Cross-linking Research Articles

Formulation and evaluation of Piroxicam nanosponge for improved internal solubility and analgesic activity

Cyclodextrin nanosponges are solid nanoparticles, designed by cross-linking of cyclodextrin polymer; it has been used widely as a good delivery system for water insoluble drugs. The aim of this study is to enhance the solubility of Piroxicam (PXM) using β-Cyclodextrin based nanosponges formulations. PXM nanosponge (PXM-NS) formulations were prepared using β-cyclodextrin and carbonyldiimidazole as a cross linker, three ratios of β-cyclodextrin to crosslinker in addition to three drug to nanosponges ratios were tested. Piroxicam nanosponge formulations were characterized for its particle size, zeta potential, physical compatibility and in vitro release. Stability studies at three temperatures (4 °C, 25 °C and 40 °C) were done for optimal formula. Finally, the in vivo analgesic activity and pharmacokinetic parameters of the optimal formula were conducted. The optimized PXM-NS formula (PXM-NS10) showed particle size (362 ± 14.06 nm), polydispersity index (0.0518), zeta potential (17 ± 1.05 mV), and %EE (79.13 ± 4.33). The dissolution study showed a significant increase in the amount of PXM dissolved compared with the unformulated drug. Stability studies confirmed that nanosponge showed accepted stability for 90 days at 4 °C and 25 °C. In vivo analgesic studies verified that there was a significant enhancement in the analgesic response to PXM in mice, and 1.42 fold enhancement in the relative bioavailability of PXM-NS10 as compared to commercial tablets. Nanosponge prepared under optimal conditions is an encouraging formula for increasing the solubility and therefore the bioavailability of Piroxicam.

Synthesis and Characterization of MIPs for Selective Removal of Textile Dye Acid Black-234 from Wastewater Sample

Herein, a molecularly imprinted polymer (MIP) was prepared using bulk polymerization and applied to wastewater to aid the adsorption of targeted template molecules using ethylene glycol dimethacrylate (EGDMA), methacrylic acid (MAA), acid black-234 (AB-234), 2,2'-azobisisobutyronitrile (AIBN), and methanol as a cross linker, functional monomer, template, initiator, and porogenic solvent, respectively. For a non-molecularly imprinted polymer (NIP), the same procedure was followed but without adding a template. Fourier-transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), and a surface area analyzer were used to determine the surface functional groups, morphology and specific surface area of the MIP and NIP. At pH 5, the AB-234 adsorption capability of the MIP was higher (94%) than the NIP (31%). The adsorption isotherm data of the MIP correlated very well with the Langmuir adsorption model with Qm 82, 83 and 100 mg/g at 283 K, 298 K, and 313 K, respectively. The adsorption process followed pseudo-second-order kinetics. The imprinted factor (IF) and Kd value of the MIP were 5.13 and 0.53, respectively. Thermodynamic studies show that AB-234 dye adsorption on the MIP and NIP was spontaneous and endothermic. The MIP proved to be the best selective adsorbent for AB-234, even in the presence of dyes with similar and different structures than the NIP.

Rational Design of Hydrogels for Cationic Antimicrobial Peptide Delivery: A Molecular Modeling Approach.

In light of the growing bacterial resistance to antibiotics and in the absence of the development of new antimicrobial agents, numerous antimicrobial delivery systems over the past decades have been developed with the aim to provide new alternatives to the antimicrobial treatment of infections. However, there are few studies that focus on the development of a rational design that is accurate based on a set of theoretical-computational methods that permit the prediction and the understanding of hydrogels regarding their interaction with cationic antimicrobial peptides (cAMPs) as potential sustained and localized delivery nanoplatforms of cAMP. To this aim, we employed docking and Molecular Dynamics simulations (MDs) that allowed us to propose a rational selection of hydrogel candidates based on the propensity to form intermolecular interactions with two types of cAMPs (MP-L and NCP-3a). For the design of the hydrogels, specific building blocks were considered, named monomers (MN), co-monomers (CM), and cross-linkers (CL). These building blocks were ranked by considering the interaction with two peptides (MP-L and NCP-3a) as receptors. The better proposed hydrogel candidates were composed of MN3-CM7-CL1 and MN4-CM5-CL1 termed HG1 and HG2, respectively. The results obtained by MDs show that the biggest differences between the hydrogels are in the CM, where HG2 has two carboxylic acids that allow the forming of greater amounts of hydrogen bonds (HBs) and salt bridges (SBs) with both cAMPs. Therefore, using theoretical-computational methods allowed for the obtaining of the best virtual hydrogel candidates according to affinity with the specific cAMP. In conclusion, this study showed that HG2 is the better candidate for future in vitro or in vivo experiments due to its possible capacity as a depot system and its potential sustained and localized delivery system of cAMP.

Interleukin-3-dependent potentiation of IgE responsiveness in mouse basophils.

Basophils produce interleukins (IL)-4 in response to various stimuli and may contribute to type 2 immune responses to various infections and allergens. We found that resting basophils freshly isolated from mice produce IL-4 in response to IL-3 but not to high-affinity Fc receptor (FcεRI) cross-linking (CL), yet both required the immunoreceptor tyrosine-based activation motif (ITAM) containing adaptor Fc receptor γ-chain (FcRγ), while basophils activated in vitro by IL-3 become responsive to FcεRI CL. Acquisition of responsiveness to FcεRI CL occurred upon infection with Trichinella spiralis or administration of superantigen. Because cultured basophils return to a quiescent state upon starvation with IL-3 with surface FcεRI levels unchanged, this acquisition is reversible and probably reflects intracellular events requiring protein synthesis. Interestingly, similar activation-associated acquisition was observed for responsiveness to other stimuli, including CD200R3 CL, which is known to signal via DAP-12, and the allergen protease papain. This acquisition of responsiveness to FcεRI CL was inhibited by Jak inhibitor. Thus, the IL-3 signal bifurcates downstream of Jak, into two distinct pathway, one leading to IL-4 production and the other to render basophils competent to respond to stimuli dependent on ITAM-containing adaptors DAP12 and FcRγ for IL-4 production.

Analysis of gelatin secondary structure in gelatin/keratin-based biomaterials

The possibility of using protein-based materials as cellular scaffold strongly depends on protein conformation, and several attempts have been made by researchers to obtain scaffold with morphology miming the extracellular matrix. It is widely recognized that the secondary structure of proteins affects the mechanical and biological properties of protein-based scaffolds. However, few studies have been published, and an exhaustive explanation is still missing. In this work the study of the gelatin structure in gelatin-based materials and the investigation of the possible correlations between structure, mechanical and biological features is reported.We have examined how the secondary structure of gelatin is affected (i) by the process used to obtain the biomaterials (solvent casting vs. electrospinning), (ii) by the concentration of cross linker (3-(Glycidyloxypropyl)trimethoxysilane) (GPTMS), and (iii) by the raw keratin extract added. Gelatin electrospun materials have shown a content of ordered structure higher than gelatin casted films, likely due to the random coil – α-helix transition occuring during electrospinning. GPTMS gives a decrease of ordered structures in gelatin casted films (random structure increasing from 20% to 60%), while it does not affect the percentage of ordered structure in electrospun samples. In the gelatin/keratin electrospun biomaterials, the presence of keratin produces a decrease of α-helix content from 31% to 2–15% and an increase of β-structures, promoting the conversion from antiparallel to parallel β-sheet. The structure of gelatin affects the mechanical performances of biomaterials. In gelatin/keratin electrospun biomaterials we have found a positive correlation between failure strain and helix conformation and a negative correlation with β-structures. Elastic modulus has opposite correlations. All gelatin-based biomaterials have been tested as scaffold for pre-osteoblastic cells showing good biocompatibility for both casted films and electrospun biomaterials.

Guargum/nanocellulose based novel crosslinked antimicrobial film with enhanced barrier and mechanical properties for food packaging

The research towards the achievement of better thermo-mechanical and barrier properties of the polymer blends comprising of guar gum (GG), nanocellulose (NC), polyethylene glycol (PG) and a cross linker i.e. glutaraldehyde (GA) has been discussed. The polymer with the optimal composition i.e., GG (0.8%), NC (0.55%), GA (0.3%) and PG (150 µL) has achieved maximum tensile strength of 41.25 MPa and minimal water vapor permeability of 2.64 × 10−8 g m−1 h−1 Pa−1. The shift of water contact angle from 56° to 104.05° after crosslinking confirms the hydrophobic nature of the film. The moisture uptake capacity of crosslinked film dropped significantly from 11.36% to 3.82%. The FTIR spectra and TGA analysis establish the fact of successful cross linkage and better thermal properties of the composite film, respectively. Soil burial of all the films exhibited more than 85% degradability within 45 days. Further, the crosslinked composite film has exhibited efficient antibacterial activity against gram positive (S. aureus and B. subtilis) and gram negative (E. coli) bacteria. The composite film has been developed as the superior choice of packaging material for enhanced shelf life of food products.

A (cross)link in the chains.

A (cross)link in the chains.

Click chemistry for 3D bioprinting.

Bioinks are employed in the fabrication of 3D scaffolds containing cells and macromolecules that can be applied in regenerative medicine. The use of such bioinks facilitates the controlled introduction and localization of macromolecules, bioactives and cells for the biofabrication of living tissues. To enable the successful preparation of the bioinks, strategies involving the use of so-called cross linkers, which may be ionic, chemical, photo-etc. based, are employed. Some of these strategies such as the use of glutaraldehyde as a crosslinker or harsh crosslinking conditions may however compromise the cytocompatibility of the bioink. To circumvent this challenge, the employment of click chemistry technology has been proposed. This is because, click chemistry can enable the preparation of well-tuned bioinks in the absence of problematic cross-linkers, while ensuring that favorable gelation rate, degradation rate, and cell viability properties of the bioinks are not compromised. Indeed, the bio-orthogonal nature of click chemistry has been suggested to enhance the maintenance of high cell viability in scaffolds. In this regard, the current study explored the potential of using different click chemistries in specific bioprinting techniques. Major bioinks produced using click chemistry were also identified, with existing challenges and future trends discussed. It is anticipated that this review will be invaluable to the tissue engineering field by providing an important resource for bioengineers and a basis of future decisions regarding the selection of the preferred click chemistry for specific bioink functionalities.

Green Synthesis of Chitosan Nano Particles at Different Temperature for Bio-Medical Applications

Chitosan is a semi biopolymer obtained from natural biopolymer Chitin by depolymerisation and de-acetylation. It is bio-degradable, non-toxic and an ideal candidate for pharmaceutical uses. But major bottle-neck of biomedical application of chitosan is that it is insoluble in water therefore we have reported here preparation of ionically cross linked chitosan nano material using tartarate ion as ionic cross linker by greener hydrothermal technique at different temperature and pressure to regulate particle sizes. To the best of our knowledge this is the first time we are reporting hydrothermal synthesis of chitosan nanoparticles at high pressure to regulate particle sizes. Hydro- dynamic particle sizes have been determined by DLS measurement. We have also studied fluorescence behaviour of these chitosan nanoparticles and studied their anti-bacterial activities by Alamar assay on E Coli and S Aureus.

Effect of Corneal Collagen Cross Linking For Keratoconus on The Ocular Higher Order Aberrations Corneal Collagen Cross Linking effect

Effect of Corneal Collagen Cross Linking For Keratoconus on The Ocular Higher Order Aberrations Corneal Collagen Cross Linking effect

Comparative studies on the role of Pr2O3 in the structural analysis (theoretical) of the molybdenum borate glasses

In this paper a comparative study on the effect of Pr2O3 in the structural analysis (theoretical) of molybdenum borate [75PbO–(25-(x + y)) B2O3–yMoO3–xPr2O3] glasses doped with 0.5 mol% and 1 mol% Pr2O3. Comparison of results obtained for 0.5% Pr2O3 with that of reported results of 1 mol% Pr2O3, in terms of parameters used to study structural properties like, cross link density (average) n̅c, force constant (average stretching) F and bonds strength in terms of density nb. Linear variation in all the parameters reported was observed with increase in the concentration of Pr2O3. Present glasses are strong in nature due to the dense structure and bond strength hence, suitable for many opto-electronic device applications.

Preparation and optimization of tetraethyl orthosilicate cross-linked chitosan-guar gum-poly(vinyl alcohol) composites reinforced with montmorillonite for sustained release of sitagliptin

Development of efficient drug carriers has become an integral part of advanced drug delivery systems. This work aims at developing composites by adopting an economically viable method for sustained release of anti-diabetic drug sitagliptin — a potent and selective dipeptidyl peptidase-IV inhibitor. To combat the harsh environment of gastrointestinal tract, the composite (F13) was prepared using biodegradable polymers namely chitosan, guar gum and poly(vinyl alcohol) with montmorillonite clay as nano-filler and tetraethyl orthosilicate as the cross linker. The composites were characterized using FT-IR, XRD, DSC and SEM techniques. Physical properties such as thickness, swelling capacity, folding endurance and water solubility were studied. In vitro analysis of composites (F17, F19 and F20) in simulated gastric medium showed <14 % cumulative release in 2 h while a sustained release was observed in simulated intestinal medium. Drug release kinetics was investigated using five mathematical models namely zero order, first order, Higuchi, Hixon-Crowell and Korsemeyer-Peppas wherein the latter was the best fit model (R2, 0.969). Antimicrobial studies of drug free composite (F13) revealed good activity against bacteria as well as fungi. The results implied that the composites were pH sensitive and could serve as a potential choice for sustained release of drugs.

Kinetic Adsorption and Release Study of Sulfadiazine Hydrochloride Drug from Aqueous Solutions on GO/P(AA-AM-MCC) Composite

The composite was made by free radical polymerization of graphene oxide and acrylic acid, with microcrystalline cellulose and acryl amid serving as the monomer, N, N-methylene bis- acryl amide (MBA) as the cross linker and potassium persulfate (KPS) as the initiator. Graphene oxide/ poly (acrylic acid-acryl amid-microcrystalline cellulose) [GO/P(AA-AM-MCC)] super adsorbent composite characterized by Fourier transform infrared (FTIR) Field emission scanning electron microscopy (FESEM) Acute Flaccid Myelitis (AFM) Differential scanning calorimetry (DSC) thermogravimetric analysis (TGA) and Brunauer–Emmett–Teller (BET). A sulfadiazine drug (SFDH) was removed from an aqueous solution using the synthesized composite as an adsorbent. To learn more about the adsorption process, we used data from the Langmuir and Freundlich models equation. The study clarified the impact of some parameters, such as adsorbate weight at the range of 0.01–0.1 g, and equilibrium time at the range (1–360) minutes. It is found that the best weight of adsorbate was 0.05 gm and a contact time was 120 minutes. Adsorption appears to follow the Freundlich and Langmuir isotherms; the kinetics of drug adsorption have been investigated using pseudo-first order and pseudo-second order rate expressions. The synthesized adsorbent also demonstrated a very high release rate and high removal efficiency of the drug SFDH from its aqueous solution.

Discussion on Digital Transformation of Small and Medium-sized Enterprises in the Post-epidemic Era

Driven by digital technology, China's digital economy is developing rapidly, and its position in the economy and society is getting higher and higher. As the main force of China's economy, employment and GDP, SMEs have been greatly impacted by the COVID-19 epidemic. It is of great practical significance to study the digital transformation of SMEs for the relief and development of SMEs after the epidemic and to promote the development of China's digital economy. A questionnaire survey was conducted on the status quo, problems and policy appeals of China's small and medium-sized enterprises' digital transformation. The survey object was the principals of 925 small and medium-sized manufacturing enterprises. The survey questions included 11 issues such as difficulties faced by enterprises in business operation, application of digital technology, effectiveness of digital transformation, and driving factors of digital transformation. On this basis, the study was carried out. The survey results show that SMEs in China generally have problems such as lack of digital transformation thinking, weak digital foundation, and large obstacles to digital transformation. The vulnerability of SMEs themselves and the differences between different types of SMEs increase the difficulty of digital transformation. The classified statistics of SMEs based on different dimensions such as the development stage, location, and scale of enterprises show that there are significant differences between different types of SMEs and the total sample, as well as between different types of SMEs in terms of difficulties faced in operation, effectiveness of digital transformation, status quo of digital transformation, application of digital technology, driving factors of digital transformation, and policy appeals; Meeting market demand, improving production efficiency and significantly reducing costs are the driving factors for SMEs to carry out digital transformation, but there are differences between different types of SMEs. In order to effectively promote the digital transformation of small and medium-sized enterprises in China, it is suggested to give full play to the guidance and policy support of government departments based on the policy demands of small and medium-sized enterprises for digital transformation, accelerate the construction of new infrastructure, and provide more solid digital transformation foundation for small and medium-sized enterprises; Take multiple measures to eliminate the shortage of digital talents, improve and innovate the talent training mechanism, and provide talent support for digital transformation; Build a digital platform and network, build a cross industry and cross link digital collaboration system, open up the digital transformation path of SMEs, and boost their digital transformation and development.

Superporous acrylic acid and HPMC hydrogels of mefenamic acid: Formulation, characterization and optimization by central composite design.

The purpose of the study was to devise the superporous hydrogels (SPHs) of mefenamic acid (MA) to acquire the sustained action of the MA in the body. The superporous hydrogels of mefenamic acid were formulated by employing the gas blowing method. The central composite rotatable design (CCRD) was applied to optimize the effect of independent formulation factors like acrylic acid (AC), HPMC and glycerol (GLY) over dependent variables like porosity, viscosity, drug content and swelling ratio of superporous hydrogels in water, phosphate buffer (pH 6.8) and in 0.1N HCl (pH 1.2). A number of characteristics such as void fraction, surface morphology by Scanning electron microscopy (SEM) and in vitro drug release study were governed along with physico-chemical analysis by Fourier transform infrared spectroscopy (FTIR), Differential scanning calorimetry (DSC) and appraised statistically by employing the ANOVA. The comparative analgesic activity of optimized superporous hydrogel formulation SPH17 was also analyzed by using tail flick method. The Fourier transform infrared spectroscopy and Differential scanning calorimetry studies approved the physical compatibility between the polymers and the drug. The Scanning electron microscopy study specified micrographic insight about the structure of formed formulations comprising presence of pores, fibers and drug-hole aggregates. The superporous hydrogels were detected to be low dense as they expressed density lower than 0.75g/cc. The decrease in concentration of the polymers and cross linker contributed towards the increase in the void fraction of the superporous hydrogel formulations. The optimized formulation SPH 17 exhibited a highly sustained release of MA for up to 10h in the both 0.1N HCl and phosphate buffer (66.6%) media. The non-fickian release of drug revealed the coupling of the diffusion and polymer relaxation mechanism of the drug release from the formulations. The obtained outcomes suggested that analgesic effect of SPH 17 was significantly (p < 0.05) higher than that of simple suspension of mefenamic acid and total analgesic effect duration for superporous hydrogel was also doubled as compared to the duration of analgesic effect produced by drug suspension. The successfully formulated SPH with HPMC K100M as a gelling agent had sustained the action of the mefenamic acid (MF) by improving its poor solubility and permeability. The introduction of inter-penetrating polymeric network (acrylic acid) using glycerol as a cross linker impart increased residence time to superporous hydrogels which ultimately enhanced the feasibility of using superporous hydrogel as oral sustained release devices particularly for gastric retention.

Effect of single and dual modifications with cross-linking and octenylsuccinylation on physicochemical, in-vitro digestibility, and emulsifying properties of cassava starch

Native cassava starch (NCS) was chemically modified by cross-linking (CL), octenylsuccinylation (OS), CL followed by OS, and OS followed by CL. The modified cassava starches (MCS) were determined for physicochemical, in-vitro digestibility, and emulsifying properties. For the dual modifications, the functional groups introduced in the first modification were partially replaced by the ones that introduced in the second modification. The X-ray diffraction pattern and relative crystallinity of cassava starch did not change by both modifications, indicating that both reactions occurred predominantly in amorphous regions as well as on the surface of starch granules and did not alter the crystalline pattern in the granules. The physicochemical and emulsifying properties of the dual MCS were predominantly affected by the functional groups introduced in the second modification. For the in-vitro digestibility, the dual MCS exhibited the highest resistant starch content of 19.48–22.00% in comparison with the NCS (6.05%) and the single MCS (10.76–14.49%), possibly due to a synergistic effect of the functional groups introduced in the first and second modifications.

Is it a requirement or a preference to use cross-links in lumbar instrumentation?

Background/Aim: The use of cross-links (CL) is controversial due to reasons such as cost increases and instrument redundancy. While there are many biomechanical studies, the clinical data is limited. The aim of this study is to present the clinical effects of CL by putting forward postoperative clinical outcomes and long-term results of patients with (CL+) and without (CL-) CL augmentation. Methods: In this retrospective cohort study, patients who underwent lumbar posterior instrumentation with CL+ (n = 164) and without CL- (n = 111) augmentation were evaluated. Demographic data, surgical results, preoperative and postoperative visual analogue scale (VAS), the Oswestry Disability Index (ODI) differences, and pseudoarthrosis and adjacent segment disease (ASD)-related recurrence for more than three years of follow-up were determined. Data of CL+ and CL- groups were compared. Results: CL+ and CL- groups were similar in terms of age and gender (P = 0.319 and P = 0.777, respectively) There was no difference between the two groups in terms of bleeding amount, duration of surgery, and duration of hospitalization (P = 0.931, P = 0.669 and P = 0.518, respectively). Groups were similar in terms of VAS and ODI differences (P = 0.915 and P = 0.983, respectively), yet there was one case of infection in the CL+ group and two cases of infection detected in the CL- group. There were 13 ASDs in the CL+ group, and eight ASDs in the CL- group. Pseudoarthrosis was seen seven times in the CL+ group, while it was four in the CL- group. Conclusion: It was observed that adding CL in patients who underwent lumbar instrumentation did not change the early period surgical results. The prevalence of complications was compatible with the scientific literature. In our study, there was no preventive advantage in terms of clinical or postoperative complications found in the use of CL.

Effect of PACK Corneal Cross Linking on Resistant Bacterial Keratitis

Effect of PACK Corneal Cross Linking on Resistant Bacterial Keratitis

Characteristics of Collagen Changes in Small Intestine Anastomoses Induced by High-Frequency Electric Field Welding.

High-frequency electric field welding-induced tissue fusion has been explored as an advanced surgical method for intestinal anastomoses; however, intrinsic mechanisms remain unclear. The aim of this study was to investigate microcosmic changes of collagen within the fusion area, with various parameters. Ex vivo small intestine was fused with mucosa-mucosa. Four levels of compressive pressure (100 kPa, 150 kPa, 200 kPa, 250 kPa) were applied for 10 s in order to fuse the colons under a power level of 140 W. Then, collagen fibers of the fusion area were examined by fibrillar collagen alignment and TEM. Three levels of power (90 W, 110 W, 140 W) and three levels of time (5 s, 10 s, 20 s) were applied in order to fuse colons at 250 kPa, and then collagen within the fusion area was examined by Raman spectroscopy. Fibrillar collagen alignment analysis showed that with the increase in compression pressure, alignment of the collagen in the fusion area gradually increased, and the arrangement of collagen fibers tended to be consistent, which was conducive to the adhesion of collagen fibers. TEM showed that pressure changed the distribution and morphology of collagen fibers. Raman spectroscopy showed that increased power and time within a certain range contributed to collagen cross linking. Peak positions of amide I band and amide III band changed. These results suggested that higher power and a longer amount of time resulted in a decrease in non-reducible cross links and an increase in reducible cross links. Compression pressure, power, and time can affect the state of collagen, but the mechanisms are different. Compressive pressure affected the state of collagen by changing its orientation; power and time denatured collagen by increasing temperature and improved the reducible cross linking of collagen to promote tissue fusion.

Cross-Linked Ionic Liquid Polymer for the Effective Removal of Ionic Dyes from Aqueous Systems: Investigation of Kinetics and Adsorption Isotherms.

In the current study, we have synthesized an imidazolium based cross-linked polymer, namely, 1-vinyl-3-ethylimidazolium bis(trifluoromethylsulfonyl)imide (poly[veim][Tf2N]-TRIM) using trimethylolpropane trimethacrylate as cross linker, and demonstrated its efficiency for the removal of two extensively used ionic dyes-methylene blue and orange-II-from aqueous systems. The detailed characterization of the synthesized poly[veim][Tf2N]-TRIM was performed with the help of 1H NMR, TGA, FT-IR and FE-SEM analysis. The concentration of dyes in aqueous samples before and after the adsorption process was measured using an UV-vis spectrophotometer. The process parameters were optimised, and highest adsorption was obtained at a solution pH of 7.0, adsorbent dosage of 0.75 g/L, contact time of 7 h and dye concentrations of 100 mg/L and 5.0 mg/L for methylene blue and orange-II, respectively. The adsorption kinetics for orange-II and methylene blue were well described by pseudo-first-order and pseudo-second-order models, respectively. Meanwhile, the process of adsorption was best depicted by Langmuir isotherms for both the dyes. The highest monolayer adsorption capacities for methylene blue and orange-II were found to be 1212 mg/g and 126 mg/g, respectively. Overall, the synthesized cross-linked poly[veim][Tf2N]-TRIM effectively removed the selected ionic dyes from aqueous samples and provided &gt;90% of adsorption efficiency after four cycles of adsorption. A possible adsorption mechanism between the synthesised polymeric adsorbent and proposed dyes is presented. It is further suggested that the proposed ionic liquid polymer adsorbent could effectively remove other ionic dyes and pollutants from contaminated aqueous systems.