The objective of this study is twofold: one, to analyze the presence of the nutrition transition in Nigeria through assessment of national food consumption trends, obesity, and noncommunicable diseases (NCDs) data over time, and two, to assess the role that indigenous knowledge and foodways can play in promoting healthy diets in the country through the case study of Enugu State, Igboland. A mixed-methods approach was utilized with quantitative data from the Nigerian Living Standards Survey and Demographic Health Survey to measure changes in obesity, diabetes, hypertension, and food consumption across Nigeria from 2003 to 2018 using Natural Language Processing and Trend Analysis. Primary qualitative data in Enugu State were collected through semi-structured interviews in 2021 with a random sampling technique undertaken to analyze the status of indigenous Igbo foods and traditions to curb the negative effects of the nutrition transition, as well as to document the motivations behind using or abandoning traditional foods in the present generation. The findings of the study depict the nutrition transition in Nigeria in multiple forms. The combined overweight and obese population in the country has experienced a 29% increase in the 15-years study period, while the NCDs hypertension and diabetes have experienced a combined 21% increase. Consumption patterns have shifted, though not always in the ways predicted from the literature, with statistically significant increases displayed in the consumption of Breads and Pastries, Starchy Roots and Tubers, Legumes, Plant and Animal Fats, Seafoods, Milk and Dairy Products, Beverages, Non-alcoholic Drinks, Vegetables, and Red Meats. The primary data analysis displayed that the traditional Igbo foodscape is defined by local, nutritious whole foods. The data depicted significant recent trends toward using ultra-processed seasoning cubes instead of local herbs as spices, with a huge shift from 0% frequency usage identified in the parents’ generation to a 35% frequency in the current generation. Eighty-three percent of the community surveyed stated that they believe that the diets of the younger generation are changing, with the majority stating that the change is for the worse. Participants from the community provided recommendations for curbing the nutrition transition and empowering indigenous foodways through policy, investment, and mindset change. Though consumption patterns are changing and Nigeria’s obesity and NCD rates are increasing, it is still far behind the rate of obesity in countries farther along in the nutrition transition such as its former colonizer Britain. Interviews conducted around Enugu State show how the indigenous food system is centered on fresh, healthy foods, primarily local tubers, legumes, vegetables, and spices. There is extensive knowledge and pride in the indigenous food system, even though there was a consensus that Igbo food culture is currently undergoing immense changes in part due to some of the younger generation’s new tastes in processed foods and convenience.