Subchannel analysis is an essential tool for analyzing the thermal-hydraulic and safety characteristics during the design of nuclear reactor cores. In the present study, a general flow sweeping mixing model is proposed to describe the flow sweeping effect in subchannel analysis, and the model form can be applied to rod bundles with arbitrary types of spacers. As an example, the general flow sweeping mixing model is applied to a wire-wrapped assembly proposed by Shanghai Jiao Tong University. In this example, the model factors are derived from numerical results, and the model coefficient is determined by experimental data. The model is evaluated by comparing it with existing models and experiment data, and the comparison results show the superiority of the new model. The crossflow rate of subchannel gaps caused by wire along the axial direction can be estimated by new model. The present study provides a new idea for the development of the flow sweeping mixing model used in subchannel analysis.