Crosstalk Effects Research Articles

“Stick–slip” fluctuations in local electrical conductivity maps on graphite surfaces: A revisit

Electrical conductivity images of graphite surfaces are routinely obtained using scanning probe microscopy. Although the acquired conductivity maps often display a trigonal pattern with smooth variations, a “stick–slip” type of fluctuation has also been reported, where the local conductivity inversely correlates with the friction force during probe scanning. In this work, we revisit the lattice-resolved variations in local conductivity on graphite surfaces and reveal a new series of behaviors. Unlike previous observations, we demonstrate that local conductivity can exhibit in-phase, out-of-phase, or mixed-mode correlations with “stick–slip” lateral force signals. These behaviors are attributed to the cross-talk effect between interface contact conductivity and lateral force, induced by the inhomogeneous conductivity of the tip apex. This mechanism is experimentally validated, showing that local conductivity variations can switch within a single scan due to spontaneous changes in the conductivity of the tip. Our findings enhance the understanding of lattice-resolved electrical conductivity data on graphite surfaces and suggest a novel approach to amplify small lateral forces using inhomogeneous probe tips.

Design of Silicon Core Coaxial TSVs to Reduce Crosstalk Effects for 3D IC Applications

This paper presents the effectiveness of the copper (Cu)-based coaxial through silicon vias (CTSVs) to reduce crosstalk noise and propagation delay. In the proposed CTSVs, the polymer liners are used as insulating material which cancels the crosstalk functional failures. The impacts of the proposed CTSVs on the electrical performance are noticed for different parameters and properties of the material. Simulations of the proposed CTSVs are executed using the standard HSPICE and SYMICAD tools. The results indicated that the effects of crosstalk are reduced using the polymer liners instead of silicon dioxide (SiO2) liners in the proposed CTSVs. The electrical performances of the proposed CTSVs are investigated for various thicknesses of Cu and BCB. Furthermore, a comparative study has been carried out for the SiO2 and benzocyclobutene (BCB) liners. It is observed that BCB liner-based CTSVs crosstalk noise and delay values are reduced by up to 25.06% and 27.8% compared to the SiO2 liner-based TSVs.

Modeling and analysis of crosstalk induced effects in graphene-carbon nanotube composite interconnects

This paper proposes an equivalent circuit model for two-line coupled multilayer graphene nanoribbon - single-wall carbon nanotube (MLGNR-SWCNT) composite interconnects (MSCs), incorporating the effects of coupling capacitance and mutual inductance. We also examine the temperature-dependent crosstalk effect on the victim line of MSCs in the time domain using decoupling techniques and the ABCD parameter matrix approach. This analysis is conducted at the global level of 7 nm, 14 nm, and 22 nm technology nodes, comparing the performance of MSCs with MLGNR, SWCNT, and copper (Cu) interconnects, validated through HSPICE simulations. Our results reveal that the crosstalk delay of all interconnects induced by dynamic crosstalk exhibits superior performance in the in-phase crosstalk mode compared to the out-of-phase mode at room temperature. In particular, MSCs demonstrate less crosstalk delay in both crosstalk modes compared to SWCNT and Cu interconnects. In addition, we analyze the crosstalk delay of the victim line for two-line coupled MSCs at varying temperatures in out-of-phase crosstalk mode, comparing them with MLGNR, SWCNT, and Cu interconnects. Simulation results indicate that the crosstalk delay is temperature-dependent, increasing with rising temperatures, and the crosstalk delay of MSCs is the least of all interconnects. Furthermore, we investigate the crosstalk noise of MSCs induced by functional crosstalk at different temperatures, comparing it with MLGNR, SWCNT, and Cu interconnects. It is observed that the crosstalk noise peak remains constant with temperature changes across all interconnects; however, the holding time and width of crosstalk noise increases with rising temperatures and MSCs have the least crosstalk noise peak and crosstalk noise width of all interconnects. Also, numerical results exhibit that reducing interconnect temperature, SWCNT diameter, and edge roughness of MLGNR are effective strategies to diminish the crosstalk delay of MSCs. In addition, increasing line spacing is identified as an effective method to reduce crosstalk noise peak of MSCs of different lengths. The proposed model results show excellent agreement with HSPICE simulation data. Therefore, our analysis of crosstalk effect manifests that MLGNR-SWCNT composite can be a promising material to replace SWCNT and copper as an ideal material for global interconnect applications in thermally variable environments.

A memristive-photoconductive transduction methodology for accurately nondestructive memory readout

Crossbar resistive memory architectures enable high-capacity storage and neuromorphic computing, accurate retrieval of the stored information is a prerequisite during read operation. However, conventional electrical readout normally suffer from complicated process, inaccurate and destructive reading due to crosstalk effect from sneak path current. Here we report a memristive-photoconductive transduction (MPT) methodology for precise and nondestructive readout in a memristive crossbar array. The individual devices present dynamic filament form/fuse for resistance modulation under electric stimulation, which leads to photogenerated carrier transport for tunable photoconductive response under subsequently light pulse stimuli. This coherent signal transduction can be used to directly detect the memorized on/off states stored in each cell, and a prototype 4 * 4 crossbar memories has been constructed and validated for the fidelity of crosstalk-free readout in recall process.

Comparing thin and volume regimes of analog holograms for wavefront sensing.

Two analog holographic wavefront sensors, for measurement of defocus, have been fabricated as both thin and volume phase transmission holograms in a self-developing photopolymer. This represents the first reported direct comparison of hologram regimes when designed for wavefront sensing. An analysis of the effect of crosstalk in the presence of one other aberration mode (astigmatism X (0/90°), coma X (horizontal), and primary spherical aberration) was carried out with each version of the sensor. The performance of thin and volume analog holographic wavefront sensors was characterized under emulated conditions associated with moderate atmospheric turbulence.

Development of a novel four-channel atomic gradiometric magnetometer for magnetocardiography: Advancing non-invasive cardiac research with enhanced sensitivity and spatial resolution

The field of magnetocardiography (MCG) has witnessed significant advancements with the use of atomic magnetometers (AMs) and gradiometers, offering numerous advantages over traditional superconducting quantum interference devices (SQUIDs). This study focuses on the development of a highly sensitive four-channel atomic gradiometer specifically designed for measuring the biomagnetic fields of a rat’s heart. By utilizing gradiometric detection and monitoring deviations in the Larmor frequency of rubidium (Rb) atoms, this gradiometer captures cardiac signals with exceptional sensitivity and spatial resolution. One of the key challenges in utilizing AMs as gradiometers lies in minimizing cross-talk effects among the sensors to ensure accurate measurements. In this study, we successfully address this challenge, leading to precise and reliable data acquisition. Furthermore, our gradiometer demonstrates a linear response across a wide range of frequencies, enhancing its versatility and applicability in various experimental setups. The achieved sensitivity of 350 fT/√Hz by our atomic gradiometer showcases its potential in assessing MCG measurements for studying cardiac electrical activities. The non-invasive nature of the technique, combined with the elimination of cryogenic cooling requirements, opens up new avenues for cardiac research and diagnostics. The enhanced spatial and spatiotemporal resolution offered by optically pumped magnetometers (OPMs) further enhances our ability to understand and analyze complex cardiac phenomena.

Digital horizontal crosstalk compensation in 8K LCD displays for enhanced image quality

AbstractAs ultra‐high‐definition displays have gained popularity, mitigating the horizontal crosstalk effect in 8K LCD panels is crucial. High display resolution requires narrower signal line integration, intensifying the coupling effect. Traditional methods like Vcom feedback and increasing analog voltage drain‐drain (AVDD) load are slower and less accurate, leading to increased power consumption. In response, we propose an advanced digital signal compensation method. In this study, we developed a predictive model and investigated the intricate relationships among AVDD, Vcom, and storage capacity (Cst) ripples on horizontal crosstalk. Optimizing the ripple change (∆G) by varying the compensation coefficient (a) and decay ratio (τ) significantly reduces crosstalk effects. The digital compensation method allows rapid and precise compensation without delays, reducing horizontal crosstalk in 8K LCD panels from 4% to below 0.9%. This surpasses the requirement of minimizing crosstalk to less than 2%, substantially enhancing the image quality of high‐resolution displays.

An in-situ polymerization strategy for gel polymer electrolyte Si||Ni-rich lithium-ion batteries

Coupling the Si-based anodes with nickel-rich LiNixMnyCo1−x−yO2 cathodes (x ≥ 0.8) in the energy-dense cell prototype suffers from the mechanical instability of the Li-Si alloys, cathode collapse upon the high-voltage cycling, as well as the severe leakage current at elevated temperatures. More seriously, the cathode-to-anode cross-talk effect of transitional metal aggravates the depletion of the active Li reservoir. To reconcile the cation utilization degree, stress dissipation, and extreme temperature tolerance of the Si-based anode||NMC prototype, we propose a gel polymer electrolyte to reinforce the mechanical integrity of Si anode and chelate with the transitional cations towards the stabilized interfacial property. As coupling the conformal gel polymer electrolyte encapsulation with the spatial arranged Si anode and NMC811 cathode, the 2.7 Ah pouch-format cell could achieve the high energy density of 325.9 Wh kg−1 (based on the whole pouch cell), 88.7% capacity retention for 2000 cycles, self-extinguish property as well as a wide temperature tolerance. Therefore, this proposed polymerization strategy provides a leap toward the secured Li batteries.

Investigation of the Doppler frequency shift effect on inter-channel switching time of free-space optically switched communication networks with distributed feedback laser array technique

To assess the impact of Doppler frequency shift and channel crosstalk on the performance of a four-channel free-space optically switched communication network, particularly in scenarios involving low Earth orbit satellites, we derived a bit error rate model under the influence of satellite-ground Doppler frequency shift and channel crosstalk in atmospheric turbulence. This model focuses on studying a four-channel distributed feedback (DFB) laser array through numerical simulation. We initially analyzed the effect of crosstalk on the system's switching time in the absence of Doppler frequency shift. Our research revealed that as the channel spacing increased, the impact of crosstalk on the system's optical switching time decreased. We utilized a primary power compensation solution, adjusting the output optical power for different channel spacings, to mitigate the influence of crosstalk on the system's switching time. After eliminating the effects of crosstalk, we further examined the impact of Doppler frequency shift on the system's switching time for different channel spacings. We proposed a secondary power compensation solution to mitigate the effects of both crosstalk and Doppler frequency shift on the system's switching time. Finally, through simulation experiments, we set the output optical power of the laser to 10.42mw when switching from channel 1 to channel 2, 9.05mw when switching from channel 1 to channel 3, and 8.68mw when switching from channel 1 to channel 4, ensuring a uniform switching time of 10ns. Our research results provide a solid theoretical foundation for enhancing the performance of free-space optically switched communication networks and for mitigating the impact of Doppler frequency shift on system switching time.

Design, calibration and testing of a novel isothermal calorespirometer prototype

A prototype of an innovative isothermal calorespirometer was developed to measure simultaneously heat production rate (calorimetry) and CO2 evolution rate (respirometry) in real-time in a static batch vessel system. The relationship between these two variables forms the calorespirometric ratio, which serves as a crucial indicator for metabolic processes and allows for the differentiation of various metabolic pathways in simple (pure culture) and complex (e.g. soil) biological systems. The heat production rate is gauged by a thermoelectric generator situated at the bottom of the measuring channel (calorimetric unit), while the CO2 evolution rate is monitored through a conductometric cell fixed on the lid of the channel (respirometric unit). The prototype is designed with a twin configuration, featuring both sample and reference channels. The spatial separation of the calorimetric and respirometric measuring units ensures the simultaneous measurement of the two rates from a single sample without the occurrence of crosstalk effects between the signals.The electrical calibration of the calorimetric unit reveals heat losses (approx. 30 %) and response times (approx. 6 min) that are comparable to those of established isothermal calorimeters. In parallel, growth experiments conducted with baker`s yeast demonstrate the applicability of the calorespirometer prototype to biological systems.

Multi-phased Kinetics and Interaction of Protein Kinase Signaling in Glycoprotein VI-Induced Platelet αIIbβ3 Integrin Activation and Degranulation.

Platelet glycoprotein VI (GPVI) stimulation activates the tyrosine kinases Syk and Btk, and the effector proteins phospholipase Cγ 2 (PLCγ2) and protein kinase C (PKC). Here, the activation sequence, crosstalk, and downstream effects of this Syk-Btk-PKC signalosome in human platelets were analyzed. Using immunoblotting, we quantified 14 regulated phospho-sites in platelets stimulated by convulxin with and without inhibition of Syk, Btk, or PKC. Convulxin induced fast, reversible tyrosine phosphorylation (pY) of Syk, Btk, LAT, and PLCγ2, followed by reversible serine/threonine phosphorylation (pS/T) of Syk, Btk, and downstream kinases MEK1/2, Erk1/2, p38, and Akt. Syk inhibition by PRT-060318 abolished all phosphorylations, except Syk pY352. Btk inhibition by acalabrutinib strongly decreased Btk pY223/pS180, Syk pS297, PLCγ2 pY759/Y1217, MEK1/2 pS217/221, Erk1/2 pT202/Y204, p38 pT180/Y182, and Akt pT308/S473. PKC inhibition by GF109203X abolished most pS/T phosphorylations except p38 pT180/Y182 and Akt pT308, but enhanced most Y-phosphorylations. Acalabrutinib, but not GF109203X, suppressed convulxin-induced intracellular Ca2+ mobilization, whereas all three protein kinase inhibitors abolished degranulation and αIIbβ3 integrin activation assessed by flow cytometry. Inhibition of autocrine ADP effects by AR-C669931 partly diminished convulxin-triggered degranulation. Kinetic analysis of GPVI-initiated multisite protein phosphorylation in human platelets demonstrates multiple phases and interactions of tyrosine and serine/threonine kinases with activation-altering feedforward and feedback loops partly involving PKC. The protein kinase inhibitor effects on multisite protein phosphorylation and functional readouts reveal that the signaling network of Syk, Btk, and PKC controls platelet granule exocytosis and αIIbβ3 integrin activation.

Task-order control in dual-tasks: Only marginal interactions between conflict at lower levels and higher processes of task organization.

When simultaneously performing two tasks that share response properties, interference can occur. Besides general performance decrements, performance in the first task is worse when the second task requires a spatially incompatible response, known as the backward crosstalk effect (BCE). The size of this BCE, similar to congruency effects in conflict tasks, is subject to a sequential modulation, with a smaller BCE after incompatible compared to compatible trials. In the present study, we focus on a potential bidirectional interaction between crosstalk (and its resolution) at a lower level of task performance and higher-order processes of task organization. Two questions were of particular interest: First, do participants switch task order more frequently after a conflict-prone incompatible trial than after a compatible trial? Second, does changing task order influence the efficiency of conflict resolution, as indexed by the size of the sequential modulation of the BCE. Across four experiments, we only found marginal evidence for an influence of lower-level conflict on higher-order processes of task organization, with only one experiment revealing a tendency to repeat task order following conflict. Our results thus suggest practical independence between conflict and task-order control. When separating processes of task selection and task performance, the sequential modulation was generally diminished, suggesting that conflict resolution in dual-tasks can be disrupted by a deliberate decision about task order, or, alternatively, by a longer inter-trial interval. Finally, the study found a strong bias towards repeating the same task order across trials, suggesting that task-order sets not only impact task performance but also guide task selection.

Functional profiling of resident cells during vascular aging

Introduction: Depending on surrounding cell types, substrate mechanics, and chemical agonists, vascular cell types – including endothelial (ECs) and smooth muscle cells (VSMC) — modulate their behavior to maintain homeostasis. Aging perturbs this homeostasis resulting in EC and SMC dysfunction, marked by impaired barrier integrity and pathological ECM remodeling. Endothelial-to-mesenchymal transition (EndMT) in ECs and “dedifferentiation” of VSMCs towards a synthetic phenotype are phenomenon under investigation as cellular drivers of the widespread dysregulation seen with aging. The overall goal of this project is to understand the effect of cross-talk between ECM and growth factor signaling on vascular cell plasticity during aging. Materials and Methods: Human aortic endothelial cells (HAECs) were seeded onto transwell inserts after seven days treatment with or without TGF-β. After growing to confluence on the insert, cells were subjected to a FITC-dextran transwell assay. A parallel group of cells was seeded onto fibronectin coated glass-bottom dishes and stained for the expression of focal adhesion proteins and cell-type markers. Mouse aortic smooth muscle cells (maSMCs) were isolated from C57Bl6 mice at 3 (young), 6 (early middle-aged; EMA), 9 (middle-age; MA), or greater than 18 months of age (old). Cells were seeded onto dye-quenched (DQ) collagen type I (Col-I) substrate before gain of fluorescence was measured in proximity to the cell as well as in the surrounding media. A parallel group of cells were allowed to grow in media containing FITC Col-I, and gain of fluorescence was measured in proximity to the cells. Each cell type (3M, 6M, 9M, and 18M) in both experiments (DQ and FITC) were further treated with MMP inhibitor, TG2 inhibitor and TGF-β1 to measure their impacts on Col-I turnover. Results: Barrier function was not impaired in ECs cultured with TGF-β1, relative to their untreated counterparts. Mouse aortic SMCs isolated from older mice had decreased rates of Col-I cleavage and were more susceptible to MMP inhibition than their younger counterparts. Conclusions: maSMCs from older mice have lower Col-I turnover than their younger counterparts. This is consistent with bulk tissue behavior, as it is well known that relative collagen levels increase in the elastic vasculature as we age. TGF-β1 treatment did not have an effect on permeability of 4kd FITC-dextran, it is feasible that there will be an impact on the larger 70kd fragments. Travis Brady is supported by the NASEM Ford Foundation Pre-doctoral Fellowship. This is the full abstract presented at the American Physiology Summit 2024 meeting and is only available in HTML format. There are no additional versions or additional content available for this abstract. Physiology was not involved in the peer review process.

Effects of crosstalk between steroid hormones mediated thyroid hormone in zebrafish exposed to 4-tert-octylphenol: Estrogenic and anti-androgenic effects

Alkylphenols, such as nonylphenol and 4-tert-octylphenol (OP), are byproducts of the biodegradation of alkylphenol ethoxylates and present substantial ecological and health risks in aquatic environments and higher life forms. In this context, our study aimed to explore the effect of OP on reproductive endocrine function in both female and male zebrafish. Over a period of 21 days, the zebrafish were subjected to varying concentrations of OP (0, 0.02, 0.1, and 0.5 μg/L), based on the lowest effective concentration (EC10 = 0.48 μg/L) identified for zebrafish embryos. OP exposure led to a pronounced increase in hepatic vitellogenin (vtg) mRNA expression and 17β-estradiol biosynthesis in both sexes. Conversely, OP exhibits anti-androgenic properties, significantly diminishes gonadal androgen receptor (ar) mRNA expression, and reduces endogenous androgen (testosterone and 11-ketotestosterone) levels in male zebrafish. Notably, cortisol and thyroid hormone (TH) levels demonstrated concentration-dependent elevations in zebrafish, influencing the regulation of gonadal steroid hormones (GSHs). These findings suggest that prolonged OP exposure may result in sustained reproductive dysfunction in adult zebrafish, which is largely attributable to the intricate reciprocal relationship between hormone levels and the associated gene expression. Our comprehensive biological response analysis of adult zebrafish offers vital insights into the reproductive toxicological effects of OP, thereby enriching future ecological studies on aquatic systems.

Complex reaction mechanisms of electrolyte decomposition at large-scale Ni-rich Li-ion battery cells including electrode crosstalk effect

Ni-rich cathodes are essential for the advancement of high-energy lithium-ion batteries but encounter significant challenges at elevated voltages, including oxygen liberation and enhanced surface reactivity, which precipitate electrolyte decomposition. This study explores the intricate reaction mechanisms of electrolyte decomposition linked to the pronounced release of oxygen from the cathode lattice in large-scale 18650 cylindrical cells employing Ni-rich LiNi0.90Mn0.05Co0.05O2(NMC90)//graphite configurations, focusing on electrode crosstalk effects at high voltages. Notably, acetals such as methoxy methanol (49.93 %) and methane diol (50.07 %) were identified at 4.7 V, with their presence escalating at 4.9 V. Formaldehyde, present at 7.21 %, along with methanol (22.77 %), methane diol (36.35 %), and methoxy methanol (33.67 %), begins to manifest at 4.9 V. The dissolution of transition metals was analyzed using Inductively Coupled Plasma Atomic Emission Spectrometry, and changes in the double-layer capacitance were assessed through electrochemical impedance spectroscopy, further validating the link between these decomposition products and cathode failure associated with oxygen release. These insights reveal the complex relationship between electrolyte decomposition and cathode degradation due to oxygen release, highlighting a critical failure mechanism in large-scale cylindrical lithium-ion batteries.

Multi-scale ground penetrating radar full waveform inversion with hybrid Tikhonov and total-variation regularization for different geometric structure

Abstract Full waveform inversion (FWI) is a high-resolution technique to estimate the parameters of dielectric permittivity (ϵ) and electrical conductivity (σ) and identify the structure of the subsurface for Ground Penetrating Radar (GPR) application. However, permittivity and conductivity parameters can be coupled in bi-parameter GPR inversion. This coupling effect leads to the crosstalk in the FWI result. To solve this problem, we propose a novel approach to use the multi-scale FWI with the hybrid regularization method, which combines Tikhonov and total-variation (TV) regularizers that simultaneously invert the ϵ and the σ parameters, which improve the inversion accuracy and reduce the crosstalk effect. The multi-scale strategy uses the Wiener filtering to process the GPR data in different frequency ranges. Then, the low frequencies signal updates the bottom part and subsequently increases the frequencies to invert for the shallow areas. The Tikhonov regularization stabilizes the reconstruction of the smoothly varying background part. In contrast, Total Variation (TV) regularization can recover the large contrasts associated with the LNAPL model. The new Tikhonov-TV (TT) regularization can mitigate the crosstalk caused by the parameter coupling effect. Numerical tests with typical GPR models demonstrate that the proposed multi-scale TT-FWI strategy can effectively eliminate the crosstalk and improve the reconstruction accuracy when the model parameters have a different structure.

Research status and hotspots on the mechanisms of liver X receptor in cancer progression: A bibliometric analysis.

The mechanism of liver X receptor in cancer has been gradually revealed in recent years. This study is committed to analyzing the current research status of the mechanism of liver × receptor in cancer progression by using bibliometric methods and to explore the development trend of liver × receptor related research in the future, in order to provide some reference for further exploration in this field. The Web of Science core collection database was used to carry out the original data retrieval. Excel software was used for data statistics. Vosviewer and CiteSpace software were used to analyze the publication situation, cooperation network, reference co-citation, keyword and term co-occurrence, term bursts, and cluster analysis, and draw visual maps. A total of 631 publications meeting the research criteria were included by December 2022, with an average of 32.5 citations per paper. The main research fields were molecular biology, oncology and cell biology, and the papers were mainly published in journals about molecular, biology and immunology. Cell is the journal with the highest citation. The United States is the most influential country, the University of California, Los Angeles is the main research institution, and Gustafsson, Jan-ake is the author with the highest output. In reference co-citation clustering, cluster#2 "cancer development" is the main cluster, and the period from 2014 to 2018 is an important stage of relevant theoretical progress. "Tumor microenvironment" with high burst and novelty became the most noteworthy term in term burst. Using bibliometric methods to reveal the current status of LXR and cancer mechanisms, and making predictions of possible future hotspots based on the analysis of the current situation, the translation of LXR anti-cancer research to clinical applications, the impact on the tumor microenvironment as a whole and more immune pathways, and the formation of a systematic cognition of the effects of more cancer cell lines and oncogenic signaling crosstalk, which is a possible direction for future research.

Variable, sometimes absent, but never negative: Applying multilevel models of variability to the backward crosstalk effect to find theoretical constraints

When performing two tasks at the same time, the congruency of the second task's features influences performance in the first task. This is called the backward crosstalk effect (BCE), a phenomenon that influences both theories of binding and of dual-task capacity limitations. The question of whether the BCE is found in all participants at all times is relevant for understanding the basis of the effect. For example, if the BCE is based on strategic choices, it can be variable, but if it is automatic and involuntary, it should never vary in whether it is present or not. Variability in observed BCE sizes was already documented and discussed when the group average effect was first reported (Hommel, 1998). Yet the theories discussed at the time did not motivate a more direct analysis of this variability, nor did the readily available statistical tools permit it.Some statistical approaches recently applied in cognitive psychology allow such a variability-focused analysis and some more recent theoretical debates would benefit from this as well. We assessed the variability of the BCE as well as a BCE-like free-choice congruency effect by applying a Bayesian multilevel modeling approach to the data from a dual-tasking experiment. Trials consisted of a two- and a four-response task. We manipulated which task was presented first and whether the response to the four-choice task was free or forced choice.RT data were best predicted by a model in which the BCE is zero in part of the population and drawn from a normal distribution truncated at zero (and thus always positive) in the rest of the population. Choice congruency bias data were best predicted by a model assuming this effect to be drawn from a normal distribution truncated at zero (but, in contrast to the RT data, without the subset of the population where it is zero).The BCE is not an inflexible and universal phenomenon that is directly linked to an inherent structural trait of human cognition. We discuss theoretical constraints implied by these results with a focus on what we can infer about the traits of the factors that influence BCE size. We suggest that future research might add further major constraints by using multi-session experiments to distinguish between-person and within-person variability. Our results show that the BCE is variable. The next step is understanding along which axes it is variable and why it varies.

Biomimetic multilayer scaffolds with prolonged retention of stem cells-recruiting and angiogenic peptides for promoting bladder regeneration

The complications of enterocystoplasy have challenged traditional bladder reconstruction methods. Tissue engineering scaffolds, involving stem cells implantation and vascularization strategies, emerge as promising alternatives. However, their applications are hindered by issues regarding the source of stem cells and the rapid loss of bioactive factors in a urinary environment. Here, a multilayer biomimetic scaffold consisting of polycaprolactone (PCL) nanofibrous mats and oxidized dextran/carboxymethyl chitosan hydrogel has been synthesized. Bone marrow homing peptide (BMHP) and vascular endothelial growth factor-mimicking peptide (VP) were incorporated into the hydrogel to recruit endogenous stem cells and promote vascularization, respectively. The results indicated that PCL mats not only reinforced the mechanical properties of composite scaffolds but also prolonged the retention of peptides via the hydrophobic surface. In vivo experiments demonstrated that BMHP and VP had crosstalk effects, amplifying their functions to accelerate bladder regeneration, enhance contractility of smooth muscle cells, inhibit fibrosis, and improve innervation. Overall, the novel functionalized scaffolds are potentially viable for urologic tissue reconstruction.

Low‐Dose and Stable X‐Ray Imaging Enabled by Low‐Dimensional Dion‐Jacobson Perovskites

AbstractMetal halide perovskites have emerged as highly promising candidates for next‐generation X‐ray detectors due to their facile and low‐cost processability, high attenuation coefficient, and tunable optoelectrical properties. In this work, quasi‐2D Dion‐Jacobson (DJ) perovskites are introduced in a flat panel X‐ray imager (FPXI) for X‐ray imaging. This study demonstrates that the diammonium interlayers in DJ perovskites play a key role in enhancing structural stability, suppressing ion migration, and improving charge transport. As a result, DJ perovskite‐based X‐ray FPXIs achieve a sensitivity of 18000 µC Gyair−1 cm−2, a low detection limit of 5.7 nGyair s−1, representing performance comparable to that of state‐of‐the‐art 3D perovskite FPXIs. Thanks to the decrease in the signal crosstalk effect of the FPXIs, a high spatial resolution of 0.54 line‐pair‐per‐pixel is achieved, which is higher than that of 3D perovskite FPXIs. Remarkably, high‐quality X‐ray imaging is achieved at a total dose of 20 µGyair, which is only 1/5 of the dose typically used in commercial equipment. This work not only provides valuable insights and guidance for the fabrication of 2D DJ perovskite X‐ray detectors but also lays the groundwork for the adoption of high‐performance, stable DJ perovskite imagers as novel flat‐panel X‐ray detectors.