Background: Outcomes and severity of acute pancreatitis is a challenging condition to diagnose. However, multiple clinico-biochemical scores, imaging, radiological imaging, and biochemical markers are used. Aims: To evaluate procalcitonin as a predictor of severity in acute pancreatitis and to correlate the levels of procalcitonin to the CT Severity Index score. Materials and Methods: In 65 study subjects, prolactin levels, CRP, blood glucose, liver function tests, BUN, creatinine, urea, CBC, and radiological investigations including whole abdomen USG, X-ray abdomen-supine and erect, and chest X-ray PA view. Following 48-72 hours of admission, a CT abdomen was done on subjects with diagnostic dilemmas. In subjects where CECT was done, necrosis scores and Balthazar grading were used for grading the CT severity index. Results: For the cut-off PCT value of 1.77 ng/ml the sensitivity, specificity, PPV, NPV, accuracy, and likelihood ratio were 74.8, 76.88, 74.8, 76.94, 74, and 15.154 respective. In the PCT cut-off value of 3.29 ng/ml, the respective values of sensitivity, specificity, PPV, NPV, accuracy, and likelihood ratio were 66.65, 84.58, 79.8, 73.31, 74, and 14.426. BCTSI score of ≥4, the respective values of sensitivity, specificity, PPV, NPV, accuracy and likelihood ratio were 62.3, 65.36, 62.3, 65.36, 65, and 3.936.