We investigate the phenomenological viability of real spin half, zero, and one dark matter candidates, which interact predominantly with third-generation heavy quarks and gluons via the 28 gauge invariant higher-dimensional effective operators. The corresponding Wilson coefficients are constrained one at a time from the relic density ${\mathrm{\ensuremath{\Omega}}}^{\mathrm{DM}}{h}^{2}\ensuremath{\approx}0.1198$. Their contributions to the thermally-averaged annihilation cross sections are shown to be consistent with the FermiLAT and H.E.S.S. experiments' projected upper bound on the annihilation cross section in the $b\overline{b}$ mode. The tree-level gluonphilic and one-loop induced heavy-quarkphilic dark matter (DM) nucleon direct detection cross sections are analyzed. The nonobservation of any excess over expected background in the case of recoiled Xe nucleus events for spin-independent DM-nucleus scattering in XENON-1T sets the upper limits on the 18 Wilson coefficients. Our analysis validates the real DM candidates for the large range of accessible mass spectrum below 2 TeV for all but one interaction induced by the said operators.