The cable support photovoltaic module system has obvious characteristics of wind-induced vibration. In order to study the wind-induced vibration response characteristics and mechanism of the double-cable support photovoltaic module systems, and further discuss the stiffness control criterion. The wind-induced vibration response of a new type of cable-truss support photovoltaic module system with a span of 35m is studied through the aeroelastic wind tunnel test. Firstly, the scaled aeroelastic test model was established to meet the aeroelastic test requirements. Then, the effects of wind direction, PV module inclination angle, and stability cable initial prestress on the wind-induced vibration response characteristics under uniform flow and turbulent field are studied. Finally, the wind-induced vibration response mechanism and stiffness control criterion are discussed. The results show that the increase of inclination angle will lead to a decrease in critical wind speed, the 0° wind direction is the most unfavorable, and the increase of initial prestress can increase the critical wind speed but is inefficient. The critical wind speed under the turbulent flow field is about 30% higher than that of the uniform flow field. The instability vibration is the result of multi-mode coupled vibration of vertical bending and torsion. It is suggested that the stiffness control criterion is more appropriate as 1/100. The research results are of great significance for the design and application of the cable support photovoltaic module system.