Cross-validation Experiments Research Articles

Solving the class imbalance problem using ensemble algorithm: application of screening for aortic dissection

BackgroundImbalance between positive and negative outcomes, a so-called class imbalance, is a problem generally found in medical data. Despite various studies, class imbalance has always been a difficult issue. The main objective of this study was to find an effective integrated approach to address the problems posed by class imbalance and to validate the method in an early screening model for a rare cardiovascular disease aortic dissection (AD).MethodsDifferent data-level methods, cost-sensitive learning, and the bagging method were combined to solve the problem of low sensitivity caused by the imbalance of two classes of data. First, feature selection was applied to select the most relevant features using statistical analysis, including significance test and logistic regression. Then, we assigned two different misclassification cost values for two classes, constructed weak classifiers based on the support vector machine (SVM) model, and integrated the weak classifiers with undersampling and bagging methods to build the final strong classifier. Due to the rarity of AD, the data imbalance was particularly prominent. Therefore, we applied our method to the construction of an early screening model for AD disease. Clinical data of 523,213 patients from the Institute of Hypertension, Xiangya Hospital, Central South University were used to verify the validity of this method. In these data, the sample ratio of AD patients to non-AD patients was 1:65, and each sample contained 71 features.ResultsThe proposed ensemble model achieved the highest sensitivity of 82.8%, with training time and specificity reaching 56.4 s and 71.9% respectively. Additionally, it obtained a small variance of sensitivity of 19.58 × 10–3 in the seven-fold cross validation experiment. The results outperformed the common ensemble algorithms of AdaBoost, EasyEnsemble, and Random Forest (RF) as well as the single machine learning (ML) methods of logistic regression, decision tree, k nearest neighbors (KNN), back propagation neural network (BP) and SVM. Among the five single ML algorithms, the SVM model after cost-sensitive learning method performed best with a sensitivity of 79.5% and a specificity of 73.4%.ConclusionsIn this study, we demonstrate that the integration of feature selection, undersampling, cost-sensitive learning and bagging methods can overcome the challenge of class imbalance in a medical dataset and develop a practical screening model for AD, which could lead to a decision support for screening for AD at an early stage.

Prediction of Pulmonary Function Parameters Based on a Combination Algorithm.

Objective: Pulmonary function parameters play a pivotal role in the assessment of respiratory diseases. However, the accuracy of the existing methods for the prediction of pulmonary function parameters is low. This study proposes a combination algorithm to improve the accuracy of pulmonary function parameter prediction. Methods: We first established a system to collect volumetric capnography and then processed the data with a combination algorithm to predict pulmonary function parameters. The algorithm consists of three main parts: a medical feature regression structure consisting of support vector machines (SVM) and extreme gradient boosting (XGBoost) algorithms, a sequence feature regression structure consisting of one-dimensional convolutional neural network (1D-CNN), and an error correction structure using improved K-nearest neighbor (KNN) algorithm. Results: The root mean square error (RMSE) of the pulmonary function parameters predicted by the combination algorithm was less than 0.39L and the R2 was found to be greater than 0.85 through a ten-fold cross-validation experiment. Conclusion: Compared with the existing methods for predicting pulmonary function parameters, the present algorithm can achieve a higher accuracy rate. At the same time, this algorithm uses specific processing structures for different features, and the interpretability of the algorithm is ensured while mining the feature depth information.

Cross-validation of a semantic segmentation network for natural history collection specimens

Semantic segmentation has been proposed as a tool to accelerate the processing of natural history collection images. However, developing a flexible and resilient segmentation network requires an approach for adaptation which allows processing different datasets with minimal training and validation. This paper presents a cross-validation approach designed to determine whether a semantic segmentation network possesses the flexibility required for application across different collections and institutions. Consequently, the specific objectives of cross-validating the semantic segmentation network are to (a) evaluate the effectiveness of the network for segmenting image sets derived from collections different from the one in which the network was initially trained on; and (b) test the adaptability of the segmentation network for use in other types of collections. The resilience to data variations from different institutions and the portability of the network across different types of collections are required to confirm its general applicability. The proposed validation method is tested on the Natural History Museum semantic segmentation network, designed to process entomological microscope slides. The proposed semantic segmentation network is evaluated through a series of cross-validation experiments designed to test using data from two types of collections: microscope slides (from three institutions) and herbarium sheets (from seven institutions). The main contribution of this work is the method, software and ground truth sets created for this cross-validation as they can be reused in testing similar segmentation proposals in the context of digitization of natural history collections. The cross-validation of segmentation methods should be a required step in the integration of such methods into image processing workflows for natural history collections.

An active semi-supervised deep learning model for human activity recognition

Human activity recognition (HAR), which aims at inferring the behavioral patterns of people, is a fundamental research problem in digital health and ambient intelligence. The application of machine learning methods in HAR has been investigated vigorously in recent years. However, there are still a number of challenges confronting the task, where one significant barrier lies in the longstanding shortage of annotations. To address this issue, we establish a new paradigm for HAR, which integrates active learning and semi-supervised learning into one framework. The main idea is to reduce the annotation cost by actively selecting the most informative samples for annotation, as well as leveraging the unlabelled instances in a semi-supervised way. In particular, we propose to utilize the massive unlabelled data via temporal ensembling of convolutional neural networks (CNN), which yields robust consensus predictions by aggregating the outputs of the training networks on different epochs. We conducted extensive experiments on three public benchmark datasets. The proposed method achieves Macro F1 values of 0.76, 0.45 and 0.91 in a low annotation scenario on PAMAP2, USCHAD and UCIHAR datasets respectively, outperforming a multitude of state-of-the-art deep models. The ablation study proves the effectiveness of the two components of the framework, i.e., active learning-based sample selection and semi-supervised model training with temporal ensembling, in alleviating the issue of insufficient labels. Cross-validation and statistical significance experiments further demonstrate the robustness and generalization ability of the proposed method. The source codes are available at https://github.com/HaixiaBi1982/ActSemiCNNAct.

ConCeptCNN: A novel multi-filter convolutional neural network for the prediction of neurodevelopmental disorders using brain connectome.

Deep convolutional neural network (CNN) and its derivatives have recently shown great promise in the prediction of brain disorders using brain connectome data. Existing deep CNN methods using single global row and column convolutional filters have limited ability to extract discriminative information from brain connectome for prediction tasks. This paper presents a novel deep Connectome-Inception CNN (ConCeptCNN) model, which is developed based on multiple convolutional filters. The proposed model is used to extract topological features from brain connectome data for neurological disorders classification and analysis. The ConCeptCNN uses multiple vector-shaped filters extract topological information from the brain connectome at different levels for complementary feature embeddings of brain connectome. The proposed model is validated using two datasets: the Neuro Bureau ADHD-200 dataset and the Cincinnati Early Prediction Study (CINEPS) dataset. In a cross-validation experiment, the ConCeptCNN achieved a prediction accuracy of 78.7% for the detection of attention deficit hyperactivity disorder (ADHD) in adolescents and an accuracy of 81.6% for the prediction of cognitive deficits at 2 years corrected age in very preterm infants. In addition to the classification tasks, the ConCeptCNN identified several brain regions that are discriminative to neurodevelopmental disorders. We compared the ConCeptCNN with several peer CNN methods. The results demonstrated that proposed model improves overall classification performance of neurodevelopmental disorders prediction tasks.

User-oriented Natural Human-Robot Control with Thin-Plate Splines and LRCN

We propose a real-time vision-based teleoperation approach for robotic arms that employs a single depth-based camera, exempting the user from the need for any wearable devices. By employing a natural user interface, this novel approach leverages the conventional fine-tuning control, turning it into a direct body pose capture process. The proposed approach is comprised of two main parts. The first is a nonlinear customizable pose mapping based on Thin-Plate Splines (TPS), to directly transfer human body motion to robotic arm motion in a nonlinear fashion, thus allowing matching dissimilar bodies with different workspace shapes and kinematic constraints. The second is a Deep Neural Network hand-state classifier based on Long-term Recurrent Convolutional Networks (LRCN) that exploits the temporal coherence of the acquired depth data. We validate, evaluate and compare our approach through both classical cross-validation experiments of the proposed hand state classifier; and user studies over a set of practical experiments involving variants of pick-and-place and manufacturing tasks. Results revealed that LRCN networks outperform single image Convolutional Neural Networks; and that users' learning curves were steep, thus allowing the successful completion of the proposed tasks. When compared to a previous approach, the TPS approach revealed no increase in task complexity and similar times of completion, while providing more precise operation in regions closer to workspace boundaries.

BMNet: A New Region-Based Metric Learning Method for Early Alzheimer's Disease Identification With FDG-PET Images.

18F-fluorodeoxyglucose (FDG)-positron emission tomography (PET) reveals altered brain metabolism in individuals with mild cognitive impairment (MCI) and Alzheimer’s disease (AD). Some biomarkers derived from FDG-PET by computer-aided-diagnosis (CAD) technologies have been proved that they can accurately diagnosis normal control (NC), MCI, and AD. However, existing FDG-PET-based researches are still insufficient for the identification of early MCI (EMCI) and late MCI (LMCI). Compared with methods based other modalities, current methods with FDG-PET are also inadequate in using the inter-region-based features for the diagnosis of early AD. Moreover, considering the variability in different individuals, some hard samples which are very similar with both two classes limit the classification performance. To tackle these problems, in this paper, we propose a novel bilinear pooling and metric learning network (BMNet), which can extract the inter-region representation features and distinguish hard samples by constructing the embedding space. To validate the proposed method, we collect 898 FDG-PET images from Alzheimer’s disease neuroimaging initiative (ADNI) including 263 normal control (NC) patients, 290 EMCI patients, 147 LMCI patients, and 198 AD patients. Following the common preprocessing steps, 90 features are extracted from each FDG-PET image according to the automatic anatomical landmark (AAL) template and then sent into the proposed network. Extensive fivefold cross-validation experiments are performed for multiple two-class classifications. Experiments show that most metrics are improved after adding the bilinear pooling module and metric losses to the Baseline model respectively. Specifically, in the classification task between EMCI and LMCI, the specificity improves 6.38% after adding the triple metric loss, and the negative predictive value (NPV) improves 3.45% after using the bilinear pooling module. In addition, the accuracy of classification between EMCI and LMCI achieves 79.64% using imbalanced FDG-PET images, which illustrates that the proposed method yields a state-of-the-art result of the classification accuracy between EMCI and LMCI based on PET images.

SAAED: Embedding and Deep Learning Enhance Accurate Prediction of Association Between circRNA and Disease.

Emerging evidence indicates that circRNA can regulate various diseases. However, the mechanisms of circRNA in these diseases have not been fully understood. Therefore, detecting potential circRNA–disease associations has far-reaching significance for pathological development and treatment of these diseases. In recent years, deep learning models are used in association analysis of circRNA–disease, but a lack of circRNA–disease association data limits further improvement. Therefore, there is an urgent need to mine more semantic information from data. In this paper, we propose a novel method called Semantic Association Analysis by Embedding and Deep learning (SAAED), which consists of two parts, a neural network embedding model called Entity Relation Network (ERN) and a Pseudo-Siamese network (PSN) for analysis. ERN can fuse multiple sources of data and express the information with low-dimensional embedding vectors. PSN can extract the feature between circRNA and disease for the association analysis. CircRNA–disease, circRNA–miRNA, disease–gene, disease–miRNA, disease–lncRNA, and disease–drug association information are used in this paper. More association data can be introduced for analysis without restriction. Based on the CircR2Disease benchmark dataset for evaluation, a fivefold cross-validation experiment showed an AUC of 98.92%, an accuracy of 95.39%, and a sensitivity of 93.06%. Compared with other state-of-the-art models, SAAED achieves the best overall performance. SAAED can expand the expression of the biological related information and is an efficient method for predicting potential circRNA–disease association.

A Robust Cybersecurity Topic Classification Tool

In this research, we use user defined labels from three internet text sources (Reddit, StackExchange, Arxiv) to train 21 different machine learning models for the topic classification task of detecting cybersecurity discussions in natural English text. We analyze the false positive and false negative rates of each of the 21 model’s in cross validation experiments. Then we present a Cybersecurity Topic Classification (CTC) tool, which takes the majority vote of the 21 trained machine learning models as the decision mechanism for detecting cybersecurity related text. We also show that the majority vote mechanism of the CTC tool provides lower false negative and false positive rates on average than any of the 21 individual models. We show that the CTC tool is scalable to the hundreds of thousands of documents with a wall clock time on the order of hours.

Series Arc Fault Detection in a Low-Voltage Power System Based on CEEMDAN Decomposition and Sensitive IMF Selection

In the series arc fault detection of a low-voltage distribution network, the features of the fault current signal are easily submerged and arc fault features are difficult to be represented, which greatly increases the difficulty of fault arc detection based on current signals. To solve these problems, a series arc fault detection method combining CEEMDAN decomposition and sensitive IMF selection is proposed. In this paper, the CEEMDAN algorithm is first applied to complete decomposition of the arc current in series faults. Then, 12 feature indicators of the arc current are defined and the frequency band division of the IMF component is realized according to the kurtosis index and energy feature which are more sensitive. The time window-based feature calculation method is proposed to obtain the local features of the time scale of each high-frequency IMF component. Accurate selection of sensitive IMF components is realized by comparing feature indexes such as the variance and root mean square value. Finally, for the current feature set, the second dimension reduction is realized by the subspace transformation algorithm and the series arc fault detection is realized based on the SVM. The actual experiments show that the optimal detection accuracy of the proposed method is 91.67% and the average accuracy of 10 crossvalidation experiments is 88.33%. It shows that the proposed sensitive IMF selection method can effectively capture the fault component signals in the current and the proposed fault feature description method has good representation and discrimination ability.

FB-CGANet: filter bank channel group attention network for multi-class motor imagery classification

Objective. Motor imagery-based brain–computer interface (MI-BCI) is one of the most important BCI paradigms and can identify the target limb of subjects from the feature of MI-based Electroencephalography signals. Deep learning methods, especially lightweight neural networks, provide an efficient technique for MI decoding, but the performance of lightweight neural networks is still limited and need further improving. This paper aimed to design a novel lightweight neural network for improving the performance of multi-class MI decoding. Approach. A hybrid filter bank structure that can extract information in both time and frequency domain was proposed and combined with a novel channel attention method channel group attention (CGA) to build a lightweight neural network Filter Bank CGA Network (FB-CGANet). Accompanied with FB-CGANet, the band exchange data augmentation method was proposed to generate training data for networks with filter bank structure. Main results. The proposed method can achieve higher 4-class average accuracy (79.4%) than compared methods on the BCI Competition IV IIa dataset in the experiment on the unseen evaluation data. Also, higher average accuracy (93.5%) than compared methods can be obtained in the cross-validation experiment. Significance. This work implies the effectiveness of channel attention and filter bank structure in lightweight neural networks and provides a novel option for multi-class motor imagery classification.

A Modified XG Boost Classifier Model for Detection of Seizures and Non-Seizures

Diagnosis of Epilepsy is immensely important but challenging process, especially while using traditional manual seizure detection methods with the help of neurologists or brain experts’ guidance which are time consuming. Thus, an automated classification method is require to quickly detect seizures and non-seizures. Therefore, a machine learning algorithm based on a modified XGboost classifier model is employed to detect seizures quickly and improve classification accuracy. A focal loss function is employed with traditional XGboost classifier model to minimize mismatch of training and testing samples and enhance efficiency of the classification model. Here, CHB-MIT SCALP Electroencephalography (EEG) dataset is utilized to test the proposed classification model. Here, data gathered for all 24 patients from CHB-MIT Database is used to analyze the performance of proposed classification model. Here, 2-class-seizure experimental results of proposed classification model are compared against several state-of-art-seizure classification models. Here, cross validation experiments determine nature of 2-class-seizure as the prediction is seizure or non-seizure. The metrics results for average sensitivity and average specificity are nearly 100%. The proposed model achieves improvement in terms of average sensitivity against the best traditional method as 0.05% and for average specificity as 1%. The proposed modified XGBoost classifier model outperforms all the state-of-art-seizure detection techniques in terms of average sensitivity, average specificity.

M2PP: a novel computational model for predicting drug-targeted pathogenic proteins

BackgroundDetecting pathogenic proteins is the origin way to understand the mechanism and resist the invasion of diseases, making pathogenic protein prediction develop into an urgent problem to be solved. Prediction for genome-wide proteins may be not necessarily conducive to rapidly cure diseases as developing new drugs specifically for the predicted pathogenic protein always need major expenditures on time and cost. In order to facilitate disease treatment, computational method to predict pathogenic proteins which are targeted by existing drugs should be exploited.ResultsIn this study, we proposed a novel computational model to predict drug-targeted pathogenic proteins, named as M2PP. Three types of features were presented on our constructed heterogeneous network (including target proteins, diseases and drugs), which were based on the neighborhood similarity information, drug-inferred information and path information. Then, a random forest regression model was trained to score unconfirmed target-disease pairs. Five-fold cross-validation experiment was implemented to evaluate model’s prediction performance, where M2PP achieved advantageous results compared with other state-of-the-art methods. In addition, M2PP accurately predicted high ranked pathogenic proteins for common diseases with public biomedical literature as supporting evidence, indicating its excellent ability.ConclusionsM2PP is an effective and accurate model to predict drug-targeted pathogenic proteins, which could provide convenience for the future biological researches.

Ligand-based discovery of new potential acetylcholinesterase inhibitors for Alzheimer’s disease treatment

ABSTRACT The enzyme acetylcholinesterase (AChE) is currently a therapeutic target for the treatment of neurodegenerative diseases. These diseases have highly variable causes but irreversible evolutions. Although the treatments are palliative, they help relieve symptoms and allow a better quality of life, so the search for new therapeutic alternatives is the focus of many scientists worldwide. In this study, a QSAR-SVM classification model was developed by using the MATLAB numerical computation system and the molecular descriptors implemented in the Dragon software. The obtained parameters are adequate with accuracy of 88.63% for training set, 81.13% for cross-validation experiment and 81.15% for prediction set. In addition, its application domain was determined to guarantee the reliability of the predictions. Finally, the model was used to predict AChE inhibition by a group of quinazolinones and benzothiadiazine 1,1-dioxides obtained by chemical synthesis, resulting in 14 drug candidates with in silico activity comparable to acetylcholine.

A General and Scalable Vision Framework for Functional Near-Infrared Spectroscopy Classification.

Functional near-infrared spectroscopy (fNIRS), a non-invasive optical technique, is widely used to monitor brain activities for disease diagnosis and brain-computer interfaces (BCIs). Deep learning-based fNIRS classification faces three major barriers: limited datasets, confusing evaluation criteria, and domain barriers. We apply more appropriate evaluation methods to three open-access datasets to solve the first two barriers. For domain barriers, we propose a general and scalable vision fNIRS framework that converts multi-channel fNIRS signals into multi-channel virtual images using the Gramian angular difference field (GADF). We use the framework to train state-of-the-art visual models from computer vision (CV) within a few minutes, and the classification performance is competitive with the latest fNIRS models. In cross-validation experiments, visual models achieve the highest average classification results of 78.68% and 73.92% on mental arithmetic and word generation tasks, respectively. Although visual models are slightly lower than the fNIRS models on unilateral finger- and foot-tapping tasks, the F1-score and kappa coefficient indicate that these differences are insignificant in subject-independent experiments. Furthermore, we study fNIRS signal representations and the classification performance of sequence-to-image methods. We hope to introduce rich achievements from the CV domain to improve fNIRS classification research.

Large-scale Text Multiclass Classification Using Spark ML Packages

Machine learning is widely used in the field of natural language processing. Text classification is an important branch of natural language processing, mainly utilized to determine the topic of news information and judge the emotional tendency reflected by social data. However, with the expansion of data scale, traditional machine learning algorithms will encounter various performance bottlenecks due to the limitation of single node resource. The machine learning library ML provided by the distributed memory computing framework spark can efficiently process large-scale datasets. Based on Spark ML, this paper uses logistic regression to classify the preprocessed data originated from standard dataset 20newsgroups. The classification accuracy and F1-score can reach 89.64% and 89.64% respectively. Meanwhile, 5-fold cross validation experiments prove that the result is reliable and procedure design is feasible.

Predicting spatiotemporal variability in radial tree growth at the continental scale with machine learning

Abstract Tree-ring chronologies encode interannual variability in forest growth rates over long time periods from decades to centuries or even millennia. However, each chronology is a highly localized measurement describing conditions at specific sites where wood samples have been collected. The question whether these local growth variabilites are representative for large geographical regions remains an open issue. To overcome the limitations of interpreting a sparse network of sites, we propose an upscaling approach for annual tree-ring indices that approximate forest growth variability and compute gridded data products that generalize the available information for multiple tree genera. Using regression approaches from machine learning, we predict tree-ring indices in space and time based on climate variables, but considering also species range maps as constraints for the upscaling. We compare various prediction strategies in cross-validation experiments to identify the best performing setup. Our estimated maps of tree-ring indices are the first data products that provide a dense view on forest growth variability at the continental level with 0.5° and 0.0083° spatial resolution covering the years 1902–2013. Furthermore, we find that different genera show very variable spatial patterns of anomalies. We have selected Europe as study region and focused on the six most prominent tree genera, but our approach is very generic and can easily be applied elsewhere. Overall, the study shows perspectives but also limitations for reconstructing spatiotemporal dynamics of complex biological processes. The data products are available at https://www.doi.org/10.17871/BACI.248.

Hepatitis C Virus Detection Model by Using Random Forest, Logistic-Regression and ABC Algorithm

This study proposes an automatic classifier for detecting the multiclass probabilities of hepatitis C virus (HCV) incidence based on patients’ blood attributes. The purpose of this study is to establish an artificial intelligence based model that can identify HCV patients and detect the disease in early stage for future treatments. This model can be applied by using clinical data and keeps the performance from imbalanced datasets. This objective was achieved using a cascade two-stage method combining the random forest (RF) and logistic regression (LR) algorithms. Two models were trained by applying the RF (Model 1) and LR (Model 2) to raw and preprocessed data, respectively. The artificial bee colony (ABC) algorithm was then used to determine the optimal threshold value required for filtering and separation, that is, the optimal combination of both models. The two-stage mixing algorithm combines algorithms of different search dimensions, thus integrating the strengths of those algorithms. The critical threshold value for separating Model 1 and Model 2 was obtained through an optimized search using the ABC algorithm. After conducting 10-fold Monte Carlo cross-validation experiments 50 times (for mean values), data from the recent pandemic were used to verify the proposed method. To evaluate the quantitative results, indicators, such as prediction accuracy, precision, recall, F1-score, and Matthews correlation coefficient, were compared with those of the latest algorithms used in relevant fields. The results indicate that the proposed model, named Cascade RF-LR (with SMOTE), can be used to detect the multiclass probabilities of HCV incidence using the ABC algorithm, thereby improving the effectiveness of relevant treatments.

Predicting miRNA-Disease Associations Based On Multi-View Variational Graph Auto-Encoder With Matrix Factorization.

MicroRNAs (miRNAs) have been proved to play critical roles in diverse biological processes, including the human disease development process. Exploring the potential associations between miRNAs and diseases can help us better understand complex disease mechanisms. Given that traditional biological experiments are expensive and time-consuming, computational models can serve as efficient means to uncover potential miRNA-disease associations. This study presents a new computational model based on variational graph auto-encoder with matrix factorization (VGAMF) for miRNA-disease association prediction. More specifically, VGAMF first integrates four different types of information about miRNAs into an miRNA comprehensive similarity network and two types of information about diseases into a disease comprehensive similarity network, respectively. Then, VGAMF gets the non-linear representations of miRNAs and diseases, respectively, from those two comprehensive similarity networks with variational graph auto-encoders. Simultaneously, a non-negative matrix factorization is conducted on the miRNA-disease association matrix to get the linear representations of miRNAs and diseases. Finally, a fully connected neural network combines linear and non-linear representations of miRNAs and diseases to get the final predicted association score for all miRNA-disease pairs. In the 10-fold cross-validation experiments, VGAMF achieves an average AUC of 0.9280 on HMDD v2.0 and 0.9470 on HMDD v3.2, which outperforms other competing methods. Besides, the case studies on colon cancer and esophageal cancer further demonstrate the effectiveness of VGAMF in predicting novel miRNA-disease associations.

Spatial-Temporal Feature Fusion Neural Network for EEG-Based Emotion Recognition

The temporal and spatial information of electroencephalogram (EEG) are essential for the emotion recognition model to learn the discriminative features. Hence, we propose a novel hybrid spatial-temporal feature fusion neural network (STFFNN) to extract the discriminative features and integrate complementary information. The generated power topographic maps, which capture dependencies among the electrodes, are fed to convolutional neural network (CNN) for spatial feature learning. Furthermore, instance normalizations (INs) and batch normalizations (BNs) within the CNN are appropriately combined to alleviate the individual difference and preserve the domain-invariant information. Meanwhile, a feedforward network is adopted for temporal feature learning. Due to the high dimensionality of EEG features, we propose a grid-search-based configurational optimization method to robustly reduce the dimensionality. Finally, inspired by the multimodal fusion strategies that leverage the complementarity of data to obtain more robust predictions, we utilize a bidirectional long short-term memory (Bi-LSTM) network for temporal and spatial feature fusion. To validate the effectiveness of the proposed method, the tenfold cross-validation experiments and subject-dependent experiments are both conducted on the DEAP database. The experimental results demonstrate that the proposed method achieves outstanding performance in emotion recognition with arousal and valence level.