Copper sulfide and Fe, Ag doped copper sulfide nanopowders were synthesized by integrated hydrothermal-green approach, using Urtica dioica leaf extract as a solvent. With Fe and Ag doping, covellite as the major phase was sustained but reduction in crystallite size and change in morphology was observed. Decrease in electrical conductivity from ∼186.24 Scm−1 for undoped copper sulfide to ∼34.97 Scm−1 and ∼23.26 Scm−1 on doping Fe and Ag, respectively, at 300 K, was witnessed due to formation of different phases of copper sulfide and incorporation/segregation of Ag/Fe into copper sulfide lattice. Conversely, Seebeck coefficient showed enhanced values on doping Fe and Ag. The maximum power factor of ∼22.22 μW/mK2 was found for undoped copper sulfide. Thus, the incorporation/segregation of Fe/Ag ions in copper sulfide lattice and grain boundaries was found to alter the thermoelectric performance of copper sulfide.