Region Of Curitiba Research Articles

Hereditary breast cancer next-generation sequencing panel evaluation in the south region of Brazil: A novel BRCA2 candidate pathogenic variant is reported.

In this article, we delineate a loosely selected cohort comprising patients with a history of early-onset breast cancer and/or a familial occurrence of cancer. The aim of this study was to gain insights into the presence of breast cancer-related gene variants in a population from a micro-region in southern Brazil, specifically the Metropolitan Region of Curitiba. This area exhibits a highly genetically mixed population, mirroring the general characteristics of the Brazilian people. Comprehensive next-generation sequencing (NGS) multigene panel testing was conducted on 12 patients from the region, utilizing three different library preparation methods. Two pathogenic variants and one candidate pathogenic variant were identified: BRCA2 c.8878C>T, p.Gln2960Ter; CHEK2 c.1100del, p.Thr367Metfs15, and BRCA2 c.3482dup, p.Asp1161Glufs3. BRCA2 c.3482dup, a novel candidate pathogenic variant, previously unpublished, is reported. The prevalence of pathogenic variants in this small cohort is similar to that described in the literature. All different library preparation methods were equally proficient in enabling the detection of these variants.

Code 1583 - preliminary steps for studies to assess the safety of an earth dam in terms of use and lowering the reservoir level for public supply during the water crisis

The spring 2021 climate forecast report from the National Institute of Meteorology (INMET) and the National Institute for Space Research (INPE) indicated an increased possibility of below-average rainfall in almost the entire region of the state of Paraná, which is consistent with the historical trend of decreasing rainfall in the Paraná River basin since the 1990s, with an intensification in the 2000s. This led to a water emergency situation in Paraná, which was decreed by the state government in 2020 and 2021. The Curitiba region depends on the Curitiba and Metropolitan Region Integrated Supply System (SAIC). Due to the intense drought in 2020 and 2021, SAIC's reservoirs suffered a significant reduction in stored water levels and volumes, reaching 28% of their total capacity in August 2020. This was the biggest water crisis in the last 90 years in the history of the state of Paraná, with several reservoirs reaching levels close to historic lows, but maintaining constant discharges in order to maintain power generation or public supply. In these cases, with the reservoirs at lower levels and with a smaller volume, the variation in the water level on the upstream slope of the earth dam varies differently from the levels when the dam and reservoir are in normal operation or outside of a water crisis. In view of the atypical behavior of reservoir levels, and based on good dam engineering practice, when the operating regime changes or the reservoir water level drops, the safety aspects of these structures should be reassessed through geotechnical analyses for conditions of rapid lowering, in order to learn how these structures behave under these conditions. This article sheds light on the important stages of this thorough technical investigation of the extensive documentation of a project like this, data on instrumentation and performance, how they were built and behaved during the construction and filling of the reservoir, knowledge of geotechnical parameters of the materials of the dam massif and foundation, recorded field observations made at the time of preliminary investigation during the design, project and construction phase; obtaining hydro-meteorological data from the region, in order to obtain the "as-built" geometry of the structure, with the aim of modeling the typical section reliably to the structure in the field in order to infer this numerical model and vice versa, and obtain results on its performance during this atypical period.

Forest fire risk zoning for the metropolitan region of Curitiba, Paraná, Brazil

Forest fires are becoming increasingly frequent throughout the globe, influencing socioeconomic and environmental aspects and endangering ecosystems and life. The forest fire risk zoning is an auxiliary tool for elaborating and implementing preventive policies. The present study aims to execute the forest fire risk zoning for the metropolitan region of Curitiba, Paraná, Brazil, testing its efficiency through the relationship with geolocated fires that occurred from 2011 to 2016. Thematic maps were made through information related to demographic density, road system, land use and cover, slope, orientation and altimetry of the terrain. The efficiency of the proposed zoning, 45.8% and 44.0% of the geolocated fires that occurred in the study area in the period 2011 to 2016 were present in areas considered with "very high" and "high" risk, respectively, demonstrating that the proposed zoning can be used to develop prevention policies for the metropolitan region of Curitiba.

Description of smallholder pig farming in the Metropolitan Region of Curitiba, Paraná, Brazil

Várias pequenas granjas de suínos existem no Brasil paralelamente à suinocultura industrial, que é realizada em fazendas de grande escala. Portanto, o objetivo deste estudo foi descrever o sistema de produção familiar de suínos na Região Metropolitana de Curitiba. Para isso foi aplicado um questionário in loco entrevistando agricultores, totalizando 362 propriedades avaliadas. A mão de obra era exclusivamente familiar em 93,4% das propriedades, 50% das propriedades tinham entre 1,1 e 10 hectares, 98,3% criavam outras espécies animais, principalmente aves, e 80,9% das propriedades cultivavam culturas, principalmente milho. As operações do ciclo completo foram desenvolvidas em 57,2% das granjas, os suínos foram mantidos em sistema confinado em 62,5% e os suínos foram mantidos ao ar livre em 20,7%. Das explorações de produção completa, 40,1% tinham entre 11 e 20 porcos, enquanto nas explorações de engorda, 88,4% tinham até 5 porcos. A maioria das propriedades visitadas (79,6%) possuía suínos de raças indefinidas. Em termos de práticas alimentares, o milho e os vegetais disponíveis localmente foram os mais utilizados; além disso, 38,1% dos agricultores utilizavam concentrado comercial, geralmente com outros alimentos. A reprodução ocorreu exclusivamente por monta natural e a idade de desmame mais citada (46,9%) foi de dois meses. Todos os entrevistados criavam suínos principalmente para consumo próprio, sendo que 78,7% também comercializavam os animais. Na região estudada, os agricultores obtiveram a renda familiar combinando a agricultura com outras atividades e afirmaram que a produção de suínos pouco contribuiu para essa renda, sendo desenvolvida principalmente devido à tradição familiar.

Entendendo o risco de descoloração como consequência de transientes hidráulicos

Abstract This paper presents an analysis of the challenges associated with discoloration risk management and the impact of hydraulic transients on water quality within distribution systems. Focusing on the Metropolitan Region of Curitiba, Paraná, Brazil, the study employs a comprehensive methodology that combines the Characteristic Method for simulating hydraulic transients and real-time monitoring of water quality parameters, such as turbidity and chlorine levels. A framework for managing discoloration risk is proposed, highlighting strategies for identifying potential causes, assessing risk severity, developing prevention and mitigation strategies, and implementing continuous improvement processes. The experimental section details the impact of hydraulic transient events on water quality, with significant findings indicating a direct correlation between flow dynamics and water quality degradation, particularly in terms of increased turbidity and decreased chlorine levels during pump deactivation. The study contributes valuable insights into effective water distribution system management, emphasizing the importance of advanced monitoring and risk management techniques to maintain high-quality water standards.

The theory of complexity and construction management: An analysis of perception and impact on the construction industry in Brazil and Bolivia

The theory of complexity derived from systems theory emphasizes complex systems and their dynamic interactions with their environment. In this sense, in project management, this theory offers invaluable perspectives, where systems involve diverse components working towards a common objective. The construction sector is facing challenges in managing project complexity, and effective strategies are required to ensure success. While projects are often perceived as predictable, the reality of construction complexity demands a shift in perspective. Currently, the linear view of construction processes is being challenged, advocating for recognizing projects as nonlinear and dynamic phenomena. This study aims to explore the application of complexity theory in construction project management, focusing on differences in complexity perception between Cochabamba and the Metropolitan Region of Curitiba. Discriminant Analysis does not reveal a significant disparity in complexity perception between the two regions, with variables such as uncertainty about the subsoil having the most influence on complexity perception.

Distributive policies in cities: legislative behavior of city councilors in the Metropolitan Region of Curitiba

RESUMO Introdução: Analisamos o efeito das variáveis territoriais e da capacidade fiscal municipal nas proposições legislativas e na destinação das políticas distributivas pelas Câmaras dos Vereadores de quatro municípios selecionados da Região Metropolitana de Curitiba. Perguntamo-nos se há associação entre proposições legislativas de caráter distributivo de iniciativa de vereadores e características socioeconômicas, demográficas e fiscais dos municípios estudados. Materiais e métodos: Foram analisadas proposições legislativas de diferentes tipos tais como indicações, requerimentos e projetos de lei de iniciativa de vereadores. Classificamos essas proposições entre distributivas e não distributivas. Foram analisados também dados geográfico-territoriais, demográficos, socioeconômicos e fiscais de Mandirituba, São José dos Pinhais, Fazenda Rio Grande e Campo Largo. Empregamos estudo de casos comparados, estatística descritiva e análise de correlação para estimar a relação entre as variáveis dos municípios e as variáveis legislativas no período entre 2012-2019. Resultados: Os resultados demonstraram que a capacidade fiscal e as características territoriais municipais são fatores que podem orientar o comportamento político e a produção legislativa municipal, sendo que vereadores do município de Mandirituba, menos urbanizado, com piores indicadores socioeconômicos e menor capacidade fiscal produziram mais políticas distributivas comparativamente aos municípios de São José dos Pinhais, Fazenda Rio Grande e Campo Largo, mais urbanizados, com melhores indicadores e mais capazes fiscalmente. Discussão: Os achados apontam para uma explicação complementar às encontradas na literatura para as variações da proposição de políticas distributivas. Para além da conexão eleitoral, a destinação dessas políticas pode estar relacionada ao desenvolvimento socioeconômico e fiscal, às características demográficas e às necessidades desiguais e demandas específicas dos municípios. O estudo corrobora a literatura sobre a importância da incorporação do território nas análises da política e dos resultados das políticas públicas.

Ecological-ICMS as a public policy instrument for biodiversity preservation: a study conducted in small municipalitiesin ParanáState, Brazil

The Ecological Tax on the Circulation of Goods and Services for Biodiversity (ICMS-E) was created in 1991 as an initiative of the government of Paraná State. It is an important public policy instrument for the preservation of biodiversity in small municipalities that house Conservation Units. The aim of this article was to analyze whether resources from the ICMS-E, added to municipal tax revenues, improve sustainable development over time. As part of the methodological procedures, a descriptive-comparative analysis was conducted between municipalities that receive and do not receive ICMS-E. For this purpose, a sampling of the 399 municipalities that comprise Paraná State was conducted, involving 193 municipalities with a population of up to 50,000 inhabitants. The comparative analysis was based on the definition of two study groups, each constituted by 76 municipalities: one called the ICMS-E Recipient Group, municipalities that receive the ecological tax; and the Control Group, composed of those that do not receive it. The main results indicate that 19.80% of the municipalities are concentrated in the North Central mesoregion, while the Metropolitan Region of Curitiba is home to 33.45% of the population of Paraná. In relation to population loss, this factor represents 44.73% in the ICMS-E Recipient Group, while in the Control Group this number is 34.21%. In relation to the Environmental Management Function, 60.53% of the municipalities in the Recipient Group applied up to 75% of this tax to this function. It was concluded that the ICMS-E is an important incentive for the preservation of biodiversity and represents a significant increase in resources for the local governments of smallmunicipalities.

Crise climática: caminhos para enfrentar seus efeitos nas habitações em Curitiba

Abstract The objective of this article is to present paths that can contribute to mitigating the effects of climate change on houses built in the metropolis of Curitiba. The analysis of the occurrence of natural disasters in the state of Paraná demonstrates that the most frequent extreme climatic event is the windstorm, and the Curitiba region is the one that most presented occurrences of windstorms in the analyzed period. Federal laws and municipal plans related to the theme are presented, as well as points that can be adopted as tools to mitigate the impacts of the climate crisis on the city. Finally, it is concluded that, through the concept of demand--side innovation policies with the use of software programs, which simulate the future scenario of climate transformations, it is possible to contribute to the development of resilient housing.

Imigração de haitianos: enfoque na comunicação em saúde

Research on the adaptation of Haitian immigrants to the Brazilian reality and to the Brazilian Public Health System (SUS) and on the way interpersonal relationship is processed in the health environment. The objective was to understand how Haitian immigrants, users of the health system, present themselves and are perceived in the relationships established with health professionals in a Primary Health Unit in the Metropolitan Region of Curitiba. It was an ethnography with participant observation, using a field diary. Results indicate difficulties for Haitian immigrants to access the health system, due to the peculiarities of their culture, and for the health professionals, as language and culture become the main barrier to care, being permeated by prejudice resulting from lack of training of some professionals. However, such difficulties can be overcome through effective strategies and better preparation to embrace this population.

Analysis of the Feasibility of Immersive Virtualization in Technical Training

Goal: propose a method of training in regulatory standards using immersive virtualization, aiming at improving student knowledge retention compared to traditional online models.
 
 Theoretical Reference: use of literature through research on similar methods already applied in immersive training, dissertations, articles and national standards.
 
 Method: practical application of training in an immersive environment in two large industries located in the metropolitan region of Curitiba, PR, where the evaluated ones completed an evaluation questionnaire according to their degree of satisfaction, which is the main parameter used in this work to prove the efficiency of the method.
 
 Results and conclusion: the practical application of immersive training, compilation of data and analysis of results confirm the viability proposed in the method. As the country develops technologically, the method will have its applicability increasingly accessible and proven.
 
 Research implications: a method of technological training developed as an alternative to the current molds, will certainly bring great contributions to the academy, and, at the same time, with the reduction of machine downtime, displacements, logistical costs and agglomerations, this work will bring contributions to the industry.
 
 Originality/Value: with the advent of the covid-19 pandemic experienced in recent times, traditional methods of professional training needed to be quickly adapted, aiming to minimize the impact caused by the restriction of physical contact between people. The proposed method provides the possibility of maintaining professional training processes, offering society the possibility of being trained effectively.

CORPORATE VENTURE CAPITAL FOR ESTABLISHING LINKS BETWEEN LARGE AND TRADITIONAL INDUSTRIAL COMPANIES AND STARTUP FIRMS: A REGIONAL INNOVATION SYSTEM SURVEY

This research aims to evaluate the actual level of understanding and application of Corporate Venture Capital (CVC) in the Regional Innovation System (RIS) present in the Metropolitan Region of Curitiba (MRC). The survey focuses the large and traditional industrial companies (LTIC) which have tremendous importance to State of Paraná, due to taxes and formal jobs generation. While the LTIC needs to innovate, creating or recovering competitive advantage, the startup firm seeks for partnerships or private equity. In this context, there is an opportunity of establishing linkages between different actors through the CVC. The article presents the results of a survey consisting of an online questionnaire and a focal group, where the data was analyzed through a qualitative approach. The research demonstrated a minor part of the survey respondents practicing CVC, although an expressive number of companies intends to invest in startups. It was also possible to observe that the risk aversion, anxiety for financial payback and different vocabulary between startup and LTIC are still barriers to an effective adhesion to CVC in this regional context. This work contributes to scientific literature when highlight the importance of understanding and properly narrowing large companies of startups. However, the asymmetries between parts and the maturity for dealing and absorbing knowledge from startups is an issue that the RIS organizations could be involved. Submited: September 2022 Accepted: December 2022 DOI: 10.18226/23190639.v10n2.06

Estimativa da massa gorda em adolescentes do sexo feminino do sul do Brasil: desenvolvimento e validação de modelos matemáticos

abstract This study aimed to develop and validate the first mathematical models, based on anthropometric properties, to estimate fat mass (FM) in a heterogeneous sample of female adolescents. A cross-sectional and quantitative study conducted with 196 individuals aged 12 to 17 years from the metropolitan region of Curitiba, Paraná, Brazil. The participants were randomly divided into two groups: regression sample (n = 169) and validation sample (n = 27). Dual-energy X-ray absorptiometry (DXA) was used as the reference method to determine body fat in relative and absolute values. Stature, body mass, waist girth and triceps, subscapular, biceps, iliac crest, abdominal, front thigh and medial calf skinfold thickness were defined as independent variables and measured according to an international technical protocol. Statistical analyzes used the Ordinary Least Square (OLS) regression model, paired t test and Pearson correlation. Four multivariate mathematical models with high determination coefficients (R2 ≥90%) and low estimated standard errors (SEE = ≤2.02 kg) were developed. Model 4 stands out for its low number of independent variables and significant statistical performance (R2 = 90%; SEE = 1.92 kg). It is concluded that the four mathematical models developed are valid for estimating FM in female adolescents in southern Brazil.

Análise custo-benefício para mudança de tecnologia: o caso de um consórcio de gerenciamento de resíduos sólidos na região metropolitana de Curitiba, Brasil

ABSTRACT Huge increases in the volume of waste produced by society have created an urgent need for new and improved municipal solid waste (MSW) processes. In many countries, traditional methods to manage MSW, such as landfills, have been abandoned in favor of more effective and environmentally efficient technologies. These include gasification (decomposition at high temperatures), recycling, and composting (of organic matter). The purpose of this research was to assess certain financial, social, and environmental indicators, especially the IRR and cost-benefit ratio of changing the technologies used in MSW processing. The research focuses on assessing these changes in the CONRESOL area — a consortium that covers almost all the municipalities in the metropolitan region of Curitiba, Brazil. To this end, scenarios were proposed that apply various technological combinations and two collection fees. Of the three proposed scenarios, the one with the best socioeconomic and environmental results (Internal Rate of Return, Net Present Value, Discounted Payback, and Benefit/Cost ratio) combines gasification, recycling, and composting. This scenario generated the least GHG emissions and the highest number of jobs.

INFÂNCIA E JUSTIÇA ESPACIAL: DESIGUALDADES INTER E INTRABAIRROS NO USO DA CIDADE POR CRIANÇAS DA REDE MUNICIPAL DE ENSINO DE CURITIBA

ABSTRACT: This study analyzes if there is inequality in the spatial experiences of children depending on where they live in the city and neighborhoods. It is a quantitative research study in which we analyzed 1060 questionnaires answered by families from 27 local schools in Curitiba, distributed in the nine regional coordination centers at the time. The data were analyzed based on authors from sociology, urban sociology, and geography. We observed that children who lived in the central-northern region of Curitiba and in the central regions of neighborhoods had more access to consolidated leisure and cultural places because they either lived near them or it was easier for them to go to these places (among other issues related to class, gender, race, time at the current neighborhood, family geographical origin). It demonstrates both a “residency effect”, responsible to generate opportunities, and spatial mobility that, as capital, pushed diverse experiences in the city. For children who lived in the poor and on the outskirts of the neighborhood and, further, living in south or extreme south Curitiba (when inter and intra-neighborhood data are crossed), the neighborhood did not present itself as a resource, but as a restriction and spatial mobility seemed to be a scarce urban capital. The configuration was one of a non-social mixture among children who lived in different parts of neighborhoods and the city. The city proved to be spatially unfair and the neighborhood presented itself as a model, teaching superior positions and status to some children and subalternity and sedentariness to others.

Fugulin scale for classifying pediatric patients in a respiratory inpatient unit: experience report.

To describe the use of the Fugulin scale to classify pediatric patients hospitalized in a respiratory unit as a subsidy for the allocation of human resources given the increase in cases of Severe Acute Respiratory Syndrome. Experience report conducted in a children's hospital in the Metropolitan Region of Curitiba with data collection from medical records and approved by the Institution and by the Research Ethics Committee. Between February and May 2022, the percentage of patients categorized in minimal and intermediate care decreased by 53 and 11.4%, respectively, while those in high dependency and semi-intensive care expanded by 31.2 and 84.2%. In addition, in just four months, there was a considerable increase in the positivity of virologies compared to the twelve months of 2021. The susceptibility of children to the development of severe respiratory infection was proven through the decrease in virologies with undetectable results. The results obtained allowed us to conclude there was a significant increase in the complexity of patients admitted to the respiratory unit, showing it is essential to provide a nursing team compatible with the care needs.

Impactos Ambientais dos Teleacoplamentos do Sistema de Consumo Urbano de Alimentos Orgânicos

Abstract The environmental impacts of the food system, especially the distances covered, are not clear to the final consumer. The aim was to evaluate and calculate the urban telecoupling and the environmental impacts and calculate the energy consumption and the environmental emissions of the organic foods. Through the calculation of quantities, distances, losses and the analysis of telecouplings, we measured Greenhouse Gas (GG) emissions, as well as the energy and carbon footprints of organic foods traded at the CEASA/PR, Curitiba. Emissions had a low environmental impact because the largest quantities of transported organics originate from production sites located within the greater Curitiba region. The study showed a consumption pattern supporting food produced in regions adjacent to the trading center in safe and healthy and safe way, which may be associated with a greater awareness of the environmental impacts resulting from the distances covered.

Height growth strategies of Mimosa scabrella along a chronosequence

Assessing variations in tree allometry is useful for understanding height growth strategies in relation to life-history trajectories, light competition and environmental restrictions. Scaling exponent and asymptotic heights obtained from height–diameter (HD) models may elucidate how trees optimise growth strategies and the potential drivers that influence tree height. Our main objective was to explore how the HD relationship in Bracatinga (Mimosa scabrella) varies along stands chronosequence and life history. The study was carried out in discontinuous stands located across the metropolitan region of Curitiba, southern Brazil. We used HD data from 300 temporary plots in chronosequences dating from a disturbance, which represented stand development after intervention, covering the life history of the species. Power and exponential models were fitted to data to describe the HD relationship over time. Mixed-effects models were applied to explain the height variations by stand characteristics. We found that tree height and allometry were influenced by stand development phase and tree life stage along the chronosequence. Changes in tree height were also driven by light competition related to certain stand characteristics, such as basal area, stem density and species diversity. We concluded that growth strategies are conditioned by interactions between light requirements along a tree’s life history and successional stand evolution. The results revealed that gradual changes in tree development might be recognised by stationary data along chronosequences. Quantifying changes in HD allometry has ecological and practical applications for explaining the strategies and drivers underpinning tree growth and providing useful knowledge for improving growing stock predictions and stand management.

Reverse logistics in gas stations in the metropolitan region of Curitiba (Brazil)

The National Solid Waste Policy (PNRS) established by Law 12,305/2010, mentions Reverse Logistics (RL) as a development tool for the return of the production cycle, and also presents instruments for shared responsibility for the life cycle of products. The RL of lubricating oils in post-consumption and return is linked to concern for the environment and sustainability in the business sphere. The aim of this study was to describe the RL process of gas stations and their tax benefits, through bibliographic and documentary research, in addition to an unstructured interview with professionals involved in the process and through a case study. It was found that compliance with environmental obligations imposed by the Government, such as the destination of used or contaminated lubricating oil packaging (OLUC), can be considered inputs that may generate PIS and COFINS credits, and the revenues obtained from the sale of the destination of OLUC may be considered as environmental revenues, as well as the structure of real estate to be measured as environmental assets.

Critical analysis of multiparity in adolescent pregnancy / Análise crítica da multiparidade na gravidez adolescente

To demonstrate the obstetric profile of teenage pregnancy and maternity parity in the metropolitan region of Curitiba, in southern Brazil, from 2009 to 2014, in order to provide information for interventions in preventing non-planned pregnancy in this population.Data regarding maternal age, gestational age, newborn weight, obstetric complications and type of delivery were collected in 4668 patients aged between 15 and 19 years, and those aged 20 to 24, with previous teenage pregnancy. An Excel table was created to store the information, later analysed. Most patients were primigravid (71%), with 22% in the second pregnancy. Multiparity was present in 29% of pregnant women. The mean age at first pregnancy was 17.3 years (standard deviation of 1.30). The main route of delivery was vaginal, in 80%. Episiotomy was performed in 70% of these deliveries. Cesarean deliveries occurred mainly due to induction failure (19.8%), cephalopelvic disproportion (14.4%) and fetal distress (11.1%). Mean gestational age was 39.1 weeks (standard deviation 1.5). Low birth weight occurred in 7% of newborns, and 4% were preterm. Most of the patients analysed were primiparous aged 17.3 years. Multiparity in adolescence proved to be a frequent phenomenon in the region studied, with a prevalence of 30%, occurring at an average age of 18.6 years old. A quarter of 20-year-old patients’ population had more than two pregnancies. The presence of episiotomy was high, performed in 70% of vaginal deliveries, a value above the recommended by WHO.]