CSS Group Research Articles

Exercise sensitivity, physical activity, and kinesiophobia in patients with chronic coronary syndrome: a cross-sectional study.

Cardiac risk factors and diseases exacerbate anxiety and may cause exercise sensitivity by increasing awareness of physical conditions. However, the extent to which exercise sensitivity influences the level of physical activity and kinesiophobia in CVD patients is unclear. The current study aimed to determine exercise sensitivity and its associated kinesiophobia and physical activity levels in patients with chronic coronary syndrome (CCS). This cross-sectional study involved 43 patients diagnosed with CCS and 45 age- and gender-matched healthy individuals. Exercise sensitivity (questionnaire created by researchers), physical activity levels (short form Physical Activity Questionnaire, IPAQ), and kinesiophobia (Tampa Kinesiophobia Scale Heart, TSK-H) were evaluated. The exercise sensitivity score (ESS, 37.40 ±7.38 and 33.65 ±5.83, p = 0.010) was higher in the CSS group. During exercise, feeling pain, depletion of energy fatigue, chest pain, chest tightness, dizziness, palpitations, dyspnoea, and fainting frightened the patients (p < 0.05). The TSK-H score was higher, and the difference was significant in CCS patients compared the healthy controls (p = 0.007). Tye physical activity level was lower in patients than in healthy controls (p < 0.001), and 58.1% of CCS patients were inactive. ESS was significantly associated with IPAQ score (r = -0.360; p = 0.018) and TKS-H score (r = 0.529; p < 0.001) in CCS patients. According to linear regression analyses, exercise sensitivity explains 25% of kinesiophobia and physical activity. Patients with CCS exhibit fear and sensitivity towards exercise, and these fears contribute to high levels of kinesiophobia and low physical activity levels. Future studies should be designed based on exercise sensitivity to increase participation in exercise-based programs.

Spectroscopic, computational, anti-bacterial studies of bivalent metal complexes of N-picolyl-amine dithiocarbamate

This study reports the synthesis of seven picolylamine dithiocarbamate complexes of M(II) {M =CoII (1), NiII (2), CuII (3), PdII (4), ZnII (5), CdII (6) and HgII (7)}. CHN analysis, conductivity measurements, magnetic susceptibility measurement, FT-IR, 1H and 13C-NMR, SEM, and XRD were used to investigate the structural geometries of the complexes. The dithiocarbamate ligand coordinates to the M(II) ion in a bidentate mode through sulfur atoms forming a square planar or tetrahedral geometry. Moreover, the surface structural analysis revealed nano-pattern properties. For instance, complexes of Cd(II) and Hg(II) showed a nano-flower pattern, averaging 2–5 µm. Furthermore, the obtained complexes exhibited biological activity properties. The results showed that the new metal (II) compounds possessed remarkable antibacterial inhibition activity against both Gram-positive and Gram-negative bacteria. Additionally, the complexes [Ni(PA-dtc)2], [Cu(PA-dtc)2], and [Pd(PA-dtc)2] were theoretically studied and their quantum parameters were evaluated using Gaussian 09 program at B3LYP/SDD level of theory. The optimized structures of all of the three complexes showed square planar geometry. The calculated bond lengths showed close values, specifically for CSS and CN group, which suggests a partially double bond character. Other quantum parameters have evaluated and showed similar properties such as the total energy, HOMO-LUMO energy gap, Affinity, Hardness, and dipole moment.

Prognostic Value of Logistic Clinical Syntax Score in Coronary Bifurcation Lesions Treated with Double Stent Technique

Introduction: In this study, we aimed to investigate the relationship between the preprocedural logistic clinical SYNTAX score (Log CSS) and major cardiovascular events (MACE) in patients with true bifurcation lesions who underwent revascularization with the double stent strategy. Patients and Methods: A total of 233 non-ST elevation myocardial infarction (NSTEMI) patients who underwent revascularization with a double stent strategy were retrospectively included in the study. Anatomical SYNTAX score (SS) and log CSS were calculated. The patients were divided into two groups according to the cut-off value determined by ROC analysis. The prediction of two-year MACE with Log CSS was evaluated. Results: MACE developed in 33.9% of patients with high Log CSS and 8.5% of patients with low Log CSS (p&lt; 0.001). In the Kaplan-Meier survival analysis, the long-term survival of the high Log CSS patients was significantly lower than the low Log CSS group (Log-rank p&lt; 0.001). In multivariate COX analyses, high Log CCS (HR= 3.781; 95% CI= 1.706-8.377; p= 0.001) was the strongest independent predictor of MACE. Conclusion: Log CSS can be a simple and useful tool to predict the development of MACE in patients with true bifurcation lesions revascularized by percutaneous coronary intervention.

Utility and optimal cut-off point of the Somatic Symptom Scale-8 for central sensitization syndrome among outpatients with somatic symptoms and related disorders

BackgroundCentral sensitization syndrome (CSS) involves severe functional symptoms due to central sensitization. for patients with severe somatic symptoms and related disorders (SSRDs), central sensitization may be responsible for their functional symptoms. We hypothesized that screening for CSS in patients with SSRDs would identify those with severe disease. The Somatic Symptom Scale-8 (SSS-8) is a simple tool to assess medical conditions related to SSRDs, but the cut-off point to identify severe cases of comorbid CSS is unknown. This study aimed to determine the optimal cut-off point of SSS-8 for screening the CSS of patients with severe SSRDs.MethodsIn total, 143 patients with SSRDs attending outpatient clinics of a university hospital in Japan were included in the study. The participants were evaluated using the SSS-8 for somatic symptoms, Hospital Anxiety and Depression Scale (HADS) for anxiety and depressive symptoms, Pain Catastrophizing Scale (PCS) for catastrophic thoughts, and Central Sensitization Inventory (CSI-A, B) for CSS. Receiver operating characteristic (ROC) curve analysis was performed using the propensity score. The area under the curve (AUC) was calculated using a propensity score considering PCS, age, sex, HADS, and CSI-B as confounders of SSS-8 and CSS to evaluate differences in diagnostic accuracy between patients with and without SSS-8. The sensitivity and specificity of the ROC analysis were then used to determine the cut-off point for discriminating severe cases of SSS-8.ResultsOf the 143 participants, 126 responded (51 CSS group and 75 non-CSS group), with a valid response rate of 88.1 percent. In the ROC analysis, the propensity score including SSS-8 was statistically more accurate. The optimal cut-off point was 13, with an AUC of 0.88, sensitivity of 84.3 percent, and specificity of 77.3 percent.ConclusionsThe SSS-8 is a useful tool for discriminating severe cases of SSRDs comorbid with CSS.

Carbazochrome sodium sulfonate is not effective for prevention of post-gastric endoscopic submucosal dissection bleeding: A retrospective study

BackgroundCarbazochrome sodium sulfonate (CSS) is conventionally administered to prevent post-endoscopic submucosal dissection (ESD) bleeding in many institutions, but research on its preventive efficacy is lacking. Therefore, we investigated the risk of post-ESD bleeding and the preventive efficacy of CSS administration.MethodsWe retrospectively reviewed 304 lesions in 259 patients with gastric neoplasms who underwent ESD at Asahikawa Medical University Hospital from 2014 to 2021. In the CSS group, CSS 100 mg/day was intravenously infused with maintenance fluid replacement on postoperative days 0–2. The risk factors of post-ESD bleeding, including CSS administration, were investigated.ResultsThe overall rate of post-ESD bleeding was 4.6% (14/304). The univariate analysis showed that atrial fibrillation (Af), warfarin intake, heparin replacement, and tumor location in the lower third were significant risk factors for increasing the likelihood of postoperative bleeding. In the multivariate analysis, Af (odds ratio [OR] 3.83, 95% CI 1.02–14.30; p < 0.05), heparin replacement (OR 4.60, 95% CI 1.02–20.70; p < 0.05), and tumor location in the lower third of the stomach (OR 6.67, 95% CI 1.43–31.00; p < 0.05) were independent factors for post-ESD bleeding. Post-ESD bleeding was observed in 5.2% (9/174) of the CSS group and 3.8% (5/130) of the non-CSS group, with no significant difference between the two groups (p = 0.783). Additionally, CSS was not shown to have preventive effects in groups with higher-risk factors, such as Af diagnosis, warfarin use, heparin replacement, and tumor location in the lower third of the stomach.ConclusionCSS administration was not effective for the prevention of the post-ESD bleeding in the overall patient population as well as in higher-risk patients. This suggests that the administration of CSS for post-ESD bleeding prevention may need to be reconsidered.

Pro-angiogenic potential of a functionalized hydrogel scaffold as a secretome delivery platform: An innovative strategy for cell homing-based dental pulp tissue engineering.

Angiogenesis is a key process that provides a suitable environment for successful tissue engineering and is even more crucial in regenerative endodontic procedures, since the root canal anatomy limits the development of a vascular network supply. Thus, sustainable and accelerated vascularization of tissue-engineered dental pulp constructs remains a major challenge in cell homing approaches. This study aimed to functionalize a chitosan hydrogel scaffold (CS) as a platform loaded with secretomes of stem cells from human exfoliated deciduous teeth (SHEDs) and evaluate its bioactive function and pro-angiogenic properties. Initially, the CS was loaded with SHED secretomes (CS-S), and the release kinetics of several trophic factors were assessed. Proliferation and chemotaxis assays were performed to analyze the effect of functionalized scaffold on stem cells from apical papilla (SCAPs) and the angiogenic potential was analyzed through the Matrigel tube formation assay with co-cultured of human umbilical vein endothelial cells and SCAPs. SHEDs and SCAPs expressed typical levels of mesenchymal stem cell surface markers. CS-S was able to release the trophic factors in a sustained manner, but each factor has its own release kinetics. The CS-S group showed a significantly higher proliferation rate, accelerated the chemotaxis, and higher capacity to form vascular-like structures. CS-S provided a sustained and controlled release of trophic factors, which, in turn, improved proliferation, chemotaxis and all angiogenesis parameters in the co-culture. Thus, the functionalization of chitosan scaffolds loaded with secretomes is a promising platform for cell homing-based tissue engineering.

Development of a genome-wide 200K SNP array and its application for high-density genetic mapping and origin analysis of Camellia sinensis.

Development of a genome-wide 200K SNP array and its application for high-density genetic mapping and origin analysis of Camellia sinensis.

Flotation separation of molybdenite from chalcopyrite using rhodanine-3-acetic acid as a novel and effective depressant

The selective separation of molybdenite from chalcopyrite is difficult because of their similar floatability in the presence of a collector. In this study, rhodanine-3-acetic acid (3-Rd) was first applied in molybdenite flotation as a novel chalcopyrite depressant, and its depression effect and mechanism were systematically investigated by flotation tests, density functional theory (DFT) calculation, zeta potential measurements, and X-ray photoelectron spectroscopy (XPS) analysis. Single mineral flotation results indicated that 3-Rd can selectively depress chalcopyrite flotation, whereas its effect on molybdenite is negligible. Mixed mineral and bench flotation tests further proved that 3-Rd is an efficient chalcopyrite depressant. The first-principle periodic calculations based on DFT predicted that 3-Rd prefers to adsorb onto Fe rather than Cu because of the more negative adsorption energy of the COO or CSS group on Fe in the chalcopyrite surface. Zeta potential measurements demonstrated that 3-Rd is adsorbed on chalcopyrite surface more selectively, and its adsorption strength is higher than that on molybdenite surface. XPS analysis further confirmed that 3-Rd is chemisorbed on chalcopyrite surface by binding with Fe active site and is adsorbed on molybdenite surface through hydrogen bonding and electrostatic interactions.

The Effect of Amisulpride on Hippocampal Neurogenesis in an Experimental Model of Stressed Rats

Rationale: Amisulpride (Sanofi) is atypical antipsychotic against both positive and negative symptoms of schizophrenia . Efficacy is observed against negative symptoms in a low dose range of ( 50-300 mg / day ) while in positive symptoms is observed in a high dose range ( 800-1200 mg / day ) Boyer et al ,( 1994 ). It is a selective and potent antagonist at dopamine D2 and D3 receptors. Also it appears to have a useful potential for treatment of depression Boyer et al ,(1999). Objectives: The current study investigated that amisulpride has antidepressant properties over a range of doses in two procedures namely the Forced Swim Test (FST) Porso et al,(1978) and immune-histopathology of Ki67. Also the effect of high versus low dose of amisulpride on hippocampal neurogenesis in male Wistar Han albino rats. Results: There is an increase of immobility time in seconds in CSS group compared with Control group with Mean ± SD (67.00±8.623 and 3.333±1.670 respectively) with P treatment with oral Amisulpride 5 ,10 mg/kg/day result in insignificant increase in Ki-67 immunostained cells in SVZ, with the maximum statistically increase with 20 mg/kg/day, with means (15.78,13.38 and 28.00 respectively )compared with CSS (Mean 8.000 ) with P values of 0.5108 ,0.8187and 0.0009 respectively and F (4,40)=6.628.

Biomechanical comparison of Kangli hollow screws with sliding compression locking plate system and conventional cannulated lag screws for fixation of type Pauwels III femoral neck fracture

Objective To compare the biomechanical performance of Kangli hollow screws with sliding compression locking plate system (KHS) and conventional cannulated lag screws for fixation of type Pauwels III femoral neck fracture. Methods 7 cadaveric femurs were selected, vertical fractures (Pauwels III fracture, at 70° to the horizontal) were artificially conducted in these cadaveric proximal femurs by an orthopaedic surgeon and fixed by KHS screws with plate system or conventional cannulated lag screws. Samples were positioned at 75° of the femoral shaft to the horizontal, embedded in the mould and fixed in the experimental console. Optical sensors were set at the femoral neck around the osteotomy line. Then the loading were input in the vertical, horizontal lateral direction and rotating direction around the femoral neck axis, the maximal and minimal values between the fractured fragments and the corresponding values of the loading were recorded. The values of stiffness in three directions were calculated and compared. The CT data of the left femur of a 25 year-old healthy male volunteer was input into the corresponding software and vertical femoral neck fracture model was generated. Two finite element analysis models were obtained after the fracture being fixed using these two different implants, and the Von Mises stress distribution on the femur, implants and the interface between the fractured fragments and the relative motion between the fractured fragments were compared. Results In the vertical, horizontal lateral direction and rotating direction around the femoral neck axis, the stiffness of the KHS were 3 904±1 148 N/mm, 4 324±1 234 N/mm and 11.45±4.95 N·m/° respectively, higher than those of the CSs method with the values of 3 020±1 150 N/mm, 3 020±854 N/mm and 6.53±4.83 N·m/° respectively. The differences between the two groups were statistically significant (t=2.7194, 4.7694 and 2.9424; P=0.0347, 0.0050 and 0.0423). In the finite element analysis test, the maximal Von Mises stress values distributing on the femur and the screws in the KHS group were 40.1 MPa and 126.4 MPa, and those in the CSs group were 98.1 MPa and 145.5 MPa respectively, and both values of the former were lower than the latter. But the Von Mises stress value on the interface between the fractured fragments in the KHS group was 14.37 MPa, which was much higher than that in the CSs groupwhich was 9.39 MPa. The gap at the fracture site of the CSs fixation model was dramatically larger than that of KHS fixation model. Conclusion The KHS screws and plate system could provide better immobilization effect for vertical femoral neck fracture compared to the cannulated lag screws. The risk of the screws failure was lower and the fracture union would be easier to obtained by the fixation of KHS screws with plate system. Key words: Femoral neck fractures; Fracture fixation, internal; Biomechanics; Finite element analysis

Synthesis and characterization of incorporating mussel mimetic moieties into photoactive hydrogel adhesive

Surgical adhesive is the optimal candidate for the replacement of traditional mechanical wound closure. In our paper, mussel adhesive proteins inspired hydrogel adhesive was prepared with 3, 4-dihydroxyphyenylanine acrylamide (DOPA-AA), poly (ethylene glycol) diacrylate (PEGDAA) and thiolated chitosan (CSS) by UV irradiation. DOPA-AA, containing catechol group and vinyl group, was successful synthesized and characterized by FTIR and 1HNMR. The gelation time, equilibrium water content, degradation, materials properties and adhesive strength of the hydrogels were studied. We found that the gelation time was retarded and the materials mechanical strength was decreased because of the inhibitory effect of catechol group. Equilibrium water content was slightly affect by the increasing concentration of DOPA-AA (1–5%). Nevertheless, catechol group can remarkably improve the adhesive properties because of the complex and durable interactions of the hydrogel, especially, the interaction between the thiol group of CSS and catechol group of DOPA-AA, which also greatly slowed down the degradation of the adhesive hydrogels. CSS and DOPA-AA was introduced to ensure the adhesive properties, DOPA-AA lend the adhesive nature to hydrogel and CSS can protect the catechol group from oxidation and enhance durable adhesion. Moreover, cytotoxicity of the resulting hydrogels showed that the L929 cell viability was weaken, it mostly probably induced by the catechol oxidation.

Crystal structure of dipotassium N-carbodi-thio-ato-l-prolinate trihydrate.

The mol-ecular and crystal structure of the l-proline-derived di-thio-carbamate-carboxyl-ate compound poly[tri-μ-aqua-(μ-2-carboxyl-atopyrrolidine-1-carbodi-thio-ato)dipotassium], [K2(C6H7NO2S2)(H2O)3] n or K2(SSC-NC4H7-COO)·3H2O, has been determined. The di-thio-carbamate moiety displays a unique coordination mode, comprising a 'side-on' π-coordinated K+ cation besides a commonly σ-chelated K+ cation. By bridging coordination of the CSS group, COO group and water mol-ecules, the K+ cations are linked into a two-dimensional coordination polymer extending parallel to the ab plane. These layers are again inter-connected by O-H⋯S hydrogen bonds.

Influence of feeding alternative fiber sources on the gastrointestinal fermentation, digestive enzyme activities and mucosa morphology of growing Greylag geese

The objective of this trial was to study the influence of dietary fiber sources on the gastrointestinal fermentation, digestive enzyme activity, and mucosa morphology of growing Greylag geese. In total, 240 Greylag geese (28-day-old) were allocated to 4 treatments (15 pens/treatment) differing in dietary fiber source: corn straw silage (CSS group), steam-exploded corn straw (SECS group), steam-exploded wheat straw (SEWS group), or steam-exploded rice straw (SERS group). At 112 days of age, 15 birds per group were euthanized to collect samples. No difference (P > 0.05) was found on all the gastrointestinal pH values and ammonia-nitrogen concentrations between the groups. The CSS and SERS groups had a lower (P < 0.05) proportion of acetic acid in the gizzard than the SECS and SEWS groups. The CSS group had a higher VFA concentration in the jejunum (P < 0.05) and acetic acid proportion (P < 0.01) in the ceca, and a lower (P < 0.01) butyric acid proportion than the other groups except for the SECS group. The SECS group had a higher (P < 0.01) acetic acid proportion and lower (P < 0.05) proportions of propionic acid and valeric acid in the ceca than the SEWS and SERS groups. Different fiber sources resulted in different VFA profiles, especially in the gizzard and ceca. Almost all gastrointestinal protease activities of the CSS group were higher (P < 0.05) than the other groups, along with lower (P < 0.01) amylase activities in the duodenum, jejunum, ileum, and ceca. Lipase activity in proventriculus was highest (P < 0.01) in the SEWS group and its cecal activity was lower (P < 0.01) in the SECS and SEWS groups than the CSS and SERS groups with a higher (P < 0.01) lipase activity in the CSS group than the SERS group. The SECS and SERS groups had a higher cellulase activity in the ceca than the CSS and SEWS groups, with a higher (P < 0.01) rectal cellulase activity in the SERS group than the other groups. There was no significant effect (P > 0.05) on the intestinal mucosa morphology. These results suggest that corn straw silage improves protein digestion while steam-exploded straw provides more energy.

The Comparison of Silver and Laser Soldering Techniques on Periodontal Tissues: A Preliminary Study

ABSTRACT Objective: The aim of this study was to compare the inflammatory effects of conventional and laser soldering methods on periodontal tissues in orthodontics. Materials and Method: Forty specimens were acquired from 10 patients whose treatment plan consisted of extraction of 4 first premolars. Before performing the extractions, a transpalatal arch (TPA) for the upper first molars and a lingual arch for the lower first molars were placed for anchorage purposes. Upper left and lower right first molar bands were soldered using the laser welding (LW) technique, and upper right and lower left first molar bands were soldered using the conventional silver soldering technique (CSS). Gingival crevicular fluid (GCF) analysis was used for determining the effects of welding procedures on periodontal tissues. All variables were analyzed by nonparametric tests. Results: Myeloperoxidase levels ranged between 2.46 and 3.56 for the CSS group and between 2.20 and 3.39 for the LW group; nitric oxide levels ranged bet...

FRI0385 Factors associated with refractoriness to NSAIDS in GOUTY arthritis

BackgroundIn gouty arthritis, we most often start with a non-steroid anti-inflammatory drug (NSAID). Many patients with gout have comorbidities that make NSAIDs use problematic. In clinical practice, we observe more...

Short stay surgery for breast cancer: an audit of an experience in a regional cancer centre in northern India

At the Institute Rotary Cancer Hospital, AIIMS, New Delhi, 246 patients of breast cancer were operated on from June 1993 to June 1996; 82 suitable patients were discharged within 48 h (short stay surgery, SSS) after surgery and 164 were discharged after 48 h (conventional stay surgery, CSS). After discharge, patients of both groups were followed in the outpatient clinic until the removal of sutures and drains. There was no mortality or readmission for a complication in either group. Mean post-operative hospital stay was 1.5 days in the SSS group, and 3.3 days in the CSS group. There was no statistically significant difference in the incidence of post-operative complications like wound infection (4.8% vs 4.2%), flap necrosis (6% vs 5.4%), seroma (14% vs 19%), and the average number of hospital visits (3.42 vs 3.2) in SSS and CSS groups, respectively. Patient acceptance of early discharge was good except in the day care group. The study supports the safety and feasibility of short stay surgery for breast cancer in certain circumstances for properly selected patients.

Electronic spectra of salts of dithiocarbamic acids

The report gives synthesis and UV spectra of a series of alkali and ammonium salts of the dithiocarbamic acids derived from dimethyl-, diethyl-, dipropyl-, dibutyl-, dipentyl-, dihexyl-, diheptyl-, dioctyl-, diisopropyl-, diisobutyl-, methylisopropylamine, piperidine, morpholine, piperazine and pyrrolidine. The absorption bands due to transitions localized in the groups CSS (λmax ~ 260 nm) and NCS (λmax ~ 280 nm) show a red shift with increasing length of the alkyl chain. Increasing polarity of solvent causes, with some of the compounds, a small red shift of λmax of the band due to CSS group, but it causes a considerable blue shift of λmax of the band due to NCS group in all the studied compounds. The absorption band near 207 nm is ascribed to the carbon disulphide produced by decomposition of the dithiocarbamates.

On classification of maps of a css complex into a css group

On classification of maps of a css complex into a css group