Cumulative Results Research Articles

Heavily eroded Pleistocene landscape and site-forming processes of the Acheulean artifacts-bearing Holocene sediments, Eastern Desert, Sudan

Since the Middle Pleistocene, the Sahara region has undergone strong environmental changes resulting from climate changes. Dry periods, constituting an ecological barrier to human presence, alternated with wet periods when the Sahara area was covered with green savanna and an extensive network of watercourses, allowing the area to be occupied by hunter-gatherer groups. Responding to the Quaternary climatic changes, hominin dispersal was channeled through vegetated corridors. Such evidence for human settlements connected to Pleistocene green corridors in the Sahara region has been discovered in the research area called EDAR (Eastern Desert Atbara River). This area comprises a cluster of Acheulean and Middle Stone Age (MSA) sites discovered in the fluvial sedimentary context. This manuscript discusses the occurrence of Middle Pleistocene Acheulean artifacts in much younger sediments documented at the site EDAR 6. These Acheulean artifacts are present within thick Holocene calcareous sandy silts formed between 2.7 ka and 8.7 ka based on an optically stimulated luminescence (OSL) chronology, which is also supported by paleomagnetic analysis. The stone gravelly artifacts mantled above the eolian deposits have been known in other Paleolithic sites under the desert environment of Northern Africa. We propose that the relocation of the Palaeolithic artifacts was due to long-lasting erosional and redepositional processes affecting the Acheulean artifacts-bearing sediments since the Middle Pleistocene. We interpret that the cumulative results of the two processes, i.e., the gravel framework dilation and the gravel overpassing, allowed the stone artifacts to be exposed at the surface or incorporated in the Holocene sediment layers.

Sistema de gestión y operación de la red semafórica de la ciudad de Lima

The research problem arose from the need to implement a system to remotely manage the traffic operations of the network of traffic lights to reduce vehicular congestion. The procedure involved designing the placement of electronic sensors to track the number of vehicles in the area. This allowed for the testing of different operational strategies for modifying the timing of the traffic light signals. A simulation model was used to test these strategies in seven intersections on Av. Petit Thouars in Lima, between Av. Alejandro Tirado and Av. 28 de Julio. Detectors were installed at the access points of secondary access streets to the main road (Av. Petit Thouars) which yielded cumulative positive results. Alternatives 1 and 2 produced a 59% reduction in queues, thus demonstrating the validity of the general hypothesis.

Micro- and Macroevolution: A Continuum or Two Distinct Types of Change?

How microevolution and macroevolution are related is one of the major unanswered questions in evolutionary biology. The most prevalent view is that microevolution and macroevolution are part of a continuum of one type of change and that macroevolution is the cumulative result of microevolution. Mathematics, however, distinguishes two fundamentally different, singular types of change: change of a vector in its parameters versus its dimensions. This mathematical distinction may help to articulate the concept of evolution by distinction of two fundamentally different types of evolution: the change of the state vector of an organism in 1) its parameters (= ‘first-order evolution’) and 2) its dimensions (= ‘second-order evolution’). This distinction can be operationalized by identifying genes and regulatory elements in the nucleotide code of an organism as dimensions and the level of expression as parameters of its state vector. This operationalization allows us to substitute the phenotype-based analysis of evolution with a genotype-based analysis and draws attention to the molecular mechanisms that change the parameters or the dimensions of the state vector, respectively. We illustrate the distinction between first- and second-order evolution with a simulation of the adaptive dynamics of a population of digital amoebae. Our genotype-based systems approach reveals that micro- and macroevolution are largely similar to first- and second-order evolution respectively, and are not a continuum of change.

An Analysis of Homicides by Off-Duty Police Officers

The current study examined 119 incidents of off-duty police shootings resulting in 123 deaths. Results show that the majority (69%) of off-duty deaths were the cumulative result of the officer being a target of a crime or interjecting themselves to assist others who were targeted. Those who intercede on behalf of others were not subjected to criminal proceedings. Other findings of note revealed how off-duty fatal police shootings frequently involved people of color. The various approaches of states, police departments, and district attorney offices in reporting of these cases was problematic. A greater transparency within the investigation is discussed.

A systematic review and meta-analysis of the association between air pollutants and the incidence of tuberculosis

ObjectiveTo investigate the association between air pollutants and the incidence of tuberculosis (TB) through a systematic review and meta-analysis, and to provide directions for future research and prevention of TB. MethodsA search was conducted for all literature related to the incidence of TB and air pollution in the database. We screened the retrieved articles and proceeded statistical analyses using random effects models to investigate the relationships between five air pollutants (PM2.5, PM10, SO2, NO2 and O3) and the incidence of TB. ResultsThe initial search identified 100 pieces of literature and 9 studies met the screening criteria after the screening. The single-day lagged risk ratio (RR) and 95% Confidence Intervals (CIs) for the combined effects estimates are as follows: PM2.5: 1.059 (0.966, 1.160); PM10: 1.000 (0.996, 1.004); SO2: 0.980 (0.954, 1.007); NO2: 1.011 (0.994, 1.027); O3: 0.994 (0.980,1.008). The cumulative lagged results for these five pollutants are listed like this: PM2.5: 1.095 (0.983, 1.219); PM10: 1.035 (1.006, 1.066); SO2: 0.964 (0.830, 1.121); NO2: 1.037 (1.010, 1.065); O3: 0.982 (0.954, 1.010). ConclusionThe single-day lag effects of PM2.5, PM10, SO2, NO2, and O3 are not statistically significantly relevant for the occurrence of TB. However, the cumulative lag results show that both PM10 and NO2 contribute to the prevalence of TB, while the statistical relationship between the cumulative lag effects of PM2.5, SO2, and O3 and the onset of TB remains unknown.

Adopting the RE-AIM analytic framework for rural program evaluation: experiences from the Advance Care Planning via Group Visits (ACP-GV) national evaluation.

To support rigorous evaluation across a national portfolio of grants, the United States Department of Veterans Affairs (VA) Office of Rural Health (ORH) adopted an analytic framework to guide their grantees' evaluation of initiatives that reach rural veterans and to standardize the reporting of outcomes and impacts. Advance Care Planning via Group Visits (ACP-GV), one of ORH's Enterprise-Wide Initiatives, also followed the Reach, Effectiveness, Adoption, Implementation, and Maintenance (RE-AIM) framework. ACP-GV is a national patient-centered intervention delivered in a large, veterans integrated healthcare system. This manuscript describes how RE-AIM was used to evaluate this national program and lessons learned from ORH's annual reporting feedback to ACP-GV on their use of the framework to describe evaluation impacts. We used patient, provider, and site-level administrative health care data from the VA Corporate Data Warehouse and national program management databases for federal fiscal years (FY) spanning October 1, 2018-September 30, 2023. Measures included cumulative and past FY metrics developed to assess program impacts. RE-AIM constructs included the following cumulative and annual program evaluation results. ACP-GV reached 54,167 unique veterans, including 19,032 unique rural veterans between FY 2018 to FY 2023. During FY 2023, implementation adherence to the ACP-GV model was noted in 91.7% of program completers, with 55% of these completers reporting a knowledge increase and 14% reporting a substantial knowledge increase (effectiveness). As of FY 2023, 66 ACP-GV sites were active, and 1,556 VA staff were trained in the intervention (adoption). Of the 66 active sites in FY 2023, 27 were sites previously funded by ORH and continued to offer ACP-GV after the conclusion of three years of seed funding (maintenance). Lessons learned developing RE-AIM metrics collaboratively with program developers, implementers, and evaluators allowed for a balance of clinical and scientific input in decision-making, while the ORH annual reporting feedback provided specificity and emphasis for including both cumulative, annual, and rural specific metrics. ACP-GV's use of RE-AIM metrics is a key step towards improving rural veteran health outcomes and describing real world program impacts.

Acupressure: a possible therapeutic strategy for anxiety related to COVID-19: a meta-analysis of randomized controlled trials.

From the end of 2019 to December 2023, the world grappled with the COVID-19 pandemic. The scope and ultimate repercussions of the pandemic on global health and well-being remained uncertain, ushering in a wave of fear, anxiety, and worry. This resulted in many individuals succumbing to fear and despair. Acupoint massage emerged as a safe and effective alternative therapy for anxiety relief. However, its efficacy was yet to be extensively backed by evidence-based medicine. This study aimed to enhance the clinical effectiveness of acupoint massage and extend its benefits to a wider population. It undertakes a systematic review of the existing randomized controlled trials (RCTs) assessing the impact of acupoint massage on anxiety treatment, discussing its potential benefits and implications. This research aims to furnish robust evidence supporting anxiety treatment strategies for patients afflicted with COVID-19 disease and spark new approaches to anxiety management. This study evaluates the evidence derived from randomised controlled trials (RCTs), quantifies the impact of acupressure on anxiety manifestations within the general population, and proposes viable supplementary intervention strategies for managing COVID-19 related anxiety. This review included RCTs published between February 2014 and July 2023, that compared the effects of acupressure with sham control in alleviating anxiety symptomatology as the outcome measure. The studies were sourced from the multiple databases, including CINAHL, EBM Reviews, Embase, Medline, PsycINFO, Scopus and Web of Science. A meta-analysis was performed on the eligible studies, and an overall effect size was computed specifically for the anxiety outcome. The Cochrane Collaboration Bias Risk Assessment Tool (RevMan V5.4) was employed to assess bias risk, data integration, meta-analysis, and subgroup analysis. The mean difference, standard mean deviation, and binary data were used to represent continuous outcomes. Of 1,110 studies of potential relevance, 39 met the criteria for inclusion in the meta-analysis. The majority of the studies reported a positive effect of acupressure in assuaging anticipatory anxiety about treatment. Eighteen studies were evaluated using the STAI scale. The acupressure procedures were thoroughly documented, and studies exhibited a low risk of bias. The cumulative results of the 18 trials showcased a more substantial reduction in anxiety in the acupressure group compared to controls (SMD = -5.39, 95% CI -5.61 to -5.17, p < 0.01). A subsequent subgroup analysis, based on different interventions in the control group, demonstrated improvement in anxiety levels with sham acupressure in improving changes in anxiety levels (SMD -1.61, 95% CI: -2.34 to -0.87, p < 0.0001), and blank controls (SMD -0.92, 95% CI: -2.37 to 0.53, p = 0.22). In the clinical research of traditional Chinese medicine treatment of anxiety, acupressure demonstrated effectiveness in providing instant relief from anxiety related to multiple diseases with a medium effect size. Considering the increasing incidence of anxiety caused by long COVID, the widespread application of acupressure appears feasible. However, the results were inconsistent regarding improvements on physiological indicators, calling for more stringent reporting procedures, including allocation concealment, to solidify the findings.

The Use of Stem Cells in Cardiac Pathologies: A Review

Despite the use of pharmacological therapies, the morbidity and mortality of cardiac diseases remain high. This paper aims to review multiple promising therapies and highlight the innovative role that stem cells can play. Stem cells have been identified as a potential therapeutic alternative to current mainstay medical and surgical interventions for cardiac pathologies, as these cells possess multipotent capabilities that could aid in cardiac regeneration and remodeling without the detriment of scar tissue. Numerous studies have explored the preliminary safety and efficacy of stem cell treatments in cardiac diseases, specifically ischemic heart disease (IHD), congenital heart disease (CHD), and dilated cardiomyopathy (DCM). IHD studies utilized intracoronary and intramyocardial delivery of various stem cell types and found efficacy with intramyocardial delivery of autologous mesenchymal stem cells injected into infarcted cardiac tissue. Similarly, CHD studies utilized intracoronary delivery of cardiosphere-derived cells in conjunction with the well-established Norwood Procedure and found benefits in cardiac function and somatic cell growth. DCM studies in murine models and subsequent clinical trials showed that transplantation with CD34+ stem cells, a cell type marked by muscle satellite cells, improved cardiac function and increased exercise capacity when delivered via intracoronary or transendocardial transplantation methods. While these cumulative results show promise, longer follow-ups and larger sample sizes are needed to validate the efficacy of this therapeutic approach for cardiac diseases in the long term. Stem cells, when combined with existing therapies, have the potential to mitigate the grave morbidity and mortality associated with cardiac pathologies.

Aurantiochytrium sp. Meal as Feed Additive for Pacific White Shrimp Reared under Low Temperature and Challenged by WSSV in Association with Thermal Stress

A study was conducted to test the inclusion of Aurantiochytrium sp. meal in the rearing of Penaeus vannamei grown in a clear water system and at a suboptimal temperature of 22 °C. The doses tested were 0 (control), 1, 2, 3, and 4% at a stocking density of 100 shrimp/m3. Rearing was carried out with aeration and individual heaters, and seawater temperature was controlled with a chiller. After nine weeks, shrimp were weighed and hemolymph was collected for hemato-immunological tests, and growth performance were calculated. Shrimp raised at 22 °C and fed a 1% of dietary supplementation of Aurantiochytrium sp. meal were superior in immunological parameters. After the dietary assay, a total of 42 shrimps (10.9 ± 0.06 g) per treatment were infected with White Spot Syndrome Virus (WSSV). They were orally infected with 2.6 ± 106 virus particles per g of the animal, maintained at a suboptimal temperature of 22 °C for 108 h, and acclimated to an optimal temperature of 28 °C for an additional 48 h. At 7 days post infection, surviving shrimp were collected for hemato-immunological analysis. Cumulative mortality results showed that shrimp fed diets containing 3% and 4% Aurantiochytrium sp. meal had higher survival than other treatments when challenged with WSSV.

Убывающие города российской Арктики: статистические тренды и публичный дискурс о причинах оттока населения

The purpose of the article is to determine the most significant causes of population decline in the regions of the Russian Arctic. The object of the study was the urban population of the subjects of the Russian Arctic. The concept of a declining city, which has received various interpretations both in foreign and domestic scientific thought, was chosen as a theoretical framework for understanding the problem. In this article, the decline of cities is understood as a cumulative result of economic and demographic factors that cause population decline in the form of natural loss and migration outflow. On the basis of statistical data, a steady demographic decline was recorded in the cities of the subjects of the Russian Arctic. This made it possible to confirm the validity of the use of this concept in relation to these territories. Based on the materials of domestic and foreign studies, the most general, systemic factors of population decline in the regions of the Russian Arctic were identified, such as: the historical context and the policy of Soviet industrialization, the specifics of the local (regional) identity of the inhabitants of the northern territories, global demographic trends. At the empirical level, a more detailed analysis of the subjective perception of the reasons for the outflow of the population from the Murmansk Oblast, reflected in the public discourse of the participants of the online community of the city of Murmansk in the social network VKontakte, was carried out. The initial analysis base included posts and comments of the community for 20212022 (a total of 23.817 posts and 926.583 comments), the target sample included 268 posts and 2621 comments. Open and axial coding techniques were used to identify three groups of urban development issues as causes of the outflow of population from the region: 1) natural and climatic conditions, 2) quality of life, 3) prospects for the development of the city. Quantitative analysis of the number of comments (under posts) and likes (under comments) allowed us to identify the most significant and persistent problems, which, of course, are of increased interest to representatives of municipal and regional authorities.

Curculigoside, a traditional Chinese medicine monomer, ameliorates oxidative stress in Alzheimer's disease mouse model via suppressing ferroptosis.

Alzheimer's disease (AD) is a neurodegenerative disorder where oxidative stress, induced by ferroptosis, has been linked to neuronal damage and cognitive deficits. The objective of this study is to investigate if the potential therapeutic agent, Curculigoside (CUR), could ameliorate AD by inhibiting ferroptosis. The potential therapeutic targets, such as GPX4 and SLC7A11, were identified using weighted gene co-expression network analysis (WGCNA). Concurrently, CUR was also screened against these potential targets using various analytical methods. For the in vivo studies, intragastric administration of CUR significantly ameliorated cognitive impairment in AD model mice induced by scopolamine and okadaic acid (OA). In vitro, CUR protected neuronal cells by altering the levels of ferroptosis-related specific markers in OA and scopolamine-induced neurotoxicity. The administration of CUR through intragastric route significantly reduced the levels of AD-promoting factors (such as Aβ1-42, p-tau) and ferroptosis-promoting factors in the hippocampus and cortex of AD mice. Furthermore, CUR up-regulated the expression of GPX4 and decreased the expression of SLC7A11 in the ferroptosis signaling pathway, thereby increasing the ratio of glutathione (GSH)/oxidized glutathione (GSSG) in vivo and vitro. In conclusion, the cumulative results suggest that the natural compound CUR may serve as a promising therapeutic agent to ameliorate AD by inhibiting ferroptosis.

Heat release and flame scale effects on turbulence dynamics in confined premixed flows

As industry transitions to a net-zero carbon future, turbulent premixed combustion will remain an integral process for power generating gas turbines, aviation engines, and high-speed propulsion due to their ability to minimize pollutant emissions. However, accurately predicting the behavior of a turbulent reacting flow field remains a challenge. To better understand the dynamics of premixed reacting flows, this study experimentally investigates the effects of combustion heat release and flame scales on the evolution of turbulence in a high-speed, confined bluff-body combustor. The combustor is operated across a range of equivalence ratios from 0.7 to 1 to isolate the role of chemical heat release, flame speed, and flame thickness on the evolution of turbulence as the flow progresses from reactants to products. High-speed particle image velocimetry and CH* chemiluminescence imaging systems are simultaneously employed to quantify turbulent flame and flow dynamics. The results notably demonstrate that the flame augments turbulence fluctuations as the flow evolves from reactants to products for all cases, which opposes most simulations of premixed turbulent reactions. Notably, turbulence fluctuations increase monotonically with the heat of combustion and corresponding turbulent flame speed. Spatial profiles of turbulence statistics are conditioned on the mean flame front, and nondimensionalizing the turbulence profiles using laminar flame properties is shown to collapse all conditions onto a single curve. The resulting nondimensional profile confirms that turbulence dynamics scales with the heat of combustion and was used to develop a novel correlation to predict the increase in turbulent fluctuations across the premixed flame. A Reynolds averaged Navier Stokes decomposition is also explored to further characterize the effects of combustion heat release on the dominant mechanisms of turbulent energy transport. The cumulative results can guide modeling capabilities to better predict flame and flow dynamics and accelerate design strategies for premixed turbines with carbon-free fuels.

Cold deformation behavior and microstructure evolution of biomedical Cu-containing L605 alloy

The effect of copper (Cu) addition on the microstructure evolution and deformation mechanism of L605 (Co-20Cr-15 W-10Ni) alloy during cold deformation was investigated by using transmission electron microscopy (TEM), X-Ray diffraction (XRD) and electron backscatter diffraction (EBSD) analysis. The results indicated that the addition of Cu slightly decreased the yield strength and ultimate tensile strength, while it significantly increased the elongation. EBSD results revealed that hexagonal close-packed (HCP) martensite was generated during cold deformation and increased with increasing cold deformation level. The deformation microstructure of both alloys at different cold deformation levels shows that the stacking faulting was the primary deformation mechanism at early stage of cold deformation, in contrast, dislocation planar-slip and face-centered cubic (FCC) to HCP martensitic transformation were prevailed at both medium and late cold deformation level. Cu addition significantly suppressed the dislocation and stacking fault multiplication at early deformation stage and delayed the martensitic transformation at medium and late deformation stage, which could be ascribed to the relatively high stacking faulting energy by Cu addition, resulting in the low strain hardening behavior in the entire deformation process. These cumulative results and analyses could provide a solid foundation for the further development of this novel type of biomedical Cu-containing cobalt-based alloy.

Genetic Variability Studies in Yellow Seeded Linseed

The experimental materials consisted of 40 yellow seeded genotypes of linseed taken from “AICRP on linseed, Department of Genetics and Plant Breeding, IGKV, Raipur”, Chhattisgarh, India along with one check variety Surabhi. Seed yield is an important trait and the cumulative result of a number of component traits controlled by polygenes and influenced greatly by the environmental factors. Hence, yield alone would not be effective for selection of superior genotypes. In order to make the selection effective one has to give emphasis on the yield attributing traits. According to analysis of variance, “significant differences exist for all the parameters investigated from yellow seeded linseed genotypes.” It demonstrates that the yellow seeded genotypes of linseed have sufficient variability in seed yield and contributing characteristics. 1000 Seed weight (7.7g) and seed yield (15g) were the highest in the YLS-31 and YLS-23 genotypes, respectively. The highest GCV was found in number of secondary branches per plant (39.5%) followed by seed yield (32.1%), harvest index (21.6%), and number of primary branches per plant (24.3%). The highest PCV was found in the number of primary branches per plant (47%). Number of secondary branches per plant (43.2%), 1000 seed weight (37.9%), number of capsules per plant (33.9%) and harvest index (22.8%) were the next most important factor.

Counting the lifetime cost of obesity: Analysis based on national England data.

Obesity has a significant impact on all-cause mortality rate and overall health care resource use (HCRU). These outcomes are also strongly linked to age, sex and local deprivation of the population. We aimed to establish the lifetime costs of obesity by demographic group/geographic area using published mortality rates and HCRU use for integrated care boards (ICB) in England in the context of costs of therapeutic intervention. Population and expected mortality rates by age, sex and deprivation were obtained from national data. Obesity class prevalence was taken from the health of the nation study. The published impact of obesity by age, group, sex and deprivation on mortality and HCRU were applied to estimate life years lost and lifetime HCRU [by sex, age band and body mass index (BMI) class for each ICB]. The year 2019 was chosen as the study basis data to avoid influences of COVID-19 pandemic on obesity rates with application of 2022/23 HCRU values. Outcomes including prevalence, deaths, life years lost, HCRU and lifetime HCRU were compared by age and sex groups across four BMI classes normal/underweight (BMI <25 kg/m2 ), overweight (25-29.9 kg/m2 ), obese class I and II (30-39.9 kg/m2 ), and obese class III (≥40), with benchmarking being set against all population being BMI <25 kg/m2 overall and by each of the 42 ICBs. We also associated future life with deaths to provide an estimate of 'future life years lost' occurring each year. Total population aged >16 years was 45.4 million (51% female). 13.7 million (28% of the total adult population) had a BMI ≥30 mg/m2 and BMI ≥40 kg/m2 were 1.50 million (12%) of these 1.0 million (68%) were female and of these 0.6 million 40% were women aged 16-49 years. In addition, 35% of those with a BMI ≥40 kg/m2 were in the top deprivation quintile (i.e. overall 20%). Mortality was based on expected deaths of 518K/year, and modelling suggested that if a BMI <25 kg/m2 was achieved in all individuals, the death rate would fall by 63K to 455K/year for the English population (12% reduction). For those with a BMI ≥40 kg/m2 the predicted reduction was 12K deaths (54% lower); while in those aged 16-49 years with a BMI ≥40 kg/m2 72% of deaths were linked to obesity. For future life years lost, we estimated 2.5 years were lost in people with BMI 30-39.9 kg/m2 6.7 years when BMI ≥40 kg/m2 . However, for those aged 16-49 years with a BMI ≥40 kg/m2 , 8.3 years were lost. HCRU, for weight reduction, the annual HCRU decrease from BMI ≥40 kg/m2 to BMI 30-39.9 kg/m2 was £342 per person and from BMI 30-39.9 to 25-29.9 kg/m2 the reduction was £316/person. However, lifetime costs were similar because of reduced life expectancy for obese individuals. In quality adjusted life years (QALY), overall, 791 689 future life years were lost (13.1% of all) in people with BMI ≥25 kg/m2 and were related to excess weight. When the NICE £30 000 per QALY value was applied to the estimated total 791 689 future life years lost then the potential QALY value reduction lost was equivalent to £24 billion/year or £522/person in the obese population. For morbidly obese men and women the potential QALY value lost was £2864/person/year. Regarding geography, across the 42 ICBs, we observed significant variation in the prevalence of BMI ≥40 (1.8%-4.3%), excess mortality (11.6%-15.4%) and HCRU linked to higher BMI (7.2%-8.8%). The areas with the greatest impact on HCRU were in the north-west, north-east and Midlands of England, while the south shows less impact. The expected increases in annual HCRU because of obesity, when considered over a lifetime, are being mitigated by the increased mortality of obese individuals. Our data suggest that simple short-term HCRU reduction brought about through BMI reduction will be insufficient to fund additional specialist weight reduction interventions. The HRCUs associated with BMI are not in most cases related to short-term health conditions. They are a cumulative result over a number of years, so for age 16-49 years reducing BMI from ≥40 to 30-39.9 kg/m2 might show an annual decrease in HCRU/person by £325/year for women and £80/year for men but this might not have immediately occurred within that year. For those aged >70 years reducing BMI from ≥40 to 30-39.9 kg/m2 might show an annual decrease in HCRU/person by £777/year for women and £796/year for men but also may not be manifest within that year. However, for the morbidly obese men and women, the potential QALY value lost was £2864 per person per year with the potential for these funds to be applied to intensive weight management programmes, including pharmacotherapy.

Efficacy of Cisplatin-Containing Chemotherapy Regimens in Patients of Pancreatic Ductal Adenocarcinoma: A Systematic Review and Meta-analysis.

The relative success of cisplatin-based chemotherapy regimens for PDAC in clinical trials warrants a review of the literature to assess the cumulative results. This study aims to assess the efficacy of cisplatin-containing regimens for PDAC in terms of survival and response outcomes using a systematic review and proportional meta-analysis. In this study, an electronic search was conducted on PubMed, Cochrane Library, Scopus, and Google Scholar to find relevant literature. The random effects model was used to assess pooled overall response rate, stable disease rate, progressive disease rate, 1-year overall survival rate, and their 95% CIs. Publication bias was assessed using funnel plot symmetry and the one-tailed Eggers' test. In all cases, p-value < 0.05 was indicative of significant results. The review is registered with PROSPERO: CRD42023459243. A total of 34 studies consisting of 1599 patients were included in this review. All the included studies were of good quality. In total, 906 patients were male, and the median age of the patients was 58-69years. Overall, 599 patients had cancer of the pancreatic head, 139 had cancer of the pancreatic body, and 102 patients had cancer of the pancreatic tail. The pooled risk ratios (RRs) revealed an overall response rate of 19.2% (95% CI, 14.6-24.2%), a stable disease rate of 42.3% (95% CI, 36.6-48.8), a 1-year overall survival rate of 40% (95% CI, 34.3-45.8), and progressive disease rate of 24.7% (95% CI, 18.8-31.2). Commonly reported adverse events were anemia, thrombocytopenia, abdominal adverse events, neutropenia, fatigue, leukopenia, alopecia, anorexia, mucositis, stomatitis, and hepatobiliary adverse events. Cisplatin-containing regimens have shown moderate efficacy with significant improvement in overall survival at 1year, stable disease rate, and progressive disease rate; however, only a small percentage of patients achieved an overall response rate.

Improvement of the occupational risk management process in the work safety system of the enterprise.

The research purpose is to improve the management of occupational risks associated with hazards as well as the organization's capabilities to identify hazardous factors (HFs) using the "BOW-TIE" method in accordance with the provisions of the ISO 45001:2019 standard. To improve occupational risk management, the "BOW-TIE" method has been introduced into occupational health and safety management systems. This approach facilitates a comprehensive description and analysis of potential risk development from identifying hazardous factors to studying the consequences. It visually integrates fault and event trees to provide a holistic view of risk dynamics. The improvement of the occupational hazard risk management process considers both internal and external factors affecting the organization, thereby increasing the probability and severity of potential hazardous events. The revised approach categorizes risk levels as acceptable, unacceptable, or verifiable. In addition, occupational risk management requires an in-depth analysis of the organization's external and internal environment to identify hazards that affect the probability and severity of potential hazardous events. This research proposes an innovative approach to occupational risk management by determining the magnitude of occupational risk as the cumulative result of assessing risks associated with all external and internal factors influencing the probability of hazardous event occurring. The introduction of the "BOW-TIE" method, combined with a comprehensive analysis of the organizational environments, facilitates a more effective and nuanced approach to occupational risk management.

Dissection of Targeting Molecular Mechanisms of Celastrol-induced Nephrotoxicity via A Combined Deconvolution Strategy of Chemoproteomics and Metabolomics.

Celastrol (Cel), derived from the traditional herb Tripterygium wilfordii Hook. f., has anti-inflammatory, anti-tumor, and immunoregulatory activities. Renal dysfunction, including acute renal failure, has been reported in patients following the administration of Cel-relative medications. However, the functional mechanism of nephrotoxicity caused by Cel is unknown. This study featured combined use of activity-based protein profiling and metabolomics analysis to distinguish the targets of the nephrotoxic effects of Cel. Results suggest that Cel may bind directly to several critical enzymes participating in metabolism and mitochondrial functions. These enzymes include voltage-dependent anion-selective channel protein 1 (essential for maintaining mitochondrial configurational and functional stability), pyruvate carboxylase (involved in sugar isomerization and the tricarboxylic acid cycle), fatty acid synthase (related to β-oxidation of fatty acids), and pyruvate kinase M2 (associated with aerobic respiration). Proteomics and metabolomics analysis confirmed that Cel-targeted proteins disrupt some metabolic biosynthetic processes and promote mitochondrial dysfunction. Ultimately, Cel aggravated kidney cell apoptosis. These cumulative results deliver an insight into the potential mechanisms of Cel-caused nephrotoxicity. They may also facilitate development of antagonistic drugs to mitigate the harmful effects of Cel on the kidneys and improve its clinical applications.

Coherent spin-control of S = 1 vanadium and molybdenum complexes.

The burgeoning field of quantum sensing hinges on the creation and control of quantum bits. To date, the most well-studied quantum sensors are optically active, paramagnetic defects residing in crystalline hosts. We previously developed analogous optically addressable molecules featuring a ground-state spin-triplet centered on a Cr4+ ion with an optical-spin interface. In this work, we evaluate isovalent V3+ and Mo4+ congeners, which offer unique advantages, such as an intrinsic nuclear spin for V3+ or larger spin-orbit coupling for Mo4+, as optically addressable spin systems. We assess the ground-state spin structure and dynamics for each complex, illustrating that all of these spin-triplet species can be coherently controlled. However, unlike the Cr4+ derivatives, these pseudo-tetrahedral V3+ and Mo4+ complexes exhibit no measurable emission. Coupling absorption spectroscopy with computational predictions, we investigate why these complexes exhibit no detectable photoluminescence. These cumulative results suggest that design of future V3+ complexes should target pseudo-tetrahedral symmetries using bidentate or tridentate ligand scaffolds, ideally with deuterated or fluorinated ligand environments. We also suggest that spin-triplet Mo4+, and by extension W4+, complexes may not be suitable candidate optically addressable qubit systems due to their low energy spin-singlet states. By understanding the failures and successes of these systems, we outline additional design features for optically addressable V- or Mo-based molecules to expand the library of tailor-made quantum sensors.

An excimer process induced a turn-on fluorescent probe for detection of ultra-low concentration of mercury ions.

The accumulation of mercury pollution in plants can induce severe injury to human beings. It is a great challenge to monitor ultra-low concentrations of mercury in complicated matrixes. In this study, we successfully developed a strategy via Hg2+-triggered naphthalene-based fluorescent probe 1, which formed excimer that subsequently emitted fluorescence for the successful detection of ultra-low concentrations of Hg2+. The coordination of N and S atoms with Hg2+ facilitated the formation of excimer from the naphthalene-conjugated planes that were in sufficiently close proximity. Suppression of CN bond rotation also induced the chelation-enhanced fluorescence (CHEF) effect, and the cumulative result of these effects was obvious fluorescent enhancement. Compared with probe 2, the other key factor for detection of Hg2+ is that the electrons of the hydroxyl group can easily transfer to a naphthalene moiety, resulting in an augmented π-electron density that enhanced the π-π stacking of the naphthalene-conjugated excimer. After detailed spectral studies and mechanism discussions, it was realized that probe 1 was able to detect ultra-low concentrations of Hg2+ in PBS buffer solution. The detection limit was calculated to be 1.98 nM. On account of the excellent performances, the probe was successfully applied in monitoring Hg2+ in water and pea sprouts with the potential for application as an advanced warning of contamination.