The article provides an analysis of the features of the dialogue of civilizations in Central Asia. The region is considered as an intercivilizational hub where Persian, Hellenistic, Babylonian, Chinese, Indian, Mongolian, Arab, and Turkic civilizations interacted and competed. As a result, a special type of culture arose that influences peoples, their national psychology, religion, and linguistic characteristics. Historically, the region was a contact zone of settled agricultural and nomadic civilizations. The impetus for the development of the region was given by its transit potential, in particular the Great Silk Road. The authors believe that at the present stage, dialogue is possible based on an understanding of the historical community of different peoples living in the region, and one’s own civilizational identity, which is based on traditional values. The political culture of the Central Asian countries has developed its own democratic principles, which are not always identical to Western ones. At the present stage, new dialogue platforms are emerging where active intercivilizational dialogue is conducted. Along with the dialogue are Afghanistan, Iran, China, Pakistan.