhance the understanding of intratumoral heterogeneity, CRC development, CTCs, and novel drug targets. By exploring the diverse molecular and clinicopathological characteristics of tumor heterogeneity using single-cell sequencing, valuable insights can be gained into early diagnosis, therapy, and prognosis of CRC. Thus, this review serves as a valuable resource for identifying prognostic markers, discovering new therapeutic targets, and advancing personalized therapy in CRC.

Beyond Vision: An Overview of Regenerative Medicine and Its Current Applications in Ophthalmological Care.

Regenerative medicine (RM) has emerged as a promising and revolutionary solution to address a range of unmet needs in healthcare, including ophthalmology. Moreover, RM takes advantage of the body's innate ability to repair and replace pathologically affected tissues. On the other hand, despite its immense promise, RM faces challenges such as ethical concerns, host-related immune responses, and the need for additional scientific validation, among others. The primary aim of this review is to present a high-level overview of current strategies in the domain of RM (cell therapy, exosomes, scaffolds, in vivo reprogramming, organoids, and interspecies chimerism), centering around the field of ophthalmology. A search conducted on clinicaltrials.gov unveiled a total of at least 209 interventional trials related to RM within the ophthalmological field. Among these trials, there were numerous early-phase studies, including phase I, I/II, II, II/III, and III trials. Many of these studies demonstrate potential in addressing previously challenging and degenerative eye conditions, spanning from posterior segment pathologies like Age-related Macular Degeneration and Retinitis Pigmentosa to anterior structure diseases such as Dry Eye Disease and Limbal Stem Cell Deficiency. Notably, these therapeutic approaches offer tailored solutions specific to the underlying causes of each pathology, thus allowing for the hopeful possibility of bringing forth a treatment for ocular diseases that previously seemed incurable and significantly enhancing patients' quality of life. As advancements in research and technology continue to unfold, future objectives should focus on ensuring the safety and prolonged viability of transplanted cells, devising efficient delivery techniques, etc.

Enhanced conjugate natural convection in a corrugated porous enclosure with Ag-MgO hybrid nanofluid

Understanding the impact of hybrid nanofluids (NF) on natural convection (NC) within complex enclosures can significantly advance the efficiency of heat transfer (HT) mechanisms. These advancements play a crucial role in various engineering applications, such as thermal systems in electronics, energy conversion, and heat exchangers. This study numerically examined the NC taking place within a sinusoidal corrugated enclosure filled with an Ag-MgO hybrid NF. This system was heated differentially by a vertical solid wall. The vertical right wall of the solid is maintained at an isothermal at a high-temperature Th, while the left vertical wall of the cavity is kept at an isothermal at a low-temperature Tc. The vertical left wall of the solid is in contact with the porous medium (PM) saturated with the cavity's hybrid NF. In contrast, the top and bottom horizontal walls are maintained adiabatic. The governing equations were solved by employing the Galerkin weighted residual finite elements approach. The porous domain is modeled by employing the Darcy-Brinkman formulation. The parameters being studied encompass the Darcy number (10−5 ≤ Da ≤ 10−2), Rayleigh number (103 ≤ Ra ≤ 106), nanoparticle volume fraction (0 ≤ ϕ ≤ 0.04), amplitude of waviness (0.05 ≤ A ≤ 0.2), and number of undulations (1 ≤ N ≤ 4). The results highlighted that the introduction of hybrid nanoparticles into the pure fluid enhances the HT rate across the parameter spectrum. The highest average Nusselt number (Nuav) is attained at Ra = 106, Da = 10−2, A = 0.2 and N = 4. The findings of the current study have practical implications for current industrial applications, particularly in the cooling of electronic devices.

Multibody dynamic modeling of the behavior of flexible instruments used in cervical cancer brachytherapy.

The steep radiation dose gradients in cervical cancer brachytherapy (BT) necessitate a thorough understanding of the behavior of afterloader source cables or needles in the curved channels of (patient-tailored) applicators. The purpose of this study is to develop and validate computer models to simulate: (1) BT source positions, and (2) insertion forces of needles in curved applicator channels. The methodology presented can be used to improve the knowledge of instrument behavior in current applicators and aid the development of novel (3D-printed) BT applicators. For the computer models, BT instruments were discretized in finite elements. Simulations were performed in SPACAR by formulating nodal contact force and motion input models and specifying the instruments' kinematic and dynamic properties. To evaluate the source cable model, simulated source paths in ring applicators were compared with manufacturer-measured source paths. The impact of discrepancies on the dosimetry was estimated for standard plans. To validate needle models, simulated needle insertion forces in curved channels with varying curvature, torsion, and clearance, were compared with force measurements in dedicated 3D-printed templates. Comparison of simulated with manufacturer-measured source positions showed 0.5-1.2mm median and<2.0mm maximum differences, in all but one applicator geometry. The resulting maximum relative dose differences at the lateral surface and at 5mm depth were 5.5% and 4.7%, respectively. Simulated insertion forces for BT needles in curved channels accurately resembled the forces experimentally obtained by including experimental uncertainties in the simulation. The models developed can accurately predict source positions and insertion forces in BT applicators. Insights from these models can aid novel applicator design with improved motion and force transmission of BT instruments, and contribute to the estimation of overall treatment precision. The methodology presented can be extended to study other applicator geometries, flexible instruments, and afterloading systems.

Research on prosthesis customization with 3D modeling and printing technology

With the development of science and technology and the maturity of technology, the application of 3D printing technology has developed from the art to the clinical medical treatment. Nowadays, the research and development and production of personalized customized orthopedic medical devices are possible, and the production line and supply chain of customized prostheses are constantly improving. The research on 3D printing and prosthesis customization technology is at the forefront of science. This article uses the method of literature review, reading, quoting, and summarizing several domestic and foreign professional experimental records and opinions, focusing on the history of 3D modeling and printing technology, the application method of this technology and the current clinical application of 3D modeling and printing technology. This paper puts forward reflection on the current shortcomings of the technology and my thinking and suggestions for future research. The conclusion of this paper is that 3D modeling and printing technology has played a great role in medical treatment, but there are still shortcomings in terms of cost and materials.

A comprehensive review of the medical and cosmetic applications of exosomes in dermatology.

Exosomes are a subset of extracellular vesicles that are released by all cell types and are theorized to play a crucial role in intercellular communication. Ranging from 40 to 160 nm in diameter, exosomes contain a variety of genetic materials including DNA, RNA, mRNA, metabolites, proteins, and lipids depending on their cellular origin. Given that intercellular communication is abetted by the exchange of cellular components via exosomes, their applied use can have important implications for disease pathology and exosome-based therapeutics. We provide a comprehensive review of the current application of exosomes in medical (and skin) diseases and in cutaneous medical aesthetics. A literature search was conducted on PubMed reviewing exosomes and their application in medical and aesthetic fields. While the therapeutic use of exosomes in the treatment of medical and cosmetic dermatological procedures is promising, it is also important to note that most studies implementing exosomes as therapeutic agents have been conducted in preclinical models, thus highlighting the need for additional studies and clinical trials. One more important note in the aesthetic world associated with exosomes is that in the United States, at the time of this writing, exosomes may only be topically applied and not injected into the skin, as is done in many countries worldwide. There is a need for additional studies and clinical trials to evaluate the safety and therapeutic effect and safety of exosomes in medical and aesthetic fields.

How Can Proteomics Help to Elucidate the Pathophysiological Crosstalk in Muscular Dystrophy and Associated Multi-System Dysfunction?

This perspective article is concerned with the question of how proteomics, which is a core technique of systems biology that is deeply embedded in the multi-omics field of modern bioresearch, can help us better understand the molecular pathogenesis of complex diseases. As an illustrative example of a monogenetic disorder that primarily affects the neuromuscular system but is characterized by a plethora of multi-system pathophysiological alterations, the muscle-wasting disease Duchenne muscular dystrophy was examined. Recent achievements in the field of dystrophinopathy research are described with special reference to the proteome-wide complexity of neuromuscular changes and body-wide alterations/adaptations. Based on a description of the current applications of top-down versus bottom-up proteomic approaches and their technical challenges, future systems biological approaches are outlined. The envisaged holistic and integromic bioanalysis would encompass the integration of diverse omics-type studies including inter- and intra-proteomics as the core disciplines for systematic protein evaluations, with sophisticated biomolecular analyses, including physiology, molecular biology, biochemistry and histochemistry. Integrated proteomic findings promise to be instrumental in improving our detailed knowledge of pathogenic mechanisms and multi-system dysfunction, widening the available biomarker signature of dystrophinopathy for improved diagnostic/prognostic procedures, and advancing the identification of novel therapeutic targets to treat Duchenne muscular dystrophy.

Porous Complex-Mediated Dual Emission of Porphyrins for the Electrochemiluminescence Bioassay.

Although porphyrins make up a promising class of electrochemiluminescence (ECL) luminophors, their aggregation-caused quenching (ACQ) characteristics lead to inferior ECL efficiency (ΦECL). Furthermore, current application of porphyrins is limited to cathodic emission. This work creatively exploited a cage-like porous complex (referred to as SWU-1) as the microreactor to recede the ACQ effect while modulating dual ECL emission of meso-tetra(4-carboxyphenyl)porphine (TCPP), which self-assembled with SWU-1 to form TCPP@SWU-1 nanocapsules (TCPP@SWU-1 NCs). As the microreactor, SWU-1 not only effectively constrained TCPP aggregation to improve electron-hole recombination efficiency but also improved stability of anion and cation radicals, thus significantly enhancing the dual emission of TCPP. Compared with TCPP aggregates, the resulting TCPP@SWU-1 NCs exhibited significantly enhanced anodic and cathodic emission, and their ΦECL was increased by 8.7-fold and 3.9-fold, respectively. Furthermore, black hole quencher-2 (BHQ2) can simultaneously quench anodic and cathodic signals. TCPP@SWU-1 NCs coupling BHQ2 conveniently achieved an ECL ratio detection of miRNA-126, and the limit of detection (S/N = 3) was 4.1 aM. This work pioneered the development of the cage-like porous complex SWU-1 as the microreactor to alleviate defects of the ACQ effect and mediate dual emission of TCPP. The coupling of dual-emitting TCPP@SWU-1 NCs and dual-function moderator BHQ2 created a novel single-luminophor-based ratio system for bioanalysis and provided a promising ECL analysis approach for miRNA-126.

Tough Hydrogels for Load-Bearing Applications.

Tough hydrogels have emerged as a promising class of materials to target load-bearing applications, where the material has to resist multiple cycles of extreme mechanical impact. A variety of chemical interactions and network architectures are used to enhance the mechanical properties and fracture mechanics of hydrogels making them stiffer and tougher. In recent years, the mechanical properties of tough, high-performance hydrogels have been benchmarked, however, this is often incomplete as important variables like water content are largely ignored. In this review, the aim is to clarify the reported mechanical properties of state-of-the-art tough hydrogels by providing a comprehensive library of fracture and mechanical property data. First, common methods for mechanical characterization of such high-performance hydrogels are introduced. Then, various modes of energy dissipation to obtain tough hydrogels are discussed and used to categorize the individual datasets helping to asses the material's (fracture) mechanical properties. Finally, current applications are considered, tough high-performance hydrogels are compared with existing materials, and promising future opportunities are discussed.

A Powerful P-N Connection: Preparative Approaches, Reactivity, and Applications of P-Stereogenic Aminophosphines.

For more than five decades, P-stereogenic aminophosphine chalcogenides and boranes have attracted scientific attention and are still in the focus of ongoing research. In the last years, novel transition metal-based synthesis methods have been discovered, in addition to the long-known use of chiral auxiliaries. Enantiomerically pure compounds with N-P+-X- (X=O, S, BH3) motifs served as valuable reactive building blocks to provide new classes of organophosphorus derivatives, thereby preserving the stereochemical information at the phosphorus atom. Over the years, intriguing applications in organocatalysis and transition metal catalysis have been reported for some representatives. Asymmetric reductions of C=C, C=N, and C=O double bonds were feasible with selected P-stereogenic aminophosphine oxides in the presence of hydrogen transfer reagents. P-stereogenic aminophosphine boranes could be easily deprotected and used as ligands for various transition metals to enable catalytic asymmetric hydrogenations of olefins and imines. This review traces the emergence of a synthetically and catalytically powerful functional compound class with phosphorus-centered chirality in its main lines, starting from classical approaches to modern synthesis methods to current applications.

Enhancing dermatology: the current landscape and future prospects of augmented and virtual reality technologies

This article aims to provide a comprehensive assessment of the current status and future potential of augmented and virtual reality (AR/VR) technologies in the field of dermatology. We conducted an extensive review of the existing literature, encompassing studies and case reports related to the utilization of AR/VR in dermatology. This analysis encompassed diverse applications, including medical education, diagnostics, and dermatologic surgery, to offer a holistic view of their current implementations. Despite the significant interest generated within the dermatological community, the integration of AR/VR technologies in dermatology has not advanced at the same pace as in surgery. Our review underscores the current applications of AR/VR, which encompass improving medical education through interactive simulations, enhancing diagnostic precision, and facilitating complex dermatologic surgical procedures. Additionally, we address the challenges and constraints associated with their practical implementation in clinical settings. Augmented and virtual reality technologies possess immense potential to transform the landscape of dermatology. While their adoption has been gradual, these technologies have showcased their ability to enhance medical education, diagnostics, and surgical interventions. The future holds promising prospects for further developments in AR/VR applications, positioning them as valuable assets for dermatologists and aspiring dermatologists alike. However, it is imperative to address issues related to accessibility, cost-effectiveness, and patient acceptance to foster their widespread integration into clinical practice.

Lactic Acid Fermentation as a Valorising Agent for Brewer’s Spent Yeast—Improving the Sensory Quality and Nutritional Potential

Brewer’s spent yeast (BSY) is one of the brewing industry’s most plentiful side-streams. Abundant, low-cost and high in nutrients, it has great potential for application in food technology and human nutrition. With the ever-increasing interest in sustainability, waste reduction and circular food systems, the use of BSY as a novel food ingredient may be the route to add exponential value while reducing the environmental impact. However, negative flavour characteristics and high amounts of alcohol severely limit the current applications of BSY. This study explores the use of processing involving lactic acid bacteria (LAB) fermentation technology as a means of improving BSY quality characteristics and examines the effects of this process on the chemical, nutritional and sensory characteristics of BSY. The results reveal that BSY is a suitable substrate for LAB fermentation, successfully supporting the growth of Lactobacillus amylovorus FST 2.11. Compared to the unfermented BSY (CBSY), fermentation significantly reduced the perceptible bitterness of the BSY as detected by a sensory panel, from 6.0 ± 2.8 units to 0.9 ± 0.7 units, respectively. Fermented BSY (PBSY) had enhanced sour and fruity flavours, and a variety of other volatile compounds and metabolites were determined. Protein profiles showed significant protein degradation, and free amino acid levels were greatly increased following fermentation, from 2.8 ± 0.2 g/100 g to 10.5 ± 0.4 g/100 g, respectively. Protein quality was high, with the CBSY and PBSY providing well over the required level (&gt;100%) of essential amino acids per gram protein, with the exception of sulphur amino acids (98%). Major physical differences were observed using scanning electron microscopy. This study concludes that LAB fermentation positively affects the sensory and nutritional characteristics of BSY and can aid in the incorporation of brewer’s spent yeast into foods for human consumption.